Contribution of systemic and airway immune responses to pediatric obesity-related asthma

Tajima, 2019, Obesity and adiposity indicators in asthma and allergic rhinitis in children, Curr Opin Allergy Clin Immunol, 19, 7, 10.1097/ACI.0000000000000504 Lang, 2018, Being overweight or obese and the development of asthma, Pediatrics, 142, 10.1542/peds.2018-2119 Schatz, 2014, Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma, J Allergy Clin Immunol, 133, 1549, 10.1016/j.jaci.2013.10.006 Gold, 2003, Body-mass index as a predictor of incident asthma in a prospective cohort of children, Pediatr Pulmonol, 36, 514, 10.1002/ppul.10376 Rzehak, 2013, Body mass index trajectory classes and incident asthma in childhood: results from 8 European Birth Cohorts–a Global Allergy and Asthma European Network initiative, J Allergy Clin Immunol, 131, 1528, 10.1016/j.jaci.2013.01.001 Gilliland, 2003, Obesity and the risk of newly diagnosed asthma in school-age children, Am J Epidemiol, 158, 406, 10.1093/aje/kwg175 Chen, 2013, Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis, Obes Rev, 14, 222, 10.1111/j.1467-789X.2012.01055.x Egan, 2013, Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies, BMC pediatrics, 13, 121, 10.1186/1471-2431-13-121 Borrell, 2013, Childhood obesity and asthma control in the GALA II and SAGE II studies, Am J Respir Crit Care Med, 187, 697, 10.1164/rccm.201211-2116OC McGarry, 2015, Obesity and bronchodilator response in black and Hispanic children and adolescents with asthma, Chest, 147, 1591, 10.1378/chest.14-2689 Forno, 2011, Decreased response to inhaled steroids in overweight and obese asthmatic children, J Allergy Clin Immunol, 127, 741, 10.1016/j.jaci.2010.12.010 Weinmayr, 2014, Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two, PLoS One, 9, 10.1371/journal.pone.0113996 Artis, 2015, The biology of innate lymphoid cells, Nature, 517, 293, 10.1038/nature14189 Dalmas, 2011, Defining macrophage phenotype and function in adipose tissue, Trends Immunol, 32, 307, 10.1016/j.it.2011.04.008 Zeyda, 2007, Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production, Int J Obes (Lond), 31, 1420, 10.1038/sj.ijo.0803632 Fantuzzi, 2005, Adipose tissue, adipokines, and inflammation, J Allergy Clin Immmunol, 115, 911, 10.1016/j.jaci.2005.02.023 Ferrante, 2007, Obesity-induced inflammation: a metabolic dialogue in the language of inflammation, J Intern Med, 262, 408, 10.1111/j.1365-2796.2007.01852.x Ferrante, 2013, The immune cells in adipose tissue, Diabetes Obes Metab, 15, 34, 10.1111/dom.12154 van Huisstede, 2013, Systemic inflammation and lung function impairment in morbidly obese subjects with metabolic syndrome, J Obes, 131349 Rastogi, 2015, Inflammation, metabolic dysregulation and pulmonary function among obese asthmatic urban adolescents, Am J Resp Crit Care Med, 191, 149, 10.1164/rccm.201409-1587OC Fantuzzi, 1999, Loss of CCR2 expression and functional response to monocyte chemotactic protein (MCP-1) during the differentiation of human monocytes: role of secreted MCP-1 in the regulation of the chemotactic response, Blood, 94, 875, 10.1182/blood.V94.3.875.415k28_875_883 Periyalil, 2015, Macrophage activation, age and sex effects of immunometabolism in obese asthma, Eur Respir J, 45, 388, 10.1183/09031936.00080514 Tashiro, 2017, Saturated fatty acid increases lung macrophages and augments house dust mite-induced airway inflammation in mice fed with high-fat diet, Inflammation, 40, 1072, 10.1007/s10753-017-0550-4 Diaz, 2015, Obesity shifts house dust mite-induced airway cellular infiltration from eosinophils to macrophages: effects of glucocorticoid treatment, Immunol Res, 63, 197, 10.1007/s12026-015-8717-2 Wood, 2018, Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients, J Allergy Clin Immunol Kim, 2015, Obesity