Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites

Cell Chemical Biology - Tập 29 - Trang 476-489.e6 - 2022
Joyce H. Lee1, Eric P. Mosher2, Young-Sam Lee3, Namandjé N. Bumpus2, James M. Berger1
1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
2Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA
3Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536, USA

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