Continuous flow scale-up of biofunctionalized defective ZnO quantum dots: A safer inorganic ingredient for skin UV protection

Yuan, 2010, New generation of chitosan-encapsulated ZnO quantum dots loaded with drug: synthesis, characterization and in vitro drug delivery response, Acta Biomater., 6, 2732, 10.1016/j.actbio.2010.01.025 Cai, 2016, pH-Sensitive ZnO quantum dots–doxorubicin nanoparticles for lung cancer targeted drug delivery, ACS Appl. Mater. Interfaces, 8, 22442, 10.1021/acsami.6b04933 Gangadoo, 2022, Probing nanoscale interactions of antimicrobial zinc oxide quantum dots on bacterial and fungal cell surfaces, Adv. Mater. Interfaces, 9 (3) van Dijken, 2000, Influence of adsorbed oxygen on the emission properties of nanocrystalline ZnO particles, J. Phys. Chem. B, 104, 4355, 10.1021/jp993998x Asok, 2012, Enhanced visible photoluminescence in ZnO quantum dots by promotion of oxygen vacancy formation, Nanoscale, 4, 4943, 10.1039/c2nr31044a Yang, 2008, Synthesis of nanocrystals via microreaction with temperature gradient: towards separation of nucleation and growth, Lab Chip, 8, 451, 10.1039/b715540a Günther, 2004, Transport and reaction in microscale segmented gas–liquid flow, Lab Chip, 4, 278, 10.1039/B403982C Knauer, 2021, Electrostatic control of au nanorod formation in automated microsegmented flow synthesis, ACS Appl. Nano Mater., 4, 1411, 10.1021/acsanm.0c02941 Wu, 2018, Continuous synthesis of tuneable sized silver nanoparticles via a tandem seed-mediated method in coiled flow inverter reactors, React. Chem. Eng., 3, 267, 10.1039/C7RE00194K Ginzburg, 2021, Zinc oxide-induced changes to sunscreen ingredient efficacy and toxicity under UV irradiation, Photochem. Photobiol. Sci., 20, 1273, 10.1007/s43630-021-00101-2 Tran, 2011, Potential photocarcinogenic effects of nanoparticle sunscreens, Australas. J. Dermatol., 52, 1, 10.1111/j.1440-0960.2010.00677.x Lewicka, 2013, Photochemical behavior of nanoscale TiO2 and ZnO sunscreen ingredients, J. Photochem. Photobiol. A Chem., 263, 24, 10.1016/j.jphotochem.2013.04.019 Osmond, 2010, Zinc oxide nanoparticles in modern sunscreens: an analysis of potential exposure and hazard, Nanotoxicology, 4, 15, 10.3109/17435390903502028 Asok, 2015, Defect-rich ZnO quantum dots as a potential multifunctional sunscreen and cosmetic active ingredient, Pure Appl. Chem., 87, 971, 10.1515/pac-2015-0307 Jose, 2004, Synthesis of CdTe quantum dots using a heterogeneous process at low temperature and their optical and structural properties, Appl. Phys. A, 79, 1833, 10.1007/s00339-004-2937-y Rempel, 2009, Insights into the kinetics of semiconductor nanocrystal nucleation and growth, J. Am. Chem. Soc., 131, 4479, 10.1021/ja809156t Thanh, 2014, Mechanisms of nucleation and growth of nanoparticles in solution, Chem. Rev., 114, 7610, 10.1021/cr400544s Lauritsen, 2010, Atomic resolution non-contact atomic force microscopy of clean metal oxide surfaces, J. Phys. Condens. Matter, 22, 10.1088/0953-8984/22/26/263001 Barnard, 2010, One-to-one comparison of sunscreen efficacy, aesthetics and potential nanotoxicity, Nat. Nanotechnol., 5, 271, 10.1038/nnano.2010.25 Gong, 2007, Origin of defect-related green emission from ZnO nanoparticles: effect of surface modification, Nanoscale Res. Lett., 2, 297, 10.1007/s11671-007-9064-6 Brus, 1986, Electronic wave functions in semiconductor clusters: experiment and theory, J. Phys. Chem., 90, 2555, 10.1021/j100403a003 Zhang, 2008, Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes, Toxicol. Appl. Pharmacol., 