Countermeasures against viral diseases of farmed fish

Adams, 1988, The potency of adjuvanted injected vaccines in rainbow trout (Salmo gairdneri Richardson) and bath vaccines in Atlantic salmon (Salmo salar L.) against furunculosis, Aquaculture, 69, 15, 10.1016/0044-8486(88)90182-2 Ahne, 2002, Spring viraemia of carp (SVC), Dis. Aquat. Org., 52, 261, 10.3354/dao052261 Amend, 1981, Potency testing of fish vaccines, Dev. Biol. Standard., 49, 447 Amend, 1969, A hematopoietic virus disease of rainbow trout and sockeye salmon, Trans. Am. Fish. Soc., 98, 796, 10.1577/1548-8659(1969)98[796:AHVDOR]2.0.CO;2 Anderson, 1979, Induction of antibody-producing cells in rainbow trout, Salmo gairdneri Richardson – by flush exposure, J. Fish Biol., 15, 317, 10.1111/j.1095-8649.1979.tb03611.x Anonymous 1: Intervet Schering-Plough Animal Health, 20671 Compact PD Technical Manual. (Published 2009) Anonymous 2: Isoprinosine, <http://www.anti-aging-drugs.com/biblio/isoprinosine_biblio.php> (Published 2011; Consulted February 16, 2012). Anonymous 3: Life cycle of Atlantic salmon, <http://www.marine.ie/home/services/operational/stock/Life+Cycle+of+the+Atlantic+Salmon.htm> (Consulted February 27, 2012). Anonymous 4: IHN outbreak may be spreading. http://fis.com/fis/worldnews/worldnews.asp?l=e&country=0&special=aquaculture&monthyear=&day=&id=52379&ndb=1&df=0 (Published 2012; Consulted May 22, 2012). Anonymous 5: IHN virus found in farmed fish. <http://www.fishfarmingxpert.com/index.php?page_id=76&article_id=94883> (Published 2012; Consulted May 17, 2012). Antipa, 1980, Vibrio anguillarum vaccination of sockeye salmon, Onchorhynchus nerka (Walbaum) by direct and hyperosmotic immersion, J. Fish Dis., 3, 161, 10.1111/j.1365-2761.1980.tb00199.x Ariel, 2002, Finfish in aquaculture and their diseases – a retrospective view on the European community, Bull. Eur. Assoc. Fish Pathol., 22, 72 Armstrong, 1993, Infectious hematopoietic necrosis virus in Atlantic salmon in British Columbia, Can. Vet. J., 34, 312 Audibert, 1993, Adjuvants: current status, clinical perspectives and future prospects, Immunol. Today, 14, 281, 10.1016/0167-5699(93)90046-N Barr, 2011, The genome sequence of Atlantic cod reveals unique immune system, Nature, 477, 207, 10.1038/nature10342 Batts, 2012, Genetic analysis of a novel nidovirus from fathead minnows, J. Gen. Virol., 93, 1247, 10.1099/vir.0.041210-0 Batts, 2011, A novel member of the family Hepeviridae from cutthroat trout (Oncorhynchus clarkii), Virus Res., 158, 116, 10.1016/j.virusres.2011.03.019 Baudin-Laurencin, 1987, IHN in France, Bull. Eur. Ass. Fish Pathol., 7, 104 Bell, 1991, High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion, J. Nutr., 121, 1163, 10.1093/jn/121.8.1163 Benmansour, A., De Kinkelin, P., 1997. Live fish vaccines: history and perspectives: In: Gudding, R., Lillehaug, A., Midtlyng, P.J., Brown, F. (Eds), Fish Vaccinology, Developments in Biological Standardization, vol. 90. Karger, Basel, Switzerland, pp. 279–289. Berg, 2006, Time of vaccination influences development of adherences, growth and spinal deformities in Atlantic salmon (Salmo salar L.), Dis. Aquat. Org., 69, 239, 10.3354/dao069239 Bernet, 2002, First report of SVC infection in koi carp in Switzerland, Bull. Eur. Assoc. Fish Pathol., 22, 229 Biacchesi, 2011, The reverse genetics applied to fish RNA viruses, Vet. Res., 42, 12, 10.1186/1297-9716-42-12 Biering, E., Villoing, S., Sommerset, I., Christie, K.E., 2005. Update on viral vaccines of fish. In: Midtlyng, P.J. (Ed.), Progress in Fish Vaccinology, Developments in Biological Standardization, vol. 121. Karger, Basel, Switzerland, pp. 97–113. Blake, 2001, Phylogenetic relationships of aquatic birnaviruses based on deduced amino acid sequences of genome segment A cDNA, Dis. Aquat. Org., 45, 89, 10.3354/dao045089 Bootland, 1999, Infectious haematopoietic necrosis virus, vol. 3, 57 Bovo, 1987, Infectious haematopoietic necrosis: first detection in Italy, Bull. Eur. Ass. Fish Pathol., 7, 124 Bowden, T., Bricknell, I., Ellis, A.E., 2003. Fish vaccination. An overview. Bodø, Norway: IntraFish; http://www.intrafish.com (Published 2003; Consulted March 27, 2003). Bowker, 2012, New aquaculture drugs under FDA review: products include antibiotics, oxidizing agents, sedative, Global Aquaculture Advocate January/February, 36 Bowser, P.R. 2009. Fish Diseases: Viral Hemorrhagic Septicaemia (VHS). Northeastern Regional Aquaculture Center (NRAC), Publication No. 201–2009. Bravo, 2007, The use of fish vaccines in the Chilean salmon industry 1999–2003, Aquaculture, 270, 36, 10.1016/j.aquaculture.2007.06.017 Bricknell, 1999, Duration of protective antibodies, and the correlation with protection in Atlantic salmon (Salmo salar L.), following vaccination with an Aeromonas salmonicida vaccine containing iron-regulated outer membrane proteins and secretory polysaccharide, Fish Shellfish Immunol., 9, 139, 10.1006/fsim.1998.0183 Brocklebank, 2002, Sudden mortality caused by cardiac deformities following seining of preharvest farmed Atlantic salmon (Salmo salar) and by cardiomyopathy of postintraperitoneally vaccinated Atlantic salmon parr in British Columbia, Can. Vet. J., 43, 129 Brückner, 2007, The OIE network of reference laboratories, J. Wildlife Dis., 43, S60 Brun, E. 2003. Epidemiology. In: Skjelstad, B. (Ed.), IPN in Salmonids: A review. ISBN 82-91743-16-9. Burrells, 2001, Dietary nucleotides: a novel supplement in fish feeds 1. Effects on resistance to disease in salmonids, Aquaculture, 199, 159, 10.1016/S0044-8486(01)00577-4 Busch, 1997, Polyvalent vaccines in fish: the interactive effects of multiple antigens, Dev. Biol. Stand., 90, 245 Callejas, et al. 2012. Use of reverse transcription-real time polymerase chain reaction (RRT-PCR) assays with Universal Probe Library (UPL) probes for the detection and genotyping of infectious pancreatic necrosis virus strains isolated in Chile. J. Virol. Meth. 183, 80–85. Carrington, A.C., Secombes, C.J., 2006. A review of CpGs and their relevance to aquaculture. Vet. Immunol. Immunopathol. 112, 87–101. Casselman, A., 2011. More salmon shenanigans in British Columbia. Nature News Blog Dec 02 2011. <http://blogs.nature.com/news/2011/12/more_salmon_shenanigans_in_bri.html>. (Published and Consulted December 2, 2011). Castric, 1980, Occurrence of viral haemorrhagic septicaemia in rainbow trout Salmo gairdneri Richardson reared in sea water, J. Fish Dis., 3, 21, 10.1111/j.1365-2761.1980.tb00180.x Castric, 1984, Experimental study of the susceptibility of two marine fish species, sea bass (Dicentrarchus labrax) and turbot (Scophthalmus maximus), to viral haemorrhagic septicaemia, Aquaculture, 41, 203, 10.1016/0044-8486(84)90283-7 Castric, 1997, Isolation of the virus responsible for sleeping disease in experimentally infected rainbow trout (Oncorhynchus mykiss), Bull. Eur. Ass. Fish Pathol., 17, 27 Castro-Nallar, 2011, Molecular phylodynamics and protein modeling of infectious salmon anaemia virus (ISAV), BMC Evolutionary Biology, 11, 349, 10.1186/1471-2148-11-349 Chappell, 2005, Genus Orthoreovirus, 447 Charerntantanakul, 2009, Adjuvants for porcine reproductive and respiratory syndrome virus vaccines, Vet. Immunol. Immunopathol., 129, 1, 10.1016/j.vetimm.2008.12.018 Chinsangaram, 2003, Novel viral disease control strategy: adenovirus expressing alpha interferon rapidly protects swine from foot-and-mouth disease, J. Virol., 77, 1621, 10.1128/JVI.77.2.1621-1625.2003 Christie, 1997, Immunization with viral antigens: infectious pancreatic necrosis, Dev. Biol. Stand., 90, 191 Christie, K.E., et al. 2003. Vaccination against infectious salmon anaemia: onset and duration of protection and carrier status post challenge. Abstract. 