Controlling persistent organic pollutants–what next?

Environmental Toxicology and Pharmacology - Tập 6 Số 3 - Trang 143-175 - 1998
Harry W. Vallack1, D.J. Bakker2, Ingvar Brandt3, Eva Broström-Lundén4, Abraham Brouwer5, Keith Bull6, Clair Gough7, Ramón Guardans8, Ivan Holoubek9, Bo Jansson10, R. Koch11, Johan Kuylenstierna1, André Lecloux12, Donald Mackay13, Patrick McCutcheon14, Paolo Mocarelli15, R D Taalman16
1Stockholm Environment Institute at York, University of York, York, United Kingdom
2TNO Institute of Environmental Sciences, Energy Research and Process Innovation, Den Helder, The Netherlands
3Department of Environmental Toxicology, University of Uppsala, Uppsala, Sweden
4Swedish Environmental Research Institute, Göteborg, Sweden
5Department of Food Technology and Nutritional Sciences, Division of Toxicology, Agricultural Unversity, Wageningen, The Netherlands
6Institute of Terrestrial Ecology, Huntingdon, United Kingdom.
7Institute for Systems Engineering and Informatics, Joint Research Centre, Ispra, Italy
8Centro de Investigacione Energeticas MedioAmbientales e tecnologecas (CIEMAT), Madrid, Spain
9Department of Environmental Chemistry and Ecotoxicology, Masaryk University, Brno, Czech Republic
10Institute of Applied Environmental Research, Stockholm University, Stockholm, Sweden
11Product Safety Department, Bayer AG, Leverkusen, Germany
12European Chemical Industry Council (CEFIC) – EURO CHLOR, Brussels, Belgium
13Environmental Modelling Centre, Trent University, Ontario, Canada
14European Commission, DG XI, Environment, Brussels, Belgium
15Facoltà di Medicina e Chirurgia, Università degli Studi di Milano, Desio-Milano, Italy
16European Chemical Industry Council (CEFIC)–Endocrine Modulators Steering Group (EMSG), Brussels, Belgium

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Tài liệu tham khảo

Aguilar, 1993, The striped dolphin epizootic in the Mediterranean Sea, Ambio, 22, 524

Alba, 1988, A preliminary study on exposure of rice farmers to pesticides, 417

Alsberg, T., Balk, L., Nylund, K., de Wit, C., Bignert, A., Olsson, M., Odsjö, T., 1993. Persistent organic pollutants and the environment, SNV Report 4246, Swedish Environmental Protection Agency.

AMAP, 1997. Arctic pollution issues: a state of the Arctic environment report Arctic Monitoring and Assessment Programme, Oslo, Norway.

Atlas, 1990, The long-range transport of organic compounds, 105

Aulerich, 1977, Current status of PC toxicity to mink, and after-effects on their reproduction, Arch. Environ. Contam. Toxicol., 6, 279, 10.1007/BF02097769

Baek, 1991, A review of polycyclic aromatic hydrocarbons-sources, fate and behaviour, Water, Air and Soil Pollution, 60, 279, 10.1007/BF00282628

Bailey, 1997, IEA: a new methodology for environmental policy?, Environ. Impact Assess. Rev., 17, 221, 10.1016/S0195-9255(97)00009-7

Balash, 1987, Effect of chlordane on testicular tissues of Swiss mice, Bull. Environ. Contam. Toxicol., 39, 434, 10.1007/BF01688307

Ballschmitter, 1996, Persistent, ecotoxic, and bioaccumulating compounds and their possible environmental effects, Pure and Appl. Chem., 68, 1771, 10.1351/pac199668091771

Banerjee, 1987, Effects of sub-chronic DDT exposure on humoral and cell-mediated immune responses in albino rats, Bull. Environ. Contam. Toxicol., 39, 827, 10.1007/BF01855862

Banerjee, 1986, Subchronic effect of DDT on humoral immune response in mice, Bull. Environ. Contam. Toxicol., 37, 433, 10.1007/BF01607785

Barnett, 1994, Pesticides, 191

Barnett, 1987, The effects of in utero exposure to hexachlorobenzene on the developing immune response of BALB/c mice, Toxocol. Lett., 39, 263, 10.1016/0378-4274(87)90242-6

Barrie, 1986, Arctic air pollution: an overview of current knowledge, Atmos. Environ., 20, 643, 10.1016/0004-6981(86)90180-0

Barrie, 1992, Arctic contaminants: sources, occurrence and pathways, Sci. Tot. Env., 122, 1, 10.1016/0048-9697(92)90245-N

Berdowski, J.J.M., Bass, J., Bloos, J.P.J., Visschedijk, A.J.H., Zandveld, P.Y.J., 1997. The European emission inventory of heavy metals and persistent organic pollutants, TNO report UBA-FB, UFOPLAN Ref. no. 104.02 672/03, Apeldoorn, p. 239.