228, 200, 10.1016/j.taap.2007.12.022 Ryman-Rasmussen, 2006, Penetration of intact skin by quantum dots with diverse physicochemical properties, Toxicol. Sci., 91, 159, 10.1093/toxsci/kfj122 Cauda, 2010, Impact of different PEGylation patterns on the long-term bio-stability of colloidal mesoporous silica nanoparticles, J. Mater. Chem., 20, 8693, 10.1039/c0jm01390k Fathyunes, 2018, The effect of graphene oxide on surface features, biological performance and bio-stability of calcium phosphate coating applied by pulse electrochemical deposition, Appl. Surf. Sci., 437, 122, 10.1016/j.apsusc.2017.12.133 Dumontel, 2017, Enhanced biostability and cellular uptake of zinc oxide nanocrystals shielded with a phospholipid bilayer, J. Mater. Chem. B, 5, 8799, 10.1039/C7TB02229H Hogg, 1966, Mutual coagulation of colloidal dispersions, Trans. Faraday Soc., 62, 1638, 10.1039/tf9666201638 Molyneux, 2004, The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity, Songklanakarin J. Sci. Technol., 26, 211 Hammes-Schiffer, 2010, Introduction: proton-coupled electron transfer, Chem. Rev., 110, 6937, 10.1021/cr100367q Schrauben, 2012, Titanium and zinc oxide nanoparticles are proton-coupled electron transfer agents, Science, 336, 1298, 10.1126/science.1220234 Chen, 2014, Influence of defects on the photocatalytic activity of ZnO, J. Phys. Chem. C, 118, 15300, 10.1021/jp5033349 Castillo-Lora, 2019, Revealing the relative electronic landscape of colloidal ZnO and TiO2 nanoparticles via equilibration studies, J. Phys. Chem. C, 123, 10262, 10.1021/acs.jpcc.9b00829 Kumaresan, 2017, Hydrothermally grown ZnO nanoparticles for effective photocatalytic activity, Appl. Surf. Sci., 418, 138, 10.1016/j.apsusc.2016.12.231 Sharma, 2012, Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2), Apoptosis, 17, 852, 10.1007/s10495-012-0705-6 Jeong, 2013, ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes, J. Dermatol. Sci., 72, 263, 10.1016/j.jdermsci.2013.08.002 Sayes, 2006, Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells, Toxicol. Sci., 92, 174, 10.1093/toxsci/kfj197 Hirakawa, 2007, Photocatalytic reactivity for O2− and OH radical formation in anatase and rutile TiO2 suspension as the effect of H2O2 addition, Appl. Catal. A, 325, 105, 10.1016/j.apcata.2007.03.015 Das, 2013, Synthesis of ZnO nanoparticles and evaluation of antioxidant and cytotoxic activity, Colloids Surf. B, 111, 556, 10.1016/j.colsurfb.2013.06.041 Ma, 2014, Impact of solar UV radiation on toxicity of ZnO nanoparticles through photocatalytic reactive oxygen species (ROS) generation and photo-induced dissolution, Environ. Pollut., 193, 165, 10.1016/j.envpol.2014.06.027 Fraiji, 1992, Static and dynamic fluorescence quenching experiments for the physical chemistry laboratory, J. Chem. Educ., 69, 424, 10.1021/ed069p424 Sruthi, 2018, Biomedical application and hidden toxicity of Zinc oxide nanoparticles, Mater. Today Chem., 10, 175, 10.1016/j.mtchem.2018.09.008 Supino, 1995, MTT assays, 137 Jain, 2005, Iron oxide nanoparticles for sustained delivery of anticancer agents, Mol. Pharm., 2, 194, 10.1021/mp0500014 George, 2010, Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping, ACS Nano, 4, 15, 10.1021/nn901503q Yang, 2009, Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition, J. Appl. Toxicol., 29, 69, 10.1002/jat.1385 Yin, 2012, Phototoxicity of nano titanium dioxides in HaCaT keratinocytes—generation of reactive oxygen species and cell damage, Toxicol. Appl. Pharmacol., 263, 81, 10.1016/j.taap.2012.06.001