Cung Cấp Tăng Cường Bằng Đối Lưu

Elsevier BV - Tập 14 - Trang 358-371 - 2017
A. M. Mehta1, A. M. Sonabend1, J. N. Bruce1
1Department of Neurological Surgery, Columbia University Medical Center, New York, USA

Tóm tắt

Cung cấp tăng cường bằng đối lưu (CED) là một kỹ thuật hứa hẹn, tạo ra một gradient áp suất ở đầu catheter truyền dịch để cung cấp thuốc trị liệu trực tiếp qua các khoảng không gian giữa các tế bào của hệ thần kinh trung ương. Kỹ thuật này giải quyết và cung cấp giải pháp cho nhiều hạn chế của các kỹ thuật thông thường, cho phép cung cấp thuốc vượt qua hàng rào máu-não theo cách có mục tiêu và an toàn để đạt được nồng độ thuốc trị liệu. CED là một kỹ thuật có thể áp dụng rộng rãi, có thể được sử dụng để cung cấp nhiều hợp chất trị liệu cho nhiều loại bệnh khác nhau, bao gồm glioma ác tính, bệnh Parkinson và bệnh Alzheimer. Mặc dù một số tiến bộ công nghệ đã được thực hiện kể từ khi phát triển vào đầu những năm 1990, nhưng các thử nghiệm lâm sàng với CED chủ yếu đã không thành công và đã nêu bật một số tham số vẫn cần được giải quyết để áp dụng lâm sàng thành công. Bài đánh giá này đề cập đến các nguyên tắc vật lý phía sau CED, những hạn chế trong kỹ thuật, cũng như cách khắc phục các hạn chế này, các thử nghiệm lâm sàng đã được thực hiện và các phát triển trong tương lai.

Từ khóa

#Cung cấp tăng cường bằng đối lưu #hệ thần kinh trung ương #hàng rào máu-não #glioma ác tính #bệnh Parkinson #bệnh Alzheimer

Tài liệu tham khảo

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