Cyclophosphamide-Induced Immunological Tolerance: an Overview

SCHWARTZ, 1959, Drug-induced immunological tolerance, Nature, 183, 1682, 10.1038/1831682a0

MEEKER, 1960, Alteration of homograft response by antimetabolites, Ann. N. Y. Acad. Sci., 87, 203, 10.1111/j.1749-6632.1960.tb23193.x

STERZL, 1960, Inhibition of the inductive phase of antibody formation by 6mercaptopurine examined by the transfer of isolated cells, Nature, 185, 256, 10.1038/185256a0

ROBINSON, 1960, 6-Mercaptopurine in immunological responsiveness, Nature, 187, 796, 10.1038/187796a0

CALNE, 1960, The rejection of renal homografts inhibition in dogs by 6mercaptopurine, Lancet, 1, 417, 10.1016/S0140-6736(60)90343-3

UPHOFF, 1961, Drug-induced immunological -tolerance- for homotransplantation, Transplant. Bull., 28, 110, 10.1097/00006534-196107000-00040

MCLAREN, 1961, Induction of tolerance to skin homografts in adult mice treated with 6-mercaptopurine, Transplant. Bull., 28, 479, 10.1097/00006534-196110000-00045

MAGUIRE, 1961, Specific immune tolerance to anaphylactic sensitization (egg albumin) induced in the guinea pig by cyclophosphamide (Cytoxan), J. Allergy, 32, 406, 10.1016/0021-8707(61)90018-1

BERENBAUM, 1963, Prolongation of homograft survival in mice with single doses of cyclophosphamide, Nature, 200, 84, 10.1038/200084a0

SUTTON, 1963, Drug effects on survival of homografts of skin, Arch. Surgery, 87, 840, 10.1001/archsurg.1963.01310170126021

Fox, 1964, Suppression of tissue immunity by cyclophosphamide, Transplantation, 64, 475, 10.1097/00007890-196407000-00004

SANTOS, 1965, A comparison of the effects of selected cytotoxic agents on allogeneic skin graft survival in rat, Bull. Johns Hopkins Hosp., 116, 327

FLOERSHEIM, 1972, Curative potencies against amanitin poisoning by cytochrome C, Science, 177, 808, 10.1126/science.177.4051.808

AISENBERG, 1967, Studies on cyclophosphamide-induced tolerance to sheep erythrocytes, J. Exp. Med., 125, 833, 10.1084/jem.125.5.833

HALLE, 1970, Prolongation of skin graft survival in mice by pretreatment with H-2 antigen and cyclophosphamide.'Rev, Eur. Etudes. Clin. Biol., 15, 1090

PEVNITSKY, 1971, Prolonged chimerism of the lymphoid tissue obtained in adult mice with the aid of cyclophosphamide, Bull. Exp. Biol. Med., 8, 71

NIRMUL, 1971, Cyclophosphamide-induced immunologic tolerance to skin homografts, Surg. Forum, 22, 287

STARZL, 1971, Cyclophosphamide and human organ transplantation, Lancet, 2, 70, 10.1016/S0140-6736(71)92046-0

KRIPKE, 1973, Brief communication: effects of chronic cyclophosphamide and methotrexate treatment on skin allograft survival in mice and rats, J. Natl. Cancer Inst., 51, 1355, 10.1093/jnci/51.4.1355

WINKELSTEIN, 1973, Mechanisms of immunosuppression: effects of cyclophosphamide on cellular immunity, Blood, 41, 273, 10.1182/blood.V41.2.273.273

MARQUET, 1975, The induction and abolition of specific immunosuppression of heart allografts in rats by use of donor blood and cyclophosphamide, J. Immunol., 115, 405, 10.4049/jimmunol.115.2.405

BRENT, 1979, Specific unresponsiveness to skin allografts in mice, V. Synergy between donor tissue extract, procarbazine hydrochloride, and antilymphocyte serum in creating a long-lasting unresponsiveness mediated by suppressor T cells. Transplantation, 27, 120

MAYUMI, 1990, Cyclophosphamide-induced chimera-type tolerance to allografts: an overview of drug-induced immunological tolerance Fukuoka, Acta Med., 81, 20

KELLY, 1966, Cell-free antigenic material employed to produce tolerance to skin grafts: tissue sources,, preservation, dose requirements and the effects of combined use with azathioprine and sublethal irradiation. Ann. N. Y. Acad. Sci., 129, 210

STARZL, 1992, Cell migration, chimerism, and graft acceptance, Lancet, 339, 1579, 10.1016/0140-6736(92)91840-5

STARZL, 1993, Chimerism after liver transplantation for type IV glycogen storage disease and type 1 Gaucher's disease, N. Engl. J. Med., 328, 745, 10.1056/NEJM199303183281101

