Corni Fructus: a review of chemical constituents and pharmacological activities
Tóm tắt
Từ khóa
Tài liệu tham khảo
Chinese Pharmacopoeia Commission. People’s Republic of China pharmacopoeia 2015 edition, 1st part. Beijing: China Medical Science Press; 2015. p. 27–8 (in Chinese).
Xiang CK. Research progress on resources and active components of Cornus officinalis. Hebei Med J. 2016;38:1886–9 (in Chinese).
Song XY, Chen Q, Qi XY. Effect of Liuwei Dihuang pill on erythrocyte aldose reductase activity in early diabetic nephropathy patients. Chin J Integr Tradit West Med. 2004;24:1087–90.
Liu XD, Fu J, Feng MZ, Zhang ZH. Effect of Jinggui Shenqi pill combined with nifedipine for the treatment of elderly hypertensive patients with spleen–kidney Yang deficiency syndrome. China J Chin Mater Med. 2015;40:4908–12 (in Chinese).
Wang Y, Wang C. Three cases of clinical application of Guchong Decoction. China J Tradit Chin Med Pharm. 2010;25:2041–3 (in Chinese).
Hatano T, Ogawa N, Kira R, Yasuhara T, Okuda T. Tannins of cornaceous plants. I. Cornusiins A, B and C, dimeric monomeric and trimeric hydrolyzable tannins from Cornus officinalis, and orientation of valoneoyl group in related tannins. Chem Pharm Bull. 1989;37:2083–90.
Hatano T, Ogawa N, Kira R, Yasuhara T, Okuda T. Tannins of cornaceous plants. II. Cornusiins D, E and F, new dimeric and trimeric hydrolyzable Tannins from Cornus officinalis. Chem Pharm Bull. 1989;37:2665–9.
Wu Y, Wang X, Shen B, Kang L, Fan E. Extraction, structure, and bioactivities of the polysaccharides from Fructus corni. Recent Pat Food Nutr Agric. 2013;5:57–61.
Yin X, You Q, Jiang Z, Zhou X. Optimization for ultrasonic-microwave synergistic extraction of polysaccharides from Cornus officinalis and characterization of polysaccharides. Int J Biol Macromol. 2016;83:226–32.
Chen H, Zhang HJ, Zhang MJ, Xiao ZH. Orthogonal test for optimization of extraction condition for volatile components of Cornus officinalis and extract analysis by GC–MS. J Third Mil Med Univ. 2007;29:1079–82 (in Chinese).
Li GY, Yao YX, Ding X. Studies on chemistry component and the biological activity of petroleum ether extraction from pre- and post-processed of Cornus officinalis. Zhong Yao Cai. 2010;33:192–5 (in Chinese).
Wen YY, Ren Q, Zhang GM, Li AN, Ding ZE. Analysis of the essential oils from Cornus officinalis by simultaneous distillation extraction coupled with gas chromatography–mass spectrometry. Food Ferment Ind. 2010;36:166–70.
Han Y, Jung HW, Park YK. Selective therapeutic effect of Cornus officinalis fruits on the damage of different organs in STZ-induced diabetic rats. Am J Chin Med. 2014;42:1169–82.
He K, Song S, Zou Z, Feng M, Wang D, Wang Y, Li X, Ye X. The hypoglycemic and synergistic effect of loganin, morroniside, and ursolic acid isolated from the fruits of Cornus officinalis. Phytother Res. 2015;30:283–91.
Lin MH, Liu HK, Huang WJ, Huang CC, Wu TH, Hsu FL. Evaluation of the potential hypoglycemic and beta-cell protective constituents isolated from Corni Fructus to tackle insulin-dependent diabetes mellitus. J Agric Food Chem. 2011;59:7743–51.
He LH. Comparative study on alpha-glucosidase inhibitory effects of total iridoid glycosides in the crude products and the wine-processed products from Cornus officinalis. Yakugaku Zasshi. 2011;131:1801–5.
Park CH, Noh JS, Tanaka T, Uebaba K, Cho EJ, Yokozawa T. The effects of Corni Fructus extract and its fractions against α-glucosidase inhibitory activities in vitro and sucrose tolerance in normal rats. Am J Chin Med. 2011;39:367–80.
Chen CC, Hsu CY, Chen CY, Liu HK. Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death. J Ethnopharmacol. 2008;117:483–90.
Yokozawa T, Kang KS, Park CH, Noh JS, Yamabe N, Shibahara N, Tanaka T. Bioactive constituents of Corni Fructus: the therapeutic use of morroniside, loganin, and 7-O-galloyl-d-sedoheptulose as renoprotective agents in type 2 diabetes. Drug Discov Ther. 2010;4:223–34.
