Construct Validity of the Patient‐Reported Outcomes Measurement Information System Gastrointestinal Symptom Scales in Systemic Sclerosis

Arthritis Care and Research - Tập 66 Số 11 - Trang 1725-1730 - 2014
Vivek Nagaraja1, Ron D. Hays2, Puja Khanna1, Brennan Spiegel3, Lin Chang4, Gil Melmed5, Roger Bolus6, Dinesh Khanna1
1University of Michigan, Ann Arbor
2RAND Corporation, Santa Monica, California, and David Geffen School of Medicine at University of California Los Angeles
3VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, Los Angeles, and VA Center for Outcomes Research and Education Los Angeles California
4Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine at University of California Los Angeles
5Cedars Sinai Medical Center, Los Angeles, California
6David Geffen School of Medicine at University of California, Los Angeles, and the VA Center for Outcomes Research and Education Los Angeles California

Tóm tắt

ObjectiveGastrointestinal (GI) involvement is common in patients with systemic sclerosis (SSc; scleroderma). The Patient‐Reported Outcomes Measurement Information System (PROMIS) GI symptom item bank captures upper and lower GI symptoms (reflux, disrupted swallowing, nausea/vomiting, belly pain, gas/bloating/flatulence, diarrhea, constipation, and fecal incontinence). The objective of this study was to evaluate the construct validity of the PROMIS GI bank in SSc.MethodsA total of 167 patients with SSc were administered the PROMIS GI bank and the University of California, Los Angeles, Scleroderma Clinical Trials Consortium Gastrointestinal Scale (GIT 2.0) instrument. GIT 2.0 is a multi‐item instrument that measures SSc‐associated GI symptoms. Product‐moment correlations and a multitrait–multimethod analysis of the PROMIS GI scales with the GIT 2.0 symptom scales were used to evaluate convergent and discriminant validity.ResultsPatients with SSc GI involvement had PROMIS GI scale scores 0.2–0.7 SD worse than the US general population. Correlations among scales measuring the same domains for the PROMIS GI and GIT 2.0 measures were large, ranging from 0.61 to 0.87 (average r = 0.77). The average correlation between different symptom scales was 0.22, supporting discriminant validity.ConclusionThis study provides support for the construct validity of the PROMIS GI scales in SSc. Future research is needed to assess the responsiveness to change of these scales in patients with SSc.

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Arthritis Care and Research

Tập 66 Số 11

1725-1730

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