Bergman, 1994, Selective retention of hydroxylated PCB metabolites in blood, Environ. Health Perspec., 102, 464, 10.1289/ehp.94102464

Bidleman, 1986, Vapor-particle partitioning of semi-volatile organic compounds: Estimates from field collections, Environ. Sci. Technol., 20, 1038, 10.1021/es00152a013

Bidleman, 1989, Toxaphene and other organochlorines in Arctic ocean fauna: evidence for atmospheric delivery, Arctic, 42, 307, 10.14430/arctic1671

Bidleman, 1993, Organochlorine pesticides in the atmosphere of the Southern Ocean and Antarctica, January-March, 1990, Mar. Poll. Bull., 26, 258, 10.1016/0025-326X(93)90064-Q

Bidleman, 1995, Decline of hexachlorocyclohexane in the arctic atmosphere and reversal of air-sea gas exchange, Geophys. Res. Lett., 22, 219, 10.1029/94GL02990

Birnbaum, 1995, Workshop on perinatal exposure to dioxin-like compounds: V. immunologic effects, Environ. Health Perspec., 103, 157, 10.1289/ehp.95103s2157

Borrell, 1991, Were PCB levels in striped dolphins affected by the western Mediterranean die-off abnormally high?, Eur. Res. Cetaceans, 5, 88

Bowes, 1975, Presence and distribution of polychlorinated biphenyls (PCB) in Arctic and subarctic marine food chains, J. Fish. Res. Board Can., 32, 2111, 10.1139/f75-249

Brandt, I., Bergman, Å., 1987. PCB methyl sulphones and related compounds: Identification of target cells and tissues in different species. Chemosphere 16, 1671–1676.

Brandt, I., Lund, J., Bergman, Å., Klasson-Wehler, E., Poellinger L., Gustafsson, J.-Å., 1985. Target cells for the PCB metabolite 4,4′-bis(methylsulphonyl)- 2,2′,5,5′-tetrachlorobiphenyl in lung and kidney. Drug Metabolism Disp. 13, 490–496.

Brandt, 1992, Comparative studies on adrenocorticolytic DDT-metabolites, Ambio, 21, 602

Bro-Rasmussen, F., 1996. Chemical hazard is a serious matter-too serious to be left for chemists to administer, (Translated from Danish) Aktuelt Miljo, No. 6, (J.H. Schultz Information Ltd.).

Broughton, 1990, Chronic health effects and immunological alterations associated with exposure to pesticides, Comments Toxicol., 4, 59

Brouwer, 1986, Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin-a transport by inhibiting the formation of the protein complex carrying both retinol and thyroxine, Toxicol. Appl. Pharmacol., 85, 301, 10.1016/0041-008X(86)90337-6

Brouwer, 1989, Polychlorinated biphenyl (PCB)-contaminated fish induce vitamin A and thyroid hormone deficiency in the common seal (Phoca vitulina), Aquat. Toxicol., 15, 99, 10.1016/0166-445X(89)90008-8

Brouwer, 1995, Functional-aspects of developmental toxicity of polyhalogenated aromatic-hydrocarbons in experimental animals and human infants, Eur. J. Pharmacol. (Environ. Toxicol. section), 293, 1, 10.1016/0926-6917(95)90015-2

Brouwer, 1998, Interactions of persistent environmental organohalogens with the thyroid hormone system: Mechanisms and possible consequences for animal and human health, Toxicol. Ind. Health, 14, 59, 10.1177/074823379801400107

Buccini, J., 1997. Persistent organic pollutants (POPs): Recent developments in the Intergovernmental Forum for Chemical Safety (IFCS), UNEP, Geneva. (http://irptc.unep.ch/pops/stpeter/stpeter1.html)

Calamari, 1991, Role of plant biomass in the global environmental partitioning of chlorinated hydrocarbons, Environ. Sci. Technol., 25, 1489, 10.1021/es00020a020

Clausen, 1975, The content of polychlorinated hydrocarbons in Arctic ecosystems, Pure Appl. Chem., 42, 223, 10.1351/pac197542010223

Colborn, 1991, Epidemiology of Great Lakes bald eagles, J. Toxocol. Environ. Health, 33, 395, 10.1080/15287399109531537

Commission of the European Communities, 1994. Technical guidance documents in support of the risk assessment regulation (1488/94) for existing substances in the context of Council Regulation 793/93/EEC, Commission of the European Communities, Brussels, Belgium.

