Cumulative arsenic exposure and lung cancer in smelter workers: A dose‐response study

American Journal of Industrial Medicine - Tập 15 Số 1 - Trang 31-41 - 1989
Lars Järup1, Göran Pershagen2, Stig Wall3
1Department of Environmental Hygiene, Karolinska Institute, and Department of Occupational Medicine, Karolinska Hospital, Stockholm, Sweden
2Department of Epidemiology, Institute of Environmental Medicine - Karolinska Institute, Stockholm, Sweden
3Department of Epidemiology and Health Care Research, University of Umeå, Umeå, Sweden

Tóm tắt

AbstractThe cause‐specific mortality was followed through 1981 in a cohort of 3,916 male Swedish smelter workers employed for at least 3 months from 1928 through 1967. Arsenic levels in the air of all workplaces within the smelter were estimated for three different time periods. Using this exposure matrix and detailed information of the work history, cumulative arsenic exposure could be computed for each worker. Standardized mortality ratios (SMRs) were calculated for several dose categories using age‐specific mortality rates from the county where the smelter was situated. A positive dose‐response relationship was found between cumulative arsenic exposure and lung cancer mortality with an overall SMR of 372 (304–450, 95% confidence interval). The lung cancer mortality was related to the estimated average intensity of exposure to arsenic but not to the duration. No positive dose‐response relationship was found between arsenic and ischemic heart disease or cerebrovascular disease. There was also no evident dose‐response relationship between estimated exposure to sulfur dioxide and lung cancer.

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Thông tin xuất bản

American Journal of Industrial Medicine

Tập 15 Số 1

31-41

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