Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

Angiogenesis - Tập 12 Số 2 - Trang 177-185 - 2009
Payaningal R. Somanath1, Nikolay L. Malinin1, Tatiana V. Byzova1
1Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, Cleveland, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Folkman J (2007) Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6:273–286

Glade-Bender J et al (2003) VEGF blocking therapy in the treatment of cancer. Expert Opin Biol Ther 3:263–276

Ribatti D (2008) Napoleone Ferrara and the saga of vascular endothelial growth factor. Endothelium 15:1–8

Dass CR, Choong PF (2008) Cancer angiogenesis: targeting the heel of Achilles. J Drug Target 16:449–454

Andreoli CM, Miller JW (2007) Anti-vascular endothelial growth factor therapy for ocular neovascular disease. Curr Opin Ophthalmol 18:502–508

Papanas N, Maltezos E (2008) Advances in treating the ischaemic diabetic foot. Curr Vasc Pharmacol 6:23–28

Simo R et al (2006) Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy. Curr Diabetes Rev 2:71–98

Stupack DG, Cheresh DA (2004) Integrins and angiogenesis. Curr Top Dev Biol 64:207–238

Hynes RO (2002) A reevaluation of integrins as regulators of angiogenesis. Nat Med 8:918–921

Folkman J (2006) Angiogenesis. Annu Rev Med 57:1–18

Ingber DE, Folkman J (1989) Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J Cell Biol 109:317–330

Cai W, Chen X (2006) Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anticancer Agents Med Chem 6:407–428

Alghisi GC, Ruegg C (2006) Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium 13:113–135

Kumar CC (2003) Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr Drug Targets 4:123–131

Plow EF et al (2000) Ligand binding to integrins. J Biol Chem 275:21785–21788

Herouy Y et al (2000) Autologous platelet-derived wound healing factor promotes angiogenesis via alphavbeta3-integrin expression in chronic wounds. Int J Mol Med 6:515–519

Leu SJ et al (2002) Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J Biol Chem 277:46248–46255

Brooks PC et al (1994) Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79:1157–1164

Brooks PC et al (1994) Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264:569–571

Van WC (1995) Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing. Head Neck 17:140–147

Lim EH et al (2005) A review: integrin alphavbeta3-targeted molecular imaging and therapy in angiogenesis. Nanomedicine 1:110–114

Cai W et al (2008) Imaging of integrins as biomarkers for tumor angiogenesis. Curr Pharm Des 14:2943–2973

Cai W et al (2008) Molecular imaging of tumor vasculature. Methods Enzymol 445:141–176

Hodivala-Dilke K (2008) alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment. Curr Opin Cell Biol 20:514–519

Somanath PR et al (2009) Integrin and growth factor receptor alliance in angiogenesis. Cell Biochem Biophys 53:53–64

D’Andrea LD et al (2006) Peptide-based molecules in angiogenesis. Chem Biol Drug Des 67:115–126

Lenz HJ (2005) Antiangiogenic agents in cancer therapy. Oncology (Williston Park) 19:17–25

Reynolds LE et al (2002) Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 8:27–34

Weis SM et al (2007) Cooperation between VEGF and beta3 integrin during cardiac vascular development. Blood 109:1962–1970

Eliceiri BP, Cheresh DA (2000) Role of alpha v integrins during angiogenesis. Cancer J 6(Suppl 3):S245–S249

Zhu J et al (2002) beta8 integrins are required for vascular morphogenesis in mouse embryos. Development 129:2891–2903

Proctor JM et al (2005) Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci 25:9940–9948

Lakhe-Reddy S et al (2006) Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation. J Biol Chem 281:19688–19699

Mahabeleshwar GH et al (2006) Integrin signaling is critical for pathological angiogenesis. J Exp Med 203:2495–2507

Chew DP, Bhatt DL (2001) Oral glycoprotein IIb/IIIa antagonists in coronary artery disease. Curr Cardiol Rep 3:63–71

