Crystal and molecular structure of 3,5-cycloandrostan-6β-ol-17-one
Tóm tắt
The crystal and molecular structure of 3,5-cycloandrostan-6β-ol-17-one has been determined by X-ray analysis,13C-NMR,1H-NMR, IR and elemental analyses. The compound was obtained from dehydroepiandrosterone (DHEA) via the 3β-tosyl derivative by refluxing in a butan-2-one/water mixture. The X-ray analysis shows that the planar cyclopropane ring is predominantlyα orientated and the formation of the C(3)-C(5) bond enables the A ring to adopt a distorted boat conformation. Spectroscopic evidence for the presence of the cyclopropane ring and the 6β-hydroxy group are presented.
Tài liệu tham khảo
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