Core fucosylation involvement in the paracrine regulation of proteinuria-induced renal interstitial fibrosis evaluated with the use of a microfluidic chip

Gansevoort, 2011, Kidney disease prognosis, lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts, Kidney Int., 80, 93, 10.1038/ki.2010.531 Hemmelgarn, 2010, Kidney disease, relation between kidney function, proteinuria, and adverse outcomes, JAMA, 303, 423, 10.1001/jama.2010.39 Iseki, 2003, Proteinuria and the risk of developing end-stage renal disease, Kidney Int., 63, 1468, 10.1046/j.1523-1755.2003.00868.x de Zeeuw, 2016, Unmet need in diabetic nephropathy: failed drugs or trials?, Lancet Diabetes Endocrinol., 4, 638, 10.1016/S2213-8587(16)30045-6 Ohashi, 2002, Peritubular capillary regression during the progression of experimental obstructive nephropathy, J. Am. Soc. Nephrol., 13, 1795, 10.1097/01.ASN.0000018408.51388.57 Eardley, 2008, The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease, Kidney Int., 74, 495, 10.1038/ki.2008.183 Choi, 2015, Mesenchymal stem cell-derived microparticles ameliorate peritubular capillary rarefaction via inhibition of endothelial-mesenchymal transition and decrease tubulointerstitial fibrosis in unilateral ureteral obstruction, Stem Cell Res. Ther., 6, 18, 10.1186/s13287-015-0012-6 Jang, 2013, Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment, Integr. Biol., 5, 1119, 10.1039/c3ib40049b Bhatia, 2014, Microfluidic organs-on-chips, Nat. Biotechnol., 32, 760, 10.1038/nbt.2989 Rayner, 2016, Engineered microvessels for the study of human disease, J. Biomech. Eng., 138, 10.1115/1.4034428 Sontheimer-Phelps, 2019, Modelling cancer in microfluidic human organs-on-chips, Nat. Rev. Cancer, 19, 65, 10.1038/s41568-018-0104-6 Zhou, 2014, Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices, Biomaterials, 35, 1390, 10.1016/j.biomaterials.2013.10.070 Wang, 2017, Novel mechanism of the pericyte-myofibroblast transition in renal interstitial fibrosis: core fucosylation regulation, Sci. Rep., 7, 16914, 10.1038/s41598-017-17193-5 Shen, 2013, Inhibition of TGF-β1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis, Kidney Int., 84, 64, 10.1038/ki.2013.82 Benam, 2016, Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro, Nat. Methods, 13, 151, 10.1038/nmeth.3697 Zheng, 2012, In vitro microvessels for the study of angiogenesis and thrombosis, Proc. Natl. Acad. Sci. USA., 109, 9342, 10.1073/pnas.1201240109 Duan, 2008, Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes, Proc. Natl. Acad. Sci. USA., 105, 11418, 10.1073/pnas.0804954105 Acosta, 2008, Chemokine signaling via the CXCR2 receptor reinforces senescence, Cell, 133, 1006, 10.1016/j.cell.2008.03.038 Dutta, 2015, BRCA1 regulates IFI16 mediated nuclear innate sensing of herpes viral DNA and subsequent induction of the innate inflammasome and interferon-beta responses, PLoS Pathog., 11, 10.1371/journal.ppat.1005030 Liang, 2019, Ablation of core fucosylation attenuates the signal transduction via T cell receptor to suppress the T cell development, Mol. Immunol., 112, 312, 10.1016/j.molimm.2019.06.011 Hahm, 2019, Investigation of site-specific differences in glycan microheterogeneity by N-glycopeptide mapping of VEGFR-IgG fusion protein, Molecules, 24, 10.3390/molecules24213924 Zhao, 2006, Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions, J. Biol. Chem., 281, 38343, 10.1074/jbc.M608764200 Tu, 2017, FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation, Breast Cancer Res., 19, 10.1186/s13058-017-0904-8 Tateno, 2009, Comparative analysis of core-fucose-binding lectins from Lens culinaris and Pisum sativum using frontal affinity chromatography, Glycobiology, 19, 527, 10.1093/glycob/cwp016 Lambers Heerspink, 2015, Albuminuria is an appropriate therapeutic target in patients with CKD: the pro view, Clin. J. Am. Soc. Nephrol., 10, 1079, 10.2215/CJN.11511114 Tanaka, 2015, Albuminuria and reduced glomerular filtration rate for predicting the renal outcomes in type 2 diabetic patients, Nephrology, 20, 531, 10.1111/nep.12446 Eardley, 2006, The relationship between albuminuria, MCP-1/CCL2, and interstitial macrophages in chronic kidney disease, Kidney Int., 69, 1189, 10.1038/sj.ki.5000212 Li, 2010, PKC-delta promotes renal tubular cell apoptosis associated with proteinuria, J. Am. Soc. Nephrol., 21, 1115, 10.1681/ASN.2009070760 Eddy, 2000, Interstitial