Crown ether–ionic liquid-based extraction chromatographic resin for separation of 90Y from 90Sr

Journal of Radioanalytical and Nuclear Chemistry - Tập 311 - Trang 1643-1648 - 2016
Yu Zou1, Juncheng Liang2, Taiwei Chu1
1Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
2National Institute of Metrology, Beijing, China

Tóm tắt

90Y was separated from 90Sr using an extraction chromatographic resin consisting of 4, 4′(5′)-bis-t-butylcyclohexano-18-crown-6 (DtBuCH18C6), 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl) amide (C2mimNTf2), and a polymer (Amberlite XAD-7). Ionic liquid was introduced into the column to improve the separation efficiency. The column showed an excellent performance for the separation of Y from Sr. After the separation, the ratio of 90Sr/90Y was <2.0 × 10−5; the column was recycled for >18 times. This study provides preliminary results on columns to produce 90Y with a high purity in radiopharmaceuticals.

Tài liệu tham khảo

Suzuki H, Sasaki Y, Sugo Y, Apichaibukol A, Kimura T (2004) Extraction and separation of Am(III) and Sr (II) by N, N, N, N-tetraoctyl-3-oxapentanediamide (TODGA). Radiochim Acta/Int J Chem Asp Nucl Sci Technol 92(8):463–466 USP yttrium Y-90 ibritumomab tiuxetan injection. USP monographs 29: http://www.pharmacopeia.cn/v29240/usp29229nf29224s29240_m89430.html Ying RJ (2015) Extraction and analysis of Strontium in water sample using a Sr2+ selective polymer as the absorbent phase. Int J Anal Chem 5:1–5 Bandara A, Senanayake G (2015) Leachability of rare-earth, calcium and minor metal ions from natural Fluorapatite in perchloric, hydrochloric, nitric and phosphoric acid solutions: effect of proton activity and anion participation. Hydrometallurgy 153:179–189 Sarma D, Malliakas CD, Subrahmanyam KS, Islama SM, Kanatzidis MG (2016) K2xSn4-xS8-x (x = 0.65-1): a new metal sulfide for rapid and selective removal of Cs+, Sr2+ and UO2 2+ ions. Chem Sci 7(2):1121–1132 Chen Z, Wu Y, Wei Y, Mimura H (2016) Preparation of silica-based titanate adsorbents and application for strontium removal from radioactive contaminated wastewater. J Radioanal Nucl Chem 307(2):931–940 Ma FY, Shi WL, Meng H, Li Z, Zhou W, Zhang L (2016) Preparation, characterization and ion-exchange behavior of polyantimonic acid-polyacrylonitrile (PAA-PAN) composite beads for strontium(II). J Radioanal Nucl Chem 308(1):155–163 Zakurdaeva OA, Nesterov SV (2015) Improved extraction-spectrophotometric method for determination of dicyclohexano-substituted crown ethers in aqueous solutions. J Radioanal Nucl Chem 303(3):1737–1744 Rais J, Tachimori S, Yoo E, Alexova J, Bubenikova M (2015) Extraction of Radioactive Cs and Sr from Nitric Acid Solutions with 25,27-Bis(1-octyloxy)calix 4–26,28-Crown-6 and Dicyclohexyl-18-Crown-6: effect of Nature of the Organic Solvent. Sep Sci Technol 50(8):1202–1212 Wankowski JL, Dietz ML (2016) Ionic Liquid (IL) Cation and Anion Structural Effects on Metal Ion Extraction into Quaternary Ammonium-based ILs. Solv Extr Ion Exchange 34(1):48–59 Horwitz EP, Chiarizia R, Dietz ML (1992) A novel strontium-selective extraction chromatographic resin. Solv Extr Ion Exchange 10(2):313–336 Dutta S, Mohapatra PK, Raut DR, Manchanda VK (2011) Chromatographicseparation of carrier free Y-90 from Sr-90 using a diglycolamide based resin for possible pharmaceutical applications. J Chromatogr A 1218(37):6483–6488 Dileep CS, Jagasia P, Das SK, Dhami PS, Tripathi SC, Gandhi PM, Tomar BS (2013) Estimation of Sr-90 in reprocessing streams using pre-packed extraction chromatographic column of 4,4 ‘(5 ‘)-bis(tert-butylcyclohexano)-18-crown-6 impregnated on amberlite XAD-7. J Radioanal