Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention

Srivastava, 2015, Modulation of microRNAs by phytochemicals in cancer: underlying mechanisms and translational significance, Biomed. Res. Int., 2015, 10.1155/2015/848710 Guarnieri, 2008, MicroRNAs: a new class of gene regulators, Ann. Med., 40, 197, 10.1080/07853890701771823 Jeong, 2011, Aberrant expression of let-7a miRNA in the blood of non-small cell lung cancer patients, Mol. Med. Rep., 4, 383 Mallick, 2010, Micro RNAs and lung cancer: biology and applications in diagnosis and prognosis, J. Carcinog., 9, 8, 10.4103/1477-3163.67074 Patnaik, 2010, Detection of microRNAs in dried serum blots, Anal. Biochem., 407, 147, 10.1016/j.ab.2010.08.004 Rothe, 2011, Global microRNA expression profiling identifies miR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer, PLoS One, 6, e20980, 10.1371/journal.pone.0020980 Enerly, 2011, MiRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors, PLoS One, 6, e16915, 10.1371/journal.pone.0016915 Hwang-Verslues, 2011, miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via down-regulation of E-cadherin and REDD1, Oncogene, 30, 2463, 10.1038/onc.2010.618 Shimono, 2009, Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells, Cell, 138, 592, 10.1016/j.cell.2009.07.011 Gregory, 2008, MicroRNAs as regulators of epithelial-mesenchymal transition, Cell Cycle, 7, 3112, 10.4161/cc.7.20.6851 Yu, 2012, MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells, J. Biol. Chem., 287, 465, 10.1074/jbc.M111.280768 Bartels, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5 Lee, 2004, MicroRNA genes are transcribed by RNA polymerase II, EMBO J., 23, 4051, 10.1038/sj.emboj.7600385 Denli, 2004, Processing of microRNAs by the microprocessor complex, Nature, 432, 231, 10.1038/nature03049 Lund, 2004, Nuclear export of miRNA precursors, Science, 303, 95, 10.1126/science.1090599 Zeng, 2002, Both natural and designed microRNAs can inhibit the expression of cognate mRNAs when expressed in human cells, Mol. Cell., 9, 1327, 10.1016/S1097-2765(02)00541-5 Hutvagner, 2001, A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA, Science, 293, 834, 10.1126/science.1062961 Schmidt, 2014, Drug target miRNAs: chances and challenges, Trends Biotechnol., 32, 578, 10.1016/j.tibtech.2014.09.002 Jackson, 2003, Expression profiling reveals off-target gene regulation by RNAi, Nat. Biotechnol., 21, 635, 10.1038/nbt831 Lewis, 2005, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targtets, Cell, 120, 15, 10.1016/j.cell.2004.12.035 Vasudevan, 2007, Switching from repression to activation: microRNAs can up-regulate translation, Science, 318, 1931, 10.1126/science.1149460 Eiring, 2010, MiR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic cells, Cell, 140, 652, 10.1016/j.cell.2010.01.007 Wu, 2010, Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region, Oncogene, 29, 2302, 10.1038/onc.2010.34 Calin, 2006, MicroRNA signatures in human cancers, Nat. Rev. Cancer, 6, 857, 10.1038/nrc1997 di Leva, 2014, MicroRNAs in cancer, Ann. Rev. Pathol., 9, 287, 10.1146/annurev-pathol-012513-104715 Bouyssou, 2014, Regulation of microRNAs in cancer metastasis, Biochim. Biophys. Acta, 22, 255 King, 2013, MicroRNAs and other non-coding RNAs as targets for anticancer drug development, Nat. Rev. Drug Discov., 12, 847, 10.1038/nrd4140 Yu, 2007, Let-7 regulates self renewal and tumorigenicity of breast cancer cells, Cell, 131, 1109, 10.1016/j.cell.2007.10.054 Johnson, 2005, RAS is regulated by the let-7 microRNA family, Cell, 120, 635, 10.1016/j.cell.2005.01.014 Kumar, 2008, Suppression of non-small cell lung tumor development by the let-7 microRNA family, Proc. Natl. Acad. Sci. U. S. A., 105, 3903, 10.1073/pnas.0712321105 Zhang, 2007, microRNAs as oncogenes and tumor suppressors, Dev. Biol., 302, 1, 10.1016/j.ydbio.2006.08.028 Takamizawa, 2004, Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened post-operative survival, Cancer Res., 64, 3753, 10.1158/0008-5472.CAN-04-0637 Calin, 2002, Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia, Proc. Natl. Acad. Sci. U. S. A., 99, 15524, 10.1073/pnas.242606799 Cimmino, 2005, MiR-15 and miR-16 induce apoptosis by targeting BCL2, Proc. Natl. Acad. Sci. U. S. A., 102, 13944, 10.1073/pnas.0506654102 Takeshita, 2010, Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via down-regulation of multiple cell-cycle genes, Mol. Ther., 18, 181, 10.1038/mt.2009.207 Xia, 2008, miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells, Int. J. Cancer, 123, 372, 10.1002/ijc.23501 Ji, 2009, MicroRNA miR-34 inhibits human pancreatic cancer tumor initiating cells, PLoS One, 4, e6816, 10.1371/journal.pone.0006816 Chang, 2007, Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis, Mol. Cell, 26, 745, 10.1016/j.molcel.2007.05.010 Javeri, 2013, Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis, Med. Oncol, 30, 413, 10.1007/s12032-012-0413-7 Srivastava, 2011, MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells, Carcinogenesis, 32, 1832, 10.1093/carcin/bgr223 Jiang, 2012, MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia, Proc. Natl. Acad. Sci. U. S. A., 109, 19397, 10.1073/pnas.1217519109 Liu, 2014, MicroRNA-451 suppresses tumor cell growth by down-regulating IL6R gene expression, Cancer Epidemiol., 38, 85, 10.1016/j.canep.2013.12.005 Liu, 2014, miR-451: potential role as tumor suppressor of human hepatoma cell growth and invasion, Int. J. Oncol., 45, 739, 10.3892/ijo.2014.2446 Lv, 2014, MicroRNA-451 regulates activating transcription factor 2 expression and inhibits liver cancer cell migration, Oncol. Rep., 32, 1021, 10.3892/or.2014.3296 Xu, 2013, MiR-203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin, Mol. Med. Rep., 8, 379, 10.3892/mmr.2013.1504 Tavazoie, 2008, Endogenous human microRNAs that suppress breast cancer metastasis, Nature, 451, 147, 10.1038/nature06487 Musiyenko, 2008, Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates protein translation and invasiveness of prostate cancer LNCaP cells, J. Mol. Med., 86, 313, 10.1007/s00109-007-0296-9 Wang, 2008, MicroRNA-183 regulates Ezrin expression in lung cancer cells, FEBS Lett., 582, 3663, 10.1016/j.febslet.2008.09.051 Crawford, 2008, MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines, Biochem. Biophys. Res. Commun., 373, 607, 10.1016/j.bbrc.2008.06.090 Ha, 2011, MicroRNAs in human diseases: from cancer to cardiovascular disease, Immune Netw., 11, 135, 10.4110/in.2011.11.3.135 Zhang, 2006, MicroRNAs: a new insight into cancer genome, Cell Cycle, 5, 2216, 10.4161/cc.5.19.3319 Chan, 2005, MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells, Cancer Res., 65, 6029, 10.1158/0008-5472.CAN-05-0137 Si, 2007, MiR-21-mediated tumor growth, Oncogene, 26, 2799, 10.1038/sj.onc.1210083 Ma, 2010, MiR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2, Cancer Lett., 298, 150, 