increases airway hyperresponsiveness via the TNF-alpha pathway and treating obesity induces recovery, PLoS One, 10, 10.1371/journal.pone.0116540 Periyalil, 2018, Obese asthmatics are characterized by altered adipose tissue macrophage activation, Clin Exp Allergy, 48, 641, 10.1111/cea.13109 Sideleva, 2012, Obesity and asthma: an inflammatory disease of adipose tissue not the airway, Am J Resp Crit Care Med, 186, 598, 10.1164/rccm.201203-0573OC Fernandez-Boyanapalli, 2013, Obesity impairs apoptotic cell clearance in asthma, J Allergy Clin Immmunol, 131, 1041, 10.1016/j.jaci.2012.09.028 Elliott, 2017, Efferocytosis signaling in the regulation of macrophage inflammatory responses, J Immunol, 198, 1387, 10.4049/jimmunol.1601520 Morita, 2016, Innate lymphoid cells in allergic and nonallergic inflammation, J Allergy Clin Immunol, 138, 1253, 10.1016/j.jaci.2016.09.011 Everaere, 2018, Innate lymphoid cells at the interface between obesity and asthma, Immunology, 153, 21, 10.1111/imm.12832 Kim, 2012, Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity, J Allergy Clin Immunol, 129, 10.1016/j.jaci.2011.10.036 Kim, 2014, Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity, Nat Med, 20, 54, 10.1038/nm.3423 Wu, 2018, Obesity may provide Pro-ILC3 development inflammatory environment in asthmatic children, J Immunol Res, 2018, 1628620, 10.1155/2018/1628620 Walker, 2013, Development and function of group 2 innate lymphoid cells, Curr Opin Immunol, 25, 148, 10.1016/j.coi.2013.02.010 Everaere, 2016, Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity, J Allergy Clin Immunol, 138, 10.1016/j.jaci.2016.03.019 Zheng, 2016, Leptin enhances TH2 and ILC2 responses in allergic airway disease, J Biol Chem, 291, 22043, 10.1074/jbc.M116.743187 Matarese, 2010, Regulatory T cells in obesity: the leptin connection, Trends Mol Med, 16, 247, 10.1016/j.molmed.2010.04.002 Kay, 2001, Allergy and allergic diseases, N Engl J Med, 344, 30, 10.1056/NEJM200101043440106 Tateda, 2001, Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia, J Immunol, 66, 3355, 10.4049/jimmunol.166.5.3355 Busse, 2001, Asthma, N Engl J Med, 344, 350, 10.1056/NEJM200102013440507 Jensen, 2013, Airway and systemic inflammation in obese children with asthma, Eur Respir J, 42, 1012, 10.1183/09031936.00124912 Rastogi, 2012, Obesity-associated asthma in children: A distinct entity, Chest, 141, 895, 10.1378/chest.11-0930 Rastogi, 2018, CDC42-related genes are upregulated in T helper cells from obese asthmatic children, J Allergy Clin Immunol, 141, 539, 10.1016/j.jaci.2017.04.016 van Panhuys, 2016, TCR signal strength alters T-DC activation and interaction times and directs the outcome of differentiation, Front Immunol, 7, 6, 10.3389/fimmu.2016.00006 Chemin, 2012, Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity, J Immunol, 189, 2159, 10.4049/jimmunol.1200156 Melendez, 2011, Signaling role of Cdc42 in regulating mammalian physiology, J Biol Chem, 286, 2375, 10.1074/jbc.R110.200329 Uddin, 2010, Prosurvival activity for airway neutrophils in severe asthma, Thorax, 65, 684, 10.1136/thx.2009.120741 Telenga, 2012, Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response, Allergy, 67, 1060, 10.1111/j.1398-9995.2012.02855.x Scott, 2016, Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype, Allergy, 71, 1037, 10.1111/all.12891 Fu, 2013, Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma, OMICS, 17, 187, 10.1089/omi.2012.0104 Rhee, 2018, Blood neutrophil count is associated with body mass index in adolescents with asthma, JSM Allergy Asthma, 3 Huang, 1999, Association between body mass index and allergy in teenage girls in Taiwan, Clin Exp Allergy, 29, 323, 10.1046/j.1365-2222.1999.00455.x Guler, 2004, Leptin: does it have any role in childhood asthma?, J Allergy Clin Immunol, 114, 254, 