Contribution of comorbidities to functional impairment is higher in heart failure with preserved than with reduced ejection fraction

Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G et al (2010) Heart disease and stroke statistics–2010 update: a report from the American Heart Association. Circulation 121(7):e46–e215

Kitzman DW, Groban L (2008) Exercise intolerance. Heart Fail Clin 4(1):99–115

Krum H, Gilbert RE (2003) Demographics and concomitant disorders in heart failure. Lancet 362(9378):147–158

Braunstein JB, Anderson GF, Gerstenblith G, Weller W, Niefeld M, Herbert R et al (2003) Noncardiac comorbidity increases preventable hospitalizations and mortality among Medicare beneficiaries with chronic heart failure. J Am Coll Cardiol 42(7):1226–1233

Kitzman DW, Little WC, Brubaker PH, Anderson RT, Hundley WG, Marburger CT et al (2002) Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA 288(17):2144–2150

Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM (2006) Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355(3):251–259. doi: 10.1056/NEJMoa052256

Lee DS, Gona P, Vasan RS, Larson MG, Benjamin EJ, Wang TJ et al (2009) Relation of Disease Pathogenesis and Risk Factors to Heart Failure With Preserved or Reduced Ejection Fraction: Insights From the Framingham Heart Study of the National Heart, Lung, and Blood Institute. Circulation 119(24):3070–3077. doi: 10.1161/CIRCULATIONAHA.108.815944

Ahmed A, Rich MW, Fleg JL, Zile MR, Young JB, Kitzman DW et al (2006) Effects of digoxin on morbidity and mortality in diastolic heart failure: the Ancillary Digitalis Investigation Group Trial. Circulation 114(5):397–403

Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ et al (2003) Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 362(9386):777–781

Perez de Isla L, Canadas V, Contreras L, Almeria C, Rodrigo JL, Aubele AL et al (2009) Diastolic heart failure in the elderly: in-hospital and long-term outcome after the first episode. Int J Cardiol 134(2):265–270

Shah SJ, Gheorghiade M (2008) Heart failure with preserved ejection fraction: treat now by treating comorbidities. JAMA 300(4):431–433

Mehrhof F, Loffler M, Gelbrich G, Ozcelik C, Posch M, Hense HW, et al. (2009 Aug 11) A network against failing hearts-Introducing the German “Competence Network Heart Failure”. Int J Cardiol

Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130(6):461–470

Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30(6):473–483

Kinsella KaWH, U.S. Census Bureau. P95/09-1, An Aging World: 2008. International Population Reports. Washington, DC: U.S. Government Printing Office; 2009

Lakhan SE, Laird C (2009) Addressing the primary care physician shortage in an evolving medical workforce. Int Arch Med 2(1):14

Primary Care Professionals: Recent Supply Trends, Projections, and Valuation of Services: United States Government Accountability Office (2008)

Redelmeier DA, Tan SH, Booth GL (1998) The treatment of unrelated disorders in patients with chronic medical diseases. N Engl J Med 338(21):1516–1520

von Haehling S, Schefold JC, Hodoscek LM, Doehner W, Mannaa M, Anker SD et al (2010) Anaemia is an independent predictor of death in patients hospitalized for acute heart failure. Clin Res Cardiol 99(2):107–113

Luderitz B, Jung W (2000) Quality of life in patients with atrial fibrillation. Arch Intern Med 160(12):1749–1757

Odden MC, Whooley MA, Shlipak MG (2004) Association of chronic kidney disease and anemia with physical capacity: the heart and soul study. J Am Soc Nephrol 15(11):2908–2915

O’Donnell DE, Laveneziana P (2007) Dyspnea and activity limitation in COPD: mechanical factors. COPD 4(3):225–236

Saraiva RM, Duarte DM, Duarte MP, Martins AF, Poltronieri AV, Ferreira ME et al (2005) Tissue Doppler imaging identifies asymptomatic normotensive diabetics with diastolic dysfunction and reduced exercise tolerance. Echocardiography 22(7):561–570

Ronco C, Haapio M, House AA, Anavekar N, Bellomo R (2008) Cardiorenal syndrome. J Am Coll Cardiol 52(19):1527–1539

Anker SD, Doehner W, Rauchhaus M, Sharma R, Francis D, Knosalla C et al (2003) Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging. Circulation 107(15):1991–1997

Guder G, Frantz S, Bauersachs J, Allolio B, Wanner C, Koller MT et al (2009) Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factors. Circ Heart Fail 2(6):563–571

Lam CS, Roger VL, Rodeheffer RJ, Bursi F, Borlaug BA, Ommen SR et al (2007) Cardiac structure and ventricular–vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota. Circulation 115(15):1982–1990

Levy D, Anderson KM, Savage DD, Kannel WB, Christiansen JC, Castelli WP (1988) Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. The Framingham Heart Study. Ann Intern Med 108(1):7–13

Dwyer EM, Asif M, Ippolito T, Gillespie M (2000) Role of hypertension, diabetes, obesity, and race in the development of symptomatic myocardial dysfunction in a predominantly minority population with normal coronary arteries. Am Heart J 139(2 Pt 1):297–304

Correa de Sa DD, Hodge DO, Slusser JP, Redfield MM, Simari RD, Burnett JC et al (2010) Progression of preclinical diastolic dysfunction to the development of symptoms. Heart 96(7):528–532

Paulus WJ, van Ballegoij JJ (2010) Treatment of heart failure with normal ejection fraction: an inconvenient truth!. J Am Coll Cardiol 55(6):526–537

Liao L, Jollis JG, Anstrom KJ, Whellan DJ, Kitzman DW, Aurigemma GP et al (2006) Costs for heart failure with normal vs reduced ejection fraction. Arch Intern Med 166(1):112–118

Alla F, Al-Hindi AY, Lee CR, Schwartz TA, Patterson JH, Adams KF Jr (2007) Relation of sex to morbidity and mortality in patients with heart failure and reduced or preserved left ventricular ejection fraction. Am Heart J 153(6):1074–1080

Kamp O, Metra M, De Keulenaer GW, Pieske B, Conraads V, Zamorano J et al (2010) Effect of the long-term administration of nebivolol on clinical symptoms, exercise capacity and left ventricular function in patients with heart failure and preserved left ventricular ejection fraction: background, aims and design of the ELANDD study. Clin Res Cardiol 99(2):75–82

Bursi F, Weston SA, Redfield MM, Jacobsen SJ, Pakhomov S, Nkomo VT et al (2006) Systolic and diastolic heart failure in the community. JAMA 296(18):2209–2216