11th International Conference of the EAFP, Malta, September 2003. Companjen, 2006, Improved uptake of plant-derived LTB-linked proteins in carp gut and induction of specific humoral immune responses upon infeed delivery, Fish Shellfish Immunol., 21, 251, 10.1016/j.fsi.2005.12.001 Companjen, A.R., et al. 2005. Development of a cost-effective oral vaccination method against viral disease in fish. In: Midtlyng P.J. (Ed), Progress in Fish Vaccinology, Developments in Biological Standardization. Karger, Basel, Switzerland, vol. 121, pp. 143–150. Corbeil, 2000, Fish DNA vaccine against infectious hematopoietic necrosis virus: efficacy of various routes of immunization, Fish Shellfish Immunol., 10, 711, 10.1006/fsim.2000.0286 Corripio-Miyar, 2009, Identification of interleukin-22 in gadoids and examination of its expression level in vaccinated fish, Mol. Immunol., 46, 2098, 10.1016/j.molimm.2009.01.024 Cottet, 2010, Bioinformatic analysis of the genome of infectious salmon anaemia virus associated with outbreaks with high mortality in Chile, J. Virol., 84, 11916, 10.1128/JVI.01202-10 Covello, J., et al., 2011a. Orally administered immunostimulants affect inflammatory gene expression and sea lice (Lepeophtheirus salmonis) burdens on Atlantic salmon (Salmo salar). In: 15th International Conference on Diseases of Fish and Shellfish, Radisson Blu Hotel, Split, Croatia, September 12–16, 2011. Covello, J., et al., 2011b. The effects of orally administered immunostimulants on Atlantic salmon (Salmo salar) immune gene expression and sea lice (Lepeophtheirus salmonis) infection. In: 52nd Annual Western Fish Disease Workshop, Vancouver Island Convention Centre, Nanaimo, British Columbia, June 14–16, 2011. Crotty, 2001, RNA virus error catastrophe: direct molecular test by using ribavirin, Proc. Natl. Acad. Sci. USA, 98, 6895, 10.1073/pnas.111085598 Cunningham, 2002, A novel variant of the infectious salmon anaemia virus (ISAV) haemagglutinin gene suggests mechanisms for virus diversity, Bull. Eur. Ass. Fish Pathol., 22, 366 CVMP: Committee for Medicinal Products for Veterinary Use; Guideline on the design of studies to evaluate the safety and efficacy of fish vaccines. November 14, 2011. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/11/WC500118226.pdf (downloaded January 1 2012). Dang, 2008, Inhibition of red sea bream iridovirus (RSIV) replication by small interfering RNA (siRNA) in a cell culture system, Antiviral Res., 77, 142, 10.1016/j.antiviral.2007.10.007 Debes, 2011, A low-pathogenic variant of infectious salmon anaemia virus (ISAV-HPR0) is highly prevalent and causes a non-clinical transient infection in farmed Atlantic salmon (Salmo salar L.) in the Faroe Islands, J. Gen. Virol., 92, 909, 10.1099/vir.0.027094-0 De Clercq, 2010, Antiretroviral drugs, Curr. Opin. Pharmacol., 10, 507, 10.1016/j.coph.2010.04.011 De Clercq, E., 1993. Antiviral agents: characteristic activity spectrum depending on the molecular target with which they interact. Academic Press, Inc., New York, NY, pp. 1–55. De Kinkelin, 1988, Vaccination against viral haemorrhagic septicaemia, 172 DFO Science, 2011. Halibut aquaculture. <http://www.dfo-mpo.gc.ca/science/Publications/article/2007/01-10-2007-eng.htm> (Published 2011; Consulted February 11, 2012). DFO, 2011. Infectious salmon anaemia (ISA) virus – Accepted testing methods. November 2011. <http://www.dfo-mpo.gc.ca/media/back-fiche/2011/20111108-eng.htm> (Published and Consulted November 08, 2011). Dikkeboom, 2004, First report of spring viraemia of carp virus (SVCV) in wild common carp in North America, J. Aquat. Anim. Health, 16, 169, 10.1577/H03-064.1 Dixon, 1999, VHSV came from the marine environment: clues from the literature, or just red herrings?, Bull. Eur. Ass. Fish Pathol., 19, 60 Dopazo, C.P., Bandín, I., 2006. Global epidemiology: Worldwide distribution of IPNV is not only a consequence of aquaculture and commercial movements of cultured fish. DIP Newsletter 30, VESO, Norway. Dobrovolskaia, 2007, Immunological properties of engineered nanomaterials, Nat. Nanotechnol., 2, 469, 10.1038/nnano.2007.223 Dorson, M., 1988. Vaccination against infectious pancreatic necrosis. In Ellis, A.E. (Ed,), Fish Vaccination. London, Academic Press Limited, pp. 162–171. Duarte, 2007, Rapid domestication of marine species, Science, 316, 382, 10.1126/science.1138042 Egidius, 1979, Bath immunization – a practical and non-stressing method of vaccinating sea farmed rainbow trout Salmo gairdneri Richardson against vibriosis, J. Fish Dis., 2, 405, 10.1111/j.1365-2761.1979.tb00392.x Einer-Jensen, 2004, Evolution of the fish rhabdovirus viral haemorrhagic septicaemia virus, J. Gen. Virol., 85, 1167, 10.1099/vir.0.79820-0 Elamanchili, 2007, “Pathogen-Mimicking” nanoparticles for vaccine delivery to dendritic cells, J. Immunother., 30, 378, 10.1097/CJI.0b013e31802cf3e3 Eldridge, 1990, Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer’s patches, J. Controlled Release, 11, 205, 10.1016/0168-3659(90)90133-E Ellis, A.E., 2002. Health and disease in Atlantic salmon farming. In: Stead, S.M., Laird, L.M. (Eds.), Handbook of salmon farming. Springer Praxis, Chichester, pp. 373–401. Ellis, 1998, Meeting the requirements for delayed release of oral vaccines for fish, J. Appl. Ichthyol., 14, 149, 10.1111/j.1439-0426.1998.tb00633.x Ellis, 1997, Vaccines for farmed fish, 411 Ellis, 1995, Recent development in oral vaccine delivery systems, Fish Pathol., 30, 293, 10.3147/jsfp.30.293 Ellis, 1988, General principles of fish vaccination, 1 Ellis, 1988, Optimizing factors for fish vaccination, 32 Elsayed, 2006, Isolation of viral hemorrhagic septicaemia virus from muskellunge, Esox masquinongy (Mitchill), in Lake St. Clair, Michigan, USA reveals a new sub-lineage of the North American genotype, J. Fish Dis., 29, 611, 10.1111/j.1365-2761.2006.00755.x Emmenegger, 2002, Genetic characterization of infectious hematopoietic necrosis virus of coastal salmonid stocks in Washington State, J. Aquat. Anim. Health, 14, 25, 10.1577/1548-8667(2002)014<0025:GCOIHN>2.0.CO;2 Emmenegger, 2000, Genetic diversity and epidemiology of infectious hematopoietic necrosis virus in Alaska, Dis. Aquat. Org., 40, 163, 10.3354/dao040163 Engelking, 1991, Comparison of representative strains of infectious hematopoietic necrosis virus by serological neutralization and cross-protection assays, Appl. Environ. Microbiol., 57, 1372, 10.1128/AEM.57.5.1372-1378.1991 Engelstad, M., 2005. Vaccination and consumer perception of seafood quality. In: Midtlyng, P.J. (Ed.), Progress in Fish Vaccinology, Developments in Biological Standardization, vol. 121. Karger, Basel, Switzerland, pp. 245–254. Enzmann, 2005, Infectious hematopoietic necrosis virus: monophyletic origin of European IHNV isolates from North-American genogroup M, Dis. Aquat. Org., 66, 187, 10.3354/dao066187 Evensen, Ø., 2009. Development in fish vaccinology with focus on delivery methodologies, adjuvants and formulations. Options Méditerranéennes, A/No. 86, The use of veterinary drugs and vaccines in Mediterranean aquaculture. Evensen, Ø., Brudeseth, B., Mutoloki, S., 2005. The vaccine formulation and its role in inflammatory processes in fish – effects and adverse effects. In: Midtlyng, P.J. (Ed.), Progress in Fish Vaccinology, Developments in Biological Standardization, vol. 121. Karger, Basel, Switzerland, pp. 117–125. FAO, 2010. The State if World Fisheries and Aquaculture 2010. Food and Agriculture Organization of the United Nations, Rome. Fast, 2009, Mutation within the Aeromonas salmonicida type III secretion system affects host macrophage activation and downstream immune responses, Fish Shellfish Immunol., 27, 721, 10.1016/j.fsi.2009.09.009 Faurez, 2010, Biosafety of DNA vaccines: new generation of DNA vectors and current knowledge on the fate of plasmids after injection, Vaccine, 28, 3888, 10.1016/j.vaccine.2010.03.040 Ferguson, 1990, Cardiomyopathy in farmed Norwegian salmon, Dis. Aquat. Org., 8, 225, 10.3354/dao008225 Ferguson, 2005, An outbreak of disease resembling heart and skeletal muscle inflammation in Scottish farmed salmon, Salmo salar L., with