Cowan, 1995, The multi-media fate model: a vital tool for predicting the fate of chemicals

Daisey, 1981, Polycyclic aromatic hydrocarbons and extractable particulate organic matter in the Arctic aerosol, Atmos. Environ., 15, 1353, 10.1016/0004-6981(81)90341-3

Darnerud, 1996, Binding of a 3,3′,4,4′-tetrachlorobiphenyl (CB–77) metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice, Toxicol., 106, 105, 10.1016/0300-483X(95)03169-G

Davis, 1989, Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, Toxicol. Lett., 48, 35, 10.1016/0378-4274(89)90183-5

Davis, 1993, Medical hypothesis: xenoestrogens as preventable causes of breast cancer, Environ. Health Perspect., 101, 372, 10.1289/ehp.93101372

De Guise, 1994, Tumours in St. Lawrence Beluga Whales (Delphinapterus leucas), Veterinary Path., 31, 444, 10.1177/030098589403100406

De Guise, 1995, Possible mechanisms of action of environmental contaminants on St. Lawrence Beluga Whales (Delphinapterus leucas), Environ. Health Perspect., 103, 73, 10.1289/ehp.95103s473

De Swart, 1993, Mitogen and antigen induced B and T cell responses of peripheral blood mononuclear cells from the harbour seals (Phoca vitulina), Veterinary Immunol. Immunopath., 37, 217, 10.1016/0165-2427(93)90195-A

De Swart, 1994, Impairment of immune function in harbour seals (Phoca vitulina) feeding on fish from polluted waters, Ambio, 23, 155

De Swart, 1995, Impaired cellular immune response in harbour seals (Phoca vitulina) feeding on environmentally contaminated herring, Clin. Exp. Immunol., 101, 480, 10.1111/j.1365-2249.1995.tb03138.x

Dewailly, 1989, High levels of PCBs in breast milk of Inuit women from Arctic Quebec, Bull. Environ. Contam. Toxicol., 43, 641, 10.1007/BF01701981

Dewailly, 1993, Inuit exposure to organochlorines through the aquatic food chain in arctic Quebec, Environ. Health Perspec., 101, 618

Dewailly, E., Bruneau, S., Laliberté, C., Belles-Iles, M., Weber, J.P., Ayotte, P., Roy, R., 1993b. Breast milk contamination by PCBs and PCDDs/PCDFs in arctic Quebec: preliminary results on the immune status of Inuit infants. in: H. Fielder, H. Frank, O. Hutzinger, W. Parzefall, A. Riss and S. Safe (Eds.), Dioxin ’93: 13th International Symposium on Chlorinated Dioxins and Related Compounds. Federal Environmental Agency, Vienna, September 1993 Organohalogen Compounds, Vol. 13, pp. 403–406.

Dewailly, 1994, High organochlorine body burden in women with estrogen receptor-positive breast cancer, J. Natl. Cancer Inst., 86, 232, 10.1093/jnci/86.3.232

Dietz, 1989, Mass deaths of harbour seals (Phoca vitulina) in Europe, Ambio, 18, 258

Duursma, 1996, Environmental compartments

ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals) 1996, Environmental Oestrogens Task Force–Compendium of test methods, Document No. 33, Brussels, Belgium.

Eriksson, 1989, The pine needle as a monitor of atmospheric pollution, Nature, 341, 42, 10.1038/341042a0

Eriksson, 1992, Neuroreceptor and behavioural effects of DDT and pyrethroids in immature and adult mammals, 2, 235

Eriksson, 1997, Developmental neurotoxicity of environmental agents in the neonate, Neurotoxicology, 18, 719

Eriksson, 1996, Developmental neurotoxicity of four ortho-substituted polychlorinated biphenyls in the neonatal mouse. Environ. Toxicol. Pharmacol., 1, 155

European Commission, 1996. European workshop on the impact of endocrine modulators on human health and wildlife, Weybridge, UK, Report of the proceedings, EUR 17549.

Facemire, 1995, Reproductive impairment in the Florida Panther: nature or nurture, Environ. Health Perspect. Suppl., 103, 79, 10.2307/3432416

Falck Jr, 1992, Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer, Arch. Environ. Health, 47, 143

Fiedler, H., 1997. Polychlorinated biphenyls (PCB), Presentation to the UNEP sub-regional meeting on identification and assessment of releases of persistent organic pollutants, St. Petersburg, Russian Federation, 1–4 July 1997. UNEP, Geneva. (http://irptc.unep.ch/pops/stpeter/stpete2c.html)

Finizio, 1997, Emission of chiral pesticides from an agricultural soil in the Fraser Valley, British Columbia, Chemosphere, 36, 345, 10.1016/S0045-6535(97)00272-5

Finizio, 1997, Octanol-air partition coefficient as a predictor of partitioning of semi-volatile organic chemicals to aerosols, Atmos. Environ., 31, 2289, 10.1016/S1352-2310(97)00013-7

Fox, 1992, Epidemiological and pathobiological evidence of contaminant-induced alterations in sexual development in free-living wildlife, 147

Fry, 1981, DDT-induced feminization of gull embryos, Science, 213, 922, 10.1126/science.7256288

Funtowicz, 1991, A new scientific methodology for global environmental issues, 137