Nucl Chem 298(1):105–110 Hawkins CA, Momen MA, Garvey SL, Kestell J, Kaminski MD, Dietz ML (2015) Evaluation of solid-supported room-temperature ionic liquids containing crown ethers as media for metal ion separation and preconcentration. Talanta 135:115–123 Tazoe H, Obata H, Yamagata T, Karube Z, Nagai H, Yamada M (2016) Determination of strontium-90 from direct separation of yttrium-90 by solid phase extraction using DGA Resin for seawater monitoring. Talanta 152:219–227 Kanapill GM, Newton GJ (1971) New method for separation of multicurie quanties of Y-90 from Sr-90. Int J Appl Radiat Isot 22(9):567–575 Kandwal P, Ansari SA, Mohapatra PK, Manchanda VK (2011) Separation of Carrier Free 90Y from 90Sr by Hollow Fiber Supported Liquid Membrane Containing Bis(2-ethylhexyl) Phosphonic Acid. Sep Sci Technol 46(6):904–911 Petrovic DZ, Trtic-Petrovic TM, Vladisavljevic GT, Stoiljkovic MM, Slavkovic-Beskoski LJ, Kumric KR (2015) Novel 90Sr-90Y generator system based on a pertraction through supported liquid membrane in hollow fiber contactor. Chem Eng Res Des 97:57–67 Chakravarty R, Pandey U, Manolkar RB, Dash A, Venkatesh M, Pillai MRA (2008) Development of an electrochemical 90Sr-90Y generator for separation of 90Y suitable for targeted therapy. Nucl Med Biol 35(2):245–253 Dai S, Ju Y, Barnes C (1999) Solvent extraction of strontium nitrate by a crown ether using room-temperature ionic liquids†. J Chem Soc, Dalton Trans 8:1201–1202 Dietz ML, Dzielawa JA, Laszak I, Young BA, Jensen MP (2003) Influence of solvent structural variations on the mechanism of facilitated ion transfer into room-temperature ionic liquids. Green Chem 5(6):682–685 Chuang JT, Lo JG (1996) Extraction chromatographic separation of carrier-free Y-90 from Sr-90/Y-90 generator by crown ether coated silica gels. J Radioanal Nucl Chem Artic 204(1):83–93 Pandey U, Dhami PS, Jagesia P, Venkatesh M, Pillai M (2008) Extraction paper chromatography technique for the radionuclidic purity evaluation of 90Y for clinical use. Anal Chem 80(3):801–807 Pandey U, Kumar Y, Dash A (2014) Validation of an extraction paper chromatography (EPC) technique for estimation of trace levels of 90Sr in 90Y solutions obtained from 90Sr/90Y generator systems. J Radioanal Nucl Chem 300(1):355–360 Shvedene NV, Borovskaya SV, Sviridov VV, Ismailova ER, Pletnev IV (2005) Measuring the solubilities of ionic liquids in water using ion-selective electrodes. Anal Bioanal Chem 381(2):427–430 Xu C, Shen X, Chen Q, Gao H (2009) Investigation on the extraction of strontium ions from aqueous phase using crown ether-ionic liquid systems. Sci China, Ser B: Chem 52(11):1858–1864 Yuan L, Peng J, Xu L, Zhai M, Li J, Wei G (2009) Radiation effects on hydrophobic ionic liquid [C4mim][NTf2] during extraction of strontium ions. J Phys Chem B 113(26):8948–8952 Bossé É, Berthon L, Zorz N, Monget J, Berthon C, Bisel I, Legand S, Moisy P (2008) Stability of [MeBu3N][Tf2N] under gamma irradiation. Dalton Trans 7:924–931 Shkrob IA, Marin TW, Chemerisov SD, Hatcher JL, Wishart JF (2011) Radiation induced redox reactions and fragmentation of constituent ions in ionic liquids. 2. Imidazolium cations. J Phys Chem B 115(14):3889–3902 Ao Y, Yuan W, Yu T, Peng J, Li J, Zhai M, Zhao L (2015) Radiolysis of crown ether–ionic liquid systems: identification of radiolytic products and their effect on the removal of Sr2+ from nitric acid. Phys Chem Chem Phys 17(5):3457–3462 Hawkins CA, Momen M, Garvey SL, Kestell J, Kaminski MD, Dietz ML (2015) Evaluation of solid-supported room-temperature ionic liquids containing crown ethers as media for metal ion separation and preconcentration. Talanta 135:115–123