Continuous digital hypothermia reduces expression of keratin 17 and 1L-17A inflammatory pathway mediators in equine laminitis induced by hyperinsulinemia

Veterinary Immunology and Immunopathology - Tập 241 - Trang 110326 - 2021
Lynne Cassimeris1, Caitlin Armstrong2, Quinnlyn C. Burger1, Simon Stokes3, Andrew van Eps2, Hannah Galantino-Homer2
1111 Research Dr., Department of Biological Sciences, Lehigh University, Bethlehem, PA, 18015, USA
2382 West Street Rd., Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, 19348, USA
3Australian Equine Laminitis Research Unit, School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia

Tài liệu tham khảo

Armstrong, 2019, The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus, PLoS One, 14, e0219234, 10.1371/journal.pone.0219234 Asplin, 2007, Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies, Vet. J., 174, 530, 10.1016/j.tvjl.2007.07.003 Blauvelt, 2018, The immunological role of IL-17 in psoriasis and psoriatic arthritis pathogenesis, Clin. Rev. Allergy Immunol., 55, 379, 10.1007/s12016-018-8702-3 Blikslager, 2006, Cyclooxygenase expression in the early stages of equine laminitis: a cytologic study, J. Vet. Intern. Med., 20, 1191, 10.1111/j.1939-1676.2006.tb00721.x Burns, 2015, Laminar inflammatory events in lean and obese ponies subjected to high carbohydrate feeding: implications for pasture-associated laminitis, Equine Vet. J., 47, 489, 10.1111/evj.12314 Carter, 2010, Novel keratins identified by quantitative proteomic analysis as the major cytoskeletal proteins of equine (Equus caballus) hoof lamellar tissue, J. Anim. Sci., 88, 3843, 10.2527/jas.2010-2964 Cassimeris, 2019, Detection of endoplasmic reticulum stress and the unfolded protein response in naturally-occurring endocrinopathic equine laminitis, BMC Vet. Res., 15, 24, 10.1186/s12917-018-1748-x Cassimeris, 2020, Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis, PLoS One, e0232920, 10.1371/journal.pone.0232920 Chessa, 2020, Antiviral and immunomodulary properties of antimicrobial peptides produced by human keratinocytes, Front. Microbiol., 11, 1155, 10.3389/fmicb.2020.01155 Chiricozzi, 2011, Integrative responses to IL-17 and TNFa in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis, J. Invest. Dermatol., 131, 677, 10.1038/jid.2010.340 Chivu-Economescu, 2017, Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells, Gastric Cancer, 20, 948, 10.1007/s10120-017-0712-y Collins, 2010, The lamellar wedge, Vet. Clin. North Am. Equine Pract., 26, 179, 10.1016/j.cveq.2010.01.004 de Laat, 2010, Equine laminitis: induced by 48 h hyperinsulinaemia in standardbred horses, Equine Vet. J., 42, 129, 10.2746/042516409X475779 de Laat, 2011, The developmental and acute phases of insulin-induced laminitis involve minimal metalloproteinase activity, Vet. Immunol. Immunopathol., 140, 275, 10.1016/j.vetimm.2011.01.013 DePianto, 2010, Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin, Nat. Genetics, 42, 910, 10.1038/ng.665 Dern, 2018, Effect of continuous digital hypothermia on lamellar inflammatory signaling when applied at a clinically-relevant timepoint in the oligofructose laminitis model, J. Vet. Intern. Med., 32, 450, 10.1111/jvim.15027 Dern, 2020, Influence of digital hypothermia on lamellar events related to IL-6/gp130 signalling in equine sepsis-related laminitis, Equine Vet. J., 52, 441, 10.1111/evj.13184 Engiles, 2015, Osteopathology in the equine distal phalanx associated with the development and progression of laminitis, Vet. Pathol., 52, 928, 10.1177/0300985815588604 Faleiros, 2011, Laminar chemokine mRNA concentrations in horses with carbohydrate overload-induced laminitis, Vet. Immunol. Immunopathol., 144, 45, 10.1016/j.vetimm.2011.07.005 Galantino-Homer, 2020, Genetics and signaling pathways of laminitis, Vet. Clin. North Am. Equine Pract., 36, 379, 10.1016/j.cveq.2020.04.001 Godman, 2016, The effect of hypothermia