Correlation of parasite density and biochemical parameters in children with malaria infection in Calabar, South-South Nigeria

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Uwem Okon Akpan1, Bassey Iya Eze1, Uwaetteh Akanimoh Emmanuel2, Inyang Wisdom Marcus3, Usoro Chinyere Adanna1
1Department of Clinical Chemistry & Immunology, University of Calabar, Calabar, Cross River State, PMB 1115, Nigeria
2Department of Chemical Pathology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
3Faculty of Medicine, University of Calabar, Calabar, Cross River State, PMB 1115, Nigeria

Tóm tắt

Abstract Background Malaria parasitemia is associated with premature, excessive hemolysis, induction of oxidative stress, and derangement in metabolism of iron, proteins, and some electrolytes. This study aims to evaluate the effects of malaria infection on ascorbic acid (AA), uric acid (UA), iron, transferrin, albumin, total iron-binding capacity (TIBC), calcium, and magnesium levels in malaria infection. Results Among the 50 malaria-infected children, 12 had severe parasitemia (PD ≥ 10,000 parasites/μl), 16 had moderate parasitemia (PD: 2000 to < 10,000 parasites/μl), and 22 children had mild parasitemia (PD < 2000 parasites/μl). The AA, iron, transferrin, and TIBC levels were significantly lower and UA and Mg higher in malaria-infected children compared with the controls. Ascorbic acid correlated negatively with UA and PD in malaria-infected children. Iron correlated positively with albumin, transferrin, and TIBC in malaria-infected children, while Ca correlated negatively with Mg levels. Conclusion Malaria infection in children is associated with reduced AA and iron parameters and increased UA and Mg levels; hence, vitamin C and iron supplementation could be useful in malaria therapy.

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Tài liệu tham khảo

Orengo JM, Evans JE, Bettiol E, Leliwa-Sytek AS, Day K, Rodriguez A (2008) Plasmodium-induced inflammation by uric acid. PLoS Pathogens 4(3):32–36

Wood LG, Gibson PG, Garg ML (2003) Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur Respir J 21:177–186

Miller KD, White NJ, Lott JA, Roberts JM, Greenwood BM (1989) Biochemical evidence of muscle injury in African children with severe malaria. J Infect Dis 159:139–142

Hassan GI, Gregory U, Maryam H (2004) Serum ascorbic acid concentration in patients with acute falciparum malaria infection: possible significance. Braz J Infect Dis 8(5):378–381

Orengo JM, Leliwa-Sytek A, Evans JE, Evans B, van de Hoef D (2009) Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response. PLoS One 4:e5194

Mita-Mendoza NK, van de Hoef DL, Lopera-Mesa TM, Doumbia S, Konate D (2013) A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria. PLoS One 8(1):e54481

Miller N, Rice -Evans C, Davies MJ (1989) A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci 84:407–412

Lopera-Mesa TM, Mita-Mendoza NK, van de Hoef DL, Doumbia S, Konate D (2011) Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria. PLoS One 7(10):e46424

Iwalokun BA, Bamiro SB, Ogunledun A (2006) Levels and interactions of plasma xanthine oxidase, catalase and liver function parameters in Nigerian children with Plasmodium falciparum infection. APMIS 114:842–850

Flora R, Zulkarnain M, Fajar NA, Faisya AF, Nurlaily I, Slamet S (2019) Serum iron levels of primary school children in malaria-endemic regions in Seluma Regency, Bengkulu province, 1st Int. Respati Health Conference (IRHC). Healthy Active Aging 2019:557–565

Spottiswoode N, Duffy P, Drakesmith H (2014) Iron, anemia and hepcidin in malaria. Front. Pharmacol 5(25):1–10

Nyakeriga AM, Troye-Blonmberg M, Dofman JR, Alexander ND, Back R, Kortok M, Chemtai AK (2004) Iron deficiency and malaria among children living on the cost of Kenya. J Infect Dis. 190:439–447

Wandier K, Shell-Duncan B, McDade TW (2009) Evaluation of iron deficiency as a nutritional adaptation to infectious disease: an evolution medicine perspective. Am J Hum Biol 21(2):172–176

Lymch S (2007) Iron metabolism. In: Kraemer K, Zimmermann MB (eds) Nutritional anaemia. Sight and Life Press, Basel., pp 59–76

Ndako JA, Joseph A, Olisa JA, Ozoadibe OY, Dojumo VT, Fajobi V (2020) Evaluation of the association between malaria infection and electrolyte variation in patients: use of Pearson correlation analytical technique. Informatics in Medicine Unlocked 21:100437

WHO (2010), Basic Malaria Microscopy, World Health Organization, Geneva, Switzerland,http://whqlibdoc.who.int/publications/2010/9789241547826_eng.pdf. Accessed 23 Dec 2021.

Peter K, Sami K, Anita W (1973) Determination of uric acid in serum, with use of uricase and a tribromophenol-aminoantipyrine chromogen. Clin Chem 19(5):522–524

Thurnham DI, Stephen JML (1979) Biochemical methods: appendix D. Nutrition and health in old age report in health and social subjects, vol 16. Her Majesty’s Stationery Office, London, pp 191–197

Stern J, Lewis WH (1957) The colorimetric estimation of calcium in serum with ocresolphthalein complexone. Clin Chim Acta 2(6):576–580

McGregor GP, Biesalski HK (2006) Rationale and impact of vitamin C in clinical nutrition. Curr. Opin. Clin. Nutr. Metab. Care. 9(25):7446–7449

Onyesom I, Ekeanyanwu RC, Achuka N (2010) Correlation between moderate Plasmodium falciparum malarial parasitaemia and antioxidant vitamins in serum of infected children in South Eastern Nigeria. Afr. J. Biochem. Res 4(12):261–264

Goetz EJ, Wasserman SI, Austen KF (1974) Enhancement of random migration and chemotactic response of human leucocytes by ascorbic acid. J. Clin. Investig 53:813

Schorah JC, Tormey WP, Robertshaw GH (1981) The effect of vitamin C supplements on body weight, serum proteins and general health of an elderly population. Am. J. Clin. Nutr 34:871–876

Onyesom I, Osioma E, Edah OC (2012) Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State. Nigeria. J. of Investig Biochem 2(1):62–64

Orjih AU (2014) Maturation of Plasmodium falciparum in multiply infected erythrocytes and the potential role in malaria pathogenesis. Parasitol. Res 113:4045–4056

Luong KVQ, Nguyen LTH (2015) The role of vitamin D in malaria. J. Infect. Dev. Countries 9:8–19

Desmansyah F, Purnamasari R, Theodorus K, Waiman S (2015) Correlation between vivax malaria infection and iron deficiency in children. Paediatr Indones 55:44–49

Lisa KS, John LO, Christopher F, Jill D, Mei Z, Peter TC (2013) Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout; a pilot randomized controlled trial. Arthritis Rheum 65(6):1636–1642

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