Crosstalk of reactive oxygen species and NF-κB signaling
Tóm tắt
Từ khóa
Tài liệu tham khảo
Vallabhapurapu S, Karin M . Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009; 27:693–733.
Hatada EN, Nieters A, Wulczyn FG, et al. The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding. Proc Natl Sci USA 1992; 89:2489–2493.
Bonizzi G, Karin M . The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004; 25:280–288.
Beinke S, Ley SC . Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 2004; 382(Pt 2):393–409.
Senftleben U, Cao Y, Xiao G, et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001; 293:1495–1499.
Xiao G, Harhaj EW, Sun SC . NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 2001; 7:401–409.
Dejardin E, Droin NM, Delhase M, et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity 2002; 17:525–535.
Liao G, Zhang M, Harhaj EW, Sun SC . Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem 2004; 279:26243–26250.
Zarnegar BJ, Wang Y, Mahoney DJ, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 2008; 9:1371–1378.
Vallabhapurapu S, Matsuzawa A, Zhang W, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 2008; 9:1364–1370.
Xiao G, Fong A, Sun SC . Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem 2004; 279:30099–30105.
Rhee SG, Yang KS, Kang SW, Woo HA, Chang TS . Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. Antioxid Redox Signal 2005; 7:619–626.
Holmgren A . Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid Redox Signal 2000; 2:811–820.
Saitoh M, Nishitoh H, Fujii M, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998; 17:2596–2606.
Liu H, Nishitoh H, Ichijo H, Kyriakis JM . Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol 2000; 20:2198–2208.
Noguchi T, Takeda K, Matsuzawa A et al. Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death. J Biol Chem 2005; 280:37033–37040.
Liu Y, Min W . Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner. Circ Res 2002; 90:1259–1266.
Li X, Luo Y, Yu L, et al. SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell Death Differ 2008; 15:739–750.
Brown DI, Griendling KK . Nox proteins in signal transduction. Free Radic Biol Med 2009; 47:1239–1253.
Quinn MT, Ammons MC, Deleo FR . The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction. Clin Sci (Lond) 2006; 111:1–20.
Ushio-Fukai M . Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 2009; 11:1289–1299.
Saito Y, Nishio K, Ogawa Y, et al. Turning point in apoptosis/necrosis induced by hydrogen peroxide. Free Radic Res 2006; 40:619–630.
Takeda M, Shirato I, Kobayashi M, Endou H . Hydrogen peroxide induces necrosis, apoptosis, oncosis and apoptotic oncosis of mouse terminal proximal straight tubule cells. Nephron 1999; 81:234–238.
Teramoto S, Tomita T, Matsui H, et al. Hydrogen peroxide-induced apoptosis and necrosis in human lung fibroblasts: protective roles of glutathione. Jpn J Pharmacol 1999; 79:33–40.
Perkins ND, Gilmore TD . Good cop, bad cop: the different faces of NF-kappaB. Cell Death Differ 2006; 13:759–772.
Reuther-Madrid JY, Kashatus D, Chen S, et al. The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Mol Cell Biol 2002; 22:8175–8183.
Tang F, Tang G, Xiang J, et al. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 2002; 22:8571–8579.
Morgan MJ, Kim YS, Liu ZG . TNFalpha and reactive oxygen species in necrotic cell death. Cell Res 2008; 18:343–349.
Morgan MJ, Liu ZG . Reactive oxygen species in TNFalpha-induced signaling and cell death. Mol Cells 2010; 30:1–12.
Wullaert A, Heyninck K, Beyaert R . Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem Pharmacol 2006; 72:1090–1101.
Nakano H, Nakajima A, Sakon-Komazawa S, et al. Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ 2006; 13:730–737.
Papa S, Bubici C, Zazzeroni F, et al. The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ 2006; 13:712–729.
Morgan MJ, Kim YS, Liu Z . Lipid rafts and oxidative stress-induced cell death. Antioxid Redox Signal 2007; 9:1471–1483.
Jones PL, Ping D, Boss JM . Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB. Mol Cell Biol 1997; 17:6970–6981.