10.1016/j.canlet.2010.06.012 Wu, 2013, MicroRNA-424-5p suppresses the expression of socs6 in pancreatic cancer, Pathol. Oncol. Res., 19, 739, 10.1007/s12253-013-9637-x Jiang, 2010, MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene, Cancer Res., 70, 3119, 10.1158/0008-5472.CAN-09-4250 Greither, 2010, Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival, Int. J. Cancer, 126, 73, 10.1002/ijc.24687 Iorio, 2005, MicroRNA gene expression deregulation in human breast cancer, Cancer Res., 65, 7065, 10.1158/0008-5472.CAN-05-1783 Lawrie, 2007, MicroRNA expression in lymphoma, Expert Opin. Biol. Ther., 7, 1363, 10.1517/14712598.7.9.1363 Diosdado, 2009, MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression, Br. J. Cancer, 101, 707, 10.1038/sj.bjc.6605037 Hayashita, 2005, A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation, Cancer Res., 65, 9628, 10.1158/0008-5472.CAN-05-2352 Dews, 2006, Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster, Nat. Genet., 38, 1060, 10.1038/ng1855 He, 2005, A microRNA polycistron as a potential human oncogene, Nature, 435, 828, 10.1038/nature03552 Ma, 2007, Tumour invasion and metastasis initiated by microRNA-10b in breast cancer, Nature, 449, 682, 10.1038/nature06174 Huang, 2008, The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis, Nat. Cell Biol., 10, 202, 10.1038/ncb1681 Yang, 2009, MicroRNAs 373 and 520c are down regulated in prostate cancer, suppress CD44 translation and enhance invasion of prostate cancer cells in vitro, Int. J. Clin. Exp. Pathol., 2, 361 Miller, 2008, MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1, J. Biol. Chem., 283, 29897, 10.1074/jbc.M804612200 Garofalo, 2008, MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer, Oncogene, 19, 3845, 10.1038/onc.2008.6 Yang, 2008, MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN, Cancer Res., 68, 425, 10.1158/0008-5472.CAN-07-2488 van Schooneveld, 2015, Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management, Breast Cancer Res., 17, 21, 10.1186/s13058-015-0526-y Jackson, 2014, MicroRNA in prostate cancer: functional importance and potential as circulating biomarkers, BMC Cancer, 14, 930, 10.1186/1471-2407-14-930 Mazeh, 2013, The diagnostic and prognostic role of microRNA in colorectal cancer – a comprehensive review, J. Cancer, 4, 281, 10.7150/jca.5836 Lin, 2010, MicroRNA in lung cancer, Br. J. Cancer, 103, 1144, 10.1038/sj.bjc.6605901 Vyas, 2013, Perspectives on new synthetic curcumin analogs and their potential anticancer properties, Curr. Pharm. Des., 19, 2047 Phuah, 2014, Regulation of microRNAs by natural agents: new strategies in cancer therapies, Biomed. Res. Int., 2014, 10.1155/2014/804510 Yang, 2010, Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR16 in MCF-7 cells, Med. Oncol., 27, 1114, 10.1007/s12032-009-9344-3 Gao, 2012, Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells, J. Exp. Clin. Cancer Res., 31, 10.1186/1756-9966-31-27 Saini, 2011, Curcumin modulates micrRNA-203-mediated regulation of the Src-Akt axis in bladder cancer, Cancer Prev. Res., 4, 1698, 10.1158/1940-6207.CAPR-11-0267 Sreenivasan, 2012, Effect of curcumin on miRNA expression in human Y79 retinoblastoma cells, Curr. Eye Res., 37, 421, 10.3109/02713683.2011.647224 Kronski, 2014, MiR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2, Mol. Oncol., 8, 581, 10.1016/j.molonc.2014.01.005 Zhao, 2014, Induction of microRNA-9 mediates cytotoxicity of curcumin against SKOV3 ovarian cancer cells, Asian Pac. J. Cancer Prev., 15, 3363, 10.7314/APJCP.2014.15.8.3363 Dahmke, 2013, Curcumin intake affects miRNA signature in murine melanoma with mmu-miR-205-5p most significantly altered, PLoS One, 8, e81122, 10.1371/journal.pone.0081122 Gregory, 2008, The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1, Nat. Cell. Biol., 10, 593, 10.1038/ncb1722 Xu, 2012, Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors, Br. J. Cancer, 106, 553, 10.1038/bjc.2011.568 Ma, 2014, Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells, Toxicol. Lett., 231, 82, 10.1016/j.toxlet.2014.09.014 Ye, 2015, Curcumin promotes apoptosis by activating the p53-miR-192/215-XIAP pathway in non-small cell lung cancer, Cancer Lett., 357, 196, 10.1016/j.canlet.2014.11.028 Mirgani, 2014, Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells, Int. J. Nanomed, 9, 403 Zamani, 2015, Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer, Phytomedicine, 22, 961, 10.1016/j.phymed.2015.05.071 Mudduluru, 2011, Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cells, Biosci. Rep., 31, 185, 10.1042/BSR20100065 Gandhy, 2012, Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (sp) transcription factors by targeting microRNAs, BMC Cancer, 12, 564, 10.1186/1471-2407-12-564 Zhang, 2014, MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells, Clin. Transl. Oncol., 16, 708, 10.1007/s12094-013-1135-9 Subramaniam, 2012, Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling, PLoS One, 7, e30590, 10.1371/journal.pone.0030590 Zhang, 2010, Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186* signaling pathway, Oncol. Rep., 24, 1217, 10.3892/or_00000975 Zhang, 2010, Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway, Biochem. Biophys. Res. Commun., 399, 1, 10.1016/j.bbrc.2010.07.013 Liang, 2013, MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells, Tumor Biol., 34, 3209, 10.1007/s13277-013-0891-z Ali, 2010, Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF, Cancer Res., 70, 3606, 10.1158/0008-5472.CAN-09-4598 Toden, 2015, Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer, Carcinogenesis, 36, 355, 10.1093/carcin/bgv006 Guo, 2015, Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation, Tumor Biol., 36, 8511, 10.1007/s13277-015-3592-y Padhye, 2009, New difluoro Knoevenagel condensates of curcumin, their Schiff bases and copper complexes as proteasome inhibitors and apoptosis inducers in cancer cells, Pharm. Res., 26, 1874, 10.1007/s11095-009-9900-8 Padhye, 2009, Fluorocurcumins as cyclooxygenase-2 inhibitor: molecular docking, pharmacokinetics and tissue distribution in mice, Pharm. Res., 26, 2438, 10.1007/s11095-009-9955-6 Bao, 2011, Anti-tumor activity of a novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancer, PLoS One, 6, e17850, 10.1371/journal.pone.0017850 Bao, 2012, Hypoxia induced aggressiveness of prostate cancer cells is linked with deregulated expression of VEGF, IL-6 and miRNAs that are attenuated by CDF, PLoS One, 7, e43726, 10.1371/journal.pone.0043726 Bao, 2012, Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment, PLoS One, 7, e50165, 10.1371/journal.pone.0050165 Roy, 2013, Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21, PLoS One, 8, e68543, 10.1371/journal.pone.0068543 Roy, 2012, Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF, J. Hematol. Oncol., 5, 58, 10.1186/1756-8722-5-58 Ahmad, 2015, Molecular docking and inhibition