Cutaneous manifestations of SARS‐CoV‐2 infection: a clinical update

Journal of the European Academy of Dermatology and Venereology - Tập 34 Số 11 - Trang 2499-2504 - 2020
Paolo Gisondi1,2, Stefano Piaserico1,3, Carolina Russo Bordin2, Mauro Alaibac3, Giampiero Girolomoni2, Luigi Naldi4,5
1P. Gisondi and S. Piaserico equally contributed to the manuscript.
2Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy
3Section of Dermatology, Department of Medicine, University of Padua, Padua, Italy
4Centro Studi GISED, Bergamo, Italy
5Division of Dermatology, San Bortolo Hospital, Vicenza, Italy

Tóm tắt

AbstractOn 11 March 2020, the World Health Organization (WHO) has declared the novel coronavirus disease (COVID‐19) a global pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 virus). A consistent number of case reports and clinical series have been already published describing a complex spectrum of skin manifestations associated with the SARS‐CoV‐2 infection. We carried out a review of the English‐language literature up to 20 May 2020, reporting original cases or case series of the cutaneous manifestations of SARS‐CoV‐2 virus infection. The following databases were consulted: PubMed, Embase, Google Scholar and ResearchGate. The search of papers was conducted by using the key term ‘COVID‐19’ or ‘SARS‐CoV‐2’ or ‘coronavirus’ combined with each of the following: ‘skin’, ‘cutaneous’, ‘dermatologic’ or ‘dermatology’, ‘manifestation’, ‘lesions’, or ‘rash’. The patterns of dermatological manifestations associated with SARS‐CoV‐2 infection could be classified into four categories: exanthema (varicella‐like, papulo‐vesicular and morbilliform rash), vascular (chilblain‐like, purpuric/petechial and livedoid lesions), urticarial and acro‐papular eruption. Lastly, other skin manifestations to be considered are the cutaneous adverse reactions to the drugs prescribed for the treatment of COVID‐19. Whether SARS‐CoV‐2 infection can directly cause a worsening of chronic inflammatory diseases such as psoriasis or atopic dermatitis remains to be determined. Dermatology's outlook in the COVID‐19 pandemic is multidimensional.

Từ khóa


Tài liệu tham khảo

Cucinotta D, 2020, WHO declares COVID‐19 a pandemic, Acta Biomed, 91, 157

10.1016/j.ijantimicag.2020.105924

10.1016/S0140-6736(20)30183-5

Su CJ, 2020, Viral exanthem in COVID‐19, a clinical enigma with biological significance, J Eur Acad Dermatol Venereol, 15, e251

Tammaro A, 2020, Cutaneous manifestations in COVID‐19: the experiences of Barcelona and Rome, J Eur Acad Dermatol Venereol, 24

Mungmungpuntipantip R, 2020, COVID‐19 and cutaneous manifestations, J Eur Acad Dermatol Venereol, 34

Hedou M, 2020, Comment on “Cutaneous manifestations in COVID‐19: a first perspective” by Recalcati S, J Eur Acad Dermatol Venereol, 21

10.1111/jdv.16470

Avellana Moreno R, 2020, Cutaneous manifestation of COVID‐19 in images: a case report, J Eur Acad Dermatol Venereol, 19

10.1111/jdv.16669

Duong TA, 2020, Did Whatsapp® reveal a new cutaneous COVID‐19 manifestation?, J Eur Acad Dermatol Venereol, 24

Skayem C, 2020, Teledermatology for COVID‐19 cutaneous lesions: substitute or supplement?, J Eur Acad Dermatol Venereol, 18

10.1016/j.jaad.2020.04.044

Galván Casas C, 2020, Classification of the cutaneous manifestations of COVID‐ 19: a rapid prospective nationwide consensus study in Spain with 375 cases, Br J Dermatol, 29

Ahouach B, 2020, Cutaneous lesions in a patient with COVID‐19: are they related?, Br J Dermatol, 30

Herrero‐Moyano M, 2020, A clinicopathological study of 8 patients with COVID‐19 pneumonia and a late‐onset exanthema, J Eur Acad Dermatol Venereol, 19

Skroza N, 2020, A late onset widespread skin rash in a previous Covid‐19 infected patient: viral or multidrug effect?, J Eur Acad Dermatol Venereol, 18

Reymundo A, 2020, Clinical and histological characterization of late appearance maculopapular eruptions in association with the coronavirus disease 2019. A case series of seven patients, J Eur Acad Dermatol Venereol, 4

10.1111/jdv.16471

Dominguez‐Santas M, 2020, Cutaneous small‐vessel vasculitis associated with novel 2019 coronavirus SARS‐CoV‐2 infection (COVID‐19), J Eur Acad Dermatol Venereol, 26

García‐Gil MF, 2020, Acral purpuric lesions (Erythema multiforme type) associated with thrombotic vasculopathy in a child during the COVID‐19 pandemic, J Eur Acad Dermatol Venereol, 20

10.1056/NEJMc2007575

10.1016/j.cell.2020.02.052

10.1016/j.cell.2020.04.004

Piccolo V, 2020, Chilblain‐like lesions during COVID‐19 epidemic: a preliminary study on 63 patients, J Eur Acad Dermatol Venereol, 24

10.1111/jdv.16387

Bouaziz JD, 2020, Vascular skin symptoms in COVID‐ 19: a french observational study, J Eur Acad Dermatol Venereol, 27

10.1111/pde.14215

López‐Robles J, 2020, Chilblain‐like lesions: a case series of 41 patients during the COVID‐19 pandemic, Clin Exp Dermatol., 5

Tagarro A, 2020, Screening and severity of coronavirus disease 2019 (COVID‐19) in children in Madrid, Spain, JAMA Pediatr, 8, e201346

10.1016/j.jaad.2020.03.036

Jimenez‐Cauhe J, 2020, Reply to “COVID‐19 can present with a rash and be mistaken for Dengue”: petechial rash in a patient with COVID‐19 infection, J Am Acad Dermatol, 10, S0190‐9622(20)3

10.1016/j.trsl.2020.04.007

10.1056/NEJMc2010472

Diaz‐Guimaraens B, 2020, Petechial skin rash associated with severe acute respiratory syndrome coronavirus 2 infection, JAMA Dermatol, 30

Manalo IF, 2020, A dermatologic manifestation of COVID‐19: transient Livedo Reticularis, J Am Acad Dermatol, 10

Fernandez‐Nieto D, 2020, Clinical and histological characterization of vesicular COVID‐19 rashes: a prospective study in a tertiary care hospital, Clin Exp Dermatol, 8

10.1542/hpeds.2020-0123

10.1111/jdv.16474

10.1111/jdv.16472

10.1016/S0140-6736(20)30937-5

10.1007/s12519-019-00269-9

10.1111/ijd.14937

10.1111/pde.14201

10.1016/j.jaad.2020.04.094

Thông tin
Thông tin xuất bản

Journal of the European Academy of Dermatology and Venereology

Tập 34 Số 11

2499-2504

Thông tin tác giả