observations on myocardial regeneration, J. Fish Dis., 28, 119, 10.1111/j.1365-2761.2004.00602.x Field, A.K., Laughlin, C.A., 1999. Antivirals. In: Granoff, A., Webster, R.G. (Eds), Encyclopedia of Virology, second ed., vol. 1. Academic Press Ltd. pp 54–68. Fijan, 1971, Isolation of the viral causative agent from the acute form of infectious dropsy of carp, Veterinarski Archiv, 41, 125 Fisher, 2007, The relationship between the emergence of Batrachochytrium dendrobatidis, the international trade in amphibians and introduced amphibian species, Fungal Biol. Rev., 21, 2, 10.1016/j.fbr.2007.02.002 Flint, 2004 Forrester, 2012, Genome-scale phylogeny of the alphavirus genus suggests a marine origin, J. Virol., 86, 2729, 10.1128/JVI.05591-11 Fringuelli, 2008, Phylogenetic analyses and molecular epidemiology of European salmonid alphaviruses (SAV) based on partial E2 and nsP3 gene nucleotide sequences, J. Fish Dis., 31, 811, 10.1111/j.1365-2761.2008.00944.x Fritsvold, 2009, Experimental transmission of cardiomyopathy syndrome (CMS) in Atlantic salmon Salmo salar, Dis. Aquat. Org., 87, 225, 10.3354/dao02123 Gagné, 2007, Isolation of viral haemorrhagic septicaemia virus from mummichog, stickleback, striped bass and brown trout in eastern Canada, J. Fish Dis., 30, 213, 10.1111/j.1365-2761.2007.00802.x Garver, 2007, First detection and confirmation of spring viraemia of carp virus in common carp, Cyprinus carpio L., from Hamilton Harbour, Lake Ontario, Can. J. Fish Dis., 30, 665, 10.1111/j.1365-2761.2007.00851.x Gaughan, 2002, Disease-translocation across geographic boundaries must be recognized as a risk even in the absence of disease identification: the case with Australian Sardinops, Rev. Fish Biol. Fish., 11, 113, 10.1023/A:1015255900836 Georgopoulou, 1985, Macromolecular absorption of proteins by epithelial cells of the posterior intestinal segment and their intracellular digestion in the rainbow trout. Ultrastructural and biochemical study, Biol. Cell, 53, 269 Gjedrem, 2010, The first family-based breeding program in aquaculture, Rev. Aquacult., 2, 2, 10.1111/j.1753-5131.2010.01011.x Gilbert, 1986, Biochemistry and clinical applications of ribavirin, Antimicrob. Agents Chemother., 30, 201, 10.1128/AAC.30.2.201 Godoy, 2008, First detection, isolation and molecular characterization of infectious salmon anaemia virus associated with clinical disease in farmed Atlantic salmon (Salmo salar) in Chile, BMC Vet. Res., 4, 28, 10.1186/1746-6148-4-28 Goodwin, 2002, First report of spring viraemia of carp virus (SVCV) in North America, J. Aquat. Anim. Health, 14, 161, 10.1577/1548-8667(2002)014<0161:FROSVO>2.0.CO;2 Goris, 2008, Potential of antiviral therapy and prophylaxis for controlling RNA viral infections of livestock, Antiviral Res., 78, 170, 10.1016/j.antiviral.2007.10.003 Graham, 2007, First laboratory confirmation of salmonid alphavirus infection in Italy and Spain, J. Fish Dis., 30, 569, 10.1111/j.1365-2761.2007.00826.x Graham, 2006, Sub-clinical infection of farmed Atlantic salmon (Salmo salar L.) with salmonid alphavirus – a prospective longitudinal study, Dis. Aquat. Org., 72, 193, 10.3354/dao072193 Graham, 2003, First isolation of sleeping disease virus from rainbow trout, Oncorhynchus mykiss (Walbaum), in the United Kingdom, J. Fish Dis., 26, 691, 10.1046/j.1365-2761.2003.00505.x Graham, 2011, A comparative study of marine salmonid alphavirus subtypes 1–6 using an experimental cohabitation challenge model, J. Fish Dis., 34, 273, 10.1111/j.1365-2761.2010.01234.x Fajfar, 2011, Genotyping of Slovenian infectious hematopoietic necrosis virus isolates based on the “mid-G” region sequences of the glycoprotein gene, Bull. Eur. Ass. Fish Pathol., 31, 47 Grischkowsky, 1976, Infectious hematopoietic necrosis virus: prevalence in certain Alaskan sockeye salmon, Oncorhynchus nerka, J. Fish. Res. Board Can., 33, 186, 10.1139/f76-024 Groocock, 2007, Detection of viral haemorrhagic septicaemia in round gobies in New York State (USA) waters of Lake Ontario and the St. Lawrence River, Dis. Aquat. Org., 76, 187, 10.3354/dao076187 Groot, C., 1996. Salmonid life histories. In: Principles of Salmonid Culture. In: Pennell, W., Barton, B.A. (Eds.), Developments in Aquaculture and Fisheries Science, vol. 29, Elsevier, Amsterdam, pp. 97–230. Gudding, 1999, Recent developments in fish vaccinology, Vet. Immunol. Immunopathol., 72, 203, 10.1016/S0165-2427(99)00133-6 Gunnarsson, V.I., 2007. http://www.fisheries.is/aquaculture/species/cod/; http://www.fisheries.is/aquaculture/species/arctic-charr/; http://www.fisheries.is/aquaculture/species/atlantic-salmon/; http://www.fisheries.is/aquaculture/species/atlantic-halibut/; http://www.fisheries.is/aquaculture/species/turbot/; http://www.fisheries.is/aquaculture/species/other-species/ (Published 2007; Consulted February 3, 2012). Haasnoot, 2007, RNA interference against viruses: strike and counterstrike, Nat. Biotechnol., 25, 1435, 10.1038/nbt1369 Haenen, 2004, The emergence of koi herpesvirus and its significance to European aquaculture, Bull. Eur. Ass. Fish Pathol., 24, 293 Hall, S.J., et al., 2011. Blue Frontiers: Managing the environmental cost of aquaculture. The Worldfish Center, Penang, Malaysia. Haller, 2002, Interferon induced Mx proteins: Dynamin like GTPases with antiviral activity, Traffic, 3, 710, 10.1034/j.1600-0854.2002.31003.x Hannon, 2002, RNA interference, Nature, 418, 244, 10.1038/418244a Harel, M., 2009. Inventor; Advanced Bionutrition., assignee. Encapsulated vaccines for the oral vaccination and boostering of fish and other animals. United States Patent US 20090238845. Harikrishnan, 2010, Effect of probiotics enriched diet on Paralichthys olivaceus infected with lymphocystis disease virus, Fish Shellfish Immunol., 29, 868, 10.1016/j.fsi.2010.07.031 Harrahy, 2001, Antibody-producing cells correlated to body weight in juvenile Chinook saslmon (Oncorhynchus tshawytscha) acclimated to optimal and elevated temperatures, Fish Shellfish Immunol., 11, 653, 10.1006/fsim.2001.0342 Hartmann, 2000, Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo, J. Immunol., 164, 1617, 10.4049/jimmunol.164.3.1617 Hartman, K.H. 2004. Koi Herpesvirus (KHV) Disease. University of Florida IFAS Extension VM-149. http://edis.ifas.ufl.edu/pdffiles/VM/VM11300.pdf (Published 2004, Revised 2008; Consulted February 16, 2012). Hasobe, 1985, On the approach to the viral chemotherapy against infectious hematopoietic necrosis virus (IHNV) in vitro and in vivo on salmonid fishes, Fish Pathol., 20, 343, 10.3147/jsfp.20.343 Hasobe, 1986, The synergism of nucleoside antibiotics combined with guanine-7-N-oxide against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV), J. Antibiotics, 39, 1291, 10.7164/antibiotics.39.1291 Håstein, T., Gudding, R., Evensen, Ø. 2005. Bacterial vaccines for fish – An update of the current situation worldwide. In: Midtlyng P.J. (Ed.), Progress in Fish Vaccinology, Developments in Biological Standardization, vol. 121. Karger, Basel, Switzerland, pp. 55–74. Haugland, 2011, Cardiomyopathy syndrome of Atlantic salmon (Salmo salar L.) is caused by a double-stranded RNA virus of the Totiviridae family, J. Virol., 85, 5275, 10.1128/JVI.02154-10 Hedrick, 2003, Host and geographic range extensions of the North American strain of viral hemorrhagic septicaemia virus, Dis. Aquat. Org., 55, 211, 10.3354/dao055211 Heppell, 2000, Application of DNA vaccine technology to aquaculture, Adv. Drug Deliv. Rev., 43, 29, 10.1016/S0169-409X(00)00075-2 Hill, 1982, Infectious pancreatic necrosis virus and its virulence, 91 Hill, B.J., 2005. The need for effective disease control in international aquaculture. In: Midtlyng, P.J. (Ed.), Progress in Fish Vaccinology, Developments in Biological Standardization, vol. 121. Karger, Basel, Switzerland, pp. 3–12. Hill, 1995, Serological classification of infectious pancreatic necrosis (IPN) virus and other aquatic birnaviruses, Ann. Rev. Fish