Crosstalk among electrical activity, trophic factors and morphogenetic proteins in the regulation of neurotransmitter phenotype specification

Abeliovich, 2007, Midbrain dopamine neuron differentiation: factors and fates, Dev. Biol., 304, 447, 10.1016/j.ydbio.2007.01.032 Alberi, 2004, Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons, Development, 131, 3229, 10.1242/dev.01128 Andersson, 2006, Identification of intrinsic determinants of midbrain dopamine neurons, Cell, 124, 393, 10.1016/j.cell.2005.10.037 Apostolova, 2010, The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2, J. Neurosci., 30, 16356, 10.1523/JNEUROSCI.3502-10.2010 Belgacem, 2011, Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord, Proc. Natl. Acad. Sci. U.S.A., 108, 4482, 10.1073/pnas.1018217108 Belgacem, 2015, Inversion of Sonic hedgehog action on its canonical pathway by electrical activity, Proc. Natl. Acad. Sci. U.S.A., 112, 4140, 10.1073/pnas.1419690112 Belousov, 2001, Acetylcholine becomes the major excitatory neurotransmitter in the hypothalamus in vitro in the absence of glutamate excitation, J. Neurosci., 21, 2015, 10.1523/JNEUROSCI.21-06-02015.2001 Belousov, 2002, Calcium-dependent regulation of cholinergic cell phenotype in the hypothalamus in vitro, J. Neurophysiol., 88, 1352, 10.1152/jn.2002.88.3.1352 Blaess, 2006, Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region, Development, 133, 1799, 10.1242/dev.02339 Borodinsky, 2007, Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction, Proc. Natl. Acad. Sci. U.S.A., 104, 335, 10.1073/pnas.0607450104 Borodinsky, 2004, Activity-dependent homeostatic specification of transmitter expression in embryonic neurons, Nature, 429, 523, 10.1038/nature02518 Briscoe, 1999, Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling, Nature, 398, 622, 10.1038/19315 Brock, 2007, Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways, Brain Res., 1145, 1, 10.1016/j.brainres.2007.01.119 Cheng, 2003, Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype, J. Neurosci., 23, 9961, 10.1523/JNEUROSCI.23-31-09961.2003 Cheng, 2005, Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes, Nat. Neurosci., 8, 1510, 10.1038/nn1569 Cheng, 2004, Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates, Nat. Neurosci., 7, 510, 10.1038/nn1221 Craven, 2004, Gata2 specifies serotonergic neurons downstream of sonic hedgehog, Development, 131, 1165, 10.1242/dev.01024 Demarque, 2010, Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior, Neuron, 67, 321, 10.1016/j.neuron.2010.06.006 Ding, 2003, Lmx1b is essential for the development of serotonergic neurons, Nat. Neurosci., 6, 933, 10.1038/nn1104 Dulcis, 2008, Illumination controls differentiation of dopamine neurons regulating behaviour, Nature, 456, 195, 10.1038/nature07569 Dulcis, 2013, Neurotransmitter switching in the adult brain regulates behavior, Science, 340, 449, 10.1126/science.1234152 Eaton, 1995, Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization, Dev. Biol., 170, 169, 10.1006/dbio.1995.1205 Flandin, 2011, Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors, Neuron, 70, 939, 10.1016/j.neuron.2011.04.020 Fleming, 2013, The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors, Dev. Cell, 27, 278, 10.1016/j.devcel.2013.10.008 Francis, 1999, Cellular and molecular determinants of sympathetic neuron development, Annu. Rev. Neurosci., 22, 541, 10.1146/annurev.neuro.22.1.541 Furmanski, 2009, Combined extrinsic and intrinsic manipulations exert complementary neuronal enrichment in embryonic rat neural precursor cultures: an in vitro and in vivo analysis, J. Comput. Neurol., 