Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking

BioEssays - Tập 27 Số 6 - Trang 625-632 - 2005
Vasily Rybakin1, Christoph S. Clemen2
1Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Germany
2Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph‐Stelzmann‐Str. 52, D‐50931 Köln, Germany.

Tóm tắt

Abstract

Coronins constitute an evolutionarily conserved family of WD‐repeat actin‐binding proteins, which can be clearly classified into two distinct groups based on their structural features. All coronins possess a conserved basic N‐terminal motif and three to ten WD repeats clustered in one or two core domains. Dictyostelium and mammalian coronins are important regulators of the actin cytoskeleton, while the fly Dpod1 and the yeast coronin proteins crosslink both actin and microtubules. Apart from that, several coronins have been shown to be involved in vesicular transport. C. elegans POD‐1 and Drosophila coro regulate the actin cytoskeleton, but also govern vesicular trafficking as indicated by mutant phenotypes. In both organisms, defects in cytoskeleton and trafficking lead to severe developmental defects ranging from abnormal cell division to aberrant formation of morphogen gradients. Finally, mammalian coronin 7 appears not to execute any cytoskeleton‐related functions, but rather participates in regulating Golgi trafficking. Here, we review recent data providing more insight into molecular mechanisms underlying the regulation of F‐actin structures, cytoskeletal rearrangements and intracellular membrane transport by coronin proteins and the way that they might link cytoskeleton with trafficking in development and disease. BioEssays 27:625–632, 2005. © 2005 Wiley Periodicals, Inc.

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BioEssays

Tập 27 Số 6

625-632

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