Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

Gottesman, 1986, The role of cAMP in regulating tumour cell growth, Cancer Surv., 5, 291

Richards, 2001, New signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells, Mol. Endocrinol., 15, 209, 10.1210/me.15.2.209

McKenzie, 1996, cAMP-mediated growth inhibition in fibroblasts is not mediated via mitogen-activated protein (MAP) kinase (ERK) inhibition. cAMP-dependent protein kinase induces a temporal shift in growth factor-stimulated MAP kinases, J. Biol. Chem., 271, 13476, 10.1074/jbc.271.23.13476

Kahan, 1992, Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition, J. Biol. Chem., 267, 13369, 10.1016/S0021-9258(18)42220-X

Hu, 1998, cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities, Biochim. Biophys. Acta, 1405, 139, 10.1016/S0167-4889(98)00098-6

Mikula, 2001, Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene, EMBO J., 20, 1952, 10.1093/emboj/20.8.1952

Cospedal, 1999, Differential regulation of extracellular signal-regulated protein kinases (ERKs) 1 and 2 by cAMP and dissociation of ERK inhibition from anti-mitogenic effects in rabbit vascular smooth muscle cells, Biochem. J., 342, 407, 10.1042/0264-6021:3420407

Arslan, 2000, Stimulatory and inhibitory effects of adenosine A(2A) receptors on nerve growth factor-induced phosphorylation of extracellular regulated kinases 1/2 in PC12 cells, Neurosci. Lett., 292, 183, 10.1016/S0304-3940(00)01461-0

Hsueh, 1995, c-jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to cAMP inhibition in lymphocytes, J. Biol. Chem., 270, 18094, 10.1074/jbc.270.30.18094

Lee, 2000, Induction of p21WAF1 expression via Sp1-binding sites by tamoxifen in estrogen receptor-negative lung cancer cells, Oncogene, 19, 3766, 10.1038/sj.onc.1203715

van Oirschot, 2001, Protein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines, J. Biol. Chem., 276, 33854, 10.1074/jbc.M104395200

L'Allemain, 1997, Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts, Oncogene, 14, 1981, 10.1038/sj.onc.1201038

Naderi, 2000, cAMP-mediated growth inhibition of lymphoid cells in G1: rapid down-regulation of cyclin D3 at the level of translation, Eur. J. Immunol., 30, 1757, 10.1002/1521-4141(200006)30:6<1757::AID-IMMU1757>3.0.CO;2-N

Kato, 1994, Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation, Cell, 79, 487, 10.1016/0092-8674(94)90257-7

Depoortere, 1996, Paradoxical accumulation of the cyclin-dependent kinase inhibitor p27kip1 during the cAMP-dependent mitogenic stimulation of thyroid epithelial cells, J. Cell Sci., 109, 1759, 10.1242/jcs.109.7.1759

LaBaer, 1997, New functional activities for the p21 family of CDK inhibitors, Genes Dev., 11, 847, 10.1101/gad.11.7.847

Cheng, 1999, The p21(Cip1) and p27(Kip1) CDK ‘inhibitors’ are essential activators of cyclin D-dependent kinases in murine fibroblasts, EMBO J., 18, 1571, 10.1093/emboj/18.6.1571

Wan, 1998, Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells, J. Biol. Chem., 273, 14533, 10.1074/jbc.273.23.14533

Chen, 1998, Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas, Lab. Invest., 78, 165

Boucher, 2001, cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition, Biochem. Biophys. Res. Commun., 285, 207, 10.1006/bbrc.2001.5147

Myklebust, 1999, Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression, J. Cell. Physiol., 180, 71, 10.1002/(SICI)1097-4652(199907)180:1<71::AID-JCP8>3.0.CO;2-N

Young, 1994, Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase. Comparison with the effects of insulin, growth factors and phorbol esters, FEBS Lett., 338, 212, 10.1016/0014-5793(94)80367-6