Dis., 5, 55, 10.1016/0959-8030(95)00011-9 Hodneland, 2005, New subtype of salmonid alphavirus (SAV), Togaviridae, from Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss in Norway, Dis. Aquat. Org., 66, 113, 10.3354/dao066113 Hoel, 1997, Vibrio antigens of polyvalent vaccines enhance the humoral response of Aeromonas salmonicida antigens in Atlantic salmon (Salmo salar L.), Fish Shellfish Immunol., 7, 71, 10.1006/fsim.1996.0063 Holland, 1992, RNA virus populations as quasispecies, Curr. Top. Microbiol. Immunol., 176, 1, 10.1007/978-3-642-77011-1_1 Horlyck, 1984, Occurrence of VHS in Danish maricultured rainbow trout, Bull. Eur. Assoc. Fish Pathol., 4, 11 Horne, 1988, Strategies of fish vaccination, 55 Hubbell, 2009, Materials engineering for immunomodulation, Nature, 462, 449, 10.1038/nature08604 Hudson, 1988, The efficacy of amantadine and other antiviral compounds against two salmonid viruses in vitro, Antiviral Research, 9, 379, 10.1016/0166-3542(88)90039-3 Hsu, 1986, Occurrence of different types of infectious hematopoietic necrosis virus in fish, Appl. Environ. Microbiol., 52, 1353, 10.1128/AEM.52.6.1353-1361.1986 Isshiki, 2001, An outbreak of VHSV (viral haemorrhagic septicaemia virus) infection in farmed Japanese flounder Paralichthys olivaceus in Japan, Dis. Aquat. Org., 47, 87, 10.3354/dao047087 Jarp, 1995, Risk factors for furunculosis, infectious pancreatic necrosis and mortality in post-smolt of Atlantic salmon, Salmo salar L., J. Fish Dis., 18, 67, 10.1111/j.1365-2761.1995.tb01267.x Jin, 2010, Cellular reactive oxygen species inhibit MPYS induction of IFNβ, PLoS ONE, 5, e15142, 10.1371/journal.pone.0015142 Joerink, 2006, Head kidney-derived macrophages of common carp (Cyprinus carpio L.) show plasticity and functional polarization upon differential stimulation, J. Immunol., 177, 61, 10.4049/jimmunol.177.1.61 Joerink, 2006, Evolutionary conservation of alternative activation of macrophages: Structural and functional characterization of arginase 1 and 2 in carp (Cyprinus carpio L.), Mol. Immunol., 43, 1116, 10.1016/j.molimm.2005.07.022 Johnson, 1982, Onset of immunity in salmonid fry vaccinated by direct immersion in Vibrio anguillarum and Yersinia ruckeri bacterins, J. Fish Dis., 5, 197, 10.1111/j.1365-2761.1982.tb00474.x Johansen, 2011, Disease interaction and pathogens exchange between wild and farmed fish populations with special reference to Norway, Aquaculture, 315, 167, 10.1016/j.aquaculture.2011.02.014 Joosten, 1997, Oral vaccination of fish against Vibrio anguillarum using alginate microparticles, Fish Shellfish Immunol., 7, 471, 10.1006/fsim.1997.0100 Jorgensen, 2003, CpG DNA induces protective antiviral immune responses in Atlantic salmon (Salmo salar L.), J. Virol., 77, 11471, 10.1128/JVI.77.21.11471-11479.2003 Kaatari, 2002, Affinity maturation in trout: clonal dominace of high affinity antibodies late in the immune response, Dev. Comp. Immunol., 26, 191, 10.1016/S0145-305X(01)00064-7 Karlsen, 2005, Genetic stability within the Norwegian subtype of salmonid alphavirus (family Togaviridae), Arch. Virol., 151, 861, 10.1007/s00705-005-0687-6 Kawai, 2006, Innate immune recognition of viral infection, Nat. Immunol., 7, 131, 10.1038/ni1303 Kayamuro, 2009, The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses, Biomaterials, 30, 5869, 10.1016/j.biomaterials.2009.07.009 Kent, 1987, Pancreas disease in pen-reared Atlantic salmon in North America, Bull. Eur. Ass. Fish Pathol., 7, 29 Kibenge, 2009, Infectious salmon anaemia virus (ISAV) isolated from the ISA disease outbreaks in Chile diverged from ISAV isolates from Norway around 1996 and was disseminated around 2005, based on surface glycoprotein gene sequences, Virol. J., 6, 88, 10.1186/1743-422X-6-88 Kibenge, 2007, Mapping of putative virulence motifs on infectious salmon anaemia virus surface glycoprotein genes, J. Gen. Virol., 88, 3100, 10.1099/vir.0.83097-0 Kibenge, 2004, Infectious salmon anaemia virus: causative agent, pathogenesis and immunity, Anim. Health Res. Rev., 5, 65, 10.1079/AHR200461 Kibenge, F.S.B., et al. 2003. The development of infectious salmon anemia virus vaccines in Canada. In: Miller, O., Cipriano, R.C. (Tech. Coords.), International response to infectious salmon anemia: prevention, control, and eradication: proceedings of a symposium; 3–4 September 2002; New Orleans, LA. Tech. Bull. 1902. Washington, DC: US Department of Agriculture, Animal and Plant Health Inspection Service; US Department of the Interior, US Geological Survey; US Department of Commerce, National Marine Fisheries Service, pp. 39–49. Kibenge, 2001, Antigenic variation among isolates of infectious salmon anaemia virus (ISAV) correlates with genetic variation of the viral haemagglutinin gene, J. Gen. Virol., 82, 2869, 10.1099/0022-1317-82-12-2869 Kibenge, 2000, A dual infection of infectious salmon anaemia (ISA) virus and a togavirus-like virus in ISA of Atlantic salmon Salmo salar in New Brunswick, Can. Dis. Aquat. Org., 42, 11, 10.3354/dao042011 Kibenge, 2005, Constitutive expression of Atlantic salmon Mx1 protein in CHSE-214 cells confers resistance to infectious salmon anaemia virus, Virol. J., 2, 75, 10.1186/1743-422X-2-75 Kibenge, 2002, Serological evidence of infectious salmon anaemia virus (ISAV) infection in farmed fish, using an indirect enzyme-linked immunosorbent assay (ELISA), Dis. Aquat. Org., 51, 1, 10.3354/dao051001 Kim, 2007, Genotyping of Korean isolates of infectious hematppoietic necrosis virus (IHNV) based on the glycoprotein gene, Arch. Virol., 152, 2119, 10.1007/s00705-007-1027-9 Kim, 2009, Effect of beta glucan on activity of antioxidant enzymes and Mx gene expression in virus infected grass carp, Fish Shellfish Immunol., 27, 336, 10.1016/j.fsi.2009.06.006 Kimura, 1990, An antiviral agent (46NW-04A) produced by Pseudomonas sp. and its activity against fish viruses, J. Aquat. Anim. Health, 2, 12, 10.1577/1548-8667(1990)002<0012:AAAPBP>2.3.CO;2 Kimura, 1983, In vitro antiviral effect of 9-(2-hydroxyethoxymethyl) guanine on the fish herpesvirus, Oncorhynchus masou virus (OMV), Antiviral Res., 3, 93, 10.1016/0166-3542(83)90030-X Kimura, 1983, In vivo antiviral effect of 9-(2-hydroxymethyl) guanine on experimental infection of chum salmon (Oncorhynchus keta) fry with Oncorhynchus masou virus (OMV), Antiviral Res., 3, 103, 10.1016/0166-3542(83)90031-1 Kitao, 2009, Characterization and expression analysis of type I interferon in common carp Cyprinus carpio L., Mol. Immunol., 46, 2548, 10.1016/j.molimm.2009.05.012 Kjøglum, 2008, Selective breeding can increase resistance of Atlantic salmon to furunculosis, infectious salmon anaemia and infectious pancreatic necrosis, Aquacult. Res., 39, 498, 10.1111/j.1365-2109.2008.01904.x Kongtorp, 2004, Heart and skeletal muscle inflammation in Atlantic salmon Salmo salar L: a new infectious disease, J. Fish Dis., 27, 351, 10.1111/j.1365-2761.2004.00549.x Koppang, 2010, Salmonid T cells assemble in the thymus, spleen, and in novel interbranchial lymphoid tissue, J. Anat., 217, 728, 10.1111/j.1469-7580.2010.01305.x Koppang, 2008, Vaccination-induced systemic autoimmunity in farmed Atlantic salmon, J. Immunol., 181, 4807, 10.4049/jimmunol.181.7.4807 Koppang, 2004, Granulomatous uveitis associated with vaccination in the Atlantic salmon, Vet. Pathol., 41, 122, 10.1354/vp.41-2-122 Kurath, G. 2012. An online database for IHN virus in Pacific salmonid fish: MEAP-IHNV. http://pubs.usgs.gov/fs/2012/3027/pdf/fs20123027.pdf (Published 2012; Consulted May 29, 2012). Kurath, 2008, Biotechnology and DNA vaccines for aquatic animals, Rev. Sci. Tech. Off. Int. Epiz., 27, 175, 10.20506/rst.27.1.1793 Kurath, G., 2005. Overview of recent DNA vaccine development for fish. In: Midtlyng P.J. (Ed), Progress in Fish Vaccinology, Developments in Biological Standardization. vol 121. Karger, Basel, Switzerland, pp. 201–213. Kurath, 2007, Fish rhabdovirus models for understanding