Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs

The American Journal of Medicine - Tập 104 - Trang 413-421 - 1998
Byron Cryer1, Mark Feldman1
1Department of Medicine, Dallas Department of Veterans Affairs Medical Center and University of Texas Southwestern Medical School, Dallas, Texas, USA

Tài liệu tham khảo

Xie, 1991, Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing, Proc Natl Acad Sci, 88, 2692, 10.1073/pnas.88.7.2692 Kujubu, 1991, TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue, J Biol Chem, 266, 12866, 10.1016/S0021-9258(18)98774-0 Picot, 1994, The x-ray crystal structure of the membrane protein prostaglandin H2 synthase-1, Nature, 367, 243, 10.1038/367243a0 DeWitt, 1993, Prostaglandin H synthase isoenzyme selectivity, Am J Med, 95, 40S, 10.1016/0002-9343(93)90396-7 Meade, 1993, Expression of the murine prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes in COX-1 cells, J Lipid Mediators, 6, 119 Williams, 1996, Prostaglandin endoperoxide synthase, Am J Physiol, 270, G393 Morita, 1995, Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2, J Biol Chem, 270, 10902, 10.1074/jbc.270.18.10902 Morham, 1995, Prostaglandin synthase-2 gene disruption causes severe renal pathology in the mouse, Cell, 83, 473, 10.1016/0092-8674(95)90125-6 Hempel, 1994, Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes, J Clin Invest, 93, 391, 10.1172/JCI116971 Kargman, 1996, Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts, Gastroenterology, 111, 445, 10.1053/gast.1996.v111.pm8690211 Ristimaki, 1997, Expression of cyclooxygenase-2 in human gastric carcinoma, Cancer Res, 57, 1276 Chan, 1995, Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337, J Pharmacol Exp Ther, 274, 1531 Langenbach, 1995, Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration, Cell, 83, 483, 10.1016/0092-8674(95)90126-4 Meade, 1993, Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs, J Biol Chem, 268, 6610, 10.1016/S0021-9258(18)53294-4 Glaser, 1995, Etodolac selectively inhibits human prostaglandin G/H synthase 2 (prostaglandin HS-2) versus human prostaglandin HS-1, Eur J Pharm, 281, 107, 10.1016/0014-2999(95)00302-2 Mitchell, 1994, Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase, Proc Natl Acad Sci, 90, 11693, 10.1073/pnas.90.24.11693 Laneuville, 1994, Differential inhibition of human prostaglandin endoperoxide H synthase-1 and -2 by nonsteroidal anti-inflammatory drugs, J Pharmacol Exp Ther, 271, 927 Patrignani, 1994, Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases, J Pharmacol Exp Ther, 271, 1705 Brideau, 1996, A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors, Inflamm Res, 45, 68, 10.1007/BF02265118 Lee, 1992, Nonessential role of leukotrienes as mediators of acute gastric mucosal injury induced by aspirin in rats, Dig Dis Sci, 37, 1282, 10.1007/BF01296573 Redfern, 1987, Effect of indomethacin on gastric mucosal prostaglandins in humans. Correlation with mucosal damage, Gastroenterology, 92, 969, 10.1016/0016-5085(87)90972-3 Colton T. Statistics in Medicine. Boston, Mass: Little, Brown and Co.; 1974. Piper, 1991, Corticosteroid use and peptic ulcer disease, Ann Intern Med, 114, 735, 10.7326/0003-4819-114-9-735 Physicians’ Desk Reference. 51st ed. Montvale, NJ: Medical Economics Co. 1997. Insel, 1990, Analgesic-antipyretics and antiinflammatory agents, 638 Crook, 1982, The pharmacokinetics of diclofenac sodium in patients with active rheumatoid disease, Eur J Clin Pharmacol, 21, 331, 10.1007/BF00637622 Small, 1990, Influence of H2 receptor antagonists on the disposition of flurbiprofen enantiomers, J Clin Pharmacol, 30, 660, 10.1002/j.1552-4604.1990.tb01870.x Davies, 1971, Ibuprofen, Drugs, 2, 416, 10.2165/00003495-197102050-00002 Hundal, 1991, Naproxen free plasma concentrations and unbound fractions in patients with osteoarthritis, Therapeut Drug Monitor, 13, 478, 10.1097/00007691-199111000-00002 Olive, 1993, Effect of age and disease on the pharmacokinetics of nimesulide, Drugs, 46, 73, 10.2165/00003495-199300461-00014 Duggan, 1977, The disposition of sulindac, Clin Pharmacol Ther, 21, 326, 10.1002/cpt1977213326 Friedel, 1988, Nabumetone, Drugs, 35, 504, 10.2165/00003495-198835050-00002 McMahon, 1987, Nabumetone kinetics in the young and elderly, Am J Med, 83, 92, 10.1016/0002-9343(87)90603-6 DeWitt, 1990, The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases, J Biol Chem, 265, 5192, 10.1016/S0021-9258(19)34105-5 Shimokawa, 1992, Prostaglandin endoperoxide synthase. The aspirin acetylation regastrointestinalon, J Biol Chem, 267, 12387, 10.1016/S0021-9258(19)49852-9 Lecomte, 1994, Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin, J Biol Chem, 269, 13207, 10.1016/S0021-9258(17)36820-5 Cryer, 1990, Comparison of salsalate and aspirin on mucosal injury and gastroduodenal mucosal prostaglandins, Gastroenterology, 99, 1616, 10.1016/0016-5085(90)90465-D Graham, 1985, Nonsteroidal anti-inflammatory effect of sulindac sulfoxide and sulfide on gastric mucosa, Clin Pharmacol Ther, 38, 65, 10.1038/clpt.1985.136 Henry, 1996, Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs, BMJ, 312, 1563, 10.1136/bmj.312.7046.1563 Willkens, 1990, An overview of the long-term safety experience of nabumetone, Drugs, 40, 34, 10.2165/00003495-199000405-00008 Lanza, 1997, Selective inhibition of cyclooxygenase-2 (COX-2) with MK-0966 (250 mg q.d.) is associated with less gastroduodenal damage than aspirin (ASA) 650 mg q.i.d. or ibuprofen (IBU) 800 mg t.i.d, Gastroenterology, 112, A194 Lanza, 1997, A pilot endoscopic study of the gastroduodenal effects of SC-5835, a novel COX-2-selective inhibitor, Gastroenterology, 112, A194