Critical review of SPECT imaging in pulmonary embolism

Clinical and Translational Imaging - Tập 2 - Trang 379-390 - 2014
Paul D. Stein1,2, H. Dirk Sostman3, Fadi Matta1
1Department of Osteopathic Medical Specialties, Michigan State University College of Osteopathic Medicine, East Lansing, USA
2Michigan State University College of Osteopathic Medicine, Detroit, USA
3Department of Radiology, Weill Cornell Medical College, New York, USA

Tóm tắt

Outcome studies have shown that pulmonary embolism can be safely excluded in patients with negative ventilation/perfusion (V/Q) single-photon emission computed tomography (SPECT). The effective radiation dose of V/Q SPECT is much less than with computed tomographic (CT) pulmonary angiography, which would make it preferable to CT angiography in many young female patients. The accuracy of V/Q SPECT, however, is difficult to assess, because most published investigations are limited by incorporation bias or partial verification bias, as well as other limitations in study design and reporting. Consequently, the accuracy of V/Q SPECT relative to planar V/Q scintigraphy or CT angiography has not been definitively determined. There is need for a prospective investigation of the accuracy of V/Q SPECT with consecutive patients, blinded interpretations, and an independent reference standard, or independent composite reference standard.

Tài liệu tham khảo

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