Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE)

Biophysik - Tập 42 Số 4 - Trang 247-256 - 2004
Ingo Langner1, Maria Blettner1, Maryanne Gundestrup2, Hans H. Storm3, Rafael Aspholm4, Anssi Auvinen5, Eero Pukkala6, Gaël P. Hammer7, Hajo Zeeb1, Jón Hrafnkelsson8, Vilhjálmur Rafnsson9, Hrafn Tulinius10, G. De Angelis11, Arduino Verdecchia11, Tor Haldorsen12, U. Tveten13, Harald Eliasch14, Niklas Hammar15, Anette Linnersjö15
1School of Public Health, Division of Epidemiology and Medical Statistics, University of Bielefeld, P.O. Box 100 131, 33501, Bielefeld, Germany
2Clinic of Aviation Medicine, Department 7522, University Hospital, Tagensjey 20, 2220 , Copenhagen N, Denmark
3Danish Cancer Society, Centre for Cancer Documentation, Department of Prevention and Documentation, Strandboulevarden, 2100, Copenhagen OE, Denmark
4Finnish Airline Pilots’ Association, 01530 , Vantaa, Finland
5Tampere School of Public Health, University of Tampere, 33014, Tampere, Finland
6Finnish Cancer Registry, Liisankatu 21B, 00170 Helsinki Finland
7Department of Tropical Hygiene and Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
8Landspitalinn, University Hospital, 105, Reykjavik, Iceland
9University of Iceland, Department of Preventive Medicine, Soltun 1, 105 , Reykjavik, Iceland
10Icelandic Cancer Registry (ICE), P.O. Box 5420, 125 , Reykjavik, Iceland
11Istituto Superiore di Sanità, Laboratory of Epidemiology & Biostatistics, Viale Regina Elena 299, 00161, Rome, Italy
12The Cancer Registry of Norway, Montebello, 0310, Oslo, Norway
13Institute for Energy Technology, P.O. Box 40, 2007 Kjeller Norway
1433 Valevägen, 18264 , Djursholm, Sweden
15Department of Epidemiology, Karolinska University Hospital, 17176 , Stockholm, Sweden

Tóm tắt

Từ khóa


Tài liệu tham khảo

Nicholas JS, Butler GC, Lackland DT, Hood WCJ, Hoel DG, Mohr LCJ (2000) Flight deck magnetic fields in commercial aircraft. Am J Ind Med 38:548–554

McCartney MA, Chatterjee BF, McCoy EC, Mortimer EA Jr, Rosenkranz HS (1986) Airplane emissions: a source of mutagenic nitrated polycyclic aromatic hydrocarbons. Mutat Res 171:99–104

Abeyratne R (2002) Forensic aspects of the aerotoxic syndrome. Med Law 21:179–199

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1999) Ionizing radiation, part 1. X- and gamma (γ)-radiation, and neutrons. 75. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Lyon

McAuley IR, Bartlett DT, Dietz G, Menzel HG, Schnuer K, Schrewe UJ (eds) (1996) Exposure of aircrew to cosmic radiation. 11. EURADOS Report 1996-01. European Commission Report on Radiation Protection 85

Lewis BJ, Tume P, Bennett LGI et al. (1999) Cosmic radiation exposure on Canadian-based commercial airline routes. Radiat Prot Dosim 86:7–24

Friedberg W (1999) A computer program for calculating flight radiation dose. Fed Air Surg Med Bull 99:9–11

Band PR (1990) Mortality and cancer incidence in a cohort of commercial airline pilots. Aviat Space Environ Med 61:299–302

Band PR, Le ND, Fang R, Deschamps M, Coldman AJ, Gallagher RP, Moody J (1996) Cohort study of Air Canada pilots: mortality, cancer incidence, and leukaemia risk. Am J Epidemiol 143:137–143

Nicholas JS, Lackland DT, Dosemeci M, Mohr LCJ, Dunbar JB, Grosche B, Hoel DG (1998) Mortality among US commercial pilots and navigators. J Occup Environ Med 40:980–985

Kaji M, Tango T, Asukata I, Tajima N, Yamamoto K, Yamamoto Y, Hokari M (1993) Mortality experience of cockpit crewmembers from Japan Airlines. Aviat Space Environ Med 64:748–750

Irvine D, Davies DM (1999) British Airways flightdeck mortality study, 1950–1992. Aviat Space Environ Med 70:548–555

Paridou A, Velonakis E, Langner I, Zeeb H, Blettner M, Tzonou A (2003) Mortality among pilots and cabin crew in Greece, 1960–1997. Int J Epidemiol 32:244–247

Haldorsen T, Reitan JB, Tveten U (2000) Cancer incidence among Norwegian airline pilots. Scand J Work Environ Health 26:106–111

Gundestrup M, Storm HH (1999) Radiation-induced acute myeloid leukaemia and other cancers in commercial jet cockpit crew: a population-based cohort study. Lancet 354:2029–2031

Hammar N, Linnersjö A, Alfredsson L, Dammström BG, Johansson M, Eliasch H (2002) Cancer incidence in airline and military pilots in Sweden 1961–1996. Aviat Space Environ Med 73:2–7

Rafnsson V, Hrafnkelsson J, Tulinius H (2000) Incidence of cancer among commercial airline pilots. Occup Environ Med 57:175–179