Feliciello, 2000, The localization and activity of cAMP-dependent protein kinase affect cell cycle progression in thyroid cells, J. Biol. Chem., 275, 303, 10.1074/jbc.275.1.303

Graves, 1993, Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells, Proc. Natl. Acad. Sci. U. S. A., 90, 10300, 10.1073/pnas.90.21.10300

Wu, 1993, Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate, Science, 262, 1065, 10.1126/science.7694366

Burgering, 1993, cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor, EMBO J., 12, 4211, 10.1002/j.1460-2075.1993.tb06105.x

Cook, 1993, Inhibition by cAMP of Ras-dependent activation of Raf, Science, 262, 1069, 10.1126/science.7694367

Sevetson, 1993, Increasing cAMP attenuates activation of mitogen-activated protein kinase, Proc. Natl. Acad. Sci. U. S. A., 90, 10305, 10.1073/pnas.90.21.10305

Mischak, 1996, Negative regulation of Raf-1 by phosphorylation of serine 621, Mol. Cell. Biol., 16, 5409, 10.1128/MCB.16.10.5409

Dhillon, 2002, Regulation of Raf-1 activation and signalling by dephosphorylation, EMBO J., 21, 64, 10.1093/emboj/21.1.64

Zimmermann, 1999, Phosphorylation and regulation of Raf by Akt (protein kinase B), Science, 286, 1741, 10.1126/science.286.5445.1741

Kubicek, 2002, Dephosphorylation of Ser-259 regulates Raf-1 membrane association, J. Biol. Chem., 277, 7913, 10.1074/jbc.M108733200

Sidovar, 2000, Phosphorylation of serine 43 is not required for inhibition of C-Raf kinase by the cAMP-dependent protein kinase, J. Biol. Chem., 275, 28688, 10.1074/jbc.M909351199

Kitayama, 1989, A ras-related gene with transformation suppressor activity, Cell, 56, 77, 10.1016/0092-8674(89)90985-9

Cook, 1993, RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts, EMBO J., 12, 3475, 10.1002/j.1460-2075.1993.tb06022.x

Altschuler, 1995, Cyclic AMP-dependent activation of Rap1b, J. Biol. Chem., 270, 10373, 10.1074/jbc.270.18.10373

Schmitt, 2001, Cyclic AMP-mediated inhibition of cell growth requires the small G protein rap1, Mol. Cell. Biol., 21, 3671, 10.1128/MCB.21.11.3671-3683.2001

Bos, 2001, Rap1 signalling: adhering to new models, Nat. Rev. Mol. Cell. Biol., 2, 369, 10.1038/35073073

Qiu, 2000, Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins, J. Biol. Chem., 275, 31921, 10.1074/jbc.M003327200

Zanassi, 2001, cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons, J. Biol. Chem., 276, 11487, 10.1074/jbc.M007631200

Vossler, 1997, cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway, Cell, 89, 73, 10.1016/S0092-8674(00)80184-1

Dugan, 1999, Differential effects of cAMP in neurons and astrocytes. Role of B-raf, J. Biol. Chem., 274, 25842, 10.1074/jbc.274.36.25842

Schmitt, 2000, β2-adrenergic receptor activates extracellular regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf, J. Biol. Chem., 275, 25342, 10.1074/jbc.M003213200

Quilliam, 1991, Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils, J. Immunol., 147, 1628, 10.4049/jimmunol.147.5.1628

Ribeiro-Neto, 2002, On the mitogenic properties of Rab1b: cAMP-induced G1/S entry requires phosphorylation of Rap1b, Proc. Natl. Acad. Sci. U. S. A., 99, 5418, 10.1073/pnas.082122499

Schmitt, 2002, PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1, Mol. Cell, 9, 85, 10.1016/S1097-2765(01)00432-4

York, 1998, Rap1 mediates sustained MAP kinase activation induced by nerve growth factor, Nature, 392, 622, 10.1038/33451