Djavaheri-Mergny M, Javelaud D, Wietzerbin J, Besancon F . NF-kappaB activation prevents apoptotic oxidative stress via an increase of both thioredoxin and MnSOD levels in TNFalpha-treated Ewing sarcoma cells. FEBS Lett 2004; 578:111–115.
Kairisalo M, Korhonen L, Blomgren K, Lindholm D . X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-kappaB activation. Biochem Biophys Res Commun 2007; 364:138–144.
Das KC, Lewis-Molock Y, White CW . Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells. Am J Physiol 1995; 269(5 Pt 1):L588–L602.
Li Y, Huang TT, Carlson EJ, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 1995; 11:376–381.
Macmillan-Crow LA, Cruthirds DL . Invited review: manganese superoxide dismutase in disease. Free Radic Res 2001; 34:325–336.
Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W . Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000; 407:390–395.
Rojo AI, Salinas M, Martin D, Perona R, Cuadrado A . Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB. J Neurosci 2004; 24:7324–7334.
Elchuri S, Oberley TD, Qi W, et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 2005; 24:367–380.
Pham CG, Bubici C, Zazzeroni F, et al. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 2004; 119:529–542.
Zhou LZ, Johnson AP, Rando TA . NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radic Biol Med 2001; 31:1405–1416.
Schreiber J, Jenner RG, Murray HL, et al. Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proc Natl Acad Sci USA 2006; 103:5899–5904.
Matsui M, Oshima M, Oshima H, et al. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev Biol 1996; 178:179–185.
Tanaka T, Hosoi F, Yamaguchi-Iwai Y, et al. Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBOJ 2002; 21:1695–1703.
Nonn L, Williams RR, Erickson RP, Powis G . The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Mol Cell Biol 2003; 23:916–922.
Xia C, Hu J, Ketterer B, Taylor JB . The organization of the human GSTP1-1 gene promoter and its response to retinoic acid and cellular redox status. Biochem J 1996; 313(Pt 1):155–161.
Dourado DF, Fernandes PA, Ramos MJ . Mammalian cytosolic glutathione transferases. Curr Protein Pept Sci 2008; 9:325–337.
Dang DT, Chen F, Kohli M, et al. Glutathione S-transferase pi1 promotes tumorigenicity in HCT116 human colon cancer cells. Cancer Res 2005; 65:9485–9494.
Hinata K, Gervin AM, Jennifer Zhang Y, Khavari PA . Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin. Oncogene 2003; 22:1955–1964.
Howells C, West AK, Chung RS . Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain. FEBS J 2010; 277:2931–2939.
Kumari MV, Hiramatsu M, Ebadi M . Free radical scavenging actions of metallothionein isoforms I and II. Free Radic Res 1998; 29:93–101.
Yao KS, Hageboutros A, Ford P, O'Dwyer PJ . Involvement of activator protein-1 and nuclear factor-kappaB transcription factors in the control of the DT-diaphorase expression induced by mitomycin C treatment. Mol Pharmacol 1997; 51:422–430.
Dinkova-Kostova AT, Talalay P . NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Arch Biochem Biophys 2010; 501:116–123.
Ahn KS, Sethi G, Jain AK, Jaiswal AK, Aggarwal BB . Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis. J Biol Chem 2006; 281:19798–19808.
Lavrovsky Y, Schwartzman ML, Levere RD, Kappas A, Abraham NG . Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci USA 1994; 91:5987–5991.
Wu G, Marin-Garcia J, Rogers TB, Lakatta EG, Long X . Phosphorylation and hypoxia-induced heme oxygenase-1 gene expression in cardiomyocytes. J Card Fail 2004; 10:519–526.
Lin CC, Chiang LL, Lin CH, et al. Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells. Eur J Pharmacol 2007; 560:101–109.
Prawan A, Kundu JK, Surh YJ . Molecular basis of heme oxygenase-1 induction: implications for chemoprevention and chemoprotection. Antioxid Redox Signal 2005; 7:1688–1703.
Lei XG, Cheng WH, McClung JP . Metabolic regulation and function of glutathione peroxidase-1. Annu Rev Nutr 2007; 27:41–61.
Sies H, Sharov VS, Klotz LO, Briviba K . Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase. J Biol Chem 1997; 272:27812–27817.