of matrix metalloproteinase-2 by novel difluorinated benzylidene curcumin analog, Am. J. Transl. Res., 7, 298 Sarkar, 2013, Down-regulation of miR-221 inhibits proliferation of pancreatic cancer cells through up-regulation of PTEN, p27kip1, p57kip2, and PUMA, Am. J. Cancer Res., 3, 465 Bao, 2012, Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression, Cancer Res., 72, 335, 10.1158/0008-5472.CAN-11-2182 Ali, 2012, Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells, Cancer Lett., 319, 173, 10.1016/j.canlet.2012.01.013 Ali, 2014, Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling, Cancer Lett., 351, 134, 10.1016/j.canlet.2014.05.013 Adams, 2004, Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents, Bioorg. Med. Chem., 12, 3871, 10.1016/j.bmc.2004.05.006 Yang, 2013, The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo, PLoS One, 8, e71130, 10.1371/journal.pone.0071130 Zhang, 2015, MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2, Toxicol. Lett., 234, 151, 10.1016/j.toxlet.2015.02.018 Hemshekhar, 2011, An overview on genus Garcinia: phytochemical and therapeutical aspects, Phytochem. Rev., 10, 325, 10.1007/s11101-011-9207-3 Padhye, 2009, Emerging role of garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs, J. Hematol. Oncol., 2, 38, 10.1186/1756-8722-2-38 Saadat, 2012, Potential role of garcinol as an anticancer agent, J. Oncol., 2012, 647206 Ciochina, 2006, Polycyclic polyprenylated acylphloroglucinols, Chem. Rev., 106, 3963, 10.1021/cr0500582 Biersack, 2016, Effects of garcinol from kokum (Garcinia indica) on the prevention and treatment of cancer, 253 Socolsky, 2015, Total synthesis and absolute configuration assignment of MRSA active garcinol and isogarcinol, Chem. Eur. J., 21, 3053, 10.1002/chem.201406077 Balasubramaniam, 2004, Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression, J. Biol. Chem., 279, 33716, 10.1074/jbc.M402839200 Parasramka, 2013, Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures, Mol. Nutr. Food Res., 57, 235, 10.1002/mnfr.201200297 Ahmad, 2012, Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells, Mol. Cancer Ther., 11, 2193, 10.1158/1535-7163.MCT-12-0232-T Sarkar, 2009, Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics, Cancer Treat. Rev., 35, 597, 10.1016/j.ctrv.2009.07.001 Zaman, 2012, Up-regulation of microRNA-21 correlates with lower kidney cancer survival, PLoS One, 7, e31060, 10.1371/journal.pone.0031060 Zaman, 2012, Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer, PLoS One, 7, e50203, 10.1371/journal.pone.0050203 Hirata, 2013, Genistein downregulates onco-miR-1260b and inhibits Wnt-signaling in renal cancer cells, Br. J. Cancer, 108, 2070, 10.1038/bjc.2013.173 Hirata, 2014, Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells, Br. J. Cancer, 110, 1645, 10.1038/bjc.2014.48 Sun, 2009, Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27ba and target gene expression, Oncol. Rep., 22, 563 Xu, 2013, Oncogenic microRNA-27a is a target for genistein in ovarian cancer cells, Anti-Cancer Agents Med. Chem., 13, 1126, 10.2174/18715206113139990006 Xia, 2014, Genistein inhibits cell growth and invasion through regulation of miR-27a in pancreatic cancer cells, Curr. Pharm. Des., 20, 5348, 10.2174/1381612820666140128215756 Chiyomaru, 2012, Genistein suppresses prostate cancer growth through inhibition of oncogenic MicroRNA151, PLoS One, 7, e43812, 10.1371/journal.pone.0043812 Chen, 2011, MicroRNAs 221/222 and genistein-mediated regulation of ARH1 tumor suppressor gene in prostate cancer, Cancer Prev. Res., 4, 76, 10.1158/1940-6207.CAPR-10-0167 Ma, 2013, Genistein down-regulates miR-223 expression in pancreatic cancer cells, Curr. Drug Targets, 14, 1150, 10.2174/13894501113149990187 de la Parra, 2016, Soy isoflavone genistein-mediated downregulation of miR-155 contributes to the anticancer effects of Genistein, Nutr. Cancer, 68, 154, 10.1080/01635581.2016.1115104 Chiyomaru, 2013, Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR, PLoS One, 8, e70372, 10.1371/journal.pone.0070372 Chiyomaru, 2013, Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer, PLoS One, 8, e58929, 10.1371/journal.pone.0058929 Majid, 2010, Regulation of minichromosome maintenance gene family by MicroRNA-1296 and genistein in prostate cancer, Cancer Res., 70, 2809, 10.1158/0008-5472.CAN-09-4176 Rabiau, 2011, miRNAs differentially expressed in prostate cancer cell lines after soy treatment, Vivo, 25, 917 Xia, 2012, Genistein inhibits cell growth and induces apoptosis through up-regulation of miR-34a in pancreatic cancer cells, Curr. Drug Targets, 13, 1750, 10.2174/138945012804545597 Li, 2009, Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells, Cancer Res., 69, 6704, 10.1158/0008-5472.CAN-09-1298 Li, 2010, MiR-146a suppresses invasion of pancreatic cancer cells, Cancer Res., 70, 1486, 10.1158/0008-5472.CAN-09-2792 Avci, 2015, Genistein-induced miR-23b expression inhibits the growth of breast cancer cells, Contemp. Oncol., 19, 32 Vaya, 1997, Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation, Free Radic. Biol. Med., 23, 302, 10.1016/S0891-5849(97)00089-0 Kwon, 2008, Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis, Clin. Exp. Immunol., 151, 165, 10.1111/j.1365-2249.2007.03539.x Yu, 2008, In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhyza glabra (licorice), Life Sci., 82, 68, 10.1016/j.lfs.2007.10.019 Hsu, 2011, Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway, Mol. Nutr. Food Res., 55, 318, 10.1002/mnfr.201000148 Jiang, 2014, The repressive effect of miR-148a on TGF beta-SMADs signal pathway is involved in the glabridin-induced inhibition of the cancer stem cells-like properties in hepatocellular carcinoma cells, PLoS One, 9, e96698, 10.1371/journal.pone.0096698 Jiang, 2016, Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: an epigenetic regulation of miR-148a/SMAD2 signaling, Mol. Carcinog., 55, 929, 10.1002/mc.22333 Mu, 2015, The repressive effect of miR-520a on NF-kB/IL-6/STAT-3 signal involved in the glabridin-induced anti-angiogenesis in human breast cancer cells, RSC Adv., 5, 34257, 10.1039/C4RA17062H Zimmermann, 2010, Glyceollin I, a novel antiestrogenic phytoalexin isolated from activated soy, J. Pharmacol. Exp. Ther., 332, 35, 10.1124/jpet.109.160382 Salvo, 2006, Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesis, Clin. Cancer Res., 12, 7159, 10.1158/1078-0432.CCR-06-1426 Carriere, 2016, Glyceollin I reverses epithelial to mesenchymal transition in letrozole resistant breast cancer through ZEB1, Int. J. Environ. Res. Public Health, 13, 10, 10.3390/ijerph13010010 Rhodes, 2012, Glyceollins as novel targeted therapeutic for the treatment of triple-negative breast cancer, Oncol. Lett., 3, 163, 10.3892/ol.2011.460 Yang, 2009, Cancer prevention by tea: animal studies, molecular mechanisms and human relevance, Nat. Rev. Cancer, 9, 429, 10.1038/nrc2641 