Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology

European Journal of Heart Failure - Tập 18 Số 1 - Trang 8-27 - 2016
Alexander R. Lyon1,2, Eduardo Bossone3, Birke Schneider4, Udo Sechtem5, Rodolfo Citro6, S. Richard Underwood1,2, Mary N. Sheppard7, Gemma A. Figtree8,9, Guido Parodi10, Yoshihiro J. Akashi11, Frank Ruschitzka12, Gerasimos Filippatos13, Alexandre Mebazaa14, Elmir Ömerovic15
1NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK
2National Heart and Lung Institute, Imperial College, London, UK
3Cardiology Division, ‘Cava de Tirreni and Amalfi Coast’ Hospital, Heart Department University of Salerno Italy
4Medizinische Klinik II, Sana Kliniken Lübeck, Germany
5Department of Cardiology , Robert Bosch Krankenhaus, Stuttgart, Germany
6University Hospital ‘San Giovanni di Dio e Ruggi d'Aragona’, Heart Department Largo Città di Ippocrate Salerno Italy
7Department of Cardiovascular Pathology St George's University Medical School London UK
8Department of Cardiology, Royal North Shore Hospital, Sydney, Australia
9North Shore Heart Research, Kolling Institute University of Sydney Australia
10Invasive Cardiology Careggi Hospital Florence Italy
11Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
12Clinic for Cardiology, University Hospital Zurich, Zurich, Switzerland
13Department of Cardiology Attikon University Hospital, University of Athens Medical School Athens Greece
14Université Paris Diderot; U942 Inserm Département d'Anestéhsie‐Réanimation Hôpitaux Universitaires Saint Louis‐Lariboisière Paris France
15Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Tóm tắt

Takotsubo syndrome is an acute reversible heart failure syndrome that is increasingly recognized in modern cardiology practice. This Position Statement from the European Society of Cardiology Heart Failure Association provides a comprehensive review of the various clinical and pathophysiological facets of Takotsubo syndrome, including nomenclature, definition, and diagnosis, primary and secondary clinical subtypes, anatomical variants, triggers, epidemiology, pathophysiology, clinical presentation, complications, prognosis, clinical investigations, and treatment approaches. Novel structured approaches to diagnosis, risk stratification, and management are presented, with new algorithms to aid decision‐making by practising clinicians. These also cover more complex areas (e.g. uncertain diagnosis and delayed presentation) and the management of complex cases with ongoing symptoms after recovery, recurrent episodes, or spontaneous presentation. The unmet needs and future directions for research in this syndrome are also discussed.

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