Ciaccio PJ, Walsh ES, Tew KD . Promoter analysis of a human dihydrodiol dehydrogenase. Biochem Biophys Res Commun 1996; 228:524–529.
Penning TM, Ohnishi ST, Ohnishi T, Harvey RG . Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase. Chem Res Toxicol 1996; 9:84–92.
Chen J, Adikari M, Pallai R, Parekh HK, Simpkins H . Dihydrodiol dehydrogenases regulate the generation of reactive oxygen species and the development of cisplatin resistance in human ovarian carcinoma cells. Cancer Chemother Pharmacol 2008; 61:979–987.
Anrather J, Racchumi G, Iadecola C . NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem 2006; 281:5657–5667.
Xu P, Huecksteadt TP, Hoidal JR . Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). Genomics 1996; 34:173–180.
Hille R, Nishino T . Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J 1995; 9:995–1003.
Maia L, Vala A, Mira L . NADH oxidase activity of rat liver xanthine dehydrogenase and xanthine oxidase-contribution for damage mechanisms. Free Radic Res 2005; 39:979–986.
Kolyada AY, Savikovsky N, Madias NE . Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages: evidence for tissue specificity. Biochem Biophys Res Commun 1996; 220:600–605.
Hughes JE, Srinivasan S, Lynch KR, et al. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ Res 2008; 102:950–958.
Guo Z, Shao L, Du Q, Park KS, Geller DA . Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter. FASEB J 2007; 21:535–542.
Morris KR, Lutz RD, Choi HS, et al. Role of the NF-kappaB signaling pathway and kappaB cis-regulatory elements on the IRF-1 and iNOS promoter regions in mycobacterial lipoarabinomannan induction of nitric oxide. Infect Immun 2003; 71:1442–1452.
Nakata S, Tsutsui M, Shimokawa H et al. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. Arterioscler Thromb Vasc Biol 2007; 27:92–98.
Li Y, Zhao Y, Li G, et al. Regulation of neuronal nitric oxide synthase exon 1f gene expression by nuclear factor-kappaB acetylation in human neuroblastoma cells. J Neurochem 2007; 101:1194–1204.
Ahmad R, Rasheed Z, Ahsan H . Biochemical and cellular toxicology of peroxynitrite: implications in cell death and autoimmune phenomenon. Immunopharmacol Immunotoxicol 2009; 31:388–396.
Liaudet L, Vassalli G, Pacher P . Role of peroxynitrite in the redox regulation of cell signal transduction pathways. Front Biosci 2009; 14:4809–4814.
Deng WG, Zhu Y, Wu KK . Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation. J Biol Chem 2003; 278:4770–4777.
Inoue H, Tanabe T . Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells. Biochem Biophys Res Commun 1998; 244:143–148.
Marnett LJ, Rowlinson SW, Goodwin DC, Kalgutkar AS, Lanzo CA . Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition. J Biol Chem 1999; 274:22903–22906.
Arakawa T, Nakamura M, Yoshimoto T, Yamamoto S . The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NF kappa B/Rel. FEBS Lett 1995; 363:105–110.
Chopra A, Ferreira-Alves DL, Sirois P, Thirion JP . Cloning of the guinea pig 5-lipoxygenase gene and nucleotide sequence of its promoter. Biochem Biophys Res Commun 1992; 185:489–495.
Schweiger D, Furstenberger G, Krieg P . Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways. J Lipid Res 2007; 48:553–564.
Uchida K . 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 2003; 42:318–343.
Kim C, Kim JY, Kim JH . Cytosolic phospholipase A(2), lipoxygenase metabolites, and reactive oxygen species. BMB Rep 2008; 41:555–559.
Gillette JR, Brodie BB, La Du BN . The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen. J Pharmacol Exp Ther 1957; 119:532–540.
Thurman RG, Ley HG, Scholz R . Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase. Eur J Biochem 1972; 25:420–430.
Nordblom GD, Coon MJ . Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450. Arch Biochem Biophys 1977; 180:343–347.
Imaoka S, Osada M, Minamiyama Y, et al. Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation. Cancer Lett 2004; 203:117–125.
Abdel-Razzak Z, Garlatti M, Aggerbeck M, Barouki R . Determination of interleukin-4-responsive region in the human cytochrome P450 2E1 gene promoter. Biochem Pharmacol 2004; 68:1371–1381.