fibrosis in mice with overload proteinuria: deficiency of TIMP-1 is not protective, Kidney Int., 58, 618, 10.1046/j.1523-1755.2000.00208.x Weber, 2016, Development of a microphysiological model of human kidney proximal tubule function, Kidney Int., 90, 627, 10.1016/j.kint.2016.06.011 Jansen, 2016, Bioengineered kidney tubules efficiently excrete uremic toxins, Sci. Rep., 6, 26715, 10.1038/srep26715 Jansen, 2015, Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations, Sci. Rep., 5, 16702, 10.1038/srep16702 Ligresti, 2016, A novel three-dimensional human peritubular microvascular system, J. Am. Soc. Nephrol., 27, 2370, 10.1681/ASN.2015070747 Vedula, 2017, A microfluidic renal proximal tubule with active reabsorptive function, PLoS One, 12, 10.1371/journal.pone.0184330 Jang, 2010, A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells, Lab Chip, 10, 36, 10.1039/B907515A Ferrell, 2012, Albumin handling by renal tubular epithelial cells in a microfluidic bioreactor, Biotechnol. Bioeng., 109, 797, 10.1002/bit.24339 Ferrell, 2010, A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells, Biotechnol. Bioeng., 107, 707, 10.1002/bit.22835 Sciancalepore, 2014, A bioartificial renal tubule device embedding human renal stem/progenitor cells, PLoS One, 9, e87496, 10.1371/journal.pone.0087496 Jang, 2011, Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells, Integr. Biol., 3, 134, 10.1039/C0IB00018C Duan, 2010, Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells, Proc. Natl. Acad. Sci. USA., 107, 21860, 10.1073/pnas.1015751107 Maeshima, 2006, Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney, J. Am. Soc. Nephrol., 17, 188, 10.1681/ASN.2005040370 DesRochers, 2013, Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity, PLoS One, 8, e59219, 10.1371/journal.pone.0059219 Linas, 1999, Endothelial cells regulate proximal tubule epithelial cell sodium transport, Kidney Int., 55, 1251, 10.1046/j.1523-1755.1999.00360.x Smith, 2012, Biology of the renal pericyte, Nephrol. Dial. Transplant., 27, 2149, 10.1093/ndt/gfs134 Stefanska, 2013, Renal pericytes: multifunctional cells of the kidneys, Pflugers Arch., 465, 767, 10.1007/s00424-013-1294-0 Homan, 2016, Bioprinting of 3D convoluted renal proximal tubules on perfusable chips, Sci. Rep., 6, 34845, 10.1038/srep34845 Rayner, 2018, Reconstructing the human renal vascular-tubular unit in vitro, Adv. Healthc. Mater., 7, 10.1002/adhm.201801120 Jenkinson, 2012, The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule, Pflugers Arch., 464, 601, 10.1007/s00424-012-1163-2 Jia, 2019, MiR-4756 promotes albumin-induced renal tubular epithelial cell epithelial-to-mesenchymal transition and endoplasmic reticulum stress via targeting Sestrin2, J. Cell. Physiol., 234, 2905, 10.1002/jcp.27107 Tang, 2009, C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy, J. Am. Soc. Nephrol., 20, 593, 10.1681/ASN.2008040434 Yard, 2001, Regulation of endothelin-1 and transforming growth factor-beta1 production in cultured proximal tubular cells by albumin and heparan sulphate glycosaminoglycans, Nephrol. Dial. Transplant., 16, 1769, 10.1093/ndt/16.9.1769 Xu, 2009, TGF-beta-induced epithelial to mesenchymal transition, Cell Res., 19, 156, 10.1038/cr.2009.5 Gewin, 2017, Progression of chronic kidney disease: too much cellular talk causes damage, Kidney Int., 91, 552, 10.1016/j.kint.2016.08.025 Anutrakulchai, 2016, Relation of peritubular capillary features to class of lupus nephritis, BMC Nephrol., 17, 169, 10.1186/s12882-016-0388-2 Choi, 2000, Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endothelial growth factor, Hum. Pathol., 31, 1491, 10.1053/hupa.2000.20373 Ikeda, 2017, Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice, Sci. Rep., 7, 10621, 10.1038/s41598-017-11089-0 Liu, 2021, The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1alpha accumulation, J. Diabetes Investig., 12, 697, 10.1111/jdi.13478 Liu, 2021, Fe3O4 magnetic nanoparticles ameliorate albumin-induced tubulointerstitial fibrosis by autophagy related to Rab7, Colloids Surf. B Biointerfaces, 198, 10.1016/j.colsurfb.2020.111470 Lin, 2008, Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney, Am. J. Pathol., 173, 1617, 10.2353/ajpath.2008.080433 Grande, 2009, Fibroblast activation and myofibroblast generation in obstructive nephropathy, Nat. Rev. Nephrol., 5, 319, 10.1038/nrneph.2009.74