Current understanding of stem cell mobilization

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Medvinsky, 1996, Definitive hematopoiesis is autonomously initiated by the AGM region, Cell, 86, 897, 10.1016/S0092-8674(00)80165-8

Oostendorp, 2002, Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity, Blood, 99, 1183, 10.1182/blood.V99.4.1183

Medvinsky, 1999, Development of the hematopoietic stem cell, Blood, 94, 3613

Cumano, 2001, Intraembryonic, but not york sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution, Immunity, 15, 477, 10.1016/S1074-7613(01)00190-X

Yoder, 1997, Engraftment of embryonic hematopoietic cells in conditioned newborn recipients, Blood, 89, 2176, 10.1182/blood.V89.6.2176

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Papayannopoulou, 2000, Mechanisms of stem-/progenitor-cell mobilization, Semin Hematol, 37, 11, 10.1016/S0037-1963(00)90084-2

Wright, 2001, Physiological migration of hematopoietic stem and progenitor cells, Science, 294, 1933, 10.1126/science.1064081

Fu, 2000, Mobilization of hematopoietic stem cells, Blood Rev, 14, 205, 10.1054/blre.2000.0138

Vaday, 2000, Extracellular matrix moieties, cytokines, and enzymes, J Leukoc Biol, 67, 149, 10.1002/jlb.67.2.149

Steidl, 2002, Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow–derived and circulating human CD34+ hematopoietic stem cells, Blood, 99, 2037, 10.1182/blood.V99.6.2037

Graf, 2001, Comparison of gene expression in CD34+ cells from bone marrow and G-CSF-mobilized peripheral blood by high-density oligonucleotide array analysis, Biol Blood Marrow transpl, 7, 486, 10.1053/bbmt.2001.v7.pm11669215

Takamatsu, 1998, Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization, Blood, 92, 3465, 10.1182/blood.V92.9.3465

To, 1997, The biology and clinical uses of blood stem cells, Blood, 89, 2233, 10.1182/blood.V89.7.2233

Link, 2000, Mechanisms of granulocyte colony-stimulating factor–induced hematopoietic progenitor-cell mobilization, Semin Hematol, 37, 25, 10.1016/S0037-1963(00)90086-6

Roberts, 1995, Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines, Blood, 86, 1600, 10.1182/blood.V86.4.1600.bloodjournal8641600

Uchida, 1997, The unexpected G0/G1 cell cycle status of mobilized hematopoietic stem cells from peripheral blood, Blood, 89, 465, 10.1182/blood.V89.2.465

Morrison, 1997, Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization, Proc Natl Acad Sci U S A, 94, 1908, 10.1073/pnas.94.5.1908

Wright, 2001, Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle, Blood, 97, 2278, 10.1182/blood.V97.8.2278

Verfaillie, 2002, Hematopoietic stem cells for transplantation, Nature Immunology, 3, 314, 10.1038/ni0402-314

Korbling, 2001, Peripheral blood stem cell vs bone marrow allotransplantation, Blood, 98, 2900, 10.1182/blood.V98.10.2900

Mohle, 1993, Expression of adhesion molecules and c-kit on CD34+ hematopoietic progenitor cells, J Hematother, 3, 483, 10.1089/scd.1.1993.2.483

Pruijt, 1999, Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9), Proc Natl Acad Sci U S A, 96, 10863, 10.1073/pnas.96.19.10863

Papayannopoulou, 1993, Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin, Proc Natl Acad Sci U S A, 90, 9374, 10.1073/pnas.90.20.9374

Levesque, 2001, Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor, Blood, 98, 1289, 10.1182/blood.V98.5.1289

Frenette, 2000, Sulfated glycans induce rapid hematopoietic progenitor cell mobilization, Blood, 96, 2460, 10.1182/blood.V96.7.2460

Sweeney, 2000, Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence, Proc Natl Acad Sci U S A, 97, 6544, 10.1073/pnas.97.12.6544

Nagasawa, 1996, Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1, Nature, 382, 635, 10.1038/382635a0

Ma, 1999, The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment, Immunity, 10, 463, 10.1016/S1074-7613(00)80046-1

Zou, 1998, Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development, Nature, 393, 595, 10.1038/31269

Hargreaves, 2001, A coordinated change in chemokine responsiveness guides plasma cell movements, J Exp Med, 194, 45, 10.1084/jem.194.1.45

