Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation

Elsevier BV - Tập 40 Số 10 - Trang 706-713 - 2017
Jin Hee Park1,2, Na Kyung Lee3, Soo Young Lee1,2
1Department of Life Science, Ewha Womans University, Seoul 03760, Korea
2The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, Korea,
3Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan 31538, Korea,

Tóm tắt

Từ khóa


Tài liệu tham khảo

Aliprantis, 2008, NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism, J Clin Invest, 118, 3775, 10.1172/JCI35711

Asagiri, 2007, The molecular understanding of osteoclast differentiation, Bone, 40, 251, 10.1016/j.bone.2006.09.023

Asagiri, 2005, Autoamplification of NFATc1 expression determines its essential role in bone homeostasis, J Exp Med, 202, 1261, 10.1084/jem.20051150

Boyle, 2003, Osteoclast differentiation and activation, Nature, 423, 337, 10.1038/nature01658

Cella, 2003, Impaired differentiation of osteoclasts in TREM-2-deficient individuals, J Exp Med, 198, 645, 10.1084/jem.20022220

Chambers, 2011, How are osteoclasts induced to resorb bone? Ann, N Y Acad Sci, 1240, 1, 10.1111/j.1749-6632.2011.06249.x

Cheng, 2003, The TNF receptor superfamily: role in immune inflammation and bone formation, Immunol Res, 27, 287, 10.1385/IR:27:2-3:287

Choi, 2013, Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis, Cell Res, 23, 524, 10.1038/cr.2013.33

Darnay, 1998, Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase, J Biol Chem, 273, 20551, 10.1074/jbc.273.32.20551

David, 2002, JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and-independent mechanisms, J Cell Sci, 115, 4317, 10.1242/jcs.00082

Dougall, 1999, RANK is essential for osteoclast and lymph node development, Genes Dev, 13, 2412, 10.1101/gad.13.18.2412

Duran, 2004, The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis, Dev Cell, 6, 303, 10.1016/S1534-5807(03)00403-9

Faccio, 2005, Vav3 regulates osteoclast function and bone mass, Nat Med, 11, 284, 10.1038/nm1194

Franzoso, 1997, Requirement for NF-kappaB in osteoclast and B-cell development, Genes Dev, 11, 3482, 10.1101/gad.11.24.3482

Fumoto, 2014, Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasis, J Bone Miner Res, 29, 830, 10.1002/jbmr.2096

Ghosh, 2002, Missing pieces in the NF-kappaB puzzle, Cell, 109, S81, 10.1016/S0092-8674(02)00703-1

Grigoriadis, 1994, c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling, Science, 266, 443, 10.1126/science.7939685

He, 2011, Erk1 positively regulates osteoclast differentiation and bone resorptive activity, PLoS One, 6, e24780, 10.1371/journal.pone.0024780

Hogan, 2003, Transcriptional regulation by calcium, calcineurin, and NFAT, Genes Dev, 17, 2205, 10.1101/gad.1102703

Humphrey, 2006, TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function, J Bone Miner Res, 21, 237, 10.1359/JBMR.051016

Ikeda, 2004, Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation, J Clin Invest, 114, 475, 10.1172/JCI200419657

Iotsova, 1997, Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2, Nat Med, 3, 1285, 10.1038/nm1197-1285

Jang, 2011, Inactivation of glycogen synthase kinase-3beta is required for osteoclast differentiation, J Biol Chem, 286, 39043, 10.1074/jbc.M111.256768

Karsenty, 2002, Reaching a genetic and molecular understanding of skeletal development, Dev Cell, 2, 389, 10.1016/S1534-5807(02)00157-0

Kim, 2002, A novel member of the leukocyte receptor complex regulates osteoclast differentiation, J Exp Med, 195, 201, 10.1084/jem.20011681

Kim, 2007, MafB negatively regulates RANKL-mediated osteoclast differentiation, Blood, 109, 3253, 10.1182/blood-2006-09-048249

Kim, 2008, NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP), Mol Endocrinol, 22, 176, 10.1210/me.2007-0237

Kim, 2009, Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice, J Clin Invest, 119, 813, 10.1172/JCI36809

Kobayashi, 2001, Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis, EMBO J, 20, 1271, 10.1093/emboj/20.6.1271

Koga, 2004, Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis, Nature, 428, 758, 10.1038/nature02444

Koga, 2005, NFAT and Osterix cooperatively regulate bone formation, Nat Med, 11, 880, 10.1038/nm1270

Kong, 1999, Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand, Nature, 402, 304, 10.1038/46303

Lee, 2005, A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation, Blood, 106, 852, 10.1182/blood-2004-09-3662

