Correcting oral contraceptive pharmacokinetic alterations due to obesity: a randomized controlled trial

Contraception - Tập 90 Số 5 - Trang 550-556 - 2014
Alison Edelman1, Ganesh Cherala2, Myrna Y. Munar2, Martha McInnis1, Frank Z. Stanczyk3, Jeffrey T. Jensen1
1Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA
2Oregon State University and Oregon Health & Science University College of Pharmacy, Portland, OR 97239, USA
3Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Edelman, 2009, Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic-pituitary-ovarian activity, Contraception, 80, 119, 10.1016/j.contraception.2009.04.011

Edelman, 2010, Metabolism and pharmacokinetics of contraceptive steroids in obese women: a review, Contraception, 82, 314, 10.1016/j.contraception.2010.04.016

Abdel-Rahman, 2004, The integration of pharmacokinetics and pharmacodynamics: understanding dose-response, Annu Rev Pharmacol Toxicol, 44, 111, 10.1146/annurev.pharmtox.44.101802.121347

Westhoff, 2012, Predictors of noncompliance in an oral contraceptive clinical trial, Contraception, 85, 465, 10.1016/j.contraception.2011.09.019

Pinter, 2002, Continuation and compliance of contraceptive use, Eur J Contracept Reprod Health Care, 7, 178, 10.1080/ejc.7.3.178.183

Edelman, 2012, Prolonged monitoring of ethinyl estradiol and levonorgestrel levels confirms an altered pharmacokinetic profile in obese oral contraceptives users, Contraception, 87, 220, 10.1016/j.contraception.2012.10.008

Westhoff, 2010, Ovarian suppression in normal-weight and obese women during oral contraceptive use: a randomized controlled trial, Obstet Gynecol, 116, 275, 10.1097/AOG.0b013e3181e79440

1992

Nicolau, 2001, Predicting antibacterial response from pharmacodynamic and pharmacokinetic profiles, Infection, 29, 11

Westhoff, 2010, Pharmacokinetics of a combined oral contraceptive in obese and normal-weight women, Contraception, 81, 474, 10.1016/j.contraception.2010.01.016

Croxatto, 1993, NORPLANT: levonorgestrel-releasing contraceptive implant, Ann Med, 25, 155, 10.3109/07853899309164160

Levonorgestrel, 1995, Clinical pharmacokinetics, Clin Pharmacokinet, 28, 203

Fotherby, 1990, Pharmacokinetics of gestagens: some problems, Am J Obstet Gynecol, 163, 323, 10.1016/0002-9378(90)90576-S

Sambol, 2006, Pharmacokinetics of single-dose levonorgestrel in adolescents, Contraception, 74, 104, 10.1016/j.contraception.2006.01.011

Hautanen, 2000, Synthesis and regulation of sex hormone-binding globulin in obesity, Int J Obes Relat Metab Disord, 24, S64, 10.1038/sj.ijo.0801281

Glasier, 2011, Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel, Contraception, 84, 363, 10.1016/j.contraception.2011.02.009

Dinger, 2011, Effectiveness of oral contraceptive pills in a large U.S. cohort comparing progestogen and regimen, Obstet Gynecol, 117, 33, 10.1097/AOG.0b013e31820095a2

Willis, 2006, Greater inhibition of pituitary-ovarian axis in oral contraceptive regimens with a shortened hormone-free interval, Contraception, 74, 100, 10.1016/j.contraception.2006.02.006

van Heusden, 2002, Residual ovarian activity during oral steroid contraception, Hum Reprod Update, 8, 345, 10.1093/humupd/8.4.345