Tsang, 2010, Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells, J. Nutr. Biochem., 21, 140, 10.1016/j.jnutbio.2008.12.003 Wang, 2011, Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α, Carcinogenesis, 32, 1881, 10.1093/carcin/bgr218 Zhou, 2014, Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer, BMC Genomics, 15, S3, 10.1186/1471-2164-15-S11-S3 Yamada, 2016, Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells, Sci. Rep., 6, 19225, 10.1038/srep19225 Zhu, 2015, Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1, Tumour Biol. Jiang, 2014, Overexpression of miR-126 sensitizes osteosarcoma cells to apoptosis induced by epigallocatechin-3-gallate, World J. Surg. Oncol., 12, 383, 10.1186/1477-7819-12-383 Siddiqi, 2011, Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer, FASEB J., 25, 1198, 10.1096/fj.10-167924 Arola-Arnal, 2011, Proanthocyanidins modulate microRNA expression in human HepG2 cells, PLoS One, 6, e25982, 10.1371/journal.pone.0025982 Tsang, 2010, Genome-wide dissection of microRNA functions and cotargeting networks using genes et signatures, Mol. Cell, 38, 140, 10.1016/j.molcel.2010.03.007 Zhou, 2014, EGCG enhances the efficacy of cisplatin by downregulating hsa-miR-98-5p in NSCLC A549 cells, Nutr. Cancer, 66, 636, 10.1080/01635581.2014.894101 Chakrabarti, 2013, Overexpression of miR-7-1 increases efficacy of green tea polyphenols for induction of apoptosis in human malignant neuroblastoma SH-SY5Y and SK-N-DZ cells, Neurochem. Res., 38, 420, 10.1007/s11064-012-0936-5 An, 2013, Involvement of microRNAs in epigallocatechin gallate-mediated UVB protection in human dermal fibroblasts, Oncol. Rep., 29, 253, 10.3892/or.2012.2083 Baselga-Escudero, 2014, Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells, Nucl. Acids Res., 42, 882, 10.1093/nar/gkt1011 Chang, 2008, Structurally related cytotoxic effects of flavonoids on human cancer cells in vitro, Arch. Pharm. Res., 31, 1137, 10.1007/s12272-001-1280-8 Chang, 2012, MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis, Breast Cancer Res., 14, R80, 10.1186/bcr3194 Peng, 2015, 3,6-Dihydroxyflavone suppresses breast carcinogenesis by epigenetically regulating miR-34a and miR-21, Cancer Prev. Res., 8, 509, 10.1158/1940-6207.CAPR-14-0357 Karmakar, 2009, Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways, Biochem. Biophys. Res. Commun., 388, 705, 10.1016/j.bbrc.2009.08.071 Chao, 2013, Subtoxic levels of apigenin inhibit expression and secretion of VEGF by uveal melanoma cells via suppression of ERK1/2 and PI3K/Akt pathways, Evidence-Based Complement, Altern. Med., 2013 Shukla, 2010, Apigenin: a promising molecule for cancer prevention, Pharm. Res., 27, 962, 10.1007/s11095-010-0089-7 Patel, 2007, Apigenin and cancer chemoprevention: progress, potential and promise, Int. J. Oncol., 30, 233 Chakrabarti, 2013, miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo, Exp. Cell Res., 319, 1575, 10.1016/j.yexcr.2013.02.025 Bao, 2013, The biology of the deadly love connection between obesity, diabetes and breast cancer, 117 Ohno, 2013, The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA 103 transgenic mice, Sci. Rep., 3, 2553, 10.1038/srep02553 Lam, 2012, Influence of quercetin-rich food intake on miRNA expression in lung cancer tissues, Cancer Epidemiol. Biomark. Prev., 21, 2176, 10.1158/1055-9965.EPI-12-0745 Noratto, 2011, Flavonol-rich fractions of yaupon holly leaves (Ilex vomitora, Aquifoliaceae) induce microRNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofibroblast CCD-18Co cells, Fitoterapia, 82, 557, 10.1016/j.fitote.2011.01.013 Appari, 2014, Sulphoraphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition, Int. J. Oncol., 45, 1391, 10.3892/ijo.2014.2539 Sonoki, 2015, Quercetin decreases Claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells, Nutrients, 7, 4578, 10.3390/nu7064578 Mackenzie, 2013, Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation, Mol. Cancer Ther., 12, 1266, 10.1158/1535-7163.MCT-12-1231 Lou, 2015, The p53/miR-34a/SIRT1 positive feedback loop in quercetin-induced apoptosis, Cell. Physiol. Biochem., 35, 2192, 10.1159/000374024 del Follo-Martinez, 2013, Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a, Nutr. Cancer, 65, 494, 10.1080/01635581.2012.725194 Wein, 2015, Quercetin induces hepatic γ-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p, J. Nutr. Biochem., 26, 1660, 10.1016/j.jnutbio.2015.08.010 Lin, 1996, The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein, and wogonin, Am. J. Chin. Med., 24, 31, 10.1142/S0192415X96000050 Chen, 2013, Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway, PLoS One, 8, e72927, 10.1371/journal.pone.0072927 Xu, 2012, Baicalin modulates microRNA expression in UVB irradiated mouse skin, J. Biomed. Res., 26, 125 Wang, 2015, Traditional Chinese medicine baicalin suppresses mESCs proliferation through inhibition of miR-294 expression, Cell. Physiol. Biochem., 35, 1868, 10.1159/000373997 Dong, 2015, Baicalein inhibits Amadori-glycated albumin-induced MCP-1 expression in retinal ganglion cells via a microRNA-124-dependent mechanism, Invest. Ophthalmol. Vis. Sci., 56, 5844, 10.1167/iovs.15-17444 Agarwal, 2006, Anticancer potential of silymarin: from bench to bed side, Anticancer Res., 26, 4457 Cufí, 2013, Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo, Sci. Rep., 3, 2459, 10.1038/srep02459 Athar, 2007, Resveratrol: a review of preclinical studies for human cancer prevention, Toxicol. Appl. Pharmacol., 224, 274, 10.1016/j.taap.2006.12.025 Tili, 2011, Resveratrol, microRNAs, inflammation, and cancer, J. Nucl. Acids, 2011 Tili, 2010, Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGF-beta signaling pathway in SW480 cells, Biochem. Pharmacol., 80, 2057, 10.1016/j.bcp.2010.07.003 Liu, 2013, Resveratrol induces apoptosis of pancreatic cancer cells by inhibiting miR-21 regulation of Bcl-2 expression, Clin. Transl. Oncol., 15, 741, 10.1007/s12094-012-0999-4 Shet, 2012, Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/microRNA-21 pathway, PLoS One, 7, e51655, 10.1371/journal.pone.0051655 Cao, 2012, PDCD4 expression inversely correlated with miR-21 levels in gastric cancers, J. Cancer Res. Clin. Oncol., 138, 611, 10.1007/s00432-011-1140-8 Dhar, 2011, Resveratrol and prostate cancer: promising role for microRNAs, Mol. Nutr. Food Res., 55, 1219, 10.1002/mnfr.201100141 Yu, 2013, MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol, Oncogene, 32, 431, 10.1038/onc.2012.74 Vislovukh, 2013, Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-774, Br. J. Cancer, 108, 2304, 10.1038/bjc.2013.243 Hagiwara, 2012, Stilbene derivatives promote AGO2-dependent tumour-suppressive microRNA activity, Sci. Rep., 2, 314, 10.1038/srep00314 Bai, 2014, Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer, Oncol. Rep., 31, 2293, 10.3892/or.2014.3090 Kumazaki, 