515, 56, 10.1002/cne.22027 Galter, 2000, Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype, Mol. Cell. Neurosci., 15, 446, 10.1006/mcne.2000.0841 Gillespie, 2005, Inhibitory synapses in the developing auditory system are glutamatergic, Nat. Neurosci., 8, 332, 10.1038/nn1397 Gomez-Lira, 2005, Programmed and induced phenotype of the hippocampal granule cells, J. Neurosci., 25, 6939, 10.1523/JNEUROSCI.1674-05.2005 Goridis, 2002, Specification of catecholaminergic and serotonergic neurons, Nat. Rev. Neurosci., 3, 531, 10.1038/nrn871 Guo, 1999, Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a, Neuron, 24, 555, 10.1016/S0896-6273(00)81112-5 Gutierrez, 2003, The GABAergic phenotype of the “glutamatergic” granule cells of the dentate gyrus, Prog. Neurobiol., 71, 337, 10.1016/j.pneurobio.2003.11.004 Gutierrez, 2003, Plasticity of the GABAergic phenotype of the “glutamatergic” granule cells of the rat dentate gyrus, J. Neurosci., 23, 5594, 10.1523/JNEUROSCI.23-13-05594.2003 Holzschuh, 2003, Genetic analysis of the roles of Hh, FGF8, and nodal signaling during catecholaminergic system development in the zebrafish brain. J. Neurosci., 23, 5507 Hoshino, 2005, Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum, Neuron, 47, 201, 10.1016/j.neuron.2005.06.007 Howard, 2005, Mechanisms and perspectives on differentiation of autonomic neurons, Dev. Biol., 277, 271, 10.1016/j.ydbio.2004.09.034 Huang, 2010, Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development, Proc. Natl. Acad. Sci. U.S.A., 107, 8422, 10.1073/pnas.0911838107 Kaufer, 1998, Acute stress facilitates long-lasting changes in cholinergic gene expression, Nature, 393, 373, 10.1038/30741 Kondo, 2011, Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3, Stem Cells, 29, 836, 10.1002/stem.624 Landis, 1983, Evidence for neurotransmitter plasticity in vivo: developmental changes in properties of cholinergic sympathetic neurons, Dev. Biol., 98, 349, 10.1016/0012-1606(83)90365-2 Levkowitz, 2003, Zinc finger protein too few controls the development of monoaminergic neurons, Nat. Neurosci., 6, 28, 10.1038/nn979 Lin, 2007, Non-cell-autonomous regulation of GABAergic neuron development by neurotrophins and the p75 receptor, J. Neurosci., 27, 12787, 10.1523/JNEUROSCI.3302-07.2007 Liu, 2008, Regulation of cholinergic phenotype in developing neurons, J. Neurophysiol., 99, 2443, 10.1152/jn.00762.2007 Lo, 1997, MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells, Curr. Biol., 7, 440, 10.1016/S0960-9822(06)00191-6 Lo, 1999, Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells, Neuron, 22, 693, 10.1016/S0896-6273(00)80729-1 Lo, 2002, Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells, Development, 129, 1553, 10.1242/dev.129.7.1553 Lopez-Coviella, 2000, Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9, Science, 289, 313, 10.1126/science.289.5477.313 Lopez-Coviella, 2005, Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons, Proc. Natl. Acad. Sci. U.S.A., 102, 6984, 10.1073/pnas.0502097102 Loy, 2011, p38alpha and p38beta mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons, J. Neurosci., 31, 12059, 10.1523/JNEUROSCI.0448-11.2011 Madziar, 2008, Nerve growth factor regulates the expression of the cholinergic locus and the high-affinity choline transporter via the Akt/PKB signaling pathway, J. Neurochem., 107, 1284, 10.1111/j.1471-4159.2008.05681.x Manabe, 2005, L3/Lhx8 is involved in the determination of cholinergic or GABAergic cell fate, J. Neurochem., 94, 723, 10.1111/j.1471-4159.2005.03261.x Marek, 2010, cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification, Nat. Neurosci., 