STOCKMAN, 1973, Differential effects of cyclophosphamide on the B and T cell compartments of adult mice, J. Immunol., 110, 277, 10.4049/jimmunol.110.1.277

MURASE, 1993, Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs, Transplantation, 55, 701, 10.1097/00007890-199304000-00003

SHIN, 1984, Drug-induced tolerance to allografts in mice, I. Difference between tumor and skin grafts. Transplantation, 37, 580

MAYUMI, 1986, Drug-induced tolerance to allograft in mice, VII. Optimal protocol and mechanism of cyclophosphamide-induced tolerance in an H-2 haplotype-identical strain combination. Transplant. Proc., 18, 363

MAYUMI, 1987, Druginduced tolerance of allografts in mice, XIII. Tolerance to the H-Y antigen. Transplant. Proc., 19, 2975

MAYUMI, 1989, allograft tolerance in adult mice induced across fully allogeneic (multimajor H-2 plus multiminor histocompatibility) antigen barriers by a tolerance-inducing method using cyclophosphamide, J. Exp. Med., 169, 213, 10.1084/jem.169.1.213

FONTALIN, 1991, Recent state of cyclophosphamide-induced skin allograft tolerance in mice, Immunobiology, 182, 323, 10.1016/S0171-2985(11)80666-2

MAYUMI, 1992, A major difference in the mechanisms of neonatally induced tolerance and cyclophosphamide-induced tolerance, Transplantation., 53, 499, 10.1097/00007890-199202010-00047

MAYUMI, 1985, Drug-induced tolerance to allografts in mice II, Tolerance to tumor allografts of large doses associated with rejection of skin allografts and tumor allografts of small doses. Immunobiology, 169, 147

MAYUMI, 1985, Drug-induced tolerance to allografts in mice, IV. Mechanisms and kinetics of cyclophosphamide-induced tolerance. Transplantation, 39, 209

MAYUMI, 1987, Druginduced tolerance to allografts in mice, X. Augmentation of split tolerance in murine combinations disparate at both H-2 and non-H-2 antigens by the use of spleen cells from donors preimmunized with recipient antigens. Immunobiology, 174, 274

FAN, 1987, Druginduced tolerance to allografts in mice, XI. Tolerance induction using F1 (donor × recipient) spleen cells as a tolerogen. Transplant. Proc., 19, 3513

MAYUMI, 1985, Drug-induced tolerance to allografts in mice, VI. Tolerance induction in H-2-haplotype-identical strain combinations in mice. Transplantation, 40, 188

MAYUMI, 1989, Induction of tolerance across major barriers using a two-step method with genetic analysis of tolerance induction, Immunobiology, 179, 86, 10.1016/S0171-2985(89)80009-9

MATSUURA, 1994, Cyclophosphamide-induced tolerance in fully allogeneic heart transplantation in mice, Cell. Immunol., 155, 501, 10.1006/cimm.1994.1142

MAEDA, 1993, Direct evidence for clonal destruction of allo-reactive T cells in the mice treated with cyclophosphamide after allo-priming, Immunology, 78, 113

DUTTON, 1967, Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes: analysis by the hot pulse technique, J. Exp. Med., 126, 443, 10.1084/jem.126.3.443

SALMON, 1971, Lymphocyte stimulation: selective destruction of cells during blastogenic response to transplantation antigens, Science, 172, 490, 10.1126/science.172.3982.490

ZOSCHKE, 1970, Specificity of antigen recognition by human lymphocytes in vitro, Science, 170, 1404, 10.1126/science.170.3965.1404

TOKUDA, 1986, Drug-induced in vitro tolerance to allogeneic antigens, I. Establishment of a tolerance induction system in a fully allogeneic murine combination. Transplantation, 42, 281

TOKUDA, 1988, Drug-induced in vitro tolerance to allogeneic antigens, 11. Further analysis of in vitro-tolerized spleen cells in a fully allogeneic murine combination. Transplantation, 45, 464

MAYUMI, 1986, Drug-induced tolerance to allografts in mice, IX. Establishment of complete chimerism by allogeneic spleen cell transplantation from donors made tolerant to H2-identical recipients. Transplantation, 42, 417

MAYUMI, 1989, The necessity of both allogeneic antigens and stem cells for cyclophosphamide-induced skin allograft tolerance in mice, Immunobiology, 178, 287, 10.1016/S0171-2985(89)80053-1

ETO, 1990, Intrathymic clonal deletion of Vβ6+ T cells in cyclophosphamide-induced tolerance to H-2compatible, Mls-disparate antigens, J. Exp. Med., 171, 97, 10.1084/jem.171.1.97