host response to DNA vaccines, CAB Reviews, 2, 1, 10.1079/PAVSNNR20072048 Kurath, 2003, Phylogeography of infectious haematopoietic necrosis virus in North America, J. Gen. Virol., 84, 803, 10.1099/vir.0.18771-0 Kuroda, 2004, Distinctive patterns of autoimmune response induced by differenttypes of mineral oil, Toxicol. Sci., 78, 222, 10.1093/toxsci/kfh063 Kuzmin, 2009, The rhabdoviruses: biodiversity, phylogenetics, and evolution, Infection, Genetics and Evolution, 9, 541, 10.1016/j.meegid.2009.02.005 Langdon, 1986, First virus isolation from Australian fish: an iridovirus-like pathogen from redfin perch. Perca fluviatilis L., J. Fish Dis., 9, 263, 10.1111/j.1365-2761.1986.tb01011.x LaPatra, 1998, Resistance to IHN virus infection in rainbow trout is increased by glucan while subsequent production of serum neutralizing activity is decreased, Fish Shellfish Immunol., 8, 435, 10.1006/fsim.1998.0151 LaPatra, 1993, Characterization of the humoral response of rainbow trout to infectious hematopoietic necrosis virus, J. Aquat. Anim. Health, 5, 165, 10.1577/1548-8667(1993)005<0165:COTHRO>2.3.CO;2 Larsen, 2004, Inhibition of infectious pancreatic necrosis virus replication by Atlantic salmon Mx1 protein, J. Virol., 78, 7938, 10.1128/JVI.78.15.7938-7944.2004 Lauring, 2010, Rationalizing the development of live attenuated virus vaccines, Nat. Biotechnol., 28, 573, 10.1038/nbt.1635 Lauscher, 2011, Immune responses in Atlantic salmon (Salmo salar) following protective vaccination against infectious salmon anaemia (ISA) and subsequent ISA virus infection, Vaccine, 29, 6392, 10.1016/j.vaccine.2011.04.074 Lecaroz, 2006, Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin, J. Microencapsul., 23, 782, 10.1080/02652040600946886 Li, 2010, Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection, Fish Shellfish Immunol., 29, 399, 10.1016/j.fsi.2010.04.020 Lieschke, 2009, Fish immunology, Current Biology, 19, R678, 10.1016/j.cub.2009.06.068 Lillehaug, 1991, Vaccination of Atlantic salmon (Salmo salar L.) against cold-water vibriosis – duration of protection and effect on growth rate, Aquaculture, 92, 99, 10.1016/0044-8486(91)90011-U Lillehaug, 1989, Oral immunization of rainbow trout, Salmo gairdneri Richardson, against vibriosis with vaccines protected against digestive degradation, J. Fish Dis., 12, 579, 10.1111/j.1365-2761.1989.tb00567.x Lillehaug, 1996, Passive transfer of specific maternal antibody does not protect Atlantic salmon (Salmo salar L.) fry against yersiniosis, Fish Shellfish Immunol., 6, 521, 10.1006/fsim.1996.0049 Long, 2004, Identification of a cDNA encoding channel catfish interferon, Dev. Comp. Immunol., 28, 97, 10.1016/S0145-305X(03)00122-8 Lorenzen, 2005, DNA vaccines for aquacultured fish, Rev. Sci. Technol. Off. Int. Epiz., 24, 201, 10.20506/rst.24.1.1565 Lorenzen, 1998, Protective immunity to VHS in rainbow trout (Onchorhynchus mykiss, Walbaum) following DNA vaccination, Fish Shellfish Immunol., 8, 261, 10.1006/fsim.1997.0134 Lorenzen, 1988, Production and characterization of monoclonal antibodies to four Egtved virus structural proteins, Dis. Aquat. Org., 4, 35, 10.3354/dao004035 Lorincz, 2011, First detection and analysis of a fish circovirus, J. Gen. Virol., 92, 1817, 10.1099/vir.0.031344-0 Løvoll, 2011, A novel totivirus and piscine reovirus (PRV) in Atlantic salmon (Salmo salar) with cardiomyopathy syndrome (CMS), Virol. J., 7, 309, 10.1186/1743-422X-7-309 Lumsden, 2007, Mortality event in freshwater drum Aplodinotus grunniens from Lake Ontario, Canada, associated with viral haemorrhagic septicaemia virus, Type IV, Dis. Aquat. Org., 76, 99, 10.3354/dao076099 MacBeath, 2009, Surveillance for infectious salmon anaemia virus HPR0 in marine Atlantic salmon farms across Scotland, Dis. Aquat. Org., 87, 161, 10.3354/dao02128 Maira, C., et al., 2008. Side effects of injectable vaccines in cod – Adapting the side-effect scale to cod. Fish Farming Xpert 3/2008, pp 57–61. http://www.pharmaq.no/sfiles/31/8/file/side_effects_of_injectable_vaccines_in_cod_kyst_s57-61.pdf (downloaded January 1, 2012). Manning, M.J., Grace, M.F., 1982. Developmental aspects of immunity and tolerance in fish. In: Roberts, R.J. (Ed.), Microbial diseases of fish. Academic Press. pp 31–46. Markland, 2000, Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with Ribavirin and demonstration of antiviral additivity with alpha interferon, Antomicrob. Agents Chemother., 44, 859, 10.1128/AAC.44.4.859-866.2000 Matsuoka, 1996, Cultured fish species affected by red sea bream iridoviral disease from 1991 to 1995, Fish Pathol., 31, 233, 10.3147/jsfp.31.233 McAlaster, T. 2011. Engineered ecosystem for salmon. http://www.theglobeandmail.com/life/food-and-wine/engineered-ecosystem-for-salmon/article1891038/?from=1891039 (Published and Consulted February 1, 2011). McAllister, 1997, Infectious pancreatic necrosis virus in the environment: relationship to effluent from aquaculture facilities, J. Fish Dis., 20, 201, 10.1046/j.1365-2761.1997.00297.x McAllister, 1992, Recovery of infectious pancreatic necrosis virus from the faeces of wild piscivorous birds, Aquaculture, 106, 227, 10.1016/0044-8486(92)90254-I McAllister, 1984, Infectious pancreatic necrosis virus: isolation from rainbow trout, Salmo gairdneri Richardson, imported into Chile, J. Fish Dis., 7, 319, 10.1111/j.1365-2761.1984.tb00938.x McCormick, 1998, Movement, migration, and smolting of Atlantic salmon (Salmo salar), Can. J. Fish. Aquat. Sci., 55, 77, 10.1139/d98-011 McGurk, C., et al. 2011. Blood biochemistry for assessing the impact of functional nutrition on pathogenesis of salmon pancreas disease (PD). In: 15th International Conference on Diseases of Fish and Shellfish, Radisson Blu Hotel, Split, Croatia, September 12–16, 2011. McLoughlin, M., 2006. Fish vaccination – A brief overview. <http://www.imb.ie/images/uploaded/documents/Fish%20Vaccine%20Overview.pdf> (Published January 25, 2006; Consulted February 27, 2012). McLoughlin, 2007, Alphavirus infections in salmonids – a review, J. Fish Dis., 30, 511, 10.1111/j.1365-2761.2007.00848.x McLoughlin, 1992, Vitamin E responsive myopathy in rainbow trout Oncorhynchus mykiss fry, Vet. Rec., 130, 224, 10.1136/vr.130.11.224 McVicar, A.H., 1987. Pancreas disease of farmed Atlantic salmon, Salmo salar. Scotland: Epidemiology and Early Pathology 67, 71–78. Midtlyng, 1996, Experimental studies on the efficacy and side effects of intraperitoneal vaccination of Atlantic salmon (Salmo salar L.) against furunculosis, Fish Shellfish Immunol., 6, 335, 10.1006/fsim.1996.0034 Midtlyng, 1998, Growth of Atlantic salmon Salmo salar after intraperitoneal administration of vaccines containing adjuvant, Dis. Aquat. Org., 32, 91, 10.3354/dao032091 Mikalsen, 2004, Protection of Atlantic salmon (Salmo salar) against infectious pancreatic necrosis after DNA vaccination, Dis. Aquat. Organ., 60, 11, 10.3354/dao060011 Mitchell, 1995, Choosing a furunculosis vaccine: points to consider, Bull. Aquacult. Assoc. Can., 95, 30 Mjaaland, 2005, Susceptibility and immune responses following experimental infection of MHC compartible Atlantic salmon (Salmo salar L.) with different infectious salmon anaemia virus isolates, Arch. Virol., 150, 2195, 10.1007/s00705-005-0588-8 Moen, 2007, Mapping of a quantitative trait locus for resistance against infectious salmon anaema in Atlantic salmon (Salmo salar): comparing survival analysis with analysis on affected/resistant data, BMC Genetics, 8, 53, 10.1186/1471-2156-8-53 Mohan, C.V., 2009. Health: National strategies for aquatic animal health management. Available at: http://thefishsite.com/articles/623/health-national-strategies-for-aquatic-animal-health-management (accessed on July 19, 2011). Mulero, 2007, Maternal transfer of immunity and ontogeny of autologous immunocompetence of fish: a mini review, Aquaculture, 268, 244, 10.1016/j.aquaculture.2007.04.046 Munro, 1984, An exocrine pancreas