2013, Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells, J. Nutr. Biochem., 24, 1849, 10.1016/j.jnutbio.2013.04.006 Yang, 2015, Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo, BMC Cancer, 15, 969, 10.1186/s12885-015-1958-6 Han, 2012, MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol, Carcinogenesis, 33, 131, 10.1093/carcin/bgr226 Qin, 2014, Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue, Nutr. Cancer, 66, 270, 10.1080/01635581.2014.868910 Bae, 2011, Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells, Mol. Cells, 32, 10.1007/s10059-011-1037-z Venkatadri, 2016, Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death, Cell Death Dis., 7, e2104, 10.1038/cddis.2016.6 Seyed, 2016, A comprehensive review on the chemotherapeutic potential of piceatannol for cancer treatment, with mechanistic insights, J. Agric. Food Chem., 64, 725, 10.1021/acs.jafc.5b05993 Liu, 2012, Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFα-mediated NFκB activation in piceatannol-treated human leukemia cells, Biochem. Pharmacol., 84, 670, 10.1016/j.bcp.2012.06.007 Zhang, 2014, Piceatannol promotes apoptosis via up-regulation of microRNA-129 expression in colorectal cancer cell lines, Biochem. Biophys. Res. Commun., 452, 775, 10.1016/j.bbrc.2014.08.150 Ke, 2015, MicroRNA-183 increases osteoclastogenesis by repressing heme oxygenase-1, Bone, 81, 237, 10.1016/j.bone.2015.07.006 Edwardson, 2013, Resistance to Anthracyclines and Taxanes in breast cancer, 227 Singh, 2013, Breast cancer stem cells and miRNAs, 367 Kovalchuk, 2008, Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin, Mol. Cancer Ther., 7, 2152, 10.1158/1535-7163.MCT-08-0021 Tormo, 2015, MicroRNA profile in response to doxorubicin treatment in breast cancer, J. Cell. Biochem., 116, 2061, 10.1002/jcb.25162 Kopp, 2012, miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression, PLoS One, 7, e50469, 10.1371/journal.pone.0050469 Xie, 2015, The role of miR-125b-mitochondria-caspase-3 pathway in doxorubicin resistance and therapy in human breast cancer, Tumor Biol., 36, 7185, 10.1007/s13277-015-3438-7 Long, 2015, MiR-193b modulates resistance to doxorubicin in human breast cancer cells by downregulating Mcl-1, Biomed. Res. Int., 10.1155/2015/373574 Hu, 2016, MiRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer, Cell Death Dis., 7, e2291, 10.1038/cddis.2016.194 Hu, 2015, MiR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer, Breast Cancer Res. Treat., 151, 269, 10.1007/s10549-015-3372-9 Zhao, 2014, Targeting HER3 with miR-450b-3p suppresses breast cancer cells proliferation, Cancer Biol. Ther., 15, 1404, 10.4161/cbt.29923 Niu, 2016, Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer, Oncogene, 35, 1302, 10.1038/onc.2015.189 Yoo, 2015, Combining miR-10b-targeted nanotherapy with low-dose doxorubicin elicits durable regressions of metastatic breast cancer, Cancer Res., 75, 4407, 10.1158/0008-5472.CAN-15-0888 Wang, 2016, Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy, Nanomed, 12, 411, 10.1016/j.nano.2015.09.014 He, 2016, MicroRNA-101 sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis via targeting Mcl-1, Mol. Med. Rep., 13, 1923, 10.3892/mmr.2015.4727 Yang, 2015, MicroRNA-522 reverses drug resistance of doxorubicin-induced HT29 colon cancer cell by targeting ABCB5, Mol. Med. Rep., 12, 3930, 10.3892/mmr.2015.3890 Zhou, 2016, Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression, Acta Pharmacol. Sin, 37, 519, 10.1038/aps.2015.153 Lin, 2016, TGF-b1-induced miR-202 mediates drug resistance by inhibiting apoptosis in human osteosarcoma, J. Cancer Res. Clin. Oncol., 142, 239, 10.1007/s00432-015-2028-9 Zhang, 2015, Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor supressing genes, Int. J. Oncol., 46, 1589, 10.3892/ijo.2015.2841 Lee, 2016, Theragnosis-based combined cancer therapy using doxorubicin-conjugated microRNA-221 molecular beacon, Biomaterials, 74, 109, 10.1016/j.biomaterials.2015.09.036 Troppan, 2015, MiR-199a and miR-497 are associated with better overall survival due to increased chemosensitivity in diffuse large B-cell lymphoma patients, Int. J. Mol. Sci., 16, 18077, 10.3390/ijms160818077 Ma, 2013, Emodin can induce K562 cells to erythroid differentiation and improve the expression of globin genes, Mol. Cell. Biochem., 382, 127, 10.1007/s11010-013-1726-3 Zhang, 1998, Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties, Oncogene, 16, 2855, 10.1038/sj.onc.1201813 Ren, 2016, miR-211 and miR-429 are involved in emodin's anti-proliferative effects on lung cancer, Int. J. Clin. Med., 9, 2085 Guo, 2013, Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a, Mol. Cell. Biochem., 382, 103, 10.1007/s11010-013-1723-6 Hua, 2015, Emodin prevents intima thickness via Wnt4/Dvl-1/β-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats, Exp. Mol. Med., 47, e170, 10.1038/emm.2015.36 Lin, 2015, Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-β/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs, Mol. Med. Rep., 12, 5865, 10.3892/mmr.2015.4158 Vyas, 2012, Perspectives on medicinal properties of mangiferin, Mini-Rev. Med. Chem., 12, 412, 10.2174/138955712800493870 Li, 2016, Mangiferin inhibition of proliferation and induction of apoptosis in human prostate cancer cells is correlated with downregulation of B-cell lymphoma-2 and upregulation of microRNA-182, Oncol. Lett., 11, 817, 10.3892/ol.2015.3924 Xiao, 2015, Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression, Oncol. Rep., 33, 2815, 10.3892/or.2015.3919 Lombo, 2006, The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives, Appl. Microbiol. Biotechnol., 73, 1, 10.1007/s00253-006-0511-6 Bianchi, 2009, Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression, BMP Rep., 42, 493, 10.5483/BMBRep.2009.42.8.493 Jiang, 2001, Caffeoyl, coumaroyl, galloyl, and hexahydroxydiphenoyl glucoses from Balanophora japonica, Chem. Pharm. Bull., 49, 887, 10.1248/cpb.49.887 Wen, 2009, Ellagitannin (BJA3121), an antiproliferative natural polyphenol compound, can regulate the expression of miRNAs in HepG2 cancer cells, Phytother. Res., 23, 778, 10.1002/ptr.2616 Ai, 2011, 1,3,4-tri-O-galloyl-6-O-caffeoyl-β-D-glucopyranose, a new anti-proliferative ellagitannin, regulates the expression of microRNAs in HepG2 cancer cells, J. South Med. Univ., 31, 1641 Banerjee, 2012, Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miR-155 in cell survival and inflammation, Breast Cancer Res. Treat., 136, 21, 10.1007/s10549-012-2224-0 Shirode, 2014, Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks, Mol. Carcinog., 53, 458, 10.1002/mc.21995 Zhou, 2015, Anti-proliferative effects of polyphenols from pomegranate rind (Punica granatum L.) on EJ bladder cancer cells via regulation of p53/miR-34a axis, Phytother. Res., 29, 415, 10.1002/ptr.5267 Phuah, 2013, Alterations of microRNA expression patterns in human cervical carcinoma cells (Ca Ski) toward 