Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders

Genes and Diseases - Tập 9 - Trang 51-61 - 2022
Zhou Yang1, Guang-li Yu1, Xiao Zhu2, Tian-hong Peng1, Yun-cheng Lv1,2
1Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, PR China
2Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541199, PR China

Tài liệu tham khảo

Tirronen, 2019, Recent advances in novel therapies for lipid disorders, Hum Mol Genet, 28, R49, 10.1093/hmg/ddz132 Mizuno, 2018, Fat mass and obesity associated (FTO) gene and hepatic glucose and lipid metabolism, Nutrients, 10, 1600, 10.3390/nu10111600 Jung, 2014, Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease, Int J Mol Sci, 15, 6184, 10.3390/ijms15046184 Gerken, 2007, The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase, Science, 318, 1469, 10.1126/science.1151710 Bi, 2019, A dynamic reversible RNA N(6) -methyladenosine modification: current status and perspectives, J Cell Physiol, 234, 7948, 10.1002/jcp.28014 Speakman, 2015, The 'fat mass and obesity related' (FTO) gene: mechanisms of impact on obesity and energy balance, Curr Obes Rep, 4, 73, 10.1007/s13679-015-0143-1 Bartosovic, 2017, N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing, Nucleic Acids Res, 45, 11356, 10.1093/nar/gkx778 Aravind, 2001, The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases, Genome Biol, 2, 10.1186/gb-2001-2-3-research0007 Jia, 2011, N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO, Nat Chem Biol, 7, 885, 10.1038/nchembio.687 Zhang, 2015, The demethylase activity of FTO (fat mass and obesity associated protein) is required for preadipocyte differentiation, PloS One, 10, 10.1371/journal.pone.0133788 Gulati, 2013, Role for the obesity-related FTO gene in the cellular sensing of amino acids, Proc Nat Acad Sci USA, 110, 2557, 10.1073/pnas.1222796110 Merkestein, 2015, FTO influences adipogenesis by regulating mitotic clonal expansion, Nat Commun, 6, 6792, 10.1038/ncomms7792 Frayling, 2007, A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity, Science, 316, 889, 10.1126/science.1141634 Church, 2010, Overexpression of Fto leads to increased food intake and results in obesity, Nat Genet, 42, 1086, 10.1038/ng.713 Yang, 2019, Glucose is involved in the dynamic regulation of m6A in patients with type 2 diabetes, J Clin Endocrinol Metabol, 104, 665, 10.1210/jc.2018-00619 Peeters, 2008, Variants in the FTO gene are associated with common obesity in the Belgian population, Mol Genet Metabol, 93, 481, 10.1016/j.ymgme.2007.10.011 Price, 2008, FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs, BMC Med Genet, 9, 4, 10.1186/1471-2350-9-4 Stratigopoulos, 2008, Regulation of Fto/Ftm gene expression in mice and humans, Am J Physiol Regul Integr Comp Physiol, 294, R1185, 10.1152/ajpregu.00839.2007 Fawcett, 2010, The genetics of obesity: FTO leads the way, Trends Genet, 26, 266, 10.1016/j.tig.2010.02.006 Tung, 2014, Obesity and FTO: changing focus at a complex locus, Cell Metabol, 20, 710, 10.1016/j.cmet.2014.09.010 Chang, 2018, The fat mass- and obesity-associated (FTO) gene to obesity: lessons from mouse models, Obesity, 26, 1674, 10.1002/oby.22301 Gerken, 2007, The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase, Science, 318, 1469, 10.1126/science.1151710 Han, 2010, Crystal structure of the FTO protein reveals basis for its substrate specificity, Nature, 464, 1205, 10.1038/nature08921 Rajecka, 2019, The role of RNA adenosine demethylases in the control of gene expression, Biochimica et biophysica acta Gene regulatory mechanisms, 1862, 343, 10.1016/j.bbagrm.2018.12.001 Zhong, 2008, MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor, Plant Cell, 20, 1278, 10.1105/tpc.108.058883 Fu, 2013, FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA, Nat Commun, 4, 1798, 10.1038/ncomms2822 Peters, 1999, Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation, Mamm Genome : Off J Int Mammalian Genome Soc, 10, 983, 10.1007/s003359901144 Chen, 2018, FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells, Biochim Biophys Acta Mol Cell Biol Lipids, 1863, 538, 10.1016/j.bbalip.2018.02.003 Guo, 2013, Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease, Dig Dis Sci, 58, 1004, 10.1007/s10620-012-2516-6 Lim, 2016, Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity, Biochem Biophys Res Commun, 479, 476, 10.1016/j.bbrc.2016.09.086 Kang, 2018, FTO reduces mitochondria and promotes hepatic fat accumulation through RNA demethylation, J Cell Biochem, 119, 5676, 10.1002/jcb.26746 Ritov, 2005, Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes, Diabetes, 54, 8, 10.2337/diabetes.54.1.8 Conte, 2010, Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle, J Dairy Sci, 93, 753, 10.3168/jds.2009-2581 Yabe, 2003, Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis, Proc Nat Acad Sci USA, 100, 3155, 10.1073/pnas.0130116100 Bravard, 2011, FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction, Diabetes, 60, 258, 