Continuous preparation for rifampicin

Journal of Flow Chemistry - Tập 8 - Trang 129-138 - 2018
Xin Li1, Zhuang Liu1, Hao Qi1, Zheng Fang1, Siyu Huang1, Shanshan Miao1, Kai Guo1,2
1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
2State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China

Tóm tắt

To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

Tài liệu tham khảo

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