Zwartkruis, 1999, Ras and Rap1: two highly related small GTPases with distinct function, Exp. Cell Res., 253, 157, 10.1006/excr.1999.4695

Wang, 2001, Cyclic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways by inhibiting Rap1, J. Biol. Chem., 276, 37242, 10.1074/jbc.M105089200

Caron, 2000, The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators, Curr. Biol., 10, 974, 10.1016/S0960-9822(00)00641-2

Arai, 2001, Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta 1 integrin-mediated hematopoietic cell adhesion, J. Biol. Chem., 276, 10453, 10.1074/jbc.M004627200

Sebzda, 2002, Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling, Nat. Immunol., 3, 251, 10.1038/ni765

Ohba, 2001, Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis, EMBO J., 20, 3333, 10.1093/emboj/20.13.3333

Tsukamoto, 1999, Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion, J. Biol. Chem., 274, 18463, 10.1074/jbc.274.26.18463

Reedquist, 2000, The small GTPase, Rap1, mediates CD31-induced integrin adhesion, J. Cell Biol., 148, 1151, 10.1083/jcb.148.6.1151

Katagiri, 2002, Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses, Mol. Cell. Biol., 22, 1001, 10.1128/MCB.22.4.1001-1015.2002

Barberis, 2000, Distinct roles of the adaptor protein shc and focal adhesion kinase in integrin signaling to ERK, J. Biol. Chem., 275, 36532, 10.1074/jbc.M002487200

Howe, 2000, Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase, Nat. Cell Biol., 2, 593, 10.1038/35023536

Mason, 1999, Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation, EMBO J., 18, 2137, 10.1093/emboj/18.8.2137

Chiloeches, 2001, S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3, Mol. Cell. Biol., 21, 2423, 10.1128/MCB.21.7.2423-2434.2001

Rommel, 1999, Differentiation stage-specific inhibition of the Raf–MEK–ERK pathway by Akt, Science, 286, 1738, 10.1126/science.286.5445.1738

Tsygankova, 2001, Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A, Mol. Cell. Biol., 21, 1921, 10.1128/MCB.21.6.1921-1929.2001

Filippa, 1999, Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase, Mol. Cell. Biol., 19, 4989, 10.1128/MCB.19.7.4989

Kim, 2001, Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1, J. Biol. Chem., 276, 12864, 10.1074/jbc.M001492200

Zhang, 2001, Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf, J. Biol. Chem., 276, 31620, 10.1074/jbc.M102808200

Gonzalez-Robayna, 2000, Follicle-stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-induced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells, Mol. Endocrinol., 14, 1283, 10.1210/me.14.8.1283

Misra-Press, 1995, A novel mitogen-activated protein kinase phosphatase: structure, expression and regulation, J. Biol. Chem., 270, 14587, 10.1074/jbc.270.24.14587

Burgun, 2000, Cyclic AMP-elevating agents induce the expression of MAP kinase phosphatase-1 in PC12 cells, FEBS Lett., 484, 189, 10.1016/S0014-5793(00)02153-0

Plevin, 1997, Cyclic AMP inhibitors inhibits PDGF-stimulated mitogen-activated protein kinase activity in rat aortic smooth muscle cells via inactivation of c-Raf-1 kinase and induction of MAP kinase phosphatase-1, Cell. Signal., 9, 323, 10.1016/S0898-6568(96)00193-3

Wellbrock, 2002, Activation of p59Fyn leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling, J. Biol. Chem., 277, 6443, 10.1074/jbc.M110684200

Mutoh, 1998, Differential signaling cascade of MAP kinase and S6 kinase depends on 3′,5′-monophosphate concentration in Schwann cells: correlation to cellular differentiation and proliferation, Brain Res., 810, 274, 10.1016/S0006-8993(98)00933-0

Cole, 1999, Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells, Endocrinology, 140, 5771, 10.1210/en.140.12.5771

Vogt Weisenhorn, 2001, Coupling of cAMP/PKA and MAPK signaling in neuronal cells is dependent on developmental stage, Exp. Neurol., 169, 44, 10.1006/exnr.2001.7651