Gaebler, 1966, Isotope effects in metabolism of 15N and 14 N from unlabelled dietary proteins, J. Biochem. Phys., 44, 1245

Gagosian, 1981, Atmospheric transport of continentally derived lipids to the tropical North Pacific, Nature, 291, 312, 10.1038/291312a0

Garcı́a-Rodrı́guez, 1996, Exposure to pesticides and cryptorchidism: geographical evidence of a possible association, Environ. Health Perspect., 104, 1090, 10.1289/ehp.961041090

George, 1966, Pesticides in the Antarctic, J. Appl. Ecol., 3, 155, 10.2307/2401454

Gilbertson, 1991, Great Lakes embryo mortality, edema and deformities syndrome (GLEMEDS) in colonial fish-eating waterbirds: similarity to chick edema disease, J. Toxicol. Environ. Health, 33, 455, 10.1080/15287399109531538

Gladen, 1988, Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk, J. Pediatr., 113, 991, 10.1016/S0022-3476(88)80569-9

Goldberg, 1975, Synthetic organohalides in the sea, Proc. Royal Soc. Lond., 189, 277, 10.1098/rspb.1975.0057

Golden, 1998, Environmental endocrine modulators and human health: An assessment of the biological evidence, Crit. Rev. Toxicol., 28, 109, 10.1080/10408449891344191

Government of Canada, 1991. Toxic chemicals in the Great Lakes and associated effects, Minister of supply and services, Catalogue Number En 37-95/1990-1E.

Grachev, 1989, Distemper virus in Baikal seals, Nature Lond., 338, 209, 10.1038/338209a0

Grasman, K.A., 1995. Developmental immunotoxicity of environmental contaminants in fish-eating birds of the Great Lakes, Abstract presented at the Conference, Chemically-induced Alterations in the Developing Immune System: The Wildlife/Human Connection, Racine, Wisconsin, February 10–12, 1995.

Gray Jnr, 1992, Chemical-induced alterations of sexual differentiation: a review of effects in humans and rodents, 203

Gregor, 1989, Evidence of atmospheric transport and deposition of organochlorine pesticides and polychlorinated biphenyls in Canadian Arctic snow, Environ. Sci. Technol., 23, 561, 10.1021/es00063a008

Guillette, 1994, Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida, Environ. Health Perspect., 102, 680, 10.1289/ehp.94102680

Han, S-L., Stone, D., 1997. Effects overview of persistent organic pollutants in the context of effects-based approaches to management, Background document for: The Workshop on Critical Limits and Effects Based Approaches for Heavy Metals and Persistent Organic Pollutants, Bad Harzburg, Germany, November 3-7, UN-ECE Convention on Long-range Transboundary Air Pollution, Task Force on Mapping.

Hargrave, 1988, Atmospheric transport of organochlorines to the Arctic Ocean, Tellus, 40B, 480, 10.1111/j.1600-0889.1988.tb00118.x

Henny, C. and R. Grove, 1996. Hypoplastic reproductive organs related to xenobiotic compounds in young male River Otter from the Columbia River. in: Proceedings of the 17th annual meeting of the Society of Environmental Toxicology and Chemistry. Washington DC, USA, November 1996.

Hoff, 1992, Annual cycle of polychlorinated biphenyls and organohalogen pesticides in air in Southern Ontario. 2. Atmospheric transport and sources, Environ. Sci. Technol., 26, 276, 10.1021/es00026a006

Holsapple, 1991, A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced changes in immunocompetence: 1991 update, Toxicology, 69, 219, 10.1016/0300-483X(91)90184-3

Hornbuckle, 1996, Dynamics of gaseous semivolatile organic compounds in a terrestrial ecosystem – effects of diurnal and seasonal climate variations, Atmos. Environ., 30, 3935, 10.1016/1352-2310(96)00135-5

Horstmann, 1997, Comparison of the bulk deposition of PCDD/F in a spruce forest and an adjacent clearing, Chemosphere, 34, 1245, 10.1016/S0045-6535(97)00422-0

Howsham, 1998, Sources of PAHs in the environment, 137

Huisman, 1995, Neurological condition in 18-month-old children perinatally exposed to polychlorinated-biphenyls and dioxins, Early Hum. Develop., 43, 165, 10.1016/0378-3782(95)01674-0

IFCS, 1996a. Persistent organic pollutants: Socioeconomic considerations for global action – Theme paper prepared for an IFCS expert meeting on persistent organic pollutants, Manila, the Philippines, 17–19 June 1996, Report no. IFCS/EXP.POPs.2 (UNEP, Geneva). (http://irptc.unep.ch/pops/indxhtms/manexp3.html)

IFCS, 1996b. Discussion paper on the development of science-based criteria for identifying further POPs, United Kingdom, Paper for IFCS meeting, Manila, 20–21 June 1996, Intergovernmental Forum on Chemical Safety, UNEP (c/o WHO) Geneva. (http://irptc.unep.ch/pops/indxhtms/manwg5.html)

