Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis
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Smith S, Witkowski A, Joshi AK . Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res 2003; 42:289–317.
White SW, Zheng J, Zhang YM . Rock. The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem 2005; 74:791–831.
Cronan JE, Thomas J . Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways. Methods Enzymol 2009; 459:395–433.
Clay HB, Parl AK, Mitchell SL, Singh L, Bell LN, Murdock DG . Altering the mitochondrial fatty acid synthesis (mtFASII) pathway modulates cellular metabolic states and bioactive lipid profiles as revealed by metabolomic profiling. PLoS One 2016; 11:e0151171.
Wu J, Sun Y, Zhao Y, et al. Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species. Cell Res 2015; 25:621–633.
Ronnett GV, Kim EK, Landree LE, Tu Y . Fatty acid metabolism as a target for obesity treatment. Physiol Behav 2005; 85:25–35.
Cooke AA, Connaughton RM, Lyons CL, McMorrow AM, Roche HM . Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome. Eur J Pharmacol 2016; 785:207–214.
Taylor EM, Jones AD, Henagan TM . A review of mitochondrial-derived fatty acids in epigenetic regulation of obesity and type 2 diabetes. J Nutrit Health Food Sci 2014; 2:1–4.
Zhang Y, Kent JW, Lee A, et al. Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population. BMC Med Genomics 2013, 6:9–22.
Arumugam S, Sreedhar R, Thandavarayan RA, Karuppagounder V, Watanabe K . Targeting fatty acid metabolism in heart failure: is it a suitable therapeutic approach. Drug Discov Today 2016; 21:1003–1008.
Kuhajda FP . Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 2006; 66:5977–5980.
Menendez JA, Lupu R . Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007; 7:763–777.
Rossi S, Graner E, Febbo P, et al. Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res 2003; 1:707–715.
Migita T, Ruiz S, Fornari A, et al. Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst 2009; 101:519–532.
Vazquez-Martin A, Colomer R, Brunet J, Lupu R, Menendez JA . Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif 2008; 41:59–85.
Jin Q, Yuan LX, Boulbes D, et al. Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res 2010; 12:R96–R110.
Jenke-Kodama H, Sandmann A, Müller R, Dittmann E . Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol 2005; 22:2027–2039.
Maier T, Jenni S, Ban N . Architecture of mammalian fatty acid synthase at 4.5 A resolution. Science 2006; 311:1258–1262.
Jenni S, Leibundgut M, Maier T, Ban N . Architecture of a fungal fatty acid synthase at 5 A resolution. Science 2006; 311:1263–1267.
Lomakin IB, Xiong Y, Steitz TA . The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell 2007; 129:319–332.
Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolásek B, Ban N . Structure of fungal fatty acid synthase and implications for iterative substrate shuttling. Science 2007; 316:254–261.
Maier T, Leibundgut M, Ban N . The crystal structure of a mammalian fatty acid synthase. Science 2008; 321:1315–1322.
Cronan JE, Thomas J . Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways. Methods Enzymol 2009; 459:395–433.
Rafi S, Novichenok P, Kolappan S, et al. Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli. J Biol Chem 2006; 281:39285–39293.
Zhang L, Liu W, Hu T, et al. Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J Biol Chem 2008; 283:5370–5379.
Kimber MS, Martin F, Lu Y, et al. The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa. J Biol Chem 2004; 279:52593–52602.
Kostrewa D, Winkler FK, Folkers G, Scapozza L, Perozzo R . The crystal structure of PfFabZ, the unique beta-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum. Protein Sci 2005; 14:1570–1580.
Nguyen C, Haushalter RW, Lee DJ, et al. Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature 2014; 505:427–431.
Zeng D, Zhao J, Chung HS, Guan Z, Raetz CR, Zhou P . Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis. J Biol Chem 2013; 288:5475–5486.
Heath RJ, White SW, Rock CO . Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res 2001; 40:467–497.
Campbell JW, Cronan JE Jr . Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery. Annu Rev Microbiol 2001; 55:305–332.
