Các yếu tố liên quan đến mệt mỏi ở thanh thiếu niên Nam Phi sống chung với HIV và đang được điều trị bằng liệu pháp kháng retrovirus

Springer Science and Business Media LLC - Tập 23 - Trang 602-608 - 2019
Bronwynè J. Coetzee1, Maria E. Loades2, Stefani Du Toit1, Ashraf Kagee1
1Department of Psychology, Stellenbosch University, Stellenbosch, South Africa
2Department of Psychology, University of Bath, Bath, UK

Tóm tắt

Mệt mỏi ở thanh thiếu niên sống chung với HIV vẫn chưa được hiểu rõ. Trong nghiên cứu này, chúng tôi đã xem xét mối quan hệ giữa mệt mỏi và các biến số nhân khẩu học cũng như tâm lý xã hội nhằm nâng cao hiểu biết về trải nghiệm triệu chứng và các yếu tố liên quan. Chúng tôi đã tuyển chọn những người tham dự liên tiếp tại các phòng khám ART ở Western Cape, Nam Phi (N = 134, độ tuổi 11-18 tuổi). Những người tham gia đã hoàn thành một loạt các bảng câu hỏi, bao gồm các thang đo mệt mỏi, mất ngủ và rối loạn tâm trạng. Gần một phần tư (24,6%) thanh thiếu niên báo cáo mức độ mệt mỏi tăng cao ảnh hưởng đến khả năng hoạt động của họ. Sự kết hợp tuyến tính giữa độ tuổi, trầm cảm và mất ngủ giải thích 40,6% biến động trong mệt mỏi. Ở những thanh thiếu niên nhiễm HIV, mệt mỏi dường như là một triệu chứng có vấn đề liên quan đến giấc ngủ kém và rối loạn tâm trạng. Cần có sự xác định và quản lý kịp thời các triệu chứng có khả năng gây tàn phế này để đạt được kết quả sức khỏe tốt hơn và duy trì sự chăm sóc trong nhóm này. Cần có các can thiệp nhằm cải thiện các triệu chứng này.

Từ khóa

#mệt mỏi #HIV #thanh thiếu niên #liệu pháp kháng retrovirus #mất ngủ #rối loạn tâm trạng