1’S-1′-acetoxychavicol acetate and cisplatin, Reprod. Sci., 20, 567, 10.1177/1933719112459220 Wang, 2013, MicroRNAs contribute to the anticancer effect of 1′-acetoxychavicol acetate in human head and neck squamous cell carcinoma cell line HN4, Biosci. Biotechnol. Biochem., 77, 2348, 10.1271/bbb.130389 Kang, 2012, Wnt/β-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells, Mol. Pharmacol., 82, 168, 10.1124/mol.112.078535 Hagiwara, 2015, A robust screening method for dietary agents that activate tumour-suppressor microRNAs, Sci. Rep., 5, 14697, 10.1038/srep14697 Esumi, 2004, Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan, Bioorg. Med. Chem. Lett., 14, 2621, 10.1016/j.bmcl.2004.02.067 Arora, 2012, Honokiol: a novel natural agent for cancer prevention and therapy, Curr. Mol. Med., 12, 1244, 10.2174/156652412803833508 Avtanski, 2015, Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner, Oncotarget, 6, 16396, 10.18632/oncotarget.3844 Zhang, 2015, Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis, Oncotarget, 6, 37335, 10.18632/oncotarget.6135 Jung, 2007, Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells, Carcinogenesis, 28, 1780, 10.1093/carcin/bgm130 Touabia, 2011, Caffeic acid, a versatile pharmacophore: an overview, Mini-Rev. Med. Chem., 11, 695, 10.2174/138955711796268750 Guerriero, 2011, Effect of lipoic acid, caffeic acid and a synthesized lipoyl-caffeic conjugate on human hepatoma cell lines, Molecules, 16, 6365, 10.3390/molecules16086365 Wang, 2015, Caffeic acid attenuates the autocrine IL-6 in hepatocellular carcinoma via the epigenetic silencing of the NF-κB-IL-6-STAT-3 feedback loop, RSC Adv., 5, 52952, 10.1039/C5RA05878C Li, 2015, Blockade of TGFβ-SMAD2 by demethylation-activated miR-148a is involved in caffeic acid-induced inhibition of cancer stem cell-like properties in vitro and in vivo, FEBS Open Bio, 5, 466, 10.1016/j.fob.2015.05.009 Alexandrov, 2012, MicroRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF), Int. J. Biochem. Mol. Biol., 3, 365 Hossan, 2014, Rosmarinic acid: a review of its anticancer action, World J. Pharm. Pharm. Sci., 3, 57 Han, 2015, Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells, Drug Des. Dev. Ther., 9, 2695 Henwood, 1990, Etoposide. A review of its pharmacodynamics and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer, Drugs, 39, 438, 10.2165/00003495-199039030-00008 Hande, 1998, Etoposide: four decades of development of a topoisomerase II inhibitor, Eur. J. Cancer, 34, 1514, 10.1016/S0959-8049(98)00228-7 Moitra, 2012, Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines, PLoS One, 7, e45268, 10.1371/journal.pone.0045268 Seviour, 2016, Functional proteomics identifies miRNAs to target a p27/Myc/phosphor-Rb signature in breast and ovarian cancer, Oncogene, 35, 691, 10.1038/onc.2014.469 Wang, 2013, MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma, Mol. Cancer, 12, 119, 10.1186/1476-4598-12-119 Rebucci, 2015, MiRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1, Mol. Cancer, 14, 79, 10.1186/s12943-015-0349-6 Xu, 2016, MicroRNA-1915-3p prevents the apoptosis of lung cancer cells by downregulating DRG2 and PBX2, Mol. Med. Rep., 13, 505, 10.3892/mmr.2015.4565 Xu, 2015, MiRNA1469 promotes lung cancer cells apoptosis through targeting STAT5a, Am. J. Cancer Res., 5, 1180 Chen, 2015, MiRNA153 reduces effects of chemotherapeutic agents or small molecular kinase inhibitor in HCC cells, Curr. Cancer Drug Targets, 15, 176, 10.2174/1568009615666150225122635 Novello, 2014, p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression, PLoS One, 9, e114757, 10.1371/journal.pone.0114757 Safayhi, 1992, Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase, J. Pharmacol. Exp. Ther., 261, 1143 Flavin, 2007, A lipoxygenase inhibitor in breast cancer brain metastases, J. Neurooncol., 82, 91, 10.1007/s11060-006-9248-4 Takada, 2006, Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression, J. Immunol., 176, 3127, 10.4049/jimmunol.176.5.3127 Kunnumakkara, 2009, Boswellic acid blocks signal transduction and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1, Mol. Cancer Res., 7, 118, 10.1158/1541-7786.MCR-08-0154 Takahashi, 2012, Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family, Carcinogenesis, 33, 2441, 10.1093/carcin/bgs286 Toden, 2015, Novel evidence for curcumin and boswellic acid-induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer, Cancer Prev. Res., 8, 431, 10.1158/1940-6207.CAPR-14-0354 Galgon, 1999, Identification and quantification of betulinic acid, Phytochem. Anal., 10, 187, 10.1002/(SICI)1099-1565(199907/08)10:4<187::AID-PCA443>3.0.CO;2-K Chowdhury, 2002, Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives, Med. Sci. Monit., 8, BR245 Cichewicz, 2004, Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection, Med. Res. Rev., 24, 90, 10.1002/med.10053 Chintharlapalli, 2011, Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and –independent downregulation of specificity proteins (Sp) transcription factors, BMC Cancer, 11, 371, 10.1186/1471-2407-11-371 Mertens-Talcott, 2013, Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10, Mol. Carcinog., 52, 591, 10.1002/mc.21893 Yang, 2015, p53-p66shc/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma, Toxicol. Lett., 238, 1, 10.1016/j.toxlet.2015.07.016 Zhao, 2013, Antagonism of betulinic acid on LPS-mediated inhibition of ABCA1 and cholesterol efflux through inhibiting nuclear factor-kappaB signaling pathway and miR-33 expression, PLoS One, 8, e74782, 10.1371/journal.pone.0074782 Ikeda, 2008, Ursolic acid: an anti-and pro-inflammatory triterpenoid, Mol. Nutr. Food Res., 52, 26, 10.1002/mnfr.200700389 Shanmugam, 2011, Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice, J. Mol. Med., 89, 713, 10.1007/s00109-011-0746-2 Wang, 2012, Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-β1/miR-21/PDCD4 pathway, Basic Clin. Pharmacol. Toxicol., 111, 106 Baltina, 2003, Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine, Curr. Med. Chem., 10, 155, 10.2174/0929867033368538 Chintharlapalli, 2009, Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18b-olean-1,12-dien-30-oate in colon cancer cells, Int. J. Cancer, 125, 1965, 10.1002/ijc.24530 Zong, 2015, Gap junction mediated miRNA intercellular transfer and gene regulation: a novel mechanism for intercellular genetic communication, Sci. Rep., 6, 19884, 10.1038/srep19884 Blaskovich, 2003, Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells, Cancer Res., 63, 1270 van der Fits, 2011, MicroRNA-21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sézary syndrome, J. Invest. Dermatol., 131, 762, 10.1038/jid.2010.349 Rasmussen, 2015, Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus, Arthritis Res. Ther., 17, 154, 10.1186/s13075-015-0660-z Du, 2012, miR-337–3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancer, PLoS One, 7, e39167, 