Yamabe N, Kang KS, Goto E, Tanaka T, Yokozawa T. Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in streptozotocin-treated diabetic rats. Biol Pharm Bull. 2007;30:520–6.
Yamabe N, Kang KS, Park CH, Tanaka T, Yokozawa T. 7-O-galloyl-d-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney. Biol Pharm Bull. 2009;32:657–64.
Lv X, Dai G, Lv G, Chen Y, Wu Y, Shen H, Xu H. Synergistic interaction of effective parts in Rehmanniae Radix and Cornus officinalis ameliorates renal injury in C57BL/KsJ-db/db diabetic mice: involvement of suppression of AGEs/RAGE/SphK1 signaling pathway. J Ethnopharmacol. 2016;185:110–9.
Jiang WL, Zhang SP, Hou J, Zhu HB. Effect of loganin on experimental diabetic nephropathy. Phytomedicine. 2012;19:217–22.
Ma W, Wang KJ, Cheng CS, Yan GQ, Lu WL, Ge JF, Cheng YX, Li N. Bioactive compounds from Cornus officinalis fruits and their effects on diabetic nephropathy. J Ethnopharmacol. 2014;153:840–5.
Xu HQ, Hao HP. Effects of iridoid total glycoside from Cornus officinalis on prevention of glomerular overexpression of transforming growth factor beta 1 and matrixes in an experimental diabetes model. Biol Pharm Bull. 2004;27:1014–8.
Qi MY, Liu HR, Dai DZ, Li N, Dai Y. Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats. J Pharm Pharmacol. 2008;60:1687–94.
Chen Y, Wu Y, Gan X, Liu K, Lv X, Shen H, Dai G, Xu H. Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway. J Ethnopharmacol. 2016;194:850–60.
Pi WX, Feng XP, Ye LH, Cai BC. Combination of morroniside and diosgenin prevents high glucose-induced cardiomyocytes apoptosis. Molecules. 2017;22:163.
Wang W, Sun F, An Y, Ai H, Zhang L, Huang W, Li L. Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity. Eur J Pharmacol. 2009;613:19–23.
Liu Y, Liu H, Zhang J. Total saponins of Cornus officinalis Sieb. ameliorates the endothelium dependent relaxation of mesenteric artery by regulating nitric oxide release in streptozotocin-induced diabetic rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012;37:757–64.
Peng Q, Wei Z, Lau BH. Fructus corni enhances endothelial cell antioxidant defenses. Gen Pharmacol. 1998;31:221–5.
Yu HH, Hur JM, Seo SJ, Moon HD, Kim HJ, Park RK, You YO. Protective effect of ursolic acid from Cornus officinalis on the hydrogen peroxide-induced damage of HEI-OC1 auditory cells. Am J Chin Med. 2009;37:735–46.
Hwang KA, Hwang YJ, Song J. Antioxidant activities and oxidative stress inhibitory effects of ethanol extracts from Cornus officinalis on raw 264.7 cells. BMC Complement Altern Med. 2016;16:196.
Cao G, Cai H, Cai B, Tu S. Effect of 5-hydroxymethylfurfural derived from processed Cornus officinalis on the prevention of high glucose-induced oxidative stress in human umbilical vein endothelial cells and its mechanism. Food Chem. 2013;140:273–9.
Xu HQ, Hao HP, Zhang X, Pan Y. Morroniside protects cultured human umbilical vein endothelial cells from damage by high ambient glucose. Acta Pharmacol Sin. 2004;25:412–5.
Kang DG, Moon MK, Lee AS, Kwon TO, Kim JS, Lee HS. Cornuside suppresses cytokine-induced proinflammatory and adhesion molecules in the human umbilical vein endothelial cells. Biol Pharm Bull. 2007;30:1796–9.
Chu Q, Hashimoto K, Satoh K, Wang Q, Sakagami H. Effect of three herbal extracts on NO and PGE2 production by activated mouse macrophage-like cells. In Vivo. 2009;544:537–44.
Choi YH, Jin GY, Li GZ, Yan GH. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting nuclear factor-kappa B activation in RAW 264.7 macrophages. Biol Pharm Bull. 2011;34:959–66.
Chu Q, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Wang Q, Sakagami H. Antitumor potential of three herbal extracts against human oral squamous cell lines. Anticancer Res. 2009;29:3211–9.
Telang NT, Li G, Sepkovic DW, Bradlow HL, Wong GY. Anti-proliferative effects of Chinese herb Cornus officinalis in a cell culture model for estrogen receptor-positive clinical breast cancer. Mol Med Rep. 2012;5:22–8.
Telang N, Li G, Katdare M, Sepkovic D, Bradlow L, Wong G. Inhibitory effects of Chinese nutritional herbs in isogenic breast carcinoma cells with modulated estrogen receptor function. Oncol Lett. 2016;12:3949–57.
