Control of pRB phosphorylation

Current Opinion in Genetics & Development - Tập 8 Số 1 - Trang 21-27 - 1998
Sibylle Mittnacht1
1Department of Cell and Molecular Biology, Institute of Cancer Research, 237, Fulham Road, London, SW3 6JB, UK

Tóm tắt

Từ khóa


Tài liệu tham khảo

Hall, 1996, Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer, Adv Cancer Res, 68, 67, 10.1016/S0065-230X(08)60352-8

Palmero, 1996, Perturbation of cell cycle regulators in human cancer, Cancer Surv, 27, 351

Sherr, 1995, Inhibitors of mammalian G1 cyclin-dependent kinases, Genes Dev, 9, 1149, 10.1101/gad.9.10.1149

Bartek, 1996, The retinoblastoma protein pathway and the restriction point, Curr Opin Cell Biol, 8, 805, 10.1016/S0955-0674(96)80081-0

DelSal, 1996, Cell cycle and cancer: critical events at the G1 restriction point, Crit Rev Oncogenesis, 7, 127, 10.1615/CritRevOncog.v7.i1-2.80

Sanchez, 1996, Curr Opin Cell Biol, 8, 318, 10.1016/S0955-0674(96)80004-4

Mittnacht, 1994, Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation, EMBO J, 13, 118, 10.1002/j.1460-2075.1994.tb06241.x

Mittnacht, 1991, G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment, Cell, 65, 381, 10.1016/0092-8674(91)90456-9

Buchkovich, 1989, The retinoblastoma protein is phosphorylated during specific phases of the cell cycle, Cell, 58, 1097, 10.1016/0092-8674(89)90508-4

DeCaprio, 1989, The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element, Cell, 58, 1085, 10.1016/0092-8674(89)90507-2

Chen, 1989, Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation, Cell, 58, 1193, 10.1016/0092-8674(89)90517-5

Ludlow, 1990, The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T, Cell, 60, 387, 10.1016/0092-8674(90)90590-B

Mittnacht, 1991, Modulation of retinoblastoma protein activity during the cell cycle, Cold Spring Harb Symp Quant Biol, 56, 197, 10.1101/SQB.1991.056.01.025

Weinberg, 1995, The retinoblastoma protein and cell cycle control, Cell, 81, 323, 10.1016/0092-8674(95)90385-2

Nelson, 1997, High molecular weight protein phosphatase type 1 dephosphorylates the retinoblastoma protein, J Biol Chem, 272, 4528, 10.1074/jbc.272.7.4528

Kwon, 1997, Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase, Proc Natl Acad Sci USA, 94, 2168, 10.1073/pnas.94.6.2168

Puntoni, 1997, Phosphorylation of protein phosphatase-1 isoforms by cdc2-cyclin B in vitro, Mol Cell Biochem, 171, 115, 10.1023/A:1006892103306

Berndt, 1997, Constitutively active protein phophatase 1 alpha causes Rb-dependent G1 arrest in human cancer cells, Curr Biol, 7, 375, 10.1016/S0960-9822(06)00185-0

Dohadwala, 1994, Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases, Proc Natl Acad Sci USA, 91, 6408, 10.1073/pnas.91.14.6408

Ludlow, 1995, Control and activity of type-1 serine/threonine protein phosphatase during the cell cycle, Semin Cancer Biol, 6, 195, 10.1006/scbi.1995.0026

Linke, 1997, p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression, Oncogene, 15, 337, 10.1038/sj.onc.1201200

Amellem, 1996, The retinoblastoma gene product is reversibly dephosphorylated and bound in the nucleus in S and G2 phases during hypoxic stress, Exp Cell Res, 227, 106, 10.1006/excr.1996.0255

Haapajarvi, 1995, Cell cycle dependent effects of UV-radiation on p53 expression and retinoblastoma protein phosphorylation, Oncogene, 11, 151

Yen, 1994, Late dephosphorylation of the RB protein in G2 during the process of induced cell differentiation, Exp Cell Res, 214, 250, 10.1006/excr.1994.1255

Lin, 1991, Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase, EMBO J, 10, 857, 10.1002/j.1460-2075.1991.tb08018.x

Lees, 1991, The retinoblastoma protein is phosphorylated on multiple sites by human cdc2, EMBO J, 10, 4279, 10.1002/j.1460-2075.1991.tb05006.x

DeCaprio, 1992, The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression, Proc Natl Acad Sci USA, 89, 1795, 10.1073/pnas.89.5.1795

Kitagawa, 1996, The consensus motif for phosphorylation by cyclin D1—Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2, EMBO J, 15, 7060, 10.1002/j.1460-2075.1996.tb01097.x

Zarkowska, 1997, Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs, Oncogene, 14, 249, 10.1038/sj.onc.1200824

Zarkowska, 1997, Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases, J Biol Chem, 272, 12738, 10.1074/jbc.272.19.12738

Gu, 1992, Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15, EMBO J, 11, 3995, 10.1002/j.1460-2075.1992.tb05493.x