Egawa, 2001, The earliest stages of B cell development require a chemokine stromal cell–derived factor/pre–B cell growth-stimulating factor, Immunity, 15, 323, 10.1016/S1074-7613(01)00185-6

Kawabata, 1999, A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution, Proc Natl Acad Sci U S A, 96, 5663, 10.1073/pnas.96.10.5663

Cheng, 2000, Hematopoietic stem cell quiescence maintained by p21cip1/waf1, Science, 287, 1804, 10.1126/science.287.5459.1804

Kollet, 2000, SDF-1 induces survival, adhesion, and migration in 3D ECM-like gels of murine CXCR4null fetal liver cells via another GPCR, Blood, 96, 65a

Janowska-Wieczorek, 2001, Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment, Blood, 98, 3143, 10.1182/blood.V98.10.3143

Sawada, 1998, Disturbed CD4+ T cell homeostasis and in vitro HIV-1 susceptibility in transgenic mice expressing T cell line-tropic HIV-1 receptors, J Exp Med, 187, 1439, 10.1084/jem.187.9.1439

Broxmeyer, 1999, Enhanced myelopoiesis in SDF-1-transgenic mice, Blood, 94, 650a

Onai, 2000, Impairment of lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow-hematopoietic progenitor cells expressing SDF-1-intrakine, Blood, 96, 2074, 10.1182/blood.V96.6.2074

Lee, 2002, Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines, Blood, 99, 4307, 10.1182/blood.V99.12.4307

Wright, 2002, Hematopoietic stem cells are uniquely selective in their migratory response to chemokines, J Exp Med, 195, 1145, 10.1084/jem.20011284

Laterveer, 1995, Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability, Blood, 85, 2269, 10.1182/blood.V85.8.2269.bloodjournal8582269

Fibbe, 2000, The role of metalloproteinases and adhesion molecules in interleukin-8-induced stem cell mobilization, Semin Hematol, 37, 19, 10.1016/S0037-1963(00)90085-4

Torensma, 1996, Induction of LFA-1 on pluripotent CD34+ bone marrow cells does not affect lineage commitment, Blood, 87, 4120, 10.1182/blood.V87.10.4120.bloodjournal87104120

Asaumi, 2001, Very late antigen-5 and leukocyte function–associated antigen-1 are critical for early stage hematopoietic progenitor cell homing, Ann Hematol, 80, 387, 10.1007/s002770100309

de Kruijf, 2001, IL-8 induced hematopoietic progenitor cell mobilization in mice coincides with MMP-9 (gelatinase-B) release from neutrophils and is not reduced in MMP-9 deficient mice, Blood, 98, 83a

King, 2001, Blood, 97, 1534, 10.1182/blood.V97.6.1534

Kronenwett, 2000, The role of cytokines and adhesion molecules for mobilization of peripheral blood stem cells, Stem Cells, 18, 320, 10.1634/stemcells.18-5-320

Aiuti, 1997, The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to the peripheral blood, J Exp Med, 185, 111, 10.1084/jem.185.1.111

Peled, 1999, Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4, Science, 283, 845, 10.1126/science.283.5403.845

Hattori, 2001, Plasma elevation of stromal-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells, Blood, 97, 3354, 10.1182/blood.V97.11.3354

Shen, 2001, CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells, J Immunol, 166, 5027, 10.4049/jimmunol.166.8.5027

Sweeney, 2002, Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice, Blood, 99, 44, 10.1182/blood.V99.1.44

Gazitt, 2001, Plasma levels of SDF-1 and expression of SDF-1 receptor on CD34+ cells in mobilized peripheral blood of non-Hodgkin's lymphoma patients, Stem Cells, 19, 37, 10.1634/stemcells.19-1-37

Voermans, 2001, In vitro migratory capacity of CD34+ cells is related to hematopoietic recovery after autologous stem cell transplantation, Blood, 97, 799, 10.1182/blood.V97.3.799

Delgado, 2001, Rapid inactivation of stromal cell–derived factor-1 by cathepsin G associated with lymphocytes, Eur J Immunol, 31, 699, 10.1002/1521-4141(200103)31:3<699::AID-IMMU699>3.0.CO;2-6

McQuibban, 2001, Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell–derived factor 1, J Biol Chem, 276, 43503, 10.1074/jbc.M107736200

