Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study

Toxicological Sciences - Tập 164 Số 2 - Trang 550-562 - 2018
Daniel C. Millard1, Qianyu Dang2, Hong Shi3, Xiaou Zhang4, Chris Strock5, Udo Kraushaar6, Haoyu Zeng7, Paul Lévesque3, H. R. Lu8, Jean‐Frédéric Gerbeau9, Joseph C. Wu10, Yingxin Li10, Greg Luerman11, Blake D. Anson12, Liang Guo12,13, Mike Clements1, Yama Abassi4, James D. Ross1, Jennifer Pierson14, Gary A. Gintant15
1Axion Biosystems Inc, Atlanta, Georgia 30309
2US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland 20993
3Bristol-Myers Squibb Company, Princeton, New Jersey 08543
4Acea Biosciences, San Diego, California 92121
5Cyprotex, Watertown, Massachusetts 01746
6Naturwissenschaftliches und Medizinisches Institut, Reutlingen, Germany
7Merck & Co., Inc., Safety & Exploratory Pharmacology Department, West Point, Pennsylvania
8Janssen, Beerse, Belgium
9Sanofi R&D Preclinical Safety, Paris, France
10Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford, California
11Ncardia, Leiden, The Netherlands
12Cellular Dynamics International a FujiFilm, Company, Madison, Wisconsin 53508
13Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21702,
14ILSI-Health and Environmental Sciences Institute, Washington, District of Columbia 20009
15Integrative Pharmacology (Dept ZR13), Integrated Science and Technology. AbbVie, North Chicago, Illinois 60064

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