Cyclin-Dependent Kinase-5/p35 Phosphorylates Presenilin 1 to Regulate Carboxy-Terminal Fragment Stability

Molecular and Cellular Neurosciences - Tập 20 - Trang 13-20 - 2002
Kwok-Fai Lau1, David R. Howlett2, Sashi Kesavapany1, Claire L. Standen1, Colin Dingwall2, Declan M. McLoughlin1,3, Christopher C.J. Miller1
1Departments of Neuroscience and Neurology, The Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, United Kingdom
2Department of Neurology, GlaxoSmithKline, New Frontiers Science Park (North), Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom
3Section of Old Age Psychiatry, The Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, United Kingdom

Tài liệu tham khảo

Ahlijanian, 2000, Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5, Proc. Natl. Acad. Sci. USA, 87, 2910, 10.1073/pnas.040577797 Bajaj, 1998, Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosis, Neurosci. Lett., 245, 45, 10.1016/S0304-3940(98)00176-1 Baumann, 1997, Distinct processing of endogenous and overexpressed recombinant presenilin 1, Neurobiol. Aging, 18, 181, 10.1016/S0197-4580(97)00004-3 Beaudette, 1993, Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain, J. Biol. Chem., 268, 20825, 10.1016/S0021-9258(19)36859-0 Brownlees, 2000, Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase- 1b/Jun N-terminal kinase-3, J. Cell Sci., 113, 401, 10.1242/jcs.113.3.401 Capell, 1998, The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex, J. Biol. Chem., 273, 3205, 10.1074/jbc.273.6.3205 Checler, 2001, The multiple paradoxes of presenilins, J. Neurochem., 76, 1621, 10.1046/j.1471-4159.2001.00244.x De Strooper, 1997, Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins, J. Biol. Chem., 272, 3590, 10.1074/jbc.272.6.3590 Dhavan, 2001, A decade of cdk5, Nature Rev. Mol. Cell Biol., 2, 749, 10.1038/35096019 Fraser, 2000, Presenilin structure, function and role in Alzheimer disease, Biochim. Biophys. Acta, 1502, 1, 10.1016/S0925-4439(00)00028-4 Guidato, 1996, Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5, J. Neurochem., 66, 1698, 10.1046/j.1471-4159.1996.66041698.x Irving, 1997, Tau phosphorylation in cells transfected with wild-type or an Alzheimer's disease mutant Presenilin-1, Neurosci. Lett., 222, 71, 10.1016/S0304-3940(97)13343-2 Kesavapany, 2001, p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction, Eur. J. Neurosci., 13, 241 Kirschenbaum, 2001, Glycogen synthase kinase-3β regulates presenilin 1 C-terminal fragment levels, J. Biol. Chem., 276, 30701, 10.1074/jbc.M102849200 Kirschenbaum, 2000, Substitution of a GSK-3beta phosphorylation site in presenilin 1 separates presenilin function from β-catenin signaling, J. Biol. Chem., 276, 7366, 10.1074/jbc.M004697200 Lau, 2000, X11α and X11β interact with presenilin-1 via their PDZ domains, Mol. Cell. Neurosci., 16, 555, 10.1006/mcne.2000.0898 Lee, 2000, Neurotoxicity induces cleavage of p35 to p25 by calpain, Nature, 405, 360, 10.1038/35012636 Mercken, 1996, Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing, FEBS Lett., 389, 297, 10.1016/0014-5793(96)00608-4 Nguyen, 2001, Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions, Neuron, 30, 135, 10.1016/S0896-6273(01)00268-9 Patrick, 1999, Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration, Nature, 402, 615, 10.1038/45159 Ratovitski, 1997, Endoproteolytic processing and stabilization of wild-type and mutant presenilin, J. Biol. Chem., 272, 24536, 10.1074/jbc.272.39.24536 Seeger, 1997, Evidence for phosphorylation and oligomeric assembly of presenilin 1, Proc. Natl. Acad. Sci. USA, 94, 5090, 10.1073/pnas.94.10.5090 Shetty, 1993, cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: Isolation and characterization, Proc. Natl. Acad. Sci. USA, 90, 6844, 10.1073/pnas.90.14.6844 Small, 2001, The role of presenilins in gamma-secretase activity: Catalyst or cofactor?, J. Neurochem., 76, 1612, 10.1046/j.1471-4159.2001.00246.x Steiner, 1998, Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation, J. Biol. Chem., 273, 32322, 10.1074/jbc.273.48.32322 Sun, 1996, Phosphorylation of the high molecular weight neurofilament protein (NF-H) by cdk-5 and p35, J. Biol. Chem., 271, 14245, 10.1074/jbc.271.24.14245 Thinakaran, 1996, Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo, Neuron, 17, 181, 10.1016/S0896-6273(00)80291-3 Tomita, 2001, The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation and γ-secretase activities of presenilins, J. Biol. Chem., 276, 33273, 10.1074/jbc.M011152200 Tsai, 1994, p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5, Nature, 371, 419, 10.1038/371419a0 Tsai, 1993, Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system, Development, 119, 1029, 10.1242/dev.119.4.1029 Walter, 1997, Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C, Proc. Natl. Acad. Sci. USA, 94, 5349, 10.1073/pnas.94.10.5349 Walter, 1998, Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms, Biochemistry, 37, 5961, 10.1021/bi971763a Wolfe, 2001, Presenilin and gamma-secretase: Structure meets function, J. Neurochem., 76, 1615, 10.1046/j.1471-4159.2001.00245.x Yu, 1998, The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin, J. Biol. Chem., 273, 16470, 10.1074/jbc.273.26.16470