10.1371/journal.pone.0039167 Shibata, 2001, Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds, J. Korean. Med. Sci., 16, S28, 10.3346/jkms.2001.16.S.S28 Wu, 2011, Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128, Acta Pharmacol. Sin., 32, 345, 10.1038/aps.2010.220 An, 2013, Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells, Oncol. Rep., 29, 523, 10.3892/or.2012.2136 Keung, 2016, Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression, J. Ginseng Res., 40, 151, 10.1016/j.jgr.2015.07.002 Wani, 1971, Plant antitumor agents. VI. The isolation and structure of Taxol, J. Am. Chem. Soc., 93, 2325, 10.1021/ja00738a045 Schiff, 1980, Taxol stabilizes microtubules in mouse fibroblast cells, Proc. Natl. Acad. Sci. U. S. A., 77, 1561, 10.1073/pnas.77.3.1561 Chen, 2014, Human cancer cell line microRNAs associated with in vitro sensitivity to paclitaxel, Oncol. Rep., 31, 376, 10.3892/or.2013.2847 Zhan, 2015, MiRNA-149 modulates chemosensitivity of ovarian cancer A2780 cells to paclitaxel by targeting MyD88, J. Ovarian Res., 8, 48, 10.1186/s13048-015-0178-7 Li, 2013, MicroRNA profile of paclitaxel-resistant serous ovarian carcinoma based on formalin-fixed paraffin-embedded samples, BMC Cancer, 13, 216, 10.1186/1471-2407-13-216 Weiner-Gorzel, 2015, Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells, Cancer Med., 4, 745, 10.1002/cam4.409 Zong, 2015, MicroRNA 130b enhances drug resistance in human ovarian cancer cells, Tumor Biol., 35, 12151, 10.1007/s13277-014-2520-x Zou, 2015, MiR-197 induces taxol resistance in human ovarian cancer cells by regulating NLK, Tumor Biol., 36, 6725, 10.1007/s13277-015-3365-7 Zhou, 2015, The clinicopathological significance of miR-1307 in chemotherapy resistant epithelial ovarian cancer, J. Ovarian Res., 8, 23, 10.1186/s13048-015-0143-5 Brozovic, 2015, The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells, Mol. Oncol., 9, 1678, 10.1016/j.molonc.2015.04.015 Wu, 2016, MicroRNA-873 mediates multidrug resistance in ovarian cancer cells by targeting ABCB1, Tumor Biol., 10.1007/s13277-016-4944-y Kim, 2014, Differential microRNA expression signatures and cell type-specific association with taxol resistance in ovarian cancer cells, Drug Des. Dev. Ther., 8, 293 Fan, 2016, MiR-125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression, Oncogenesis, 5, e197, 10.1038/oncsis.2016.1 Shen, 2014, MiR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT, PLoS One, 9, e109299, 10.1371/journal.pone.0109299 Chen, 2014, MicroRNA 490-3p enhances the drug-resistance of human ovarian cancer cells, J. Ovarian Res., 7, 84, 10.1186/s13048-014-0084-4 Gao, 2015, MicroRNA-134 suppresses endometrial cancer stem cells by targeting POGLUT1 and Notch pathway proteins, FEBS Lett., 589, 207, 10.1016/j.febslet.2014.12.002 Chang, 2016, Dicer elicits paclitaxel chemosensitization and suppresses cancer stemness in breast cancer by repressing AXL, Cancer Res., 76, 3916, 10.1158/0008-5472.CAN-15-2555 Su, 2016, MiR-520h is crucial for DAPK2 regulation and breast cancer progression, Oncogene, 35, 1134, 10.1038/onc.2015.168 Xue, 2016, MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity, Oncogene, 35, 448, 10.1038/onc.2015.96 Li, 2014, Circulating miR-19a and miR-205 in serum may predict the sensitivity of luminal A subtype of breast cancer patients to neoadjuvant chemotherapy with epirubicin plus paclitaxel, PLoS One, 9, e104870, 10.1371/journal.pone.0104870 Frères, 2015, Neodjuvant chemotherapy in breast cancer patients induces miR-34a and miR-122 expression, J. Cell. Physiol., 230, 473, 10.1002/jcp.24730 Chatterjee, 2015, MiR-16 targets Bcl-2 in paclitaxel-resistant lung cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis, Cell. Signal., 27, 189, 10.1016/j.cellsig.2014.11.023 Chatterjee, 2014, MiR-17-5p downregulation contributes to paclitaxel resistance of lung cancer cells through altering Beclin 1 expression, PLoS One, 9, e95716, 10.1371/journal.pone.0095716 Zhang, 2015, Simultaneous delivery of therapeutic antagomirs with paclitaxel fort he management of metastatic tumors by a pH-responsive anti-microbial peptide-mediated liposomal delivery system, J. Contr. Release, 197, 208, 10.1016/j.jconrel.2014.11.010 Dai, 2016, Combined delivery of let-7b micro-RNA and paclitaxel via biodegradable nanoassemblies for the treatment of KRAS mutant cancer, Mol. Pharm., 13, 520, 10.1021/acs.molpharmaceut.5b00756 Jin, 2015, Antagonism of miR-21 sensitizes human gastric cancer cells to paclitaxel, Cell. Biochem. Biophys., 72, 275, 10.1007/s12013-014-0450-2 Huang, 2014, MiRNA27a is a biomarker for predicting chemosensitivity and prognosis in metastatic or recurrent gastric cancer, J. Cell. Biochem., 115, 549, 10.1002/jcb.24689 Liu, 2016, Overexpression of miR-203 sensitizes paclitaxel (taxol)-resistant colorectal cancer cells through targeting the salt-inducible kinase 2 (SIK2), Tumor Biol. Liu, 2016, Low-dose DANN-demethylating agent enhances the chemosensitivity of cancer cells by targeting cancer stem cells via the upregulation of microRNA-497, J. Cancer Res. Clin. Oncol., 142, 1431, 10.1007/s00432-016-2157-9 Fujita, 2015, MiR-130a activates apoptotic signaling through activation of caspase-8 in taxane-resistant prostate cancer cells, Prostate, 75, 1568, 10.1002/pros.23031 Peng, 2014, MiR-634 sensitizes nasopharyngeal carcinoma cells to paclitaxel and inhibits cell growth both in vitro and in vivo, Int. J. Clin. Exp. Pathol., 7, 6784 Peng, 2015, MiR-1204 sensitizes nasopharyngeal carcinoma cells to paclitaxel both in vitro and in vivo, Cancer Biol. Ther., 16, 261, 10.1080/15384047.2014.1001287 Huang, 2015, Up-regulation of miR-877 induced by paclitaxel inhibits hepatocellular carcinoma cell proliferation though targeting FOXM1, Int. J. Clin. Exp. Pathol., 8, 1515 Du, 2013, A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel, RNA Biol., 10, 1700, 10.4161/rna.26541 Li, 2013, Andrographolide antagonizes cigarette smoke extract-induced inflammatory response and oxidative stress in human alveolar epithelial A549 cells through induction of microRNA-128, Exp. Lung Res., 39, 463, 10.3109/01902148.2013.857443 Lu, 2016, The alteres microRNA profile in andrographolide-induced inhibition of hepatoma tumor growth, Gene, 588, 124, 10.1016/j.gene.2016.05.012 Jansson, 2015, MiR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2, Oncogene, 34, 1908, 10.1038/onc.2014.130 Aruoma, 1992, Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid, Xenobiotica, 22, 257, 10.3109/00498259209046624 González-Vallinas, 2014, Expression of microRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of rosemary diterpenes in colon and pancreatic cancer, PLoS One, 9, e98556, 10.1371/journal.pone.0098556 Duggal, 2012, Involvement of microRNA181a in differentiation and cell cycle arrest induced by a plant-derived antioxidant carnosic acid and vitamin D analog doxercalciferol in human leukemia