Matsuoka, 1994, Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase, Mol Cell Biol, 14, 7265, 10.1128/MCB.14.11.7265

Perez, 1997, Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes, Oncogene, 14, 2373, 10.1038/sj.onc.1201197

Matsushime, 1994, D-type cyclin-dependent kinase activity in mammalian cells, Mol Cell Biol, 14, 2066, 10.1128/MCB.14.3.2066

Massagué, 1995, Mammalian antiproliferative signals and their targets, Curr Opin Genet Dev, 5, 91, 10.1016/S0959-437X(95)90059-4

Polyak, 1994, p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest, Genes Dev, 8, 9, 10.1101/gad.8.1.9

Li, 1995, Transforming growth factor-β activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site, J Biol Chem, 270, 26750, 10.1074/jbc.270.45.26750

Chin, 1996, Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1, Science, 272, 719, 10.1126/science.272.5262.719

Harvat, 1997, The role of p27Kip1 in gamma interferon-mediated growth arrest of mammary epithelial cells and related defects in mammary carcinoma cells, Oncogene, 14, 2111, 10.1038/sj.onc.1201055

Kuniyasu, 1997, Growth inhibitory effect of interferon-beta is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line, Cell Growth Differ, 8, 47

Sangfelt, 1997, Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-alpha in hematopoietic cell lines, Oncogene, 14, 415, 10.1038/sj.onc.1200832

Koff, 1993, Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β, Science, 260, 536, 10.1126/science.8475385

Reynisdottir, 1995, Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β, Genes Dev, 9, 1831, 10.1101/gad.9.15.1831

Iavarone, 1997, Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15, Nature, 387, 417, 10.1038/387417a0

Tiefenbrun, 1996, Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest, Mol Cell Biol, 16, 3934, 10.1128/MCB.16.7.3934

Peeper, 1997, Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein, Nature, 386, 177, 10.1038/386177a0

Mittnacht, 1997, Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein, Curr Biol, 7, 219, 10.1016/S0960-9822(97)70094-0

Filmus, 1994, Induction of cyclin D1 overexpression by activated ras, Oncogene, 9, 3627

Liu, 1995, Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells, Mol Cell Biol, 15, 3654, 10.1128/MCB.15.7.3654

Albanese, 1995, Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions, J Biol Chem, 270, 23589, 10.1074/jbc.270.40.23589

Lavoie, 1996, Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway, J Biol Chem, 271, 20608, 10.1074/jbc.271.34.20608

Steiner, 1995, Identification of a Myc-dependent step during the formation of active G1 cyclin—cdk complexes, EMBO J, 14, 4814, 10.1002/j.1460-2075.1995.tb00163.x

Vlach, 1996, Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc, EMBO J, 15, 6595, 10.1002/j.1460-2075.1996.tb01050.x

Galaktionov, 1996, Cdc25 cell-cycle phosphatase as a target of c-myc, Nature, 382, 511, 10.1038/382511a0

Koff, 1992, Formation and activation of a cyclin E—cdk2 complex during the G1 phase of the human cell cycle, Science, 257, 1689, 10.1126/science.1388288

Sheaff, 1997, Cyclin E—CDK2 is a regulator of p27Kip1, Genes Dev, 11, 1464, 10.1101/gad.11.11.1464

Hirai, 1997, Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells, J Biol Chem, 272, 13, 10.1074/jbc.272.1.13

Rodriguez, 1994, Phosphatidylinositol-3-OH kinase as a direct target of Ras [see comments], Nature, 370, 527, 10.1038/370527a0

Ridley, 1994, Signal transduction through the GTP-binding proteins Rac and Rho, J Cell Sci, 18, 127, 10.1242/jcs.1994.Supplement_18.19

Connell-Crowley, 1997, Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation, Mol Biol Cell, 8, 287, 10.1091/mbc.8.2.287

Hinds, 1992, Regulation of retinoblastoma protein functions by ectopic expression of human cyclins, Cell, 70, 993, 10.1016/0092-8674(92)90249-C

Ewen, 1993, Functional interactions of the retinoblastoma protein with mammalian D-type cyclins, Cell, 73, 487, 10.1016/0092-8674(93)90136-E

Knudsen, 1996, Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites, J Biol Chem, 271, 8313, 10.1074/jbc.271.14.8313

Leone, 1997, Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F, Nature, 387, 422, 10.1038/387422a0

Alevizopoulos, 1997, Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins, EMBO J, 16, 5322, 10.1093/emboj/16.17.5322

Lukas, 1997, Cyclin E-induced S phase without activation of the pRb/E2F pathway, Genes Dev, 11, 1479, 10.1101/gad.11.11.1479

Hurford, 1997, pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes, Genes Dev, 11, 1447, 10.1101/gad.11.11.1447

Geng, 1996, Regulation of cyclin E transcription by E2Fs and retinoblastoma protein, Oncogene, 12, 1173

White, 1997, Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?, Tr Biochem Sci, 22, 77, 10.1016/S0968-0004(96)10067-0