Chang JS, Chiang LC, Hsu FF, Lin CC. Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro. Am J Chin Med. 2004;32:717–25.
Jeong EJ, Kim TB, Yang H, Kang SY, Kim SY, Sung SH, Kim YC. Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells. Phytomedicine. 2012;19:317–21.
Wang X, Liu J, Jin N, Xu D, Wang J, Han Y, Yin N. Fructus corni extract-induced neuritogenesis in PC12 cells is associated with the suppression of stromal interaction molecule 1 expression and inhibition of Ca2+ influx. Exp Ther Med. 2015;9:1773–9.
Bhakta HK, Park CH, Yokozawa T, Tanaka T, Jung HA, Choi JS. Potential anti-cholinesterase and β-site amyloid precursor protein cleaving enzyme 1 inhibitory activities of cornuside and gallotannins from Cornus officinalis fruits. Arch Pharm Res. 2017;40:836–53.
Yao RQ, Zhang L, Wang W, Li L. Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats. Brain Res Bull. 2009;79:69–76.
Wang W, Xu J, Li L, Wang P, Ji X, Ai H, Zhang L, Li L. Neuroprotective effect of morroniside on focal cerebral ischemia in rats. Brain Res Bull. 2010;83:196–201.
Yin L, Chen Y, Qu Z, Zhang L, Wang Q, Zhang Q, Li L. Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats. J Neuroimmunol. 2014;274:28–37.
Zhao L, Ding Y, Zhang L, Li L. Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria–fornix transected rats. Eur J Pharmacol. 2010;647:68–74.
Qu Z, Zheng N, Zhang Y, Zhang L, Liu J, Wang Q, Yin L. Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice. Neurol Res. 2016;38:831–7.
Ding X, Wang MY, Yao YX, Li GY, Cai BC. Protective effect of 5-hydroxymethylfurfural derived from processed Fructus Corni on human hepatocyte L02 injured by hydrogen peroxide and its mechanism. J Ethnopharmacol. 2010;128:373–6.
Wang MY, Zhao FM, Peng HY, Lou CH, Li Y, Ding X, Yu XY, Yang GM, Xu DQ, Jiang LH, Zhang X, Ye LH, Cai BC. Investigation on the morphological protective effect of 5-hydroxymethylfurfural extracted from wine-processed Fructus corni on human L02 hepatocytes. J Ethnopharmacol. 2010;130:424–8.
Jiang ZQ, Ma YX, Li MH, Zhan XQ, Zhang X, Wang MY. 5-Hydroxymethylfurfural protects against ER stress-induced apoptosis in GalN/TNF-α-injured L02 hepatocytes through regulating the PERK-eIF2α signaling pathway. Chin J Nat Med. 2015;13:896–905.
Park CH, Noh JS, Tanaka T, Roh SS, Lee JC, Yokozawa T. Polyphenol isolated from Corni Fructus, 7-O-galloyl-d-sedoheptulose, modulates advanced glycation endproduct-related pathway in type 2 diabetic db/db mice. Arch Pharmacal Res. 2015;38:1270–80.
Lee NH, Seo CS, Lee HY, Jung DY, Lee JK, Lee JA, Song KY, Shin HK, Lee MY, Seo YB, Kim H, Ha H. Hepatoprotective and antioxidative activities of Cornus officinalis against acetaminophen-induced hepatotoxicity in mice. Evid Based Complement Altern Med. 2012;2012:1–8.
Sun H, Li L, Zhang A, Zhang N, Lv H, Sun W, Wang X. Protective effects of sweroside on human MG-63 cells and rat osteoblasts. Fitoterapia. 2013;84:174–9.
Kim JY, Kim YK, Choi MK, Oh J, Kwak HB, Kim JJ. Effect of Cornus Officinalis on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation. J Bone Metab. 2012;19:121.
An YA, Hwang JY, Lee JS, Kim YC. Cornus officinalis methanol extract upregulates melanogenesis in melan-a cells. Toxicol Res. 2015;31:165–72.
Liu X, Zeng YQ, Liang YZ, Zou C, Liu H, Qiu F, Liang CL, Jin XW, Su ZR, Dai Z. Medicinal herbs Fructus corni and Semen cuscutae suppress allograft rejection via distinct immune mechanisms. Oncotarget. 2016;7:35680.
Cho K, Lee HJ, Lee SY, Woo H, Lee MN, Seok JH, et al. Oleanolic acid and ursolic acid derived from Cornus officinalis Sieb. et Zucc. suppress epidermal growth factor- and phorbol ester-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Phytother Res. 2011;25:760–4.