Iwata, 1993, Distribution of persistent organochlorines in the oceanic air and surface seawater and the role of ocean on their global transport and fate, Environ. Sci. Technol., 27, 1080, 10.1021/es00043a007

Iwata, 1994, Geographical distribution of persistent organochlorines in air, water and sediments from Asia and Oceania, and their implications for global redistribution from lower latitudes, Environ. Pollut., 85, 15, 10.1016/0269-7491(94)90234-8

Jacobson, 1996, Intellectual impairment in children exposed to polychlorinated biphenyls in utero, New Engl. J. Med., 335, 783, 10.1056/NEJM199609123351104

Jacobson, 1984, Prenatal exposure to an environmental toxin: a test of the multiple effects model, Developmental Psychol., 20, 523, 10.1037/0012-1649.20.4.523

Jacobson, 1990, Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children, J. Pediatr., 116, 38, 10.1016/S0022-3476(05)81642-7

Jansen, 1993, Estrogenic and antiestrogenic actions of PCBs in the female rat – in vitro and in vivo studies, Reprod. Toxicol., 7, 237, 10.1016/0890-6238(93)90230-5

Jensen, 1976, Anthropogenic substances in seal from the Baltic: Methyl sulphone metabolites of PCB and DDT, Ambio, 5, 257

Jensen, 1977, Effects of PCB and DDT on mink (Mustela vision) during the reproductive season, Ambio, 6, 239

Jonsson, C.-J., Rodriguez-Martinez, H., Lund, B.-O., Bergman, Å., Brandt, I., 1991. Adrenocortical toxicity of 3-methylsulfonyl-DDE in mice. II. Mitochondrial changes following ecologically relevant doses. Fundam. Appl. Toxicol. 16, 365–374.

Jonsson, C.J., Lund, B.-O., Bergman, Å., Brandt, I., 1992. Adrenocortical toxicity of 3-methylsulhonyl-DDE (III): Studies in fetal and suckling mice. Reproductive Toxicol. 6, 233–240.

Kennedy, 1988, Confirmation of cause recent seal deaths, Nature Lond., 335, 404, 10.1038/335404a0

Key, 1994, Organochlorines in the environment and breast cancer, Brit. Med. J., 308, 1520, 10.1136/bmj.308.6943.1520

Kidd, 1995, Correlation between stable nitrogen isotope ratios and concentrations of organochlorines in biota from a freshwater food web, Sci. Tot. Environ., 160/161, 381, 10.1016/0048-9697(95)04371-7

Kinloch, 1992, Inuit foods and diet: a preliminary assessment of benefits and risks, Sci. Tot. Environ., 122, 247, 10.1016/0048-9697(92)90249-R

Koopman-Esseboom, 1994, Effects of dioxins and polychlorinated-biphenyls on thyroid-hormone status of pregnant-women and their infants, Pediatr. Res., 36, 468, 10.1203/00006450-199410000-00009

Koopman-Esseboom, 1996, Effects of polychlorinated biphenyl dioxin exposure and feeding type on infants mental and psychomotor development, Pediatrics, 97, 700, 10.1542/peds.97.5.700

Krieger, 1994, Breast cancer and serum organochlorines – a prospective study among white, black and Asian women, J. Natl. Cancer Inst., 86, 589, 10.1093/jnci/86.8.589

Lahvis, 1993, In vitro lymphocyte response of bottlenose dolphins (Tursiops truncatus): mitogen induced proliferation, Marine Environ. Res., 35, 115, 10.1016/0141-1136(93)90023-S

Loganathan, 1994, Global organochlorine contamination trends: an overview, Ambio, 23, 187

López-Martı́n, 1994, Organochlorine residue levels in the European mink (Mustela lutreola) in Northern Spain, Ambio, 23, 294

Lukoyanov, N.F., Zhukov, G.P., Meshkova V.G., Golovko, R.G., 1992. Experimental investigation of polydispersed solid aerosol deposition on the snow surface. IEM Proc., 55(155), pp. 36–50 (in Russian).

Lund, J., Brandt, I., Poellinger, L., Bergman, Å., Klasson-Wehler, E., Gustafsson, J.-Å., 1985. Target cells for the polychlorinated biphenyl metabolite 4,4′-bis(methylsulfonyl)-2,2′,5,5′-tetrachlorobiphenyl. Characterization of high affinity binding in rat and mouse lung cytosol. Mol. Pharmacol. 27, 314–323.

Lund, B.O., Bergman, Å., Brandt, I., 1988. Metabolic activation and toxicity of a DDT-metabolite, 3-methylsulphonyl-DDE, in the adrenal zona fasciculata in mice. Chem. Biol. Interactions 65, 25–40.

