Contribution of Extracellular Signal-Regulated Kinase to UTP-Induced Interleukin-6 Biosynthesis in HaCaT Keratinocytes

1 Neuner P, Urbanski A, Trautinger F, Moller A, Kirnbauer R, Kapp A, et al. Increased IL-6 production by monocytes and keratinocytes in patients with psoriasis. J Invest Dermatol. 1991;97:27–33. 2 Torseth JW, Nickoloff BJ, Basham TY, Merigan TC. Beta interferon produced by keratinocytes in human cutaneous infection with herpes simplex virus. J Infect Dis. 1987;155:641–648. 10.1042/BJ20031089 10.1073/pnas.1834448100 5 Novak I. ATP as a signaling molecule: the exocrine focus. News Physiol Sci. 2003;18:12–17. 10.1016/S0165-6147(96)01023-1 SCHWIEBERT E M, 2003, 1615, 7 8 North RA. Molecular physiology of P2X receptors. Physiol Rev. 2002;82:1013–1067. 10.1113/jphysiol.2005.088435 10 Koles L, Furst S, Illes P. P2X and P2Y receptors as possible targets of therapeutic manipulations in CNS illnesses. Drug News Perspect. 2005;18:85–101. 10.1007/s002100000310 12 Kameda T, Matsuzaki N, Sawai K, Okada T, Saji F, Matsuda T, et al. Production of interleukin-6 by normal human trophoblast. Placenta. 1990;11:205–213. ZHONG J, 1999, 19, 4305, 10.1523/JNEUROSCI.19-11-04305.1999 14 Matsubara M, Tamura T, Ohmori K, Hasegawa K. Histamine H₁ receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca²⁺-dependent protein kinase C, Raf/MEK/ERK and IKK/IκB/NF-κB signal cascades. Biochem Pharmacol. 2005;69:433–449. 10.1126/science.1072682 MATSUBARA M, 2004, 566, 195, 10.1016/j.febslet.2004.04.028 17 Burrell HE, Bowler WB, Gallagher JA, Sharpe GR. Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y₁, P2Y₂, and P2Y₄ receptors. J Invest Dermatol. 2003;120:440–447. 10.1038/sj.bjp.0702653 19 Yoshida H, Kobayashi D, Ohkubo S, Nakahata N. ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes. Eur J Pharmacol. 2006;540:1–9. 20 Chae HJ, Byun JO, Chae SW, Kim HM, Choi HI, Pae HO, et al. p38 MAPK and NF-κB on IL-6 release in human gingival fibroblasts. Immunopharmacol Immunotoxicol. 2005;27:631–646. 10.1254/jphs.FP0050839 22 Fima E, Shahaf G, Hershko T, Apte RN, Livneh E. Expression of PKCε in NIH-3T3 cells promotes production of the pro-inflammatory cytokine interleukin-6. Eur Cytokine Netw. 1999;10:491–500. BOYER J L, 2000, 57, 805, 10.1124/mol.57.4.805 10.1074/jbc.M504819200 25 Hill BJ, Sturek M. Pharmacological characterization of a UTP-sensitive P2Y nucleotide receptor in organ cultured coronary arteries. Vascul Pharmacol. 2002;39:83–88. 26 Yang X, Zhu MJ, Sreejayan N, Ren J, Du M. Angiotensin II promotes smooth muscle cell proliferation and migration through release of heparin-binding epidermal growth factor and activation of EGF-receptor pathway. Mol Cells. 2005;20:263–270. 27 Li DQ, Luo L, Chen Z, Kim HS, Song XJ, Pflugfelder SC. JNK and ERK MAP kinases mediate induction of IL-1β, TNF-α and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006;82:588–596. 28 Schafer R, Sedehizade F, Welte T, Reiser G. ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells. Am J Physiol Lung Cell Mol Physiol. 2003;285:L376–L385. 10.1096/fj.02-0037rev 30 Dobrydneva Y, Blackmore P. 2-Aminoethoxydiphenyl borate directly inhibits store-operated calcium entry channels in human platelets. Mol Pharmacol. 2001;60:541–552. 10.1038/sj.bjp.0706197 32 Cadwallader K, Beltman J, McCormick F, Cook S. Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca²⁺ and protein kinase C in endothelin-stimulated Rat-1 cells. Biochem J. 1997;321:795–804. 1994, 304, 611, 10.1042/bj3040611 10.1242/jcs.02436 10.1074/jbc.271.38.23512 10.1074/jbc.M502593200 37 Mackay AR, Ballin M, Pelina MD, Farina AR, Nason AM, Hartzler JL, et al. Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines. Invasion Metastasis. 1992;12:168–184. WOO MOON-SOOK, 2005, 335, 1017, 10.1016/j.bbrc.2005.07.174 39 Wang F, Zhang XL, Zhou Y, Ye L, Qi Z, Wu J. Type IVB piliated Salmonella typhi enhance IL-6 and NF-κB production in human monocytic THP-1 cells through activation of protein kinase C. Immunobiology. 2005;210:283–293. 40 Milenkovic I, Weick M, Wiedemann P, Reichenbach A, Bringmann A. P2Y receptor-mediated stimulation of Muller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation. Invest Ophthalmol Vis Sci. 2003;44:1211–1220. 10.1042/BJ20021030 10.1074/jbc.M312230200 43 Wu SS, Jacamo RO, Vong SK, Rozengurt E. Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in intestinal epithelial cells: roles of calcium, Src, Rho kinase, and the cytoskeleton. Cell Signal. 2006;18:1932–1940.