13, 944, 10.1038/nn.2582 Mori, 2004, The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons, Eur. J. Neurosci., 19, 3129, 10.1111/j.0953-816X.2004.03415.x Noh, 2010, Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map, Nat. Neurosci., 13, 232, 10.1038/nn.2478 Paina, 2011, Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo, J. Neurosci., 31, 2675, 10.1523/JNEUROSCI.3110-10.2011 Panman, 2011, Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells, Cell Stem Cell, 8, 663, 10.1016/j.stem.2011.04.001 Robertshaw, 2013, Irx3 and Pax6 establish differential competence for Shh-mediated induction of GABAergic and glutamatergic neurons of the thalamus, Proc. Natl. Acad. Sci. U.S.A., 110, E3919, 10.1073/pnas.1304311110 Root, 2008, Embryonically expressed GABA and glutamate drive electrical activity regulating neurotransmitter specification, J. Neurosci., 28, 4777, 10.1523/JNEUROSCI.4873-07.2008 Rudge, 1996, CNTF induces raphe neuronal precursors to switch from a serotonergic to a cholinergic phenotype in vitro, Mol. Cell. Neurosci., 7, 204, 10.1006/mcne.1996.0016 Russek-Blum, 2008, Dopaminergic neuronal cluster size is determined during early forebrain patterning, Development, 135, 3401, 10.1242/dev.024232 Schotzinger, 1990, Acquisition of cholinergic and peptidergic properties by sympathetic innervation of rat sweat glands requires interaction with normal target, Neuron, 5, 91, 10.1016/0896-6273(90)90037-G Simon, 2004, Midbrain dopaminergic neurons: control of their cell fate by the engrailed transcription factors, Cell Tissue Res., 318, 53, 10.1007/s00441-004-0973-8 Spitzer, 2012, Activity-dependent neurotransmitter respecification, Nat. Rev. Neurosci., 13, 94, 10.1038/nrn3154 Spitzer, 2015, Neurotransmitter Switching? No Surprise, Neuron, 86, 1131, 10.1016/j.neuron.2015.05.028 Stanke, 1999, The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons, Development, 126, 4087, 10.1242/dev.126.18.4087 Stanke, 2006, Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling, Development, 133, 141, 10.1242/dev.02189 Stull, 2001, Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins, Brain Res. Dev. Brain Res., 130, 91, 10.1016/S0165-3806(01)00216-4 Swapna, 2012, Interplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation, Proc. Natl. Acad. Sci. U.S.A., 109, 16336, 10.1073/pnas.1202818109 Tanabe, 1998, Specification of motor neuron identity by the MNR2 homeodomain protein, Cell, 95, 67, 10.1016/S0092-8674(00)81783-3 Thomas, 2004, MAPK cascade signalling and synaptic plasticity, Nat. Rev. Neurosci., 5, 173, 10.1038/nrn1346 van Doorninck, 1999, GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei, J. Neurosci., 19, RC12, 10.1523/JNEUROSCI.19-12-j0002.1999 Varela-Nallar, 2010, Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses, Proc. Natl. Acad. Sci. U.S.A., 107, 21164, 10.1073/pnas.1010011107 Wallen, 2003, Transcriptional control of dopamine neuron development, Ann. N. Y. Acad. Sci., 991, 48, 10.1111/j.1749-6632.2003.tb07462.x Wichterle, 2002, Directed differentiation of embryonic stem cells into motor neurons, Cell, 110, 385, 10.1016/S0092-8674(02)00835-8 Yao, 2010, Identification of a Smad4/YY1-recognized and BMP2-responsive transcriptional regulatory module in the promoter of mouse GABA transporter subtype I (Gat1) gene, J. Neurosci., 30, 4062, 10.1523/JNEUROSCI.2964-09.2010 Zervas, 2004, Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1, Neuron, 43, 345, 10.1016/j.neuron.2004.07.010 Zhao, 2003, The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain, Proc. Natl. Acad. Sci. U.S.A., 100, 9005, 10.1073/pnas.1537759100