Tài liệu tham khảo

Joint United Nations Programme on HIV/AIDS [UNAIDS]. Ending the AIDS epidemic for adolescents, with adolescents UNAIDS 2016 | REFERENCE A practical guide to meaningfully engage adolescents in the AIDS response. Geneva; 2016. www.unaids.org/sites/default/files/media…/ending-AIDS-epidemic-adolescents_en.pdf. Montaner JSG, Lima VD, Harrigan PR, Lourenço L, Yip B, Nosyk B, et al. Expansion of HAART coverage is associated with sustained decreases in HIV/AIDS morbidity, mortality and HIV transmission: the “HIV treatment as prevention” experience in a Canadian setting. Sluis-Cremer N, editor. PLoS ONE. 2014;9(2):e87872. https://doi.org/10.1371/journal.pone.0087872. Herbst AJ, Cooke GS, Bärnighausen T, KanyKany A, Tanser F, Newell M. Adult mortality and antiretroviral treatment roll-out in rural KwaZulu-Natal, South Africa. Bull World Health Organ. 2009;87(10):754–62. Volberding PA, Deeks SG. Antiretroviral therapy and management of HIV infection. Lancet. 2010;376(9734):49–62. Jong E, Oudhoff LA, Epskamp C, Wagener MN, van Duijn M, Fischer S, et al. Predictors and treatment strategies of HIV-related fatigue in the combined antiretroviral therapy era. AIDS. 2010;24(10):1387–405. Schifitto G, Deng L, Yeh T, Evans SR, Ernst T, Zhong J, et al. Clinical, laboratory, and neuroimaging characteristics of fatigue in HIV-infected individuals. J Neurovirol. 2011;17(1):17–25. Low Y, Preud’homme X, Goforth HW, Omonuwa T, Krystal AD. The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study. Sleep. 2011;34(12):1723–6. https://doi.org/10.5665/sleep.1446. Coetzee B, Loades ME, Du Toit S, Read R, Kagee A. Fatigue among South African adolescents living with HIV: is the Chalder Fatigue Questionnaire a suitable measure and how common is fatigue? Vulnerable Child Youth Stud. 2018;20:1–12. https://doi.org/10.1080/17450128.2018.1510147. Voss JG, Portillo CJ, Holzemer WL, Dodd MJ. Symptom cluster of fatigue and depression in HIV/AIDS. J Prev Interv Community. 2007;33(1–2):19–34. https://doi.org/10.1300/J005v33n01_03. Yancey JR, Thomas SM. Chronic fatigue syndrome: diagnosis and treatment. Am Fam Physician. 2012;86(8):741–6. Loades ME, Coetzee B, Du Toit S, Kagee A. ‘… But i’m still tired’: the experience of fatigue among South African adolescents receiving antiretroviral therapy. AIDS Care. 2018;30(6):746–50. https://doi.org/10.1080/09540121.2017.1394433. Darko DF, McCutchan JA, Kripke DF, Gillin JC, Golshan S. Fatigue, sleep disturbance, disability, and indices of progression of HIV infection. Am J Psychiatry. 1992;149(4):514–20. https://doi.org/10.1176/ajp.149.4.514. Lee KA, Portillo CJ, Miramontes H. The fatigue experience for women with human immunodeficiency virus. J Obstet Gynecol neonatal Nurs JOGNN. 1999;28(2):193–200. Walker K, McGown A, Jantos M, Anson J. Fatigue, depression, and quality of life in HIV-positive men. J Psychosoc Nurs Ment Health Serv. 1997;35(9):32–40. Breitbart W, McDonald MV, Rosenfeld B, Monkman ND, Passik S. Fatigue in ambulatory AIDS patients. J Pain Symptom Manag. 1998;15(3):159–67. Henderson M, Safa F, Easterbrook P, Hotopf M. Fatigue among HIV-infected patients in the era of highly active antiretroviral therapy. HIV Med. 2005;6(5):347–52. https://doi.org/10.1111/j.1468-1293.2005.00319.x. Voss JG. Predictors and correlates of fatigue in HIV/AIDS. J Pain Symptom Manag. 2005;29(2):173–84. Simmonds MJ, Novy D, Sandoval R. The differential influence of pain and fatigue on physical performance and health status in ambulatory patients with human immunodeficiency virus. Clin J Pain. 2005;21(3):200–6. Barroso J, Carlson JR, Meynell J. Physiological and psychological markers associated with HIV-Related fatigue. Clin Nurs Res. 2003;12(1):49–68. https://doi.org/10.1177/1054773803238740. Sullivan PS, Dworkin MS. Adult and adolescent spectrum of HIV disease investigators, the adult, of HIV disease investigators as prevalence and correlates of fatigue among persons with HIV infection. J Pain Symptom Manag. 2003;25(4):329–33. Paddison J, Fricchione G, Gandhi RT, Freudenreich O. Fatigue in psychiatric HIV patients: a pilot study of psychological correlates. Psychosomatics. 2009;50(5):455–60. https://doi.org/10.1176/appi.psy.50.5.455. Dodd M, Janson S, Facione N, Faucett J, Froelicher ES, Humphreys J, et al. Advancing the science of symptom management. J Adv Nurs. 2001;33(5):668–76. Loades ME, Kagee A. Exploring our understanding of fatigue among adolescents living with HIV: highlighting the unknown. J Health Psychol. 2017;1:1359105317710320. Barroso J, Voss JG. Fatigue in HIV and AIDS: an analysis of evidence. J Assoc Nurses AIDS Care. 2013;24(1):S5–14. Ferrando S, Evans S, Goggin K, Sewell M, Fishman B, Rabkin J. Fatigue in HIV illness: relationship to depression, physical limitations, and disability. Psychosom Med. 1998;60(6):759–64. Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, et al. Development of a fatigue scale. J Psychosom Res. 1993;37(2):147–53. Cella M, Chalder T. Measuring fatigue in clinical and community settings. J Psychosom Res. 2010;69(1):17–22. Norris T, Collin SM, Tilling K, Nuevo R, Stansfeld SA, Sterne JA, et al. Natural course of chronic fatigue syndrome/myalgic encephalomyelitis in adolescents. Arch Dis Child. 2017;102(6):522–8. https://doi.org/10.1136/archdischild-2016-311198. Chung KF, Kan KKK, Yeung WF. Assessing insomnia in adolescents: comparison of insomnia severity index, athens insomnia scale and sleep quality index. Sleep Med. 2011;12(5):463–70. Chorpita BF, Moffitt CE, Gray J. Psychometric properties of the revised child anxiety and depression scale in a clinical sample. Behav Res Ther. 2005;43(3):309–22. Van Oort FVA, Greaves-Lord K, Verhulst FC, Ormel J, Huizink AC. The developmental course of anxiety symptoms during adolescence: the TRAILS study. J Child Psychol Psychiatry. 2009;50(10):1209–17. https://doi.org/10.1111/j.1469-7610.2009.02092.x. Weiss D., Chorpita BF. Revised Children’s Anxiety and Depression Scale User’s Guide. 2011. https://www.childfirst.ucla.edu/resources.html www.childfirst.ucla.edu. Gay C, Portillo CJ, Kelly R, Coggins T, Davis H, Aouizerat BE, et al. Self-reported medication adherence and symptom experience in adults with HIV. J Assoc Nurses AIDS Care. 2011;22(4):257–68. Wagner GJ, Ryan GW. Relationship between routinization of daily behaviors and medication adherence in HIV-positive drug users. AIDS Patient Care STDS. 2004;18(7):385–93. https://doi.org/10.1089/1087291041518238. Wagner GJ, Goggin K, Remien RH, Rosen MI, Simoni J, Bangsberg DR, et al. A closer look at depression and its relationship to HIV antiretroviral adherence. Ann Behav Med. 2011;42(3):352–60. Nduna M, Jewkes RK, Dunkle KL, Jama Shai NP, Colman I. Prevalence and factors associated with depressive symptoms among young women and men in the Eastern Cape Province, South Africa. J Child Adolesc Ment Health. 2013;25(1):43–54. https://doi.org/10.2989/17280583.2012.731410. Robertson BA, Ensink K, Parry CD, Chalton D. Performance of the Diagnostic Interview Schedule for Children Version 2.3 (DISC‐2.3) in an Informal Settlement Area in South Africa. J Am Acad Child Adolesc Psychiatry. 1999;38(9):1156–64. Uthman OA, Magidson JF, Safren SA, Nachega JB. Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis. Curr HIV/AIDS Rep. 2014;11(3):291–307. https://doi.org/10.1007/s11904-014-0220-1.