Orita H, Coulter J, Lemmon C, et al. Selective inhibition of fatty acid synthase for lung cancer treatment. Clin Cancer Res 2007; 13:7139–7145.
He L, Zhang L, Liu X, et al. Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination. J Med Chem 2009; 52:2465–2481.
Hardwicke MA, Rendina AR, Williams SP, et al. A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat Chem Biol 2014; 10:774–779.
Liu W, Luo C, Han C, et al. A new beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: molecular cloning, enzymatic characterization, and structural modeling. Biochem Biophys Res Commun 2005; 333:1078–1086.
Liu W, Du L, Zhang L, Chen J, Shen X, Jiang H . Helicobacter pylori acyl carrier protein: expression, purification, and its interaction with beta-hydroxyacyl-ACP dehydratase. Protein Expr Purif 2007; 52:74–81.
Pasta S, Witkowski A, Joshi AK, Smith S . Catalytic residues are shared between two pseudosubunits of the dehydratase domain of the animal fatty acid synthase. Chem Biol 2007; 14:1377–1385.
Jones G, Willett P, Glen RC, Leach AR, Taylor R . Development and validation of a genetic algorithm for flexible docking. J Mol Biol 1997; 267:727–748.
Willemsen MJ, André T, Wanner R, et al. Microscale thermophoresis: interaction analysis and beyond. J Mol Struct 2014; 1077:101–113.
Maximino P, Horta PM, Santos LC, Oliveira CL, Fisberg M . Fatty acid intake and metabolic syndrome among overweight and obese women. Rev Bras Epidemiol 2015; 18:930–942.
Wen S, Niu Y, Lee SO, et al. Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells. Mol Carcinog 2016 Feb 19. doi: 10.1002/mc.22468
Harriman G, Greenwood J, Bhat S, et al. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci USA 2016; 113:E1796–1805.
Zhang JS, Lei JP, Wei GQ, Chen H, Ma CY, Jiang HZ . Natural fatty acid synthase inhibitors as potent therapeutic agents for cancers: a review. Pharm Biol 2016; 54:1919–1925.
Kuhajda FP, Pizer ES, Li JN, Mani NS, Frehywot GL, Townsend CA . Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA 2000; 97:3450–3454.
Hardwicke MA, Rendina AR, Williams SP, et al. A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat Chem Biol 2014; 10:774–779.
Otwinowski Z, Minor W . Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 1997; 276:307–326.
Adams PD, Afonine PV, Bunkóczi G, et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Cryst D 2010; 66:213–221.
Emsley P, Cowtan K . Coot: model-building tools for molecular graphics. Acta Cryst D 2004; 60:2126–2132.
Jones G, Willett P, Glen RC, Leach AR, Taylor R . Development and validation of a genetic algorithm for flexible docking. J Mol Biol 1997; 267:727–748.
Konarev PV, Petoukhov MV, Volkov VV, Svergun DI . ATSAS 2.1, a program package for small-angle scattering data analysis. J Appl Crystallogr 2006; 9:277–286.
Konarev PV, Volkov VV, Sokolova AV, Koch MHJ, Svergun DI . PRIMUS: a Windows PC-based system for small-angle scattering data analysis. J Appl Crystallogr 2003; 36:1277–1282.
Svergun DI, Barberato C, Koch MHJ . CRYSOL - a program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates. J Appl Crystallogr 1995; 28:768–773.
Svergun DI . Determination of the regularization parameter in indirect-transform methods using perceptual criteria. J Appl Crystallogr 1992; 25:495–503.
Svergun DI . Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. Biophys J 1999; 76:2879–2886.
Svergun DI, Petoukhov MV, Koch MHJ . Determination of domain structure of proteins from X-ray solution scattering. Biophys J 2001; 80:2946–2953.
Volkov VV, Svergun DI . Uniqueness of ab initio shape determination in small-angle scattering. J Appl Crystallogr 2003; 36:860–864.