Li, 2000, RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism, Proc Natl Acad Sci USA, 97, 1566, 10.1073/pnas.97.4.1566

Li, 2002, p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function, Endocrinology, 143, 3105, 10.1210/endo.143.8.8954

Lin, 2015, The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors, Sci Signal, 8, ra54, 10.1126/scisignal.2005867

Lomaga, 1999, TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling, Genes Dev, 13, 1015, 10.1101/gad.13.8.1015

Mao, 2006, PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2, J Clin Invest, 116, 2869, 10.1172/JCI28775

Matsumoto, 2004, Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1, J Biol Chem, 279, 45969, 10.1074/jbc.M408795200

Miyauchi, 2010, The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis, J Exp Med, 207, 751, 10.1084/jem.20091957

Mizukami, 2002, Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6, Mol Cell Biol, 22, 992, 10.1128/MCB.22.4.992-1000.2002

Moon, 2012, Akt induces osteoclast differentiation through regulating the GSK3beta/NFATc1 signaling cascade, J Immunol, 188, 163, 10.4049/jimmunol.1101254

Naito, 1999, Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice, Genes Cells, 4, 353, 10.1046/j.1365-2443.1999.00265.x

Nakashima, 2011, Evidence for osteocyte regulation of bone homeostasis through RANKL expression, Nat Med, 17, 1231, 10.1038/nm.2452

Ninomiya-Tsuji, 1999, The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway, Nature, 398, 252, 10.1038/18465

Nishikawa, 2010, Blimp1-mediated repression of negative regulators is required for osteoclast differentiation, Proc Natl Acad Sci USA, 107, 3117, 10.1073/pnas.0912779107

Oikawa, 2012, Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion, J Cell Biol, 197, 553, 10.1083/jcb.201111116

Park, 2016, Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation, Sci Rep, 6, 26186, 10.1038/srep26186

Putney, 2005, Capacitative calcium entry: sensing the calcium stores, J Cell Biol, 169, 381, 10.1083/jcb.200503161

Sheridan, 2002, Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3, J Biol Chem, 277, 48664, 10.1074/jbc.M207029200

Shin, 2014, PKCbeta positively regulates RANKL-induced osteoclastogenesis by inactivating GSK-3beta, Mol Cells, 37, 747, 10.14348/molcells.2014.0220

Shinohara, 2008, Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals, Cell, 132, 794, 10.1016/j.cell.2007.12.037

Taguchi, 2009, A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals, Genes Cells, 14, 1331, 10.1111/j.1365-2443.2009.01351.x

Takayanagi, 2002, Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts, Dev Cell, 3, 889, 10.1016/S1534-5807(02)00369-6

Teitelbaum, 2000, Bone resorption by osteoclasts, Science, 289, 1504, 10.1126/science.289.5484.1504

Teitelbaum, 2003, Genetic regulation of osteoclast development and function, Nat Rev Genet, 4, 638, 10.1038/nrg1122

Vaananen, 1990, Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts, J Cell Biol, 111, 1305, 10.1083/jcb.111.3.1305

Wada, 2005, The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis, Nat Med, 11, 394, 10.1038/nm1203

Wagner, 2002, Functions of AP1 (Fos/Jun) in bone development, Ann Rheum Dis, 61, ii40, 10.1136/ard.61.suppl_2.ii40

Wang, 1992, Bone and haematopoietic defects in mice lacking c-fos, Nature, 360, 741, 10.1038/360741a0

Wong, 1998, The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor, J Biol Chem, 273, 28355, 10.1074/jbc.273.43.28355

Wong, 1999, TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src, Mol Cell, 4, 1041, 10.1016/S1097-2765(00)80232-4

Xiong, 2011, Matrix-embedded cells control osteoclast formation, Nat Med, 17, 1235, 10.1038/nm.2448

Yagi, 2007, Induction of DC-STAMP by alternative activation and downstream signaling mechanisms, J Bone Miner Res, 22, 992, 10.1359/jbmr.070401

Yamashita, 2007, NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1, J Biol Chem, 282, 18245, 10.1074/jbc.M610701200

Yasuda, 1998, Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL, Proc Natl Acad Sci USA, 95, 3597, 10.1073/pnas.95.7.3597

Ye, 2002, Distinct molecular mechanism for initiating TRAF6 signalling, Nature, 418, 443, 10.1038/nature00888

Zaidi, 2007, Skeletal remodeling in health and disease, Nat Med, 13, 791, 10.1038/nm1593

Zhao, 2009, Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis, Nat Med, 15, 1066, 10.1038/nm.2007

Zou, 2007, Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption, J Cell Biol, 176, 877, 10.1083/jcb.200611083