Controversial conclusions from two randomized controlled trials for acupuncture’s effects on polycystic ovary syndrome or in vitro fertilization support

MacPherson, 2017 Huang, 2011, Acupuncture for infertility: is it an effective therapy?, Chin J Integr Med, 17, 386, 10.1007/s11655-011-0611-8 Nandi, 2014, Acupuncture in IVF: a review of current literature, J Obstet Gynaecol, 34, 555, 10.3109/01443615.2014.919997 Wu, 2017, Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: a randomized clinical trial, JAMA, 317, 2502, 10.1001/jama.2017.7217 Smith, 2018, Effect of acupuncture vs sham acupuncture on live births among women undergoing in vitro fertilization: a randomized clinical trial, JAMA, 319, 1990, 10.1001/jama.2018.5336 Li, 2013, Puzzles and hypotheses of acupuncture, Zhongguo Zhong Xi Yi Jie He Za Zhi, 33, 1445 Wang, 2017, Sweet acupuncture, a type of comfortable acupuncture, Zhong Yi Yao Dao Bao, 23, 7 Wayne, 2008, Japanese-style acupuncture for endometriosis-related pelvic pain in adolescents and young women: results of a randomized sham-controlled trial, J Pediatr Adolesc Gynecol, 21, 247, 10.1016/j.jpag.2007.07.008 Kuang, 2013, Acupuncture and clomiphene citrate for live birth in polycystic ovary syndrome: study design of a randomized controlled trial, Evid Based Complement Alternat Med, 2013, 10.1155/2013/527303 Wu, 2017, Acupuncture for infertility in polycystic ovary syndrome—reply, JAMA, 318, 1502, 10.1001/jama.2017.13394 Legro, 2014, Letrozole versus clomiphene for infertility in the polycystic ovary syndrome, N Engl J Med, 371, 119, 10.1056/NEJMoa1313517 Tso, 2014, Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome, Cochrane Database Syst Rev, 11, CD006105 Regidor, 2018, Management of women with PCOS using myo-inositol and folic acid. New clinical data and review of the literature, Horm Mol Biol Clin Investig, 34 Vause, 2010, Ovulation induction in polycystic ovary syndrome, J Obstet Gynaecol Can, 32, 495, 10.1016/S1701-2163(16)34504-2 Smith, 2006, Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer, Fertil Steril, 85, 1352, 10.1016/j.fertnstert.2005.12.015 Gu, 2018, Acupuncture for women undergoing in vitro fertilization, JAMA, 320, 1384, 10.1001/jama.2018.10542 Di Paola, 2018, Are we choosing the correct FSH starting dose during controlled ovarian stimulation for intrauterine insemination cycles? Potential application of a nomogram based on woman’s age and markers of ovarian reserve, Arch Gynecol Obstet, 298, 1029, 10.1007/s00404-018-4906-2 Reyes-Muñoz, 2018, Polycystic ovary syndrome: implication for drug metabolism on assisted reproductive techniques—a literature review, Adv Ther, 35, 1805, 10.1007/s12325-018-0810-1 Smith, 2012, Acupuncture to improve live birth rates for women undergoing in vitro fertilization: a protocol for a randomized controlled trial, Trials, 18, 60, 10.1186/1745-6215-13-60 Chambers, 2017, Assisted reproductive technology in Australia and New Zealand: cumulative live birth rates as measures of success, Med J Aust, 207, 114, 10.5694/mja16.01435