Luster, 1988, Methods evaluation: development of a testing battery to assess chemical-induced immunotoxicity – National Toxicology Program’s guidelines for immunotoxicity evaluation in mice, Fund. Appl. Toxicol., 10, 2, 10.1016/0272-0590(88)90247-3

Luster, 1995, Immunotoxicology and risk assessment, 1, 51

Mac, 1991, Environmental contaminants and the reproductive success of lake trout in the Great Lakes: an epidemiological approach, J. Toxicol. Environ. Health, 33, 375, 10.1080/15287399109531536

Mackay, 1995, Transport of contaminants to the Arctic: partitioning, processes and models, Sci. Tot. Environ., 160/161, 25, 10.1016/0048-9697(95)04342-X

Martineau, 1987, Levels of organochlorine chemicals in tissues of beluga whales (Delphinapterus leucas) from the St. Lawrence estuary, Quebec, Canada, Arch. Environ. Contam. Toxicol., 16, 137, 10.1007/BF01055795

Martineau, 1988, Pathology of stranded beluga whales (Delphinapterus leucas) from the St. Lawrence estuary, Quebec, Canada, J. Comp. Path., 98, 287, 10.1016/0021-9975(88)90038-2

Mason, 1989, Water pollution and otter distribution: a review, Lutra, 2, 97

McConnachie, 1991, Immunological consequences of exposure to pentachlorophenol, Arch. Environ. Health, 46, 249, 10.1080/00039896.1991.9937456

Mes, 1987, PCBs in human populations, III, 39

Mocarelli, 1996, Change in sex ratio with exposure to dioxin, The Lancet, 348, 409, 10.1016/S0140-6736(05)65030-1

Moore, 1997, Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum, Toxicol. Appl. Pharmacol., 142, 160, 10.1006/taap.1996.8022

Morse, 1996, Alterations in rat-brain thyroid-hormone status following prenatal and postnatal exposure to polychlorinated-biphenyls (aroclor-1254), Toxicol. Appl. Pharmacol., 136, 269, 10.1006/taap.1996.0034

Muir, 1988, Organochlorine contaminants in Arctic marine food chains: accumulation of specific polychlorinated biphenyls and chlordane-related compounds, Environ. Sci. Technol., 22, 1070, 10.1021/es00174a012

Muir, 1990, Geographic variation of chlorinated hydrocarbons in burbot (Lota lota) from remote lakes and rivers in Canada, Arch. Environ, Contam. Toxicol., 19, 530, 10.1007/BF01059072

Muir, 1992, Arctic marine ecosystem contamination, Sci. Tot. Env., 122, 75, 10.1016/0048-9697(92)90246-O

Muir, 1995, Spatial trends and historical profiles of organochlorine pesticides in Arctic lake sediments, Sci. Tot. Environ., 160/161, 447, 10.1016/0048-9697(95)04378-E

Mulvad, 1996, Exposure of Greenlandic Inuit to organochlorines and heavy metals through the marine food-chain: an international study, Sci. Tot. Env., 186, 137, 10.1016/0048-9697(96)05093-0

Murray, 1979, Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet, Toxicol. Appl. Pharmacol., 50, 241, 10.1016/0041-008X(79)90149-2

Nagayama, J., Nagayama, M., Masuda, Y., 1992. Genotoxicity of highly toxic organochlorine congeners in cultured human lymphocytes, Dioxin ’93: 13th International Symposium on Chlorinated Dioxins and Related Compounds, in: Fielder, H., Frank, H., Hutzinger, O., Parzefall, W., Riss, A., Safe, S. (Eds.). (Federal Environmental Agency, Vienna, September 1993) Organohalogen Compounds, Vol. 13, pp. 165–167.

Norstrom, 1988, Organochlorine contaminants in Arctic marine food chains: identification, geographical distribution and temporal trends in polar bears, Environ. Sci. Technol., 22, 1063, 10.1021/es00174a011

Olsson, 1991, Otter survival and toxic chemical implications for otter conservation programmes, 191

Olsson, M., Bignert, A., Odsj, T., Persson, W., Litzén, K., Eriksson, U., Häggberg, L., Alsberg, T., 1997. Temporal trends of organochlorines in Northern Europe, 1967-1995 support long ranged transport but not the ‘grass-hopper effect’. In: R. Hites (Ed.), Dioxin ’97, Organohalogen Compounds, Vol 33, pp. 99–104.

Osterhaus, 1988, Identification of virus causing recent seal deaths, Nature, 335, 20, 10.1038/335020a0

Osterhaus, A.D.M.E., De Swart, R.L., Ross, P.S., Timmerman, H.H., Van Loveren, H., Reijnders, P.J.H., Vos, J.G., 1995. Impairment of immune function in harbour seals (Phoca vitulina) feeding on fish contaminated through the food chain, Abstract presented at the Conference. Chemically-induced Alterations in the Developing Immune System: The Wildlife/Human Connection, Racine, Wisconsin, February 10-12, 1995.