Grewal, 2000, Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap1-extracellular signal-regulated kinase pathway, J. Biol. Chem., 275, 34433, 10.1074/jbc.M004728200

Grewal, 1999, Extracellular-signal-regulated kinase signalling in neurons, Curr. Opin. Neurobiol., 9, 544, 10.1016/S0959-4388(99)00010-0

Patterson, 2001, Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase, Neuron, 32, 123, 10.1016/S0896-6273(01)00443-3

Deeble, 2001, Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells, Mol. Cell. Biol., 21, 8471, 10.1128/MCB.21.24.8471-8482.2001

Kievit, 2001, Analysis of the role of the mitogen-activated protein kinase in mediating cyclic-adenosine 3′,5′-monophosphate effects on prolactin promoter activity, Mol. Endocrinol., 15, 614, 10.1210/me.15.4.614

Swanson, 1998, AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene, J. Biol. Chem., 273, 24065, 10.1074/jbc.273.37.24065

Verheijen, 1997, Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras, J. Biol. Chem., 272, 3423, 10.1074/jbc.272.6.3423

Morice, 1999, Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain, Eur. J. Neurosci., 11, 1995, 10.1046/j.1460-9568.1999.00609.x

Iacovelli, 2001, Thyrotropin activates mitogen-activated protein kinase pathway in FRTL-5 by a cAMP-dependent protein kinase A-independent mechanism, Mol. Pharmacol., 60, 924, 10.1124/mol.60.5.924

Busca, 2000, Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes, EMBO J., 19, 2900, 10.1093/emboj/19.12.2900

Wojnowski, 1997, Endothelial apoptosis in Braf-deficient mice, Nat. Genet., 16, 293, 10.1038/ng0797-293

Chen, 1999, Elevation of cyclic adenosine 3′,5′-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells, Cancer Res., 59, 213

Thorson, 1998, 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity, Mol. Cell. Biol., 18, 5229, 10.1128/MCB.18.9.5229

Barnier, 1995, The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression, J. Biol. Chem., 270, 23381, 10.1074/jbc.270.40.23381

Zwartkruis, 1998, Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling, EMBO J., 17, 5905, 10.1093/emboj/17.20.5905

Vaillancourt, 1994, B-Raf dependent regulation of the MEK-1/MAP kinase pathway in PC12 cells and regulation by cAMP, Mol. Cell. Biol., 14, 6522, 10.1128/MCB.14.10.6522

Kao, 2001, Identification of the mechanisms regulating the differential activation of the MAPK cascade by epidermal growth factor and nerve growth factor in PC12 cells, J. Biol. Chem., 276, 18169, 10.1074/jbc.M008870200

MacNicol, 1999, Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase, J. Biol. Chem., 274, 13193, 10.1074/jbc.274.19.13193

Crepieux, 2001, The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation, Oncogene, 20, 4696, 10.1038/sj.onc.1204632

Kobierski, 1999, Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase, J. Neurochem., 73, 129, 10.1046/j.1471-4159.1999.0730129.x

Lindquist, 2000, β3- and α1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in brown adipocytes, J. Biol. Chem., 275, 22670, 10.1074/jbc.M909093199

Dremier, 2000, Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways, Biochem. Biophys. Res. Commun., 267, 7, 10.1006/bbrc.1999.1919

Laroche-Joubert, N. et al. (2002) PKA-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I. J. Biol. Chem. 10.1074/jbc.M201868200 (http://www.jbc.org)

von Lintig, 2000, Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells, Oncogene, 19, 4029, 10.1038/sj.onc.1203741

Mei, 2002, Differential signaling of cyclic AMP. Opposing effects of exchange protein directly activated by cAMP and cAMP-dependent protein kinase A on protein kinase B activation, J. Biol. Chem., 277, 11497, 10.1074/jbc.M110856200