Valenzuela-Fernandez, 2002, Leukocyte elastase negatively regulates stromal cell-derived factor-1 (SDF)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4, J Biol Chem, 277, 15677, 10.1074/jbc.M111388200

Levesque, 2001, SDF-1α is inactivated by proteolytic cleavage in the bone marrow of mice mobilized by either G-CSF or cyclophosphamide, Blood, 98, 831a

Lapidot, 1999, A single dose of human G-CSF inhibited production of SDF-1 in the bone marrow and upregulated CXCR4 expression on immature and mature hematopoietic cells prior to their mobilization, Blood, 94, 606a

Petit, 2001, Involvement of SDF-1/CXCR4 interactions in G-CSF induced mobilization of human and murine stem/progenitor cells, Blood, 98, 811a

Petit, 2002, G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and upregulating CXCR4, Nature Immunology, 3, 687, 10.1038/ni813

Dale, 2000, Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia, Blood, 96, 2317, 10.1182/blood.V96.7.2317

Pelletier, 2000, Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells, Blood, 96, 2682, 10.1182/blood.V96.8.2682

Cinamon, 2001, Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines, Nature Immunology, 2, 515, 10.1038/88710

Poznansky, 2000, Active movement of T cells away from a chemokine, Nat Med, 6, 543, 10.1038/75022

Heissig, 2000, In vivo inhibition of metalloproteinases blocks chemo-cytokine induced endothelial and hematopoietic stem cell mobilization, Blood, 96, 540a

Heissig, 2002, Matrix recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand, Cell, 109, 625, 10.1016/S0092-8674(02)00754-7

Peled, 2000, The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells, Blood, 95, 3289, 10.1182/blood.V95.11.3289

Kollet, 2001, Exclusive homing of human CD38−/low CXCR4+ stem cells to the spleen and bone marrow of immune deficient mice within 1–6 hours, Blood, 97, 3283, 10.1182/blood.V97.10.3283

Rosu-Myles, 2000, The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression, Proc Natl Acad Sci U S A, 97, 14626, 10.1073/pnas.97.26.14626

Bhatia, 1997, Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice, Proc Natl Acad Sci U S A, 94, 5320, 10.1073/pnas.94.10.5320

Kollet, 2002, Sorted human cord blood CD34+CXCR4− cells contain internal CXCR4 which can oscillate in vivo and rescue low SDF-1 dependent repopulation in NOD/SCID mice, Blood, in press

Aiuti, 1999, Human CD34+ cells express CXCR4 and its ligand stromal cell–derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus, Blood, 94, 62, 10.1182/blood.V94.1.62.413k04_62_73

Lataillade, 2002, Stromal cell–derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34+ cells, Blood, 99, 1117, 10.1182/blood.V99.4.1117

Cashman, 2002, Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice, Blood, 99, 792, 10.1182/blood.V99.3.792

Viardot, 1998, The human immunodeficiency virus (HIV)-type 1 coreceptor CXCR-4 (fusin) is preferentially expressed on the more immature CD34+ hematopoietic stem cells, Ann Hematol, 77, 193, 10.1007/s002770050442

Glimm, 2002, Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice, Blood, 99, 3454, 10.1182/blood.V99.9.3454

Lambertsen, 1984, A model of intramedullary hematopoietic microenvironments based on stereologic study of the distribution of endocloned marrow colonies, Blood, 63, 287, 10.1182/blood.V63.2.287.287

Nilsson, 1998, Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ, J Histochem Cytochem, 46, 371, 10.1177/002215549804600311

Imai, 1999, Selective transendothelial migration of hematopoietic progenitor cells, Blood, 93, 149, 10.1182/blood.V93.1.149

Ponomaryov, 2000, Increased expression of the chemokine SDF-1 following DNA damage, J Clin Invest, 106, 1331, 10.1172/JCI10329

Nilsson, 2001, Spatial localization of transplanted hemopoietic stem cells, Blood, 97, 2293, 10.1182/blood.V97.8.2293

Spencer, 2001, Enumeration of bone marrow “homing” haemopoietic stem cells from G-CSF-mobilized normal donors and influence on engraftment following allogeneic transplantation, Bone Marrow Transplant, 28, 1019, 10.1038/sj.bmt.1703289

Podesta, 2001, Transplantation hematopoiesis, Curr Opin Hematol, 8, 331, 10.1097/00062752-200111000-00003