10.1016/j.jaci.2004.03.053 Santamaria, 2005, Relationship between exhaled nitric oxide and body mass index in children and adolescents, J Allergy Clin Immunol, 116, 1163, 10.1016/j.jaci.2005.07.018 Han, 2014, Adiposity, fractional exhaled nitric oxide, and asthma in U.S. children, Am J Resp Crit Care Med, 190, 32, 10.1164/rccm.201403-0565OC Holguin, 2011, Obesity and asthma: an association modified by age of asthma onset, J Allergy Clin Immunol, 127, 10.1016/j.jaci.2011.03.036 Dixon, 2016, Mechanisms of asthma in obesity. Pleiotropic aspects of obesity produce distinct asthma phenotypes, Am J Respir Cell Mol Biol, 54, 601, 10.1165/rcmb.2016-0017PS To, 2004, Is obesity associated with asthma in young children?, J Pediatr, 144, 162, 10.1016/j.jpeds.2003.09.047 Musaad, 2009, Comparison of anthropometric measures of obesity in childhood allergic asthma: Central obesity is most relevant, J Allergy Clin Immunol, 123, 1321, 10.1016/j.jaci.2009.03.023 Rastogi, 2014, Association of pulmonary function with adiposity and metabolic abnormalities in urban minority adolescents, Ann Amer Thor Soc, 11, 744, 10.1513/AnnalsATS.201311-403OC Sideleva, 2014, The many faces of asthma in obesity, J Cell Biochem, 115, 421, 10.1002/jcb.24678 Grotta, 2013, Obesity increases eosinophil activity in asthmatic children and adolescents, BMC Pulm Med, 13, 39, 10.1186/1471-2466-13-39 Desai, 2013, Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma, Am J Resp Crit Care Med, 188, 657, 10.1164/rccm.201208-1470OC Scott, 2013, Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial, Clin Experiment Allergy, 43, 36, 10.1111/cea.12004 Williams, 2013, Obesity and airway responsiveness: role of TNFR2, Pulm Pharmacol Ther, 26, 444, 10.1016/j.pupt.2012.05.001 Silva, 2017, Obesity promotes prolonged ovalbumin-induced airway inflammation modulating T helper type 1 (Th1), Th2 and Th17 immune responses in BALB/c mice, Clin Exp Immunol, 189, 47, 10.1111/cei.12958 Johnston, 2007, Allergic airway responses in obese mice, Am J Respir Crit Care Med, 176, 650, 10.1164/rccm.200702-323OC Yanagisawa, 2014, Obese mice are resistant to eosinophilic airway inflammation induced by diesel exhaust particles, J Appl Toxicol, 34, 688, 10.1002/jat.2925 Kim, 2011, Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines, Am J Pathol, 179, 2730, 10.1016/j.ajpath.2011.08.008 Shore, 2007, Obesity and asthma: lessons from animal models, J Appl Physiol, 102, 516, 10.1152/japplphysiol.00847.2006 Calixto, 2010, Obesity enhances eosinophilic inflammation in a murine model of allergic asthma, Br J Pharmacol, 159, 617, 10.1111/j.1476-5381.2009.00560.x Dietze, 2012, Obesity lowers the threshold of allergic sensitization and augments airway eosinophilia in a mouse model of asthma, Allergy, 67, 1519 Murphy, 2009, PRKCA: a positional candidate gene for body mass index and asthma, Am J Hum Genet, 85, 87, 10.1016/j.ajhg.2009.06.011 Melen, 2010, Analyses of shared genetic factors between asthma and obesity in children, J Allergy Clin Immunol, 126, 10.1016/j.jaci.2010.06.030 Rastogi, 2013, Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma, Sci Rep, 3, 2164, 10.1038/srep02164 Jeong, 2019, DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma, Int J Environ Res Public Health, 16, 10.3390/ijerph16040600 Morjaria, 2008, The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial, Thorax, 63, 584, 10.1136/thx.2007.086314 Howarth, 2005, Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma, Thorax, 60, 1012, 10.1136/thx.2005.045260 Rennard, 2007, The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease, Am J Resp Crit Care Med, 175, 926, 10.1164/rccm.200607-995OC Leung, 2004, The relation between obesity and asthmatic airway inflammation, Pediatr Allergy Immunol, 15, 344, 10.1111/j.1399-3038.2004.00164.x