disease of farmed Atlantic salmon in Scotland, Helgoländer Meeresunters, 37, 571 Murias, A. 2012. Global agreement expands ISA vaccine distribution. FIS – Worldnews. <http://www.fis.com/fis/worldnews/worldnews.asp?l=e&country=0&special=&monthyear=&day=&id=49095&ndb=1&df=0> (Published and Consulted January 13, 2012). Murphy, 1999, Vaccination against viral diseases, 241 Murray, 2010, Epidemiological investigation into the re-emergence and control of an outbreak of infectious salmon anaemia in the Shetland Islands, Scotland, Dis. Aquat. Org., 91, 189, 10.3354/dao02262 Murray, 2005, A framework for understanding the potential for emerging diseases in aquaculture, Prev. Vet. Med., 67, 223, 10.1016/j.prevetmed.2004.10.012 Murray, 2002, Shipping and the spread of infectious salmon anemia in Scottish aquaculture, Emerg. Infect. Dis., 8, 1, 10.3201/eid0801.010144 Mutoloki, 2011, Sequence similarities of the capsid gene of Chilean and European isolates of infectious pancreatic necrosis virus point towards a common origin, J. Gen. Virol., 92, 1721, 10.1099/vir.0.030270-0 Mutoloki, 2004, Sequential study of antigen persistence and concomitant inflammatory reactions relative to side effects and growth of Atlantic salmon (Salmo salar L.) following intraperitoneal injection with oil-adjuvanted vaccines, Fish Shellfish Immunol., 16, 633, 10.1016/j.fsi.2003.10.002 Nakanishi, 2002, Development of a new vaccine delivery method for fish: percutaneous administration by immersion with application of multiple puncture instrument, Vaccine, 20, 3764, 10.1016/S0264-410X(02)00291-8 Nakanishi, 1997, Antigen uptake and immune responses after immersion vaccination, Dev. Biol. Stand., 90, 59 Nelson, 1995, Isolation of a toga-like virus from farmed Atlantic salmon Salmo salar with pancreas disease, Dis. Aquat. Org., 22, 25, 10.3354/dao022025 Newman, 1993, Bacterial vaccines for fish, Ann. Rev. Fish Dis., 3, 145, 10.1016/0959-8030(93)90033-8 Nielsen, 2011, Mapping uncertainties in the upstream: the case of PLGA nanoparticles in salmon vaccines, Nanoethics, 5, 57, 10.1007/s11569-011-0111-5 Nichol, 1995, Molecular epizootiology and evolution of the glycoprotein and non-virion protein genes of infectious hematopoietic necrosis virus, a fish rhabdovirus, Vir. Res., 38, 159, 10.1016/0168-1702(95)00054-T Ning, 1998, Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits TH2 cytokine response, J. Immunol., 22, 3487, 10.4049/jimmunol.160.7.3487 Nishizawa, 2006, Nucleotide diversity of Japanese isolates of infectious hematopoietic necrosis virus (IHNV) based on the glycoprotein gene, Dis. Aquat. Org., 71, 267, 10.3354/dao071267 Nishizawa, 1991, Characterization of structural proteins of hirame rhabdovirus, HRV, Dis. Aquat. Org., 10, 167, 10.3354/dao010167 Nordmo, 1997, Strengths and weaknesses of different challenge methods, Dev. Biol. Stand., 90, 303 Norwegian Veterinary Institute reports. Available at: <http://www.vetinst.no/nor/Forskning/Publikasjoner/Fiskehelserapporten>. Nylund, 2007, Transmission of infectious salmon anaemia virus (ISAV) in farmed populations of Atlantic salmon (Salmo salar), Arch. Virol., 152, 151, 10.1007/s00705-006-0825-9 O’Dowd, 1999, The primary and secondary antibody responses to IROMP antigens in Atlantic salmon (Salmo salar L.) immunised with A+ and A− Aeromonas salmonicida bacterins, Fish Shellfish Immunol., 9, 125, 10.1006/fsim.1998.0182 Ohta, 2011, Anti-viral effects of interferon administration on sevenband grouper. Epinephelus septemfasciatus, Fish Shellfish Immunol., 30, 1064, 10.1016/j.fsi.2011.02.003 OIE, 2011. Manual of Diagnostic Tests for Aquatic Animals 2011. <http://www.oie.int/international-standard-setting/aquatic-manual/access-online/> (Published 2011; Consulted February 11, 2012). OIE, 2012a. OIE Listed Diseases. <http://www.oie.int/animal-health-in-the-world/oie-listed-diseases-2012/> (Published 2012; Consulted February 11, 2012). OIE, 2012b. Infectious salmon anaemia. <http://web.oie.int/wahis/public.php?WAHIDPHPSESSID=7c523a0d118dfebe366ba309085c0324&page=disease_outbreak_map&disease_type=Aquatic&disease_id=160> (Published 2012; Consulted May 26, 2012). Okamoto, 1993, Resistance of a rainbow trout strain to infectious pancreatic necrosis, Aquaculture, 117, 71, 10.1016/0044-8486(93)90124-H Olivier, 2002, Disease interactions between wild and cultured fish – perspectives from the American Northeast (Atlantic Provinces), Bull. Eur. Ass. Fish Pathol., 22, 103 Ooi, 2008, Innate immunomodulation with recombinant interferon-α enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus, Dev. Comp. Immunol., 32, 1211, 10.1016/j.dci.2008.03.010 Palacios, 2010, Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus, PLoS One, 5, e11487, 10.1371/journal.pone.0011487 Peeler, 2004, Qualitative risk assessment of routes of transmission of the exotic fish parasite Gyrodactylus salaries between river catchments in England and Wales, Prev. Vet. Med., 64, 175, 10.1016/j.prevetmed.2004.05.005 Perelberg, 2005, Protection of cultured Cyprinus carpio against a lethal viral disease by an attenuated virus vaccine, Vaccine, 23, 3396, 10.1016/j.vaccine.2005.01.096 Pilstrøm, L., 2005. Adaptive immunity in teleosts: humoral immunity. In: Midtlyng P.J. (Ed.), Progress in Fish Vaccinology, Developments in Biological Standardization, vol. 121. Karger, Basel, Switzerland, pp. 23. Plant, 2011, Advances in fish vaccine delivery, Dev. Comp. Immunol., 35, 1256, 10.1016/j.dci.2011.03.007 Plarre, 2005, Prevalence of infectious salmon anaemia virus (ISAV) in wild salmonids in western Norway, Dis. Aquat. Org., 66, 71, 10.3354/dao066071 Plumb, 2010 Poppe, T.T., Sande, R.D., 1994. Cardiomyopathy in farmed Atlantic salmon: a review, introducing an ultrasound technique for clinical examination. Norwegian School of Veterinary Science. Oslo. Poppe, 2003, First description of cardiomyopathy syndrome (CSM)-related lesions in wild Atlantic salmon Salmo salar in Norway, Dis. Aquat. Org., 56, 87, 10.3354/dao056087 Poulos, 2006, Purification and characterization of infectious myonecrosis virus of penaeid shrimp, J. Gen. Virol., 87, 987, 10.1099/vir.0.81127-0 Purcell, et al., 2006. Conservation of Toll-Like Receptor Signaling Pathways in Teleost Fish. Comp. Biochem. Physiol. Part D. Genomics. Proteomics 1, 77–88. Quentel, 1997, Antigen uptake and immune responses after oral vaccination, Dev. Biol. Stand., 90, 69 Randall, 2008, Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures, J. Gen. Virol., 89, 1, 10.1099/vir.0.83391-0 Raynard, 1993, Development towards an experimental protocol for the transmission of pancreas disease of Atlantic salmon Salmo salar, Dis. Aquat. Org., 15, 123, 10.3354/dao015123 Rich, 2003, Timeline Z-DNA: the long road to biological function, Nat. Rev. Genet., 4, 566, 10.1038/nrg1115 Richter, 1999, Transgenic plants as edible vaccines, Curr. Top. Microbiol. Immunol., 240, 159 Rijkers, 1980, The immune system of cyprinid fish. Kinetics and temperature dependence of antibody-producing cells in carp (Cyprinus carpio), Immunology, 41, 91 Rimstad, 2011, Examples of emerging virus diseases in salmonid aquaculture, Aquacult. Res., 42, 86, 10.1111/j.1365-2109.2010.02670.x Rimstad, 2001, Characterization of the infectious salmon anaemia virus genomic segment that encodes the putative haemagglutinin, J. Virol., 75, 5352, 10.1128/JVI.75.11.5352-5356.2001 Rivas-Aravena, 2011, Inhibitory effect of a nucleotide analog on ISAV infection, J. Virol., 85, 8037, 10.1128/JVI.00533-11 Roberts, 2005, Infectious pancreatic necrosis in Atlantic salmon, Salmo salar L., J. Fish Dis., 28, 383, 10.1111/j.1365-2761.2005.00642.x Roberts, R.J., Shepherd, C.J., 1974. Handbook of trout and salmon diseases. Fishing News, Surrey, England, pp. 40–42. Robertsen, 2008, Expression of interferon and interferon-induced genes in salmonids in response to virus infection, interferon-inducing compounds and vaccination, Fish Shellfish