Continuing Burden of Refractory Epilepsy

Annals of Pharmacotherapy - Tập 55 Số 3 - Trang 406-408 - 2021
Marnie T. Janson1, Jacquelyn Bainbridge2
1Veterans Affairs Eastern Colorado Health Care System, Aurora, CO, USA
2University of Colorado, Aurora, CO, USA

Tóm tắt

Epilepsy is one of the most common neurological diseases, and uncontrolled seizures remain a significant problem for one-third of patients with epilepsy on drug therapy. Ongoing seizures affect the morbidity and mortality of patients with epilepsy. Premature death is up to 3 times higher in those with epilepsy than in the general population. Quality of life is affected by refractory epilepsy with physical, social, and psychological consequences. Patients may be stigmatized by society, institutions, and their own shame surrounding seizures. Questions remain on how to treat refractory epilepsy, also called drug-resistant, pharmacoresistant, or intractable epilepsy. Cenobamate, a novel antiseizure medication, may provide additional benefit for refractory epilepsy treatment.

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