cells, MicroRNA, 1, 26, 10.2174/2211536611201010026 Schobert, 2011, Anticancer active illudins: recent developments of a potent alkylating compound class, Curr. Med. Chem., 18, 790, 10.2174/092986711794927766 Liu, 2009, Modulation of DNA methylation by a sesquiterpene lactone parthenolide, J. Pharmacol. Exp. Ther., 329, 505, 10.1124/jpet.108.147934 Pickering, 2011, Nucleolin protein interacts with microprocessor complex to affect biogenesis of microRNAs 15a and 16, J. Biol. Chem., 286, 44095, 10.1074/jbc.M111.265439 Rao, 2011, Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells, Chem. Res. Toxicol., 24, 238, 10.1021/tx100318m Yeh, 2013, A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells, Carcinogenesis, 34, 2918, 10.1093/carcin/bgt255 Zhang, 2012, Zerumbone, a Southeast Asian ginger sesquiterpene, induced apoptosis of pancreatic carcinoma cells through p53 signaling pathway, evidence-based complement, Altern. Med., 2012 Thebault, 2005, Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells, J. Biol. Chem., 280, 39423, 10.1074/jbc.M503544200 Lu, 2006, The role of Ca2+ in (-)-menthol-induced human promyelocytic leukemia HL-60 cell death, In Vivo, 20, 69 Schobert, 2007, Monoterpenes as drug shuttles: cytotoxic (6-aminomethylnicotinate)-dichloridoplatinum(II) complexes with potential to overcome cisplatin resistance, J. Med. Chem., 50, 1288, 10.1021/jm061379o Worthen, 1998, The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L, Anticancer Res., 18, 1527 Reindl, 2008, Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions, Chem. Biol., 15, 459, 10.1016/j.chembiol.2008.03.013 Bhattacharya, 2015, PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a, Biomaterials, 51, 91, 10.1016/j.biomaterials.2015.01.007 Li, 2014, Paeoniflorin inhibited the tumor invasion and metastasis in human hepatocellular carcinoma cells, Bratisl. Lek. Listy, 115, 427 Li, 2015, Paeoniflorin inhibits proliferation and induces apoptosis of human glioma cells via microRNA-16 upregulation and matrix metalloproteinase-9 downregulation, Mol. Med. Rep., 12, 2735, 10.3892/mmr.2015.3718 Li, 2016, Paeoniflorin inhibits doxorubicin-induced cardiomyocete apoptosis by downregulating microRNA-1 expression, Exp. Ther. Med., 11, 2407, 10.3892/etm.2016.3182 Sun, 2002, Apoptosis and differentiation induced by sodium selenite combined with all-trans retinoic acid (ATRA) in NB4 cells, Zhonghua Xue Ye Xue Za Zhi, 23, 628 Rossi, 2010, Non-coding RNAs change their expression profile after retinoid induced differentiation of the promyelocytic cell line NB4, BMC Res., 3, 24, 10.1186/1756-0500-3-24 Garzon, 2007, MicroRNA gene expression during retinoid acid-induced differentiation of human acute promyelocytic leukemia, Oncogene, 26, 4148, 10.1038/sj.onc.1210186 Terao, 2011, Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets, J. Biol. Chem., 286, 4027, 10.1074/jbc.M110.184994 Meseguer, 2011, MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 (SF2/ASF), J. Biol. Chem., 286, 4150, 10.1074/jbc.M110.167817 Annabali, 2012, A new module in neural differentiation control: two microRNAs upregulated by retinoic acid, miR-9 and miR-103, target the differentiation inhibitor ID2, PLoS One, 7, e40269, 10.1371/journal.pone.0040269 Khan, 2015, MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid, BMC Cancer, 15, 345, 10.1186/s12885-015-1374-y Yang, 2013, Retinoic acid-induced HOXA5 expression is co-regulated by HuR and miR-130a, Cell. Signal., 25, 1476, 10.1016/j.cellsig.2013.03.015 Zhang, 2015, Retinoic acid induces embryonic stem cell differentiation by altering both encoding RNA and miRNA expression, PLoS One, 10, e0132566, 10.1371/journal.pone.0132566 Jian, 2011, Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663, J. Hematol. Oncol., 4, 20, 10.1186/1756-8722-4-20 Zhang, 2015, Gap junctions enhance the antiproliferative effect of microRNA-124-3p in glioblastoma cells, J. Cell. Physiol., 230, 2476, 10.1002/jcp.24982 Chen, 2014, MicroRNA-302b-inhibited E2F3 transcription factor is related to all trans retinoic acid-induced glioma cell apoptosis, J. Neurochem., 131, 731, 10.1111/jnc.12820 van Breemen, 2008, Multitargeted therapy of cancer by lycopene, Cancer Lett., 269, 339, 10.1016/j.canlet.2008.05.016 Li, 2016, MicroRNA-let-7f-1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate cancer, Mol. Med. Rep., 13, 2708, 10.3892/mmr.2016.4841 Fleet, 2012, Vitamin D and cancer: a review of molecular mechanisms, Biochem. J., 441, 61, 10.1042/BJ20110744 Alvares-Díaz, 2012, MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells, Hum. Mol. Gen., 21, 2157, 10.1093/hmg/dds031 Gocek, 2011, MicroRNA-32 up-regulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis, Cancer Res., 71, 6230, 10.1158/0008-5472.CAN-11-1717 Padi, 2013, MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice, Gastroenterology, 145, 437, 10.1053/j.gastro.2013.04.012 González-Duarte, 2015, Calcitriol increases Dicer expression and modifies the microRNAs signature in SiHa cervical cancer cells, Biochem. Cell Biol., 93, 376, 10.1139/bcb-2015-0010 Guan, 2013, 1,25-Dihydroxyvitamin D3 up-regulates expression of hsa-let-7a-2 through the interaction of VDR/VDRE in human lung cancer A549 cells, Gene, 522, 142, 10.1016/j.gene.2013.03.065 Giangreco, 2013, Tumor suppressor microRNAs, miR-100 and miR-125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue, Cancer Prev. Res., 6, 483, 10.1158/1940-6207.CAPR-12-0253 Mohri, 2009, MicroRNA regulates human vitamin D receptor, Int. J. Cancer, 125, 1328, 10.1002/ijc.24459 Wang, 2009, MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3, Cell Cycle, 8, 736, 10.4161/cc.8.5.7870 Borkowski, 2014, Genetic mutation of p53 and suppression of the miR-17∼92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D signaling, Cancer Res., 75, 666, 10.1158/0008-5472.CAN-14-1329 Zitman-Gal, 2014, Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment, Cardiovasc. Diabetol., 13, 8, 10.1186/1475-2840-13-8 Rimbach, 2010, Gene-regulatory activity of α-tocopherol, Molecules, 15, 1746, 10.3390/molecules15031746 Gaedicke, 2008, Vitamin E dependent microRNA regulation in rat liver, FEBS Lett., 582, 3542, 10.1016/j.febslet.2008.09.032 Shirode, 2010, Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression of Akt and NFκB signaling, Biomed. Pharmacother., 64, 327, 10.1016/j.biopha.2009.09.018 Ji, 2012, Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in non-small cell lung cancer cells, Int. J. Cancer, 131, 2668, 10.1002/ijc.27549 Chen, 2006, Neuroprotective diterpenes from the fruiting body of Antrodia camphorate, J. Nat. Prod., 69, 689, 10.1021/np0581263 Chiang, 2010, Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways, Biochem. Pharmacol., 79, 162, 10.1016/j.bcp.2009.08.022 Kumar, 2011, Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles, Mut. Res., 707, 42, 10.1016/j.mrfmmm.2010.12.009