ETO, 1990, Sequential mechanisms of cyclophosphamide-induced skin allograft tolerance including the intrathymic clonal deletion followed by late breakdown of the clonal deletion, J. Immonol., 145, 1303, 10.4049/jimmunol.145.5.1303

ETO, 1990, The requirement of intrathymic mixed chimerism and clonal deletion for a long-lasting skin allograft tolerance in cyclophosphamide-induced tolerance, Eur. J. Immunol., 20, 2005, 10.1002/eji.1830200919

ETO, 1991, Similarity and difference in the mechanisms of neonatally induced tolerance and cyclophosphamide-induced tolerance in mice, J. Immunol., 147, 2439, 10.4049/jimmunol.147.8.2439

TOMITA, 1992, Mechanisms of cyclophosphamide-induced tolerance to IE-encoded alloantigens: evidence of clonal deletion in MHC antigen-reactive cells for skin allograft rejection, Transplantation, 53, 602, 10.1097/00007890-199203000-00022

MAEDA, 1993, Role of peripheral hemopoietic chimerism in achieving donor-specific tolerance in adult mice, J. Immunol., 150, 753, 10.4049/jimmunol.150.3.753

TOMITA, 1990, Evidence for involvement of clonal anergy in MHC class I and class II disparate skin allograft tolerance after the termination of intrathymic clonal deletion, J. Immunol., 145, 4026, 10.4049/jimmunol.145.12.4026

TOMITA, 1990, Importance of suppressor T cells in cyclophosphamide-induced tolerance to the non-H-2-encoded alloantigens: is mixed chimerism really required in maintaining a skin allograft tolerance? J, Immunol., 144, 463

KAPPLER, 1987, T cell tolerance by clonal elimination in the thymus, Cell, 49, 273, 10.1016/0092-8674(87)90568-X

KAPPLER, 1988, Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex, Nature, 332, 35, 10.1038/332035a0

MACDONALD, 1988, T-cell receptor V(3 use predicts reactivity and tolerance to Mlsa-encoded antigens, Nature, 332, 40, 10.1038/332040a0

MACDONALD, 1988, Intrathymic elimination of Mlsa-reactive (V(3 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens, J. Exp. Med., 167, 2005, 10.1084/jem.167.6.2005

NOMOTO, 1992, Interference with cyclophosphamide-induced skin allograft tolerance by cyclosporin A, J. Immunol., 149, 2668, 10.4049/jimmunol.149.8.2668

DUKOR, 1970, Prevention of cyclophosphamide-induced tolerance to erythrocytes by pretreatment with cortisone, Proc. Soc. Exp. Biol. Med., 133, 280, 10.3181/00379727-133-34456

MAYUMI, 1985, Drug-induced tolerance to allografts in mice, V. Prolongation of skin graft survival in tolerant mice with combined immunosuppressive treatments. Transplantation, 39, 335

ALEXANDER, 1994, A new strategy for prolonging xenograft survival, Transplantation, 58, 14, 10.1097/00007890-199407000-00003

MAYUMI, 1985, Drug-induced tolerance to allografts in mice, VIII. Effects of thymectomy and/or splenectomy on tolerance induction in an H-2-haplotype-indentical strain combination. Transplantation, 40, 438

OPELZ, 1973, Effect of splenectomy on human renal transplants, Transplantation, 15, 605, 10.1097/00007890-197306000-00013

ALEXANDEE, 1987, Present experiences in a series of 26 ABO-incompatible living donor renal allografts, Transplant. Proc., 19, 4538

ABU-ELMAGD, 1993

CHERNYAKHOVSKAYA, 1984, Immunological status of mice with long-standing allogeneic or xenogeneic neonatal heart grafts, Transplantation, 38, 267, 10.1097/00007890-198409000-00014

MAYUMI, 1987, Drug-induced tolerance to allografts in mice, XII. The relationships between tolerance, chimerism, and graft-versus-host disease. Transplantation, 44, 286

ETO, 1991, Specific destruction of host-reactive mature T cells of donor origin prevents graft-versus-host disease in cyclophosphamide-induced tolerant mice, J. Immunol., 46, 1402, 10.4049/jimmunol.146.5.1402

NISHIMURA, 1991, Recombinant human granulocyte colony-stimulating factor improves the compromised state of recipient mice without affecting the induction of specific tolerance in the cyclophosphamide-induced tolerance system, J. Immunol., 146, 2639, 10.4049/jimmunol.146.8.2639

UMESUE, 1995, Xenogeneic (rat→mouse) skin tolerance induced by monoclonal antibodies, xenogeneic cells, and cyclophosphamide, Transplant. Proc., 27, 315