Immunol., 25, 351, 10.1016/j.fsi.2008.02.004 Robertsen, 2003, Atlantic salmon interferon genes: cloning, sequence analysis, expression, and biological activity, J. Interferon Cytokine Res., 23, 601, 10.1089/107999003322485107 Roger, 2007, Epidemiological observations of pancreas disease of farmed Atlantic salmon, Salmo salar L., in Ireland, J. Fish Dis., 30, 157, 10.1111/j.1365-2761.2007.00799.x Rodger, 2000, Cardiomyopathy syndrome in farmed Scottish salmon, Vet. Rec., 146, 500, 10.1136/vr.146.17.500 Rodgers, 2011, The spread of pathogens through trade in aquatic animals and their products, Rev. Sci. Tech. Off. Int. Epiz., 30, 241, 10.20506/rst.30.1.2034 Rodroguez-Ramilo, 2011, QTL detection for Aeromonas salmonicida resistance related traits in turbot (Scophthalmus maximus), BMC Genomics, 12, 541, 10.1186/1471-2164-12-541 Rombout, 2011, Teleost intestinal immunology, Fish Shellfish Immunol., 31, 616, 10.1016/j.fsi.2010.09.001 Rombout, 1989, Immunological importance of the second gut segment in carp I. Uptake and process of antigens by epithelial cells and macrophages, J. Fish Biol., 35, 13, 10.1111/j.1095-8649.1989.tb03388.x Rombout, 1985, Uptake and transport of intact macromolecules in the intestinal epithelium of carp (Cyprinus carpio) and the possible immunological implications, Cell and Tissue Res., 239, 519, 10.1007/BF00219230 Romero-Brey, 2009, Genetic analysis of aquabirnaviruses isolated from wild fish reveals occurrence of natural reassortment of infectious pancreatic necrosis virus, J. Fish Dis., 32, 585, 10.1111/j.1365-2761.2009.01020.x Rosenlund, 2006, Worldwide status and perspectives on gadoid culture, ICES J. Marine Sci., 63, 194, 10.1016/j.icesjms.2005.11.012 Ross, 1994, An outbreak of viral haemorrhagic septicaemia (VHS) in turbot (Scophthalmus maximus) in Scotland, Bull. Eur. Assoc. Fish Pathol., 14, 213 Rowley, 1998, Isolation of salmon pancreas disease virus (SPDV) from Scottish farmed salmon, J. Fish Dis., 21, 469, 10.1046/j.1365-2761.1998.00130.x Rudakova, 2007, Occurrence and genetic typing of infectious hematopoietic necrosis virus in Kamchatka, Russia, Dis. Aquat. Org., 75, 1, 10.3354/dao075001 Ruiz, 2009, New tools to study RNA interference to fish viruses: fish cell lines permanently expressing siRNAs targeting the viral polymerase of viral hemorrhagic septicaemia virus, Antiviral Res., 82, 148, 10.1016/j.antiviral.2009.02.200 Saksida, S., 2004. Investigation of the 2001–2003 IHN epizootic in farmed Atlantic salmon in British Columbia. <http://www.agf.gov.bc.ca/ahc/fish_health/IHNV_report_2003.pdf>. (Published February 18, 2004; Consulted May 16, 2012). Salonius, 2007, The road to licensure of a DNA vaccine, Curr. Opin. Invest. Drugs, 8, 635 Santi, 2004, Identification of putative motifs involved in the virulence of infectious pancreatic necrosis virus, Virology, 322, 31, 10.1016/j.virol.2003.12.016 Schliehe, 2011, Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy, J. Control Release, 151, 278, 10.1016/j.jconrel.2011.01.005 Schlosser, 2008, TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses, Vaccine, 26, 1626, 10.1016/j.vaccine.2008.01.030 Schlotfeldt, 1991, Occurrence of viral haemorrhagic septicaemia in turbot (Scophthalmus maximus) – a natural outbreak, Bull. Eur. Ass. Fish Pathol., 11, 105 Schyth, 2006, Antiviral activity of small interfering RNAs: specificity testing using heterologous virus reveals interferon-related effects overlooked by conventional mismatch controls, Virology, 349, 134, 10.1016/j.virol.2006.01.009 Secombes, 2011, Fish immunity: the potential impact on vaccine development and performance, Aquacult. Res., 42, 90, 10.1111/j.1365-2109.2010.02673.x Seth, 2005, Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3, Cell, 122, 669, 10.1016/j.cell.2005.08.012 Sharpe, 2007, Physiological stress responses to automated and hand vaccine injection procedures in yearling coho salmon, N. Am. J. Aquacult., 69, 180, 10.1577/A06-004.1 Shivappa, R., et al. 2008. Spring viraemia of carp in the United States of America: evaluation of current diagnostics, in: Bondad-Reantaso, M.G., Mohan, C.V., Crumlish, M., and Subasinghe, R.P. (Eds.), Diseases in Asian Aquaculture VI. Fish Health Section, Asian Fisheries Society, Manila, Philippines. pp. 143-156. Shoemaker, 2006, Efficacy of a Oralject (TM) Streptococcus iniae modified bacterin delivered using technology in Nile tilapia (Oreochromis niloticus), Aquaculture, 255, 151, 10.1016/j.aquaculture.2005.12.016 Siripornadulsil, 2007, Microalgal vaccines, Adv. Exp. Med. Biol., 616, 122, 10.1007/978-0-387-75532-8_11 Siwicki, 2003, Influence of Methisoprinol on the replication of rhabdoviruses isolated from carp (Cyprinus carpio) and catfish (Ictalurus melas): in vitro study, Polish J. Vet. Sci., 6, 47 Skall, 2005, Viral haemorrhagic septicaemia virus in marine fish and its implications for fish farming – a review, J. Fish Dis., 28, 509, 10.1111/j.1365-2761.2005.00654.x Smail, 1999, Viral haemorrhagic septicaemia, 123 Smail, 1992, Infectious pancreatic necrosis (IPN) virus Sp serotype in farmed Atlantic salmon, Salmo salar L., post-smolts associated with mortality and clinical disease, J. Fish Dis., 15, 77, 10.1111/j.1365-2761.1992.tb00639.x Smail, 1985, Infectious pancreatic necrosis virus persistence in farmed Atlantic salmon (Salmo salar), 277 Smee, 1999, Mode of action of ribavirin against cowpox and monkeypox viruses, Antiviriral Res., 41, A52 Snieszko, 1974, The effects of environmental stress on outbreaks of infectious diseases of fish, J. Fish Biol., 6, 197, 10.1111/j.1095-8649.1974.tb04537.x Snow, 2004, Genetic population structure of marine viral haemorrhagic septicaemia virus (VHSV), Dis. Aquat. Org., 61, 11, 10.3354/dao061011 Sommerset, 2005, Vaccines for fish in aquaculture, Expert Rev. Vaccines, 4, 89, 10.1586/14760584.4.1.89 Sørum, 2004, Effects of anaesthetization and vaccination on feed intake and growth in Atlantic salmon (Salmo salar L.), Aquaculture, 232, 333, 10.1016/S0044-8486(03)00529-5 Soucy-Faulkner, 2010, Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression, PLoS Pathog., 6, e1000930, 10.1371/journal.ppat.1000930 Stagg, R.M. et al. 2001. Epizootiological investigations into an outbreak of infectious salmon anemia (ISA) in Scotland, FRS Marine Laboratory Report 13/01, p. 60 (Aberdeen, UK). St-Hilaire, S. 2000. Epidemiology of infectious hematopoietic necrosis disease in net-pen reared Atlantic salmon in British Columbia, Canada. PhD Thesis, University of Guelph, Guelph, Ontario. St-Hilaire, 2001, Infectious hematopoietic necrosis virus antibody profiles in naturally and experimentally infected Atlantic salmon Salmo salar, Dis. Aquat. Org., 46, 7, 10.3354/dao046007 Stone, 2003, Nucleotide sequence analysis of the glycoprotein gene of putative spring viraemia of carp virus and pike fry rhabdovirus isolates reveals four genogroups, Dis. Aquat. Org., 53, 203, 10.3354/dao053203 Storset, 2007, Response to selection for resistance against infectious pancreatic necrosis in Atlantic salmon (Salmo salar L.), Aquaculture, 272, 62, 10.1016/j.aquaculture.2007.08.011 Strandskog, 2008, Double-stranded RNA- and CpG DNA-induced immune responses in Atlantic salmon: Comparison and synergies, Vaccine, 26, 4704, 10.1016/j.vaccine.2008.06.054 Suzuki, 1988, Antiviral activity of various 1-β-d-arabinofuranosyl-E-5-halogenvinyluracils and E-5-bromovinyl-2′-deoxyuridine against salmon herpes virus, Oncorhynchus masou virus (OMV), Antiviral Res., 7, 79, 10.1016/0166-3542(87)90023-4 Svasand, 2004, The status and perspectives for the species, 433 Swan, 2008, Identification of a localized mucosal immune response in rainbow trout, Oncorhynchus mykiss (Wlabaum), following immunization with a protein-hapten antigen, J. Fish Dis., 31, 383, 10.1111/j.1365-2761.2008.00918.x Tacchi, 2011, Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar), Fish Shellfish Immunol., 31, 704, 10.1016/j.fsi.2011.02.023 