Copper(I)‐Catalyzed Azide–Alkyne Cycloadditions in Microflow: Catalyst Activity, High‐T Operation, and an Integrated Continuous Copper Scavenging Unit
Tóm tắt
Từ khóa
Tài liệu tham khảo
Wu P., 2007, Aldrichimica Acta, 40, 7
Ceylan S., 2010, Synlett, 2009
Hessel V., 2011, Chim. Oggi, 29, 81
Hessel V., 2012, Chem. Eng. Technol., 35
Baxendale I. R., 2007, New Avenues to Efficient Chemical Synthesis—Emerging Technologies
http://www.syrris.com(accessed June 2012).
Hartman R. L., 2012, Org. Process Res. Dev., 16
The amount of copper allowed in APIs is 15 ppm:Note for guidance on specification limits for residues of metal catalysts.The European Agency for the evaluation of medicinal products—Evaluation of medicines for human use. London (UK) 17 december 2002.
Triazole collected as described in Figure 4 was loaded in a glass syringe and combined in flow with aq. EDTA solution to establish a slug flow regime. The biphasic stream was next delivered to an Asia FLLEX extraction module.