Ottar, 1981, The transfer of airborne pollutants to the Arctic regions, Atmos. Environ., 15, 1439, 10.1016/0004-6981(81)90350-4

Ouellet, 1997, Hind limb deformities (ectromelia, ectrodactyly) in free living anurans from agricultural habitats, J. Wildl. Dis., 33, 95, 10.7589/0090-3558-33.1.95

Perera, 1981, Carcinogenicity of airborne fine particulate benzo(a)pyrene: An appraisal of the evidence and the need for control, Environ. Health Perspect., 42, 163, 10.1289/ehp.8142163

Peterson, 1987, Stable isotopes in ecosystem studies, Annu. Rev. Ecol. Syst., 18, 293, 10.1146/annurev.es.18.110187.001453

Peterson, 1992, Male reproductive system ontogeny: effects of perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in Chemically-Induced Alterations, 175

Quaß, U., Fermann, M., 1997. Identification of relevant industrial sources of dioxins and furans in Europe, (The European Dioxin Inventory). Final Report, Materialen No. 43, published by North Rhine-Westphalia State Environment Agency (LUA NRW)), ISSN 0947-5206.

Rahn, 1981, Progress in Arctic air chemistry 1977-1980: a comparison of the first and second symposium, Atmos. Environ., 15, 1345, 10.1016/0004-6981(81)90339-5

Rappe, 1974, Chemical behavior of pesticides, 29

Reijnders, 1986, Reproductive failure in common seals feeding on fish from polluted coastal waters, Nature, 324, 456, 10.1038/324456a0

Renn, 1995, Style of using scientific expertise: a comparative framework, Sci. Public Policy, 22, 147, 10.1093/spp/22.3.147

Renn, 1995, Fairness and Competence in Citizen Participation

Repetto, 1996

Risebrough, 1972, Chlorinated hydrocarbons in Antarctic birds, 63

Ritter, L., Soloman, K.R., Forget, J., Stemeroff, M., O’Leary, C., 1995. Persistent organic pollutants, an assessment report on DDT, Aldrin, Dieldrin, Endrin, Chlordane, Heptachlor, Hexachlorobenzene, Mirex, Toxaphene, Polychlorinated biphenyls, Dioxins and Furans. Report No. PCS/95.38 prepared for the International Programme on Chemical Safety (IPCS) within the framework of the Inter-Organization Programme for the Sound Management of Chemicals (IOMC). (http://irptc.unep.ch/pops/indxhtms/asses0.html)

Rogan, 1986, Neonatal effects of transplacental exposure to PCBs and DDE, J. Pediatr., 109, 335, 10.1016/S0022-3476(86)80397-3

Rola, 1993

Ross, 1995, Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbor seals fed herring from the Baltic Sea, Environ. Health Perspec., 103, 162, 10.1289/ehp.95103162

Safe, 1994, Polychlorinated-biphenyls (PCBs)-environmental-impact, biochemical and toxic responses, and implications for risk assessment, Crit. Rev. Toxicol., 24, 87, 10.3109/10408449409049308

Safe, 1997, Is there an association between exposure to environmental estrogens and breast cancer?, Environ. Health Perspec., 105, 675, 10.1289/ehp.97105s3675

Segstro, M., Muir, D., Hobson, K., Stewart, R., Olpinski, S., 1993. Are unexpectedly high levels of PCBs and other organochlorines in walrus due to predation on seals? Presented at the International Conference on Marine Mammal Biology, Galveston, Texas, November 1993.

Seys, A., 1997. Dioxins-related compounds in the chemical industry-Presentation to the UNEP sub-regional meeting on identification and assessment of releases of persistent organic pollutants, St. Petersburg, Russian Federation, 1-4 July 1997. UNEP, Geneva. (http://irptc.unep.ch/pops/stpeter/stpete13.html)

Sicre, 1987, Aliphatic and aromatic hydrocarbons in Mediterranean aerosol, Int. Environ. Anal. Chem., 29, 73, 10.1080/03067318708078412

Simonich, 1995, Global distribution of persistent organochlorine compounds, Science, 269, 1851, 10.1126/science.7569923

Sjöberg, 1995

Sladen, 1966, DDT residues in Adelie penguins and a crabeater seal from Antarctica, Nature, 210, 637, 10.1038/210670a0

Svensson, B.G., Hallberg, T., Nilsson, A., Åkesson, B., Schütz, A., Hagmar, L., 1993. Immunological competence and liver function in subjects consuming fish with organochlorine contaminants, Dioxin ’93: 13th International Symposium on Chlorinated Dioxins and related compounds, Federal Environmental Agency, Vienna, September 1993, Organohalogen Compounds, Vol. 13, pp.175–178.