Maranian AM, Steinhubl SR (2002) Glycoprotein IIb/IIIa receptor inhibitor-thrombolytic combination therapy for acute myocardial infarction. Curr Cardiol Rep 4:313–319

Cannon CP (2003) Oral platelet glycoprotein IIb/IIIa receptor inhibitors—part II. Clin Cardiol 26:401–406

Rosove MH (2004) Platelet glycoprotein IIb/IIIa inhibitors. Best Pract Res Clin Haematol 17:65–76

Said SM et al (2007) Glycoprotein IIb/IIIa inhibitor-induced thrombocytopenia: diagnosis and treatment. Clin Res Cardiol 96:61–69

Maeshima Y et al (2002) Tumstatin an endothelial cell-specific inhibitor of protein synthesis. Science 295:140–143

Sudhakar A et al (2003) Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci USA 100:4766–4771

Mould AP et al (1998) Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1. Biochem J 331((Pt 3)):821–828

Humphries MJ (2004) Monoclonal antibodies as probes of integrin priming and activation. Biochem Soc Trans 32:407–411

De S et al (2003) Molecular pathway for cancer metastasis to bone. J Biol Chem 278:39044–39050

Mahabeleshwar GH et al (2007) Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res 101:570–580

Borges E et al (2000) Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. J Biol Chem 275:39867–39873

Soldi R et al (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 18:882–892

Schneller M et al (1997) Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF. EMBO J 16:5600–5607

Vuori K, Ruoslahti E (1994) Association of insulin receptor substrate-1 with integrins. Science 266:1576–1578

Doerr ME, Jones JI (1996) The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells. J Biol Chem 271:2443–2447

Falcioni R et al (1997) Alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines. Exp Cell Res 236:76–85

Folgiero V et al (2008) Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas. PLoS ONE 3:e1592

Wang JF et al (2001) Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration. J Biol Chem 276:41950–41957

Napione L et al (2007) Integrins: a flexible platform for endothelial vascular tyrosine kinase receptors. Autoimmun Rev 7:18–22

Mahabeleshwar GH et al (2008) Integrin affinity modulation in angiogenesis. Cell Cycle 7:335–347

Masson-Gadais B et al (2004) Integrin alphavbeta3 requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 8:37–52

Pampori N et al (1999) Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem 274:21609–21616

Byzova TV et al (2002) Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Blood 99:4434–4442

Ginsberg MH et al (2005) Integrin regulation. Curr Opin Cell Biol 17:509–516

Cheresh DA, Stupack DG (2008) Regulation of angiogenesis: apoptotic cues from the ECM. Oncogene 27:6285–6298

Arnaout MA et al (2007) Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol 19:495–507

Phillips DR et al (2001) Integrin tyrosine phosphorylation in platelet signaling. Curr Opin Cell Biol 13:546–554

Chandhoke SK et al (2004) Beta 3 integrin phosphorylation is essential for Arp3 organization into leukocyte alpha V beta 3-vitronectin adhesion contacts. J Cell Sci 117:1431–1441

Butler B et al (2003) Lig, -dependent activation of integrin alpha vbeta 3. J Biol Chem 278:5264–5270

Feng W (2008) The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J Cell Biol 183:1145–1157

Johnson FM, Gallick GE (2007) SRC family nonreceptor tyrosine kinases as molecular targets for cancer therapy. Anticancer Agents Med Chem 7:651–659

Kefalas P et al (1995) Signalling by the p60c-src family of protein-tyrosine kinases. Int J Biochem Cell Biol 27:551–563

Basson MD (2008) An intracellular signal pathway that regulates cancer cell adhesion in response to extracellular forces. Cancer Res 68:2–4

Coluccia AM et al (2008) Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib. Blood 112:1346–1356

Eliceiri BP et al (1999) Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 4:915–924

Schwartzberg PL et al (1997) Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev 11:2835–2844

Lowell CA et al (1996) Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood 87:1780–1792

McHugh KP et al (2000) Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest 105:433–440

Soriano P et al (1991) Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693–702