Tam, 1999, Ribavirin polarizes human T cell responses towards a type 1 cytokine profile, J. Hepatol., 30, 376, 10.1016/S0168-8278(99)80093-2 Tal, 2009, Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling, Proc. Natl Acad. Sci. USA, 106, 2770, 10.1073/pnas.0807694106 Tan, 2004, RNAi, a new therapeutic strategy against viral infection, Cell Res., 14, 460, 10.1038/sj.cr.7290248 Tanaka, 1999, Transfer of maternal antibody from mother to egg may have no protective meaning for larvae of Red sea bream Pagnus major, a marine teleost, Fish Sci., 65, 240, 10.2331/fishsci.65.240 Tatner, 1987, The quantitative relationship between vaccine dilution, length of immersion time and antigen uptake, using a radiolabeled Aeromonas salmonicida bath in direct immersion experiments with rainbow trout, Salmo gairdneri, Aquaculture, 62, 173, 10.1016/0044-8486(87)90164-5 Tatner, 1983, Susceptibility and immunity to Vibrio anguillarum in post-hatching rainbow trout fry, Salmo gairdneri, Dev. Comp. Immunol., 7, 465, 10.1016/0145-305X(83)90031-9 Tatner, 1984, The tissue localization of Aeromonas salmonicida in rainbow trout, Salmo gairdneri, following 3 methods of administration, J. Fish. Biol., 25, 95, 10.1111/j.1095-8649.1984.tb04854.x Thompson, 2007, Toll-like receptors, RIG-I like RNA helicases and the antiviral innate immune response, Immunol. Cell Biol., 85, 435, 10.1038/sj.icb.7100100 Thorarinsson, 2006, Effects of disease risk, vaccine efficacy, and market price on the economics of fish vaccination, Aquaculture, 256, 42, 10.1016/j.aquaculture.2006.01.033 Tobar, 2011, Oral vaccination of Atlantic salmon (Salmo alar) against salmonid rickettsial septicaemia, Vaccine, 29, 2336, 10.1016/j.vaccine.2010.12.107 Tordo, 2005, Family Rhabdoviridae, 623 Tort, 2003, Fish immune system: a crossroads between innate and adaptive responsesa, Immunologia, 22, 277 Traxler, 1996, First detection of infectious hematopoietic necrosis virus in marine fishes, Fish Health Section/American Fisheries Society Newsletter, 24, 7 Traxler, 1989, An infectious hematopoietic necrosis epizootic in sockeye salmon Oncorhynchus nerka in Weaver Creek spawning channel, Fraser River system, B.C., Canada, Dis. Aquat. Org., 6, 221, 10.3354/dao006221 Traxler, G.S., Kent, M.L., Poppe, T.T., 1998. Viral diseases. In Diseases of seawater netpen-reared salmonid fishes. Kent, M.L., Poppe, T.T. (Eds.), Fisheries and Oceans Canada, 138pp. Traxler, 1993, Transmission of infectious hematopoietic necrosis virus in seawater, Dis. Aquat. Org., 16, 111, 10.3354/dao016111 Troyer, 2000, Genetic analyses reveal unusually high diversity of infectious hematopoietic necrosis virus in rainbow trout aquaculture, J. Gen. Virol., 81, 2823, 10.1099/0022-1317-81-12-2823 Tucker, 1999, Detecting pan-Atlantic migration in salmon (Salmo salar) using 137Cs, Can. J. Fish. Aquat. Sci., 56, 2235, 10.1139/f99-267 Vandenberg, 2004, Oral vaccines for finfish: academic theory or commercial reality?, Anim. Health Res. Rev., 5, 301, 10.1079/AHR200488 Vandenberg, G.W. et al., 2003. A novel system for oral vaccination of salmonids against furunculosis In: Proceedings of the Aquaculture America, Louisville, KY. Vike, 2009, ISA virus in Chile: evidence of vertical transmission, Arch. Virol., 154, 1, 10.1007/s00705-008-0251-2 Walker, 2010, Emerging viral diseases of fish and shrimp, Vet. Res., 41, 51, 10.1051/vetres/2010022 Wang, 2006, In vitro effects of recombinant zebrafish IFN on spring viraemia of carp virus and infectious hematopoietic necrosis virus, J. Interferon Cytokine Res., 26, 256, 10.1089/jir.2006.26.256 Wang, 1996, Detection of infectious hematopoietic necrosis virus in rainbow trout Oncorhynchus mykiss from an outbreak in Taiwan by serological and polymerase chain reaction assays, Dis. Aquat. Org., 26, 237, 10.3354/dao026237 Warg, 2007, Comparison of multiple genes of spring viraemia of carp viruses isolated in the United States, Virus Genes, 35, 87, 10.1007/s11262-006-0042-3 Watanabe, 2002, Isolation of aquabirnavirus and viral haemorrhagic septicaemia virus (VHSV) from wild marine fishes, Fish Pathol., 37, 189, 10.3147/jsfp.37.189 Weaver, 2005, Togaviridae, 999 Webster, 1992, Evolution and ecology of influenza A viruses, Microbiological Reviews, 56, 152, 10.1128/MMBR.56.1.152-179.1992 Wedemeyer, G., 1996. Physiology of Fish in Intensive Culture Systems. Chapman & Hall, London. Weeratna, 2000, The potential of CpG oligodeoxynucleotides as mucosal adjuvants, Crit. Rev. Immunol., 21, 310 Weyts, 1999, Interactions between the immune system and the hypothalamo-pituitary-interrenal axis in fish, Fish Shellfish Immunol., 9, 1, 10.1006/fsim.1998.0170 Wiik-Nielsen, 2012, First detection of piscine reovirus (PRV) in marine fish species, Dis. Aquat. Org., 97, 255, 10.3354/dao02425 Winton, 1997, Immunization with viral antigens: infectious haematopoietic necrosis, Dev. Biol. Stand., 90, 211 Winton, 1991, Recent advances in detection and control of infectious hematopoietic necrosis virus in aquaculture, Ann. Rev. Fish Dis., 1, 83, 10.1016/0959-8030(91)90024-E Winton, J.R., Kurath, G., Batts, W., 2008. Molecular Epidemiology of Viral Hemorrhagic Septicemia Virus in the Great Lakes Region. US Geological Survey Fact Sheet 2008–3003. Workenhe, 2010, The fight between teleost fish immune response and aquatic viruses, Mol. Immunol., 47, 2525, 10.1016/j.molimm.2010.06.009 Wolf, K., 1988a. Infectious pancreatic necrosis. In: Fish viruses and fish viral diseases. Cornell University Press, Ithaca, pp. 115–157. Wolf, 1988 Wray, 1985, Effect of ribavirin triphosphate on primer generation and elongation during influenza virus transcription in vitro, Antiviriral Res., 5, 39, 10.1016/0166-3542(85)90013-0 Xie, 2005, Inhibition of reporter gene and iridovirus-tiger frog virus in fish cell by RNA interference, Virology, 338, 43, 10.1016/j.virol.2005.04.040 Yada, 2002, Interaction between endocrine and immune systems in fish, Int. Rev. Cytol., 220, 35, 10.1016/S0074-7696(02)20003-0 Yanong, P.E., 2008. Use of vaccines in finfish aquaculture. University of Florida IFAS Extension FA156. <http://edis.ifas.ufl.edu/pdffiles/FA/FA15600.pdf> (Published 2008, Reviewed 2011; Consulted February 12, 2012). Ye, 2011, The differential dynamics of antibody subpopulation expression during affinity maturation in a teleost, Fish Shellfish Immunol., 30, 372, 10.1016/j.fsi.2010.11.013 Yoshimizu, 1996, Disease problems of salmonid fish in Japan caused by international trade, Rev. Sci. Tech. Off. Int. Epiz., 15, 533, 10.20506/rst.15.2.937 Zhang, 2007, The innate immune response to grass carp hemorrhagic virus (GCHV) in cultured Carassius auratus blastulae (CAB) cells, Dev. Comp. Immunol., 31, 232, 10.1016/j.dci.2006.05.015 Zapata, 2006, Ontogeny of the immune system of fish, Fish Shellfish Immunol., 20, 126, 10.1016/j.fsi.2004.09.005 Zenke, 2010, Development of siRNA expression vector utilizing rock bream β-actin promoter: a potential therapeutic tool against viral infection in fish, Appl. Microbiol. Biotechnol., 85, 679, 10.1007/s00253-009-2177-3 Zhang, 2011, Recent findings on the structure and function of teleost IgT, Fish Shellfish Immunol., 31, 627, 10.1016/j.fsi.2011.03.021 Zhou, 2002, Vaccination of the grouper, Epinephalus awoara, against vibriosis using the ultrasonic technique, Aquaculture, 203, 229, 10.1016/S0044-8486(01)00634-2 Zhou, 2002, Ultrasonic immunization of sea bream, Pagrus major (Temminck & Schlegel), with a mixed vaccine against Vibrio alginolyticus and V. anguillarum, J. Fish Dis., 25, 325, 10.1046/j.1365-2761.2002.00383.x Zwollo, 2005, B Cell heterogeneity in the teleost kidney: Evidence for a maturation gradient from anterior to posterior kidney, J. Immunol., 174, 6608, 10.4049/jimmunol.174.11.6608 Zwollo, 2010, Comparative analyses of B cell populatyions in trout kidney and mouse bone marrow; establishing “B cell signatures”, Dev. Comp. Immunol., 34, 1291, 10.1016/j.dci.2010.08.003