Morgan ET, Li-Masters T, Cheng PY . Mechanisms of cytochrome P450 regulation by inflammatory mediators. Toxicology 2002; 181–182:207–210.
Dulos J, Kaptein A, Kavelaars A, Heijnen C, Boots A . Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b. Arthritis Res Ther 2005; 7:R1271–R1280.
Caro AA, Cederbaum AI . Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol 2004; 44:27–42.
Cederbaum AI, Wu D, Mari M, Bai J . CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med 2001; 31:1539–1543.
Nieto N, Friedman SL, Cederbaum AI . Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem 2002; 277:9853–9864.
Kabe Y, Ando K, Hirao S, Yoshida M, Handa H . Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal 2005; 7:395–403.
Meyer M, Schreck R, Baeuerle PA . H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 1993; 12:2005–2015.
Hirota K, Matsui M, Iwata S, et al. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci USA 1997; 94:3633–3638.
Hirota K, Murata M, Sachi Y, et al. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J Biol Chem 1999; 274:27891–27897.
Paulsen CE, Carroll KS . Orchestrating redox signaling networks through regulatory cysteine switches. ACS Chem Biol 2010; 5:47–62.
Groen A, Lemeer S, van der Wijk T, et al. Differential oxidation of protein-tyrosine phosphatases. J Biol Chem 2005; 280:10298–10304.
Nakashima I, Kato M, Akhand AA, et al. Redox-linked signal transduction pathways for protein tyrosine kinase activation. Antioxid Redox Signal 2002; 4:517–531.
Nakashima I, Takeda K, Kawamoto Y, et al. Redox control of catalytic activities of membrane-associated protein tyrosine kinases. Arch Biochem Biophys 2005; 434:3–10.
Kamata H, Honda S, Maeda S, et al. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120:649–661.
den Hertog J, Groen A, van der Wijk T . Redox regulation of protein-tyrosine phosphatases. Arch Biochem Biophys 2005; 434:11–15.
Toledano MB, Leonard WJ . Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro. Proc Natl Acad Sci USA 1991; 88:4328–4332.
Toledano MB, Ghosh D, Trinh F, Leonard WJ . N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65. Mol Cell Biol 1993; 13:852–860.
Matthews JR, Kaszubska W, Turcatti G, Wells TN, Hay RT . Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappa B. Nucleic Acids Res 1993; 21:1727–1734.
Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, Hay RT . Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res 1992; 20:3821–3830.
Klatt P, Lamas S . Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress. Eur J Biochem 2000; 267:4928–4944.
Pineda-Molina E, Klatt P, Vazquez J, et al. Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding. Biochemistry 2001; 40:14134–14142.
Nishi T, Shimizu N, Hiramoto M, et al. Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo. J Biol Chem 2002; 277:44548–44556.
Ando K, Hirao S, Kabe Y, et al. A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res 2008; 36:4327–4336.
Matthews JR, Botting CH, Panico M, Morris HR, Hay RT . Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res 1996; 24:2236–2242.
Kelleher ZT, Matsumoto A, Stamler JS, Marshall HE . NOS2 regulation of NF-kappaB by S-nitrosylation of p65. J Biol Chem 2007; 282:30667–30672.
Nowak DE, Tian B, Jamaluddin M, et al. RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes. Mol Cell Biol 2008; 28:3623–3638.
Zhong H, May MJ, Jimi E, Ghosh S . The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 2002; 9:625–636.
Zhong H, Voll RE, Ghosh S . Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1998; 1:661–671.
Gloire G, Piette J . Redox regulation of nuclear post-translational modifications during NF-kappaB activation. Antioxid Redox Signal 2009; 11:2209–2222.
Jamaluddin M, Wang S, Boldogh I, Tian B, Brasier AR . TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway. Cellular signalling 2007; 19:1419–1433.
Liu J, Yoshida Y, Yamashita U . DNA-binding activity of NF-kappaB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase. Mol Immunol 2008; 45:3984–3989.
Schieven GL, Kirihara JM, Myers DE, Ledbetter JA, Uckun FM . Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes. Blood 1993; 82:1212–1220.