on influx of leukocytes in the digital lamellae of horses with oligofructose-induced laminitis, Vet. Immunol. Immunopathol., 178, 22, 10.1016/j.vetimm.2016.05.013 Goni, 2009 Hobbs, 2015, Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes, Nat. Genet., 47, 933, 10.1038/ng.3355 Holl, 2015, Generation of a de novo transcriptome from equine lamellar tissue, BMC Genomics, 16, 739, 10.1186/s12864-015-1948-8 Jin, 2014, Keratin 17: a critical player in the pathogenesis of psoriasis, Med. Res. Rev., 34, 438, 10.1002/med.21291 Kim, 2006, A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth, Nature, 441, 362, 10.1038/nature04659 Kuwano, 2002, A gross and histopathological study of an ectopic white line development in equine laminitis, J. Vet. Med. Sci., 64, 893, 10.1292/jvms.64.893 Lane, 2017, Lamellar events related to insulin-like growth factor-1 receptor signalling in two models relevant to endocrinopathic laminitis, Equine Vet. J., 49, 643, 10.1111/evj.12663 Leise, 2018, The role of neutrophils in equine laminitis, Cell Tissue Res., 371, 541, 10.1007/s00441-018-2788-z Leise, 2015, Use of laser capture microdissection for the assessment of equine lamellar basal epithelial cell signalling in the early stages of laminitis, Equine Vet. J., 47, 478, 10.1111/evj.12283 Life Technologies, 2011 Loftus, 2009, Leukocyte-derived and endogenous matrix metalloproteinases in the lamellae of horses with naturally acquired and experimentally induced laminitis, Vet. Immunol. Immunopathol., 129, 221, 10.1016/j.vetimm.2008.11.003 Patterson-Kane, 2018, Paradigm shifts in understanding equine laminitis, Vet. J., 231, 33, 10.1016/j.tvjl.2017.11.011 Pollitt, 2010, The anatomy and physiology of the suspensory apparatus of the distal phalanx, Vet. Clin. North Am. Equine Pract., 26, 29, 10.1016/j.cveq.2010.01.005 Pollitt, 2016, The suspensory apparatus of the distal phalanx in normal horses, Equine Vet. J. Suppl., 48, 496, 10.1111/evj.12459 Qiao, 2019, Mechanical stretch exacerbates psoriasis by stimulating keratinocyte proliferation and cytokine production, J. Invest. Dermatol., 139, 1470, 10.1016/j.jid.2018.12.019 Ragno, 2019, From table to stable: a comparative review of selected aspects of human and equine metabolic syndrome, J. Equine Vet. Sci., 79, 131, 10.1016/j.jevs.2019.06.003 Stokes, 2019, Continuous digital hypothermia prevents lamellar failure in the euglycemic hyperinsulinaemic clamp model of equine laminitis, Equine Vet. J., 51, 658, 10.1111/evj.13072 Stokes, 2020, Effect of digital hypothermia on lamellar inflammatory signaling in the euglycemic hyperinsulinemic clamp laminitis model, J. Vet. Intern. Med., 34, 1606, 10.1111/jvim.15835 Takahashi, 2020, Psoriasis and antimicrobial peptides, Int. J. Mol. Sci., 21, 6791, 10.3390/ijms21186791 van Eps, 2019, Are there shared mechanisms in the pathophysiology of different clinical forms of laminitis and what are the implications for prevention and treatment?, Vet. Clin. North Am. Equine Pract., 35, 379, 10.1016/j.cveq.2019.04.001 van Eps, 2012, Digital hypothermia inhibits early lamellar inflammatory signalling in the oligofructose laminitis model, Equine Vet. J., 44, 230, 10.1111/j.2042-3306.2011.00416.x Wang, 2010, 140 Watts, 2018, Association of sustained supraphysiologic hyperinsulinemia and inflammatory signaling within the digital lamellae in light-breed horses, J. Vet. Intern. Med., 33, 1483, 10.1111/jvim.15480 Yan, 2020, Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1a pathway, Oncol. Rep., 44, 103, 10.3892/or.2020.7611 Yang, 2019, Keratin 17 in disease pathogenesis: from cancer to dermatoses, J. Pathol., 247, 158, 10.1002/path.5178 Ye, 2012, Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction, BMC Bioinformatics, 13, 134, 10.1186/1471-2105-13-134 Zhang, 2019, Keratin 6, 16 and 17 - critical barrier alarmin molecules in skin wounds and psoriasis, Cells, 8, 807, 10.3390/cells8080807