10.2337/db10-0281 Tews, 2011, Regulation of FTO and FTM expression during human preadipocyte differentiation, Horm Metab Res, 43, 17, 10.1055/s-0030-1265130 Grunnet, 2009, Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue, Diabetes, 58, 2402, 10.2337/db09-0205 Ronkainen, 2015, Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue, Sci Rep, 5, 9233, 10.1038/srep09233 Schneeberger, 2013, Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance, Cell, 155, 172, 10.1016/j.cell.2013.09.003 Seoane-Collazo, 2014, Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats, Endocrinology, 155, 1679, 10.1210/en.2013-1839 de Araujo, 2019, The partial inhibition of hypothalamic IRX3 exacerbates obesity, EBioMed, 39, 448, 10.1016/j.ebiom.2018.11.048 Berulava, 2015, N6-adenosine methylation in MiRNAs, PloS One, 10, 10.1371/journal.pone.0118438 Kajimura, 2009, Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex, Nature, 460, 1154, 10.1038/nature08262 Tews, 2013, FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes, Endocrinology, 154, 3141, 10.1210/en.2012-1873 Zhao, 2014, FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis, Cell Res, 24, 1403, 10.1038/cr.2014.151 Lee, 2011, miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression, Mol Cell Biol, 31, 626, 10.1128/MCB.00894-10 Marcinkiewicz, 2006, The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion, J Biol Chem, 281, 11901, 10.1074/jbc.M600171200 Gray, 2012, Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes, J Biol Chem, 287, 8444, 10.1074/jbc.M111.294124 Wang, 2015, Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism, Sci Signal, 8, ra127, 10.1126/scisignal.aab3357 Yoshida, 2002, Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase, J Lipid Res, 43, 1770, 10.1194/jlr.C200010-JLR200 Mizunoe, 2020, Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes, Sci Rep, 10, 634, 10.1038/s41598-020-57428-6 Cavadas, 2016, The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing, Nat Rev Endocrinol, 12, 723, 10.1038/nrendo.2016.107 de Araujo, 2020, Hypothalamic IRX3: a new player in the development of obesity, Trends Endocrinol Metabol, 31, 368, 10.1016/j.tem.2020.01.002 Velloso, 2011, Altered hypothalamic function in diet-induced obesity, Int J Obes, 35, 1455, 10.1038/ijo.2011.56 Stratigopoulos, 2011, Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling, J Biol Chem, 286, 2155, 10.1074/jbc.M110.188482 Stratigopoulos, 2016, Hypomorphism of Fto and Rpgrip1l causes obesity in mice, J Clin Invest, 126, 1897, 10.1172/JCI85526 Tung, 2015, FTO is necessary for the induction of leptin resistance by high-fat feeding, Mol Metab, 4, 287, 10.1016/j.molmet.2015.01.011 LJ, 2007, A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants, Science (New York, NY), 316, 1341, 10.1126/science.1142382 Banales-Luna, 2020, Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects, Sci Rep, 10, 11478, 10.1038/s41598-020-67832-7 Dunn, 1982, Hyperlipidemia and diabetes, Med Clin, 66, 1347 Pan, 1997, Skeletal muscle triglycerid e levels are inversely related to insulin action, Diabetes, 46, 983, 10.2337/diab.46.6.983 Gleissner, 2007, Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis, Hypertension, 50, 276, 10.1161/HYPERTENSIONAHA.107.089854 Zhang, 2004, Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK), Canc Res, 64, 1902, 10.1158/0008-5472.CAN-03-3361 Lin, 2014, Fat mass and obesity-associated (FTO) protein interacts with CaMKII and modulates the activity of CREB signaling pathway, Hum Mol Genet, 23, 3299, 10.1093/hmg/ddu043 Dressel, 2003, The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells, Mol Endocrinol, 17, 2477, 10.1210/me.2003-0151 Hardie, 2012, AMPK: a nutrient and energy sensor that maintains energy homeostasis, Nat Rev Mol Cell Biol, 13, 251, 10.1038/nrm3311 Fujii, 2008, Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice, Diabetes, 57, 2958, 10.2337/db07-1187 Haemmerle, 2002, Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis, J Biol Chem, 277, 4806, 10.1074/jbc.M110355200 Medina-Gomez, 2007, Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1), Publ Health Nutr, 10, 1132, 10.1017/S1368980007000614 Bonnefont, 2004, Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects, Mol Aspect Med, 25, 495, 10.1016/j.mam.2004.06.004 Mo, 2017, Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice, J Hypertens, 35, 810, 10.1097/HJH.0000000000001255 Wu, 2019, Liraglutide improves lipid metabolism by enhancing cholesterol efflux associated with ABCA1 and ERK1/2 pathway, Cardiovasc Diabetol, 18, 146, 10.1186/s12933-019-0954-6 Yvan-Charvet, 2010, Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses, Arterioscler Thromb Vasc Biol, 30, 139, 10.1161/ATVBAHA.108.179283 Li, 2010, Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice, J Biol Chem, 285, 33499, 10.1074/jbc.M110.159772 Tung, 2011, From GWAS to biology: lessons from FTO, Ann N Y Acad Sci, 1220, 162, 10.1111/j.1749-6632.2010.05903.x