Schoonbroodt S, Ferreira V, Best-Belpomme M, et al. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress. J Immunol 2000; 164:4292–4300.
Takada Y, Mukhopadhyay A, Kundu GC, et al. Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. J Biol Chem 2003; 278:24233–24241.
Canty TG Jr, Boyle EM, Jr ., Farr A, et al. Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha. Circulation 1999; 100(19 Suppl):II361–II364.
Fan C, Li Q, Ross D, Engelhardt JF . Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. J Biol Chem 2003; 278:2072–2080.
Imbert V, Rupec RA, Livolsi A, et al. Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 1996; 86:787–798.
Lluis JM, Buricchi F, Chiarugi P, Morales A, Fernandez-Checa JC . Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. Cancer Res 2007; 67:7368–7377.
Koong AC, Chen EY, Giaccia AJ . Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res 1994; 54:1425–1430.
Beraud C, Henzel WJ, Baeuerle PA . Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 1999; 96:429–434.
Fan C, Li Q, Zhang Y, et al. IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest 2004; 113:746–755.
Llacuna L, Mari M, Lluis JM, et al. Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion. Am J Pathol 2009; 174:1776–1785.
Kil IS, Kim SY, Park JW . Glutathionylation regulates IkappaB. Biochem Biophys Res Commun 2008; 373:169–173.
Wu M, Bian Q, Liu Y, et al. Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome. Free Radic Biol Med 2009; 46:62–69.
Panopoulos A, Harraz M, Engelhardt JF, Zandi E . Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem 2005; 280:2912–2923.
Reynaert NL, van der Vliet A, Guala AS, et al. Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Sci USA 2006; 103:13086–13091.
Korn SH, Wouters EF, Vos N, Janssen-Heininger YM . Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase. J Biol Chem 2001; 276:35693–35700.
Byun MS, Jeon KI, Choi JW, Shim JY, Jue DM . Dual effect of oxidative stress on NF-kappakB activation in HeLa cells. Exp Mol Med 2002; 34:332–339.
Kapahi P, Takahashi T, Natoli G, et al. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 2000; 275:36062–36066.
Reynaert NL, Ckless K, Korn SH, et al. Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation. Proc Natl Acad Sci USA 2004; 101:8945–8950.
Rossi A, Kapahi P, Natoli G, et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 2000; 403:103–108.
Herscovitch M, Comb W, Ennis T, et al. Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347. Biochem Biophys Res Commun 2008; 367:103–108.
Jaspers I, Zhang W, Fraser A, Samet JM, Reed W . Hydrogen peroxide has opposing effects on IKK activity and IkappaBalpha breakdown in airway epithelial cells. Am J Respir Cell Mol Biol 2001; 24:769–777.
Kamata H, Manabe T, Oka S, Kamata K, Hirata H . Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops. FEBS Lett 2002; 519:231–237.
Cross JV, Templeton DJ . Thiol oxidation of cell signaling proteins: Controlling an apoptotic equilibrium. J Cell Biochem 2004; 93:104–111.
Xia Y, Makris C, Su B, et al. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci USA 2000; 97:5243–5248.
Yang J, Lin Y, Guo Z, et al. The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol 2001; 2:620–624.
Blonska M, Shambharkar PB, Kobayashi M, et al. TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem 2005; 280:43056–43063.
Ryabinina OP, Subbian E, Iordanov MS . D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol 2006; 7:7.
Liu HH, Xie M, Schneider MD, Chen ZJ . Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci USA 2006; 103:11677–11682.
Shim JH, Xiao C, Paschal AE, et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 2005; 19:2668–2681.
Sato S, Sanjo H, Takeda K, et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 2005; 6:1087–1095.
Takaesu G, Surabhi RM, Park KJ, et al. TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J Mol Biol 2003; 326:105–115.
Li Q, Engelhardt JF . Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem 2006; 281:1495–1505.
Madrid LV, Mayo MW, Reuther JY, Baldwin AS Jr . Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 2001; 276:18934–18940.
Dan HC, Cooper MJ, Cogswell PC, et al. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev 2008; 22:1490–1500.
Murata H, Ihara Y, Nakamura H, et al. Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. J Biol Chem 2003; 278:50226–50233.