Corneal replacement using a synthetic hydrogel cornea, AlphaCor™: device, preliminary outcomes and complications

Chirila TV, Constable IJ, Crawford GJ, Russo AV . Method of producing a keratoprosthesis. US patent 5,458,819, 17 October 1995.

Vijayasekaran S, Hicks CR, Chirila TV, Fitton JH, Clayton AB, Lou X et al. Histologic evaluation during healing of hydrogel core-and-skirt keratoprostheses in the rabbit eye. Cornea 1997; 16: 352–359.

Chirila TV, Vijayasekaran S, Horne R, Chen YC, Dalton P, Constable IJ et al. Interpenetrating polymer network (IPN) as a permanent joint between the elements of a new type of artificial cornea. J Biomed Mater Res 1994; 28: 745–753.

Crawford GJ, Hicks CR, Lou X, Vijayasekaran S, Tan D, Mulholland B et al. The Chirila keratoprosthesis: phase I human clinical trial. Ophthalmology 2002; 109: 883–889.

Hicks CR, Fitton JH, Chirila TV, Crawford GJ, Constable IJ . Keratoprostheses: advancing toward a true artificial cornea. Surv Ophthalmol 1997; 42: 175–189.

Hicks CR, Crawford GJ, Tan DT, Snibson GR, Sutton GL, Gondhowiardjo TD et al. Outcomes of implantation of an artificial cornea AlphaCor: the effects of prior ocular herpes simplex infection. Cornea 2002; in press.