Kawasaki, 1998, A family of cAMP-binding proteins that directly activate Rap1, Science, 282, 2275, 10.1126/science.282.5397.2275

de Rooij, 1998, Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP, Nature, 396, 474, 10.1038/24884

Ambrosini, 2000, cAMP cascade leads to Ras activation in cortical neurons, Mol. Brain Res., 75, 54, 10.1016/S0169-328X(99)00294-6

Iida, 2001, Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons, J. Neurosci., 21, 6459, 10.1523/JNEUROSCI.21-17-06459.2001

Tsygankova, 2000, Cyclic AMP activates Ras, Oncogene, 19, 3609, 10.1038/sj.onc.1203680

Cass, 2000, Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation, Oncogene, 19, 924, 10.1038/sj.onc.1203393

Ciullo, 2001, cAMP signaling selectively influences Ras effectors pathways, Oncogene, 20, 1186, 10.1038/sj.onc.1204219

Pham, 2000, The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP, Curr. Biol., 10, 555, 10.1016/S0960-9822(00)00473-5

Crespo, 1994, Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits, Nature, 369, 418, 10.1038/369418a0

Daaka, 1997, Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A, Nature, 390, 88, 10.1038/36362

Crespo, 1995, Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition, J. Biol. Chem., 270, 25259, 10.1074/jbc.270.42.25259

Saxena, 1999, Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase, Nat. Cell Biol., 1, 305, 10.1038/13024

Blanco-Aparicio, 1999, A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase, J. Cell Biol., 147, 1129, 10.1083/jcb.147.6.1129

Yee, 1997, Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals, Mol. Cell. Biol., 17, 921, 10.1128/MCB.17.2.921

D'Angelo, 1997, cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation, J. Cell. Biochem., 67, 353, 10.1002/(SICI)1097-4644(19971201)67:3<353::AID-JCB7>3.0.CO;2-V

Chen, 1994, Suppression of Ras-induced transformation of NIH 3T3 cells by activated G alpha s, Science, 263, 1278, 10.1126/science.8122111

Scott, 1996, A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells, Biochem. J., 318, 965, 10.1042/bj3180965

Osinski, 2000, Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis, Biochem. Pharmacol., 60, 381, 10.1016/S0006-2952(00)00328-2

Thoresen, 1999, Effects of cAMP on ERK mitogen-activated protein kinase activity in hepatocytes do not parallel the bidirectional regulation of DNA synthesis, Cell Biol. Int., 23, 13, 10.1006/cbir.1998.0314

Piiper, 2000, Pertussis toxin inhibits cholecystokinin- and epidermal growth factor-induced mitogen-activated protein kinase activation by disinhibition of the cAMP signaling pathway and inhibition of c-Raf-1, Mol. Pharmacol., 58, 608, 10.1124/mol.58.3.608

Yamaguchi, 2000, cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway, Kidney Int., 57, 1460, 10.1046/j.1523-1755.2000.00991.x

Zou, 1999, Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy, J. Biol. Chem., 274, 9760, 10.1074/jbc.274.14.9760

Seger, 2001, The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis, J. Biol. Chem., 276, 13957, 10.1074/jbc.M006852200

Greenberg, 2001, Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway, J. Biol. Chem., 276, 45456, 10.1074/jbc.M104436200

Yarwood, 1996, Cyclic AMP stimulates the phosphorylation and activation of p42 and p44 mitogen-activated protein kinases in 3T3-F442A preadipocytes, Biochem. Biophys. Res. Commun., 224, 734, 10.1006/bbrc.1996.1092

Yonehara, 2001, Involvement of mitogen-activated protein kinase in cyclic adenosine 3′,5′-monophosphate-induced hormone gene expression in rat pituitary GH(3) cells, Endocrinology, 142, 2811, 10.1210/en.142.7.2811

Fujita, T. et al. (2002) New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells: checkpoint of modulation by cyclic AMP. J. Biol. Chem. 10.1074/jbc.M110364200 (http://www.jbc.org)