Klinghoffer RA et al (1999) Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18:2459–2471

Su X, Mi J et al (2008) RGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase. Blood 112:592–602

Stockmann C et al (2008) Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456:814–818

Jones PL et al (1997) Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J Cell Biol 139:279–293

Woodard AS et al (1998) The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration. J Cell Sci 111(Pt 4):469–478

Trusolino L et al (1998) Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: implications for tumor invasion. J Cell Biol 142:1145–1156

Rahman S et al (2005) Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells. BMC Cell Biol 6:8

Roskoski R Jr (2008) VEGF receptor protein-tyrosine kinases: structure and regulation. Biochem Biophys Res Commun 375:287–291

Igarashi KI et al (1998) Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2. Biochem Biophys Res Commun 246:95–99

Le Boeuf F et al (2004) Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. J Biol Chem 279:39175–39185

Laramee M et al (2007) The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. J Biol Chem 282:7758–7769

Graells J et al (2004) Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling. J Invest Dermatol 123:1151–1161

Dardik R et al (2005) Molecular mechanisms underlying the proangiogenic effect of factor XIII. Arterioscler Thromb Vasc Biol 25:526–532

Dardik R et al (2006) Evaluation of the pro-angiogenic effect of factor XIII in heterotopic mouse heart allografts and FXIII-deficient mice. Thromb Haemost 95:546–550

Dardik R, Inbal A (2006) Complex formation between tissue transglutaminase II (tTG) and vascular endothelial growth factor receptor 2 (VEGFR-2): proposed mechanism for modulation of endothelial cell response to VEGF. Exp Cell Res 312:2973–2982

Lee SC et al (2007) Autocrine VEGF signaling is required for vascular homeostasis. Cell 130:691–703

Chen J et al (2005) Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med 11:1188–1196

Somanath PR et al (2007) Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem 282:22964–22976

Wijelath ES et al (2006) Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism. Circ Res 99:853–860

Vlahakis NE et al (2007) Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem 282:15187–15196

Becker PM et al (2005) Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability. Circ Res 96:1257–1265

Pan Q et al (2007) Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J Biol Chem 282:24049–24056

Pellet-Many C et al (2008) Neuropilins: structure, function and role in disease. Biochem J 411:211–226

Qu CK (2002) Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. Biochim Biophys Acta 1592:297–301

Maile LA, Clemmons DR (2002) Regulation of insulin-like growth factor I receptor dephosphorylation by SHPS-1 and the tyrosine phosphatase SHP-2. J Biol Chem 277:8955–8960

Ling Y et al (2003) Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for membrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor. Mol Endocrinol 17:1824–1833

Ling Y et al (2005) DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. J Biol Chem 280:3151–3158

Ling Y et al (2005) Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells. Mol Biol Cell 16:3353–3364

Clemmons DR et al (2007) Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress. Growth Horm IGF Res 17:265–270

Kwon M et al (2006) Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of phosphatidylinositol-3 (PI-3) kinase is required for insulin-like growth factor-I-dependent PI-3 kinase activation in smooth muscle cells. Endocrinology 147:1458–1465

Edderkaoui M et al (2007) Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. J Biol Chem 282:26646–26655

Mitola S et al (2006) Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1. Circ Res 98:45–54

Lieskovska J et al (2006) The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells. J Biol Chem 281:25041–25053

Chabot C et al (2009) New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival. Mol Cell Biol 29:241–253

Mattila E et al (2008) The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling. J Cell Sci 121:3570–3580

Yamaoka-Tojo M et al (2006) IQGAP1 mediates VE-cadherin-based cell–cell contacts and VEGF signaling at adherence junctions linked to angiogenesis. Arterioscler Thromb Vasc Biol 26:1991–1997

Tzima E et al (2005) VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. J Biol Chem 280:2405–2408

Ukropec JA et al (2002) Regulation of VE-cadherin linkage to the cytoskeleton in endothelial cells exposed to fluid shear stress. Exp Cell Res 273:240–247