Crystal structure determination of a neutral neurotoxin BmK M4 fromButhus martensii Karsch at 0.20 nm

Xiaolin He1, Xinqi Liu1, Z. Zeng1, Hongmin Li1, Miao Wang1, Ying Zhang1, Dacheng Wang1
1Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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Rochat, H., Benard, P., Couraud, F., Scorpion toxins: chemistry and mode of action, in Advances in Cytopharmacology (eds. Cecareli, B., Clementi, F.), New York: Raven Press, 1979, 3: 357.

Couraud, F., Jover, E., Debois, J. M. et al., Two types of scorpion toxin receptor sites, one related to activation, the other to the inactivation of the action potential sodium channel, Toxicon, 1982, 20: 9.

Gordon, D., Matineauclaire, M. F., Cestele, S. et al., Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channel, J. Biol. Chem., 1996, 271: 8034.

Xiong, Y. M., Ling, M. H., Lan, Z. D. et al., The cDNA sequence of an excitatory insect selective neurotoxin from the scorpionButhus martensii Larsch with analgesic activity from scorpion BmK, Toxicon, 1999, 37: 335.

Li, H. M., Zhao, T., Jin, L. et al., A series of bioactivity-variant neurotoxins from scorpionButhus martensii Karsch: purification, crystallization and crystallographic analysis, Acta Cryst., 1999, D55.

Xiong, Y. M., Ling, M. H., Wang, D. C. et al., The cDNA and genomic DNA sequences of a mammalian neurotoxin from the scorpionButhus martensii Karsch, Toxicon, 1997, 35: 1025.

Xiong, Y. M., Ling, M. H., Zhao, T. et al., The cDNA sequences of two anti-mammalian toxins from East-Asia Scorpio, Acta Biochem. Biophys. Sinica, 1997, 29: 200.

Luo, M. J., Xiong, Y. M., Wang, M. et al., Purification and sequence determination of a new neutral mammalian neurotoxin from the scorpionButhus martensii Karsch, Toxicon, 1997, 35: 723.

Li, H. M., Wang, D. C., Zeng, Z. H. et al., Crystal structure of an acidic neurotoxin from scorpionButhus martensii Karsch at 1.85Å resolution, J. Mol. Biol., 1996, 261: 415.

Li, H. M., Jin, L., Zeng, Z. H. et al., Structure determination of an acidic neurotoxin (BmK M8) fromButhus martensii Karsch at 0.25 nm resolution, Science in China (in Chinese), Ser. C, 1996, 26: 213.

Fontecilla-Camps, J. C., Habersetzer-Rochat, C., Orthorhomic crystals and three-dimensional structure of the potent toxin II from the scorpionAndroctonus australis Hector, Proc. Natl. Acad. Sci. USA, 1988, 85: 7443.

Broekaer, W. F., Terras, F. R. G., Lammue, B. P. A. et al., Plant defensins: novel antimicrobial peptides as components of the host defense system, Plant Physiol., 1995, 108: 1353.

Gao, G. H., Dai, J. X., Ding, M. et al., Solution conformation of brazzin by1H nuclear magnetic resonance: resonance assignment and secondary structure, Int. J. Biomacromol., 1999, 24: 351.

Vita, C., Engineering novel proteins by transfer of active site to natural scaffolds, Curr. Opion. Biotech., 1997, 8: 429.

Stewart, D. E., Sarker, A., Wampler, J. E., Occurrence and role ofcis peptide bonds in protein structures, J. Mol. Biol., 1990, 214: 253.