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Sự hội tụ của hai cơ chế bệnh sinh chính trong polyp mũi: phản ứng miễn dịch với Staphylococcus aureus và quá trình tái cấu trúc đường thở
Tóm tắt
Bài tổng quan này đề cập đến hai cơ chế bệnh sinh có liên quan đến sự phát sinh của polyp mũi: quá trình tái cấu trúc độc đáo được tìm thấy trong mô polyp mũi và phản ứng miễn dịch của bệnh nhân mắc polyp mũi đối với Staphylococcus aureus. Hai giả thuyết này hội tụ về cùng một hướng ở những khía cạnh khác nhau, bao gồm việc giảm sản xuất chất nền ngoại bào, rối loạn điều chỉnh T và gia tăng phản ứng miễn dịch Th2. Ở những bệnh nhân bị polyp mũi, phản ứng miễn dịch quá mức đối với Staphylococcus aureus có thể làm trầm trọng thêm quá trình tái cấu trúc đường thở.
Từ khóa
#bệnh sinh polyp mũi #phản ứng miễn dịch #Staphylococcus aureus #tái cấu trúc đường thở #mô polyp mũiTài liệu tham khảo
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