Milanov L, Dimitrov D, Danon S (1999) Cancer incidence in Republic of Bulgaria aircrew, 1964–1994. Aviat Space Environ Med 70:681–685

Ballard TJ, Lagorio S, De Santis M, De Angelis G, Santaquilani M, Caldora M, Verdecchia A (2002) A retrospective cohort mortality study of Italian commercial airline cockpit crew and cabin attendants, 1965–96. Int J Occup Environ Health 8:87–96

Zeeb H, Blettner M, Hammer GP, Langner I (2002) Cohort mortality study of German cockpit crew, 1960–1997. Epidemiology 13:693–699

Pukkala E, Aspholm R, Auvinen A et al. (2002) Incidence of cancer among Nordic airline pilots over five decades: occupational cohort study. BMJ 325:567–569

Boice JD, Land CE, Preston DL (1996) Ionizing radiation. In: Schottenfeld D, Fraumen JF (eds) Cancer epidemiology and prevention. Oxford University Press, New York, pp 319–346

Cardis E, Gilbert ES, Carpenter L et al. (1995) Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers of three countries. Radiat Res 142:117–132

Freedman D, Freedman DM, Sigurdson A et al. (2003) Risk of melanoma among radiologic technologists in the United States. Int J Cancer 103:556–562

Mohan AK, Hauptmann M, Freedman DM et al. (2003) Cancer and other causes of mortality among radiologic technologists in the United States. Int J Cancer 103:259--267

Blettner M, Zeeb H, Auvinen A et al. (2003) Mortality from cancer and other causes of male airline cockpit crew in Europe. Int J Cancer 106:946–952

Hammer GP, Zeeb H, Tveten U, Blettner M (2000) Comparing different methods of estimating cosmic radiation exposure of airline personnel. Radiat Environ Biophys 39:227–231

Tveten U, Haldorsen T, Reitan JB (2000) Cosmic radiation and airline pilots: exposure pattern as a function of aircraft type. Radiat Prot Dosim 87:157–165

De Angelis G, Caldora M, Santaquilani M, Scipione R, Verdecchia A (2001) Health risks from radiation exposure for civilian aviation flight personnel: a study of Italian airline crew members. Radiat Res 156:689–694

UNSCEAR (2000) Report. Sources and effects of ionizing radiation. Report to the General Assembly, with Scientific Annexes. United Nations Scientific Committee on the Effects of Atomic Radiation. United Nations, New York

Breslow NE, Day NE (1987) Statistical methods in cancer research, vol. 2. The design and analysis of cohort studies. IARC Scientific Publications No. 82, Lyon

Rittgen W, Becker N (2000) SMR analysis of historical follow-up studies with missing death certificates. Biometrics 56:1164–1169

Newcombe RG, Altman DG (2001) Proportions and their differences. In: Altman DG, Machin D, Bryant TN, Gardner MJ (eds) Statistics with confidence, 2nd edn. BMJ Books, London, pp 45–56

Mittlböck M, Waldhör T (2000) Adjustments for R2-measures for Poisson regression models. Comp Stat Data Anal 34:461–472

European Commission. Council Directive 96/29 Euratom (1996) Off J Eur Commun 39:1–18

Blettner M, Grosche B, Zeeb H (1998) Occupational cancer risk in pilots and flight attendants: current epidemiological knowledge. Radiat Environ Biophys 37:75–80

Bottollier-Depois JF, Chau Q, Bouisset P, Kerlau G, Plawinski L, Lebaron-Jacobs L (2000) Assessing exposure to cosmic radiation during long-haul flights. Radiat Res 153:526–532

Feng YJ, Chen WR, Sun TP, Duan SY, Jia BS, Zhang HL (2002) Estimated cosmic radiation doses for flight personnel. Space Med Med Eng (Beijing) 15:265–269

Oksanen PJ (1998) Estimated individual annual cosmic radiation doses for flight crews. Aviat Space Environ Med 69:621–625

Zeeb H, Blettner M, Langner I et al. (2003) Mortality from cancer and other causes among airline cabin attendants in Europe: a collaborative cohort study in eight countries. Am J Epidemiol 158:35–46

Rafnsson V, Hrafnkelsson J, Tulinius H, Sigurgeirsson B, Olafsson JH (2003) Risk factors for cutaneous malignant melanoma among aircrews and a random sample of the population. Occup Environ Med 60:815–820

Diffey BL, Roscoe AH (1990) Exposure to solar ultraviolet radiation in flight. Aviat Space Environ Med 61:1032–1035

Ron E, Preston DL, Kishikawa M et al. (1998) Skin tumor risk among atomic-bomb survivors in Japan. Cancer Causes Control 9:393--401

Austin DF, Reynolds P (1997) Investigation of an excess of melanoma among employees of the Lawrence Livermore National Laboratory. Am J Epidemiol 145:524–531

Sont WN, Zielinski JM, Ashmore JP et al. (2001) First analysis of cancer incidence and occupational radiation exposure based on the National Dose Registry of Canada. Am J Epidemiol 153:309–318

Shore RE (2001) Radiation-induced skin cancer in humans. Med Pediatr Oncol 36:549--554

Boice JDJ, Blettner M, Auvinen A (2000) Epidemiologic studies of pilots and aircrew. Health Phys 79:576–584