Kim SH, Kim BK, Lee YC. Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma. J Inflamm. 2012;9:9.
Kang DG, Choi DH, Lee JK, Lee YJ, Moon MK, Yang SN, Kwon TO, Kwon JW, Kim JS, Lee HS. Endothelial NO/cGMP-dependent vascular relaxation of cornuside isolated from the fruit of Cornus officinalis. Planta Med. 2007;73:1436–40.
Song JH, Park K, Shim A, Kwon BE, Ahn JH, Choi YJ, Kim JK, Yeo SG, Yoon K, Ko HJ. Complete sequence analysis and antiviral screening of medicinal plants for human Coxsackievirus A16 isolated in Korea. Osong Public Health Res Perspect. 2015;6:52–8.
Wu HZ. The clinical effect of Jinkui Shenqi pill on type 2 diabetes. Pharmacol Clin Chin Mater Med. 2013;29:191–3 (in Chinese).
Liu ZW. Curative effect valuation on Jingui Senqi pill in the treatment of diabetic nephropathy. Chin J Basic Med Tradit Chin Med. 2014;20(821–2):31.
Li X, Li Y. Clinical study on Liuwei Dihuang pills combined with liraglutide and metformin in treatment of type 2 diabetes mellitus. Drugs Clin. 2016;31:1146–50 (in Chinese).
He K, Zhu LH, Lu XW. Clinical observation of Liuwei Dihuang pills combined with metformin in the treatment of type 2 diabetes. Chin Tradit Pat Med. 2016;38:50–2.
Menzies FM, Fleming A, Rubinsztein DC. Compromised autophagy and neurodegenerative diseases. Nat Rev Neurosci. 2015;16:345–57.
Nah J, Yuan J, Jung YK. Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach. Mol Cells. 2015;38:381–9.
Zhou ZY. Chinese internal medicine. Beijing: China Press of Traditional Chinese Medicine; 2003. p. 157, 176, 183, 308, 316, 327 (in Chinese).
Lin SK, Yan SH, Lai JN, Tsai TH. Patterns of Chinese medicine use in prescriptions for treating Alzheimer’s disease in Taiwan. Chin Med. 2016;11:12.
Yeung WF, Chung KF, Zhang NL, Zhang SP, Yung KP, Chen PX, Ho YY. Identification of Chinese medicine syndromes in persistent insomnia associated with major depressive disorder: a latent tree analysis. Chin Med. 2016;11:4.
Cai H, Cao G, Cai B. Rapid simultaneous identification and determination of the multiple compounds in crude Fructus Corni and its processed products by HPLC–MS/MS with multiple reaction monitoring mode. Pharm Biol. 2013;51:273–8.
Zhang YE, Liu EH, Li HJ, Li P. Chemical constituents from the fruit of Cornus officinalis. Chin J Nat Med. 2009;7:365–7 (in Chinese).
Han SY, Pan Y, Ding G, Cai BC. Application of 1H-NMR and 13C-NMR spectra in the structure identification of iridoids from Cornus officinalis. Chin Arch Tradit Chin Med. 2004;22:56–9 (in Chinese).
Park JY, Han AR, Kil YS, Kang U, Kim SH, Nam SJ, Seo EK. A new secoiridoid glycoside from the fruits of Cornus officinalis (Cornaceae). Nat Prod Res. 2016;30:1504–10.
He J, Ye XS, Wang XX, Yang YN, Zhang PC, Ma BZ, Zhang WK, Xu JK. Four new iridoid glucosides containing the furan ring from the fruit of Cornus officinalis. Fitoterapia. 2017;120:136–41.
Han SY, Pan Y, Yang GM, Cai BC. Research on components of Cornus officinalis extracted by supercritical carbon dioxide. Zhongguo Zhong Yao Za Zhi. 2003;28:1148–50, 83 (in Chinese).
Xie X, Wang R, Shi Y. Chemical constituents from the fruits of Cornus officinalis. Biochem Syst Ecol. 2012;45:120–3.
Yang L, Wang Z, Huang L. Isolation and structural characterization of a polysaccharide FCAP1 from the fruit of Cornus officinalis. Carbohydr Res. 2010;345:1909–13.
Wang LL, Zhang T, Chen SQ, Shang CL. Study on the correlation between the quality of Cornus officinalis and the contents of the inorganic elements in the planting soil. Zhong Yao Cai. 2011;34:1167–72 (in Chinese).
Hsu JH, Wu YC, Liu IM, Cheng JT. Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis. Neurosci Lett. 2006;404:112–6.
Gu H, Jiang Z, Wang M, Jiang H, Zhao F, Ding X, Cai B, Zhan Z. 5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis. Neural Regen Res. 2013;8:2605–14.