Correction of β-thalassemia mutant by base editor in human embryos

Puping Liang1, Chenhui Ding2, Hongwei Sun1, Xiaowei Xie1, Yanwen Xu2, Xiya Zhang1, Yu Sun1, Yuanyan Xiong1, Wenbin Ma1, Yongxiang Liu2, Yali Wang2, Jian-Pei Fang3, Dan Liú4, Zhou Songyang4,1, Canquan Zhou2, Junjiu Huang1
1Key Laboratory of Gene Engineering of the Ministry of Education, Guangzhou Key Laboratory of Healthy Aging Research and State Key Laboratory of Biocontrol, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, China
2Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, 510275, Guangzhou, China
3Department of Pediatrics, Second Affiliated Hospital, Sun Yat-sen University, 510120, Guangzhou, China
4Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza 77030, Houston, TX, USA

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