Contributions of individual layer 2–5 spiny neurons to local circuits in macaque primary visual cortex

Visual Neuroscience - Tập 13 Số 5 - Trang 907-922 - 1996
Edward M. Callaway1, Anne K. Wiser1
1Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla

Tóm tắt

AbstractWe studied excitatory local circuits in the macaque primary visual cortex (V1) to investigate their relationships to the magnocellular (M) and parvocellular (P) streams. Sixty-two intracellularly labeled spiny neurons in layers 2–5 were analyzed. We made detailed observations of the laminar and columnar specificity of axonal arbors and noted correlations with dendritic arbors. We find evidence for considerable mixing of M and P streams by the local circuitry in V1. Such mixing is provided by neurons in the primary geniculate recipient layer 4C, as well as by neurons in both the supragranular and infragranular layers. We were also interested in possible differences in the axonal projections of neurons with different dendritic morphologies. We found that layer 4B spiny stellate and pyramidal neurons have similar axonal arbors. However, we identified two types of layer 5 pyramidal neuron. The majority have a conventional pyramidal dendritic morphology, a dense axonal arbor in layers 2–4B, and do not project to the white matter. Layer 5 projection neurons have an unusual “backbranching” dendritic morphology (apical dendritic branches arc downward rather than upward) and weak or no axonal arborization in layers 2–4B, but have long horizontal axonal projections in layer 5B. We find no strong projection from layer 5 pyramidal neurons to layer 6. In macaque V1 there appears to be no single source of strong local input to layer 6; only a minority of cells in layers 2–5 have axonal branches in layer 6 and these are sparse. Our results suggest that local circuits in V1 mediate interactions between M and P input that are complex and not easily incorporated into a simple framework.

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Tài liệu tham khảo

10.1146/annurev.ne.06.030183.001245

Livingstone, 1984, Journal of Neuroscience, 4, 2830, 10.1523/JNEUROSCI.04-11-02830.1984

Fitzpatrick, 1985, Journal of Neuroscience, 5, 3329, 10.1523/JNEUROSCI.05-12-03329.1985

10.1017/S0952523800002406

Casagrande, 1995, Cerebral Cortex, Vol. 10, 201

Wiser, 1996, Journal of Neuroscience, 16, 2724, 10.1523/JNEUROSCI.16-08-02724.1996

Callaway, 1993, Society for Neuroscience Abstracts, 19, 240

Valverde, 1985, Cerebral Cortex, Vol. 3, 207

Callaway, 1992, Journal of Neuroscience, 12, 570, 10.1523/JNEUROSCI.12-02-00570.1992

Usrey, 1994, Society for Neuroscience Abstracts, 20, 1578

Blasdel, 1985, Journal of Neuroscience, 5, 3350, 10.1523/JNEUROSCI.05-12-03350.1985

Blasdel, 1984, Journal of Neuroscience, 4, 880, 10.1523/JNEUROSCI.04-03-00880.1984

10.1111/j.1460-9568.1989.tb00798.x

10.1016/0165-0270(89)90131-3

10.1038/380442a0

10.1093/cercor/3.5.412

10.1002/cne.902330205

Nealey, 1994, Journal of Neuroscience, 14, 2069, 10.1523/JNEUROSCI.14-04-02069.1994

10.1146/annurev.ne.16.030193.002101

10.1002/cne.903050303

10.1002/cne.902210106

Martin, 1984, Journal of Physiology, 353, 463, 10.1113/jphysiol.1984.sp015347

Martin, 1984, Cerebral Cortex, Vol. 2, 241, 10.1007/978-1-4615-6610-6_9

10.1093/cercor/3.2.148

10.1002/cne.901760203

10.1002/cne.901640303

10.1073/pnas.89.8.3566

Katz, 1989, Journal of Neuroscience, 9, 1389, 10.1523/JNEUROSCI.09-04-01389.1989

Katz, 1987, Journal of Neuroscience, 7, 1223, 10.1523/JNEUROSCI.07-04-01223.1987

10.1002/cne.903240106

Horton, 1996, Journal of Neuroscience, 16, 1791, 10.1523/JNEUROSCI.16-05-01791.1996

10.1098/rstb.1984.0021

Gilbert, 1983, Journal of Neuroscience, 3, 1116, 10.1523/JNEUROSCI.03-05-01116.1983

10.1038/280120a0

10.1002/cne.901590303

10.1146/annurev.ne.11.030188.001345

10.1002/cne.902570106

10.1002/cne.901470404

Fitzpatrick, 1994, Visual Neuroscience, 11, 307, 10.1017/S0952523800001656

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Visual Neuroscience

Tập 13 Số 5

907-922

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