Swain, 1992, Chapter 22: Exposure and effects of airborne contamination

Tanabe, 1982, Global distribution and atmospheric transport of chlorinated hydrocarbons: HCH isomers and DDT compounds in the Western Pacific, Eastern Indian and Antarctic Ocean, J. Oceanog. Soc. Jpn., 5, 97

Tattersfield, 1997

Thomann, 1992, An equilibrium model of organic chemical accumulation in aquatic food webs with sediment interaction, Environ. Toxicol. Chem., 11, 615, 10.1002/etc.5620110505

Thomas, 1992, Arctic terrestrial ecosystem contamination, Sci. Tot. Environ., 122, 135, 10.1016/0048-9697(92)90247-P

Thomas, 1992, Organochlorine endocrine disrupters in human tissue, 365

Toppari, 1996, Male reproductive health and environmental xenoestrogens, Environ. Health Perspect., 104, 741, 10.1289/ehp.96104s4741

Tryphonas, 1991, Effect of chronic exposure of PCB (Aroclor 1254) on specific and non-specific immune parameters in the rhesus (Macaca mulatta) monkey, Fund. Appl. Toxicol., 16, 773, 10.1016/0272-0590(91)90163-X

UN-ECE, 1994. State of knowledge report of the UN ECE task force on persistent organic pollutants (Draft, April 1994). For the UN-ECE Convention on Long-range Transboundary Air Pollution.

UN-ECE, 1998a. Draft Protocol to the Convention on Long-range Air Pollution on Persistent Organic Pollutants, (EB.AIR/1998/2), Convention on Long-range Transboundary Air Pollution, United Nations Economic and Social Council, Economic Commission for Europe.

UN-ECE, 1998b. Draft Executive Body Decision 1998/2 on information to be submitted and the procedure for adding substances to Annexes I, II or II to the POPs Protocol, Convention on Long-range Transboundary Air Pollution, United Nations Economic and Social Council, Economic Commission for Europe.

UNEP, 1996. UNEP survey on sources of POPs, A report prepared for an IFCS expert meeting on persistent organic pollutants, Manila, the Philippines, 17–19 June 1996, UNEP, Geneva. (http://irptc.unep.ch/pops/indxhtms/manexp3.html)

Van Birgelen, 1996, Synergistic effect of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in the rat, Environ. Health Perspect., 104, 550

Van Jaarsveld, 1997, Modelling transport and deposition of persistent organic pollutants in the European region, Atmos. Environ., 31, 1011, 10.1016/S1352-2310(96)00251-8

Van Leeuwen, 1996, Risk assessment and management of new and existing chemicals, Environ. Toxicol. Pharmacol., 2, 243, 10.1016/S1382-6689(96)00072-5

Van Velsen, 1986, The subchronic oral toxicity of the beta-isomer of hexachlorocyclohexane in rats, Fund. Appl. Toxicol., 6, 697, 10.1016/0272-0590(86)90183-1

Vozhzennikov, 1997

Wania, 1997, Obstacles to deriving critical loads for persistent organic pollutants, 1997

Wania, 1993, Global fractionation and cold condensation of low volatility organochlorine compounds in Polar Regions, Ambio, 22, 10

Wania, 1996, Tracking the distribution of persistent organic pollutants, Environ. Sci. Technol., 30, 390, 10.1021/es962399q

Weber, 1996, Organochlorine compounds in fish off the Antarctic Peninsula, Chemosphere, 33, 377, 10.1016/0045-6535(96)00204-4

Weisglas-Kuperus, 1995, Immunological effect of background prenatal and postnatal exposure to dioxins and polychlorinated biphenyls in Dutch infants, Pediatr. Res., 38, 404, 10.1203/00006450-199509000-00022

Weschler, 1981, Identification of selected organics in the arctic aerosol, Atmos. Environ., 15, 1365, 10.1016/0004-6981(81)90342-5

WHO, 1996, Persistent organic pollutants, WHO, Geneva.

Wolfe, D., Marquardt, H., 1993. The tumor promoting potential of plychlorinated dioxins and biphenyls: mechanisms of action in different in vitro assays, in: Fielder, H., Frank, H., Hutzinger, O., Parzefall, W., Riss, A., Safe, S. (Eds.), Dioxin ’93: 13th International Symposium on Chlorinated Dioxins and Related Compounds, (Federal Environmental Agency, Vienna, September 1993) Organohalogen Compounds, Vol. 13, pp. 163–166.

Wolff, 1993, Blood levels of organochlorine residues and risk of breast cancer, J. Nat. Cancer Inst., 85, 648, 10.1093/jnci/85.8.648

Wren, 1991, Cause-effect linkages between chemicals and populations of mink (Mustela vision) and otter (Lutra canadensis) in the Great Lakes basin, J. Toxicol. Environ. Health, 33, 549, 10.1080/15287399109531540

Wynne, 1996, Misunderstood Misunderstandings: social identities and public uptake of science