Considering the ‘Alternatives’ for Next-Generation Anti-Staphylococcus aureus Vaccine Development

Trends in Molecular Medicine - Tập 25 - Trang 171-184 - 2019
Eóin C. O’Brien1, Rachel M. McLoughlin1
1Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152–160 Pearse Street, Dublin 2, Ireland

Tài liệu tham khảo

Laupland, 2013, The changing epidemiology of Staphylococcus aureus bloodstream infection: a multinational population-based surveillance study, Clin. Microbiol. Infect., 19, 465, 10.1111/j.1469-0691.2012.03903.x Williamson, 2013, Incidence, trends and demographics of Staphylococcus aureus infections in Auckland, New Zealand, 2001–2011, BMC Infect. Dis., 13, 569, 10.1186/1471-2334-13-569 Hassoun, 2017, Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment, Crit. Care, 21, 211, 10.1186/s13054-017-1801-3 Andreassen, 2017, The impact of methicillin-resistant S. aureus on length of stay, readmissions and costs: a register based case-control study of patients hospitalized in Norway, Antimicrob. Resist. Infect. Control, 6, 74, 10.1186/s13756-017-0232-x Lee, 2018, Methicillin-resistant Staphylococcus aureus, Nat. Rev. Dis. Primers, 4, 18033, 10.1038/nrdp.2018.33 Acree, 2017, S. aureus infections in Chicago, 2006–2014: increase in CA MSSA and decrease in MRSA incidence, Infect. Control Hosp. Epidemiol., 38, 1226, 10.1017/ice.2017.177 Crowley, 2017, UK Renal Registry 19th Annual Report: Chapter 10. Epidemiology of reported infections in patients receiving dialysis in England between January 2015 and December 2015: a joint report from Public Health England and the UK Renal Registry, Nephron, 137, 251, 10.1159/000481372 Delorme, 2017, A longitudinal analysis of methicillin-resistant and sensitive Staphylococcus aureus incidence in respect to specimen source, patient location, and temperature variation, Int. J. Infect. Dis., 54, 50, 10.1016/j.ijid.2016.11.405 Fowler, 2014, Where does a Staphylococcus aureus vaccine stand?, Clin. Microbiol. Infect., 20, 66, 10.1111/1469-0691.12570 Giersing, 2016, Status of vaccine research and development of vaccines for Staphylococcus aureus, Vaccine, 34, 2962, 10.1016/j.vaccine.2016.03.110 Bagnoli, 2012, Inferring reasons for the failure of Staphylococcus aureus vaccines in clinical trials, Front. Cell. Infect. Microbiol., 2, 16, 10.3389/fcimb.2012.00016 Krishna, 2012, Innate and adaptive immune responses against Staphylococcus aureus skin infections, Semin. Immunopathol., 34, 261, 10.1007/s00281-011-0292-6 Fattom, 2015, Efficacy profile of a bivalent Staphylococcus aureus glycoconjugated vaccine in adults on hemodialysis: Phase III randomized study, Hum. Vaccin. Immunother., 11, 632, 10.4161/hv.34414 Fowler, 2013, Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial, JAMA, 309, 1368, 10.1001/jama.2013.3010 McNeely, 2014, Mortality among recipients of the Merck V710 Staphylococcus aureus vaccine after postoperative S. aureus infections: an analysis of possible contributing host factors, Hum. Vaccin. Immunother., 10, 3513, 10.4161/hv.34407 Levy, 2015, Safety and immunogenicity of an investigational 4-component Staphylococcus aureus vaccine with or without AS03B adjuvant: results of a randomized phase I trial, Hum. Vaccin. Immunother., 11, 620, 10.1080/21645515.2015.1011021 Begier, 2017, SA4Ag, a 4-antigen Staphylococcus aureus vaccine, rapidly induces high levels of bacteria-killing antibodies, Vaccine, 35, 1132, 10.1016/j.vaccine.2017.01.024 Spellberg, 2008, The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus, Infect. Immun., 76, 4574, 10.1128/IAI.00700-08 Misstear, 2014, Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus, J. Infect. Dis., 209, 1479, 10.1093/infdis/jit636 von Kockritz-Blickwede, 2008, Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model, Am. J. Pathol., 173, 1657, 10.2353/ajpath.2008.080337 Wiese, 2013, A nationwide study of comorbidity and risk of reinfection after Staphylococcus aureus bacteraemia, J. Infect., 67, 199, 10.1016/j.jinf.2013.04.018 McDonald, 2012, TH17 deficiency in human disease, J. Allergy Clin. Immunol., 129, 1429, 10.1016/j.jaci.2012.03.034 Joshi, 2012, Immunization with Staphylococcus aureus iron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model, Hum. Vaccin. Immunother., 8, 336, 10.4161/hv.18946 Ishigame, 2009, Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses, Immunity, 30, 108, 10.1016/j.immuni.2008.11.009 Holley, 2012, Th1 and Th17 cells regulate innate immune responses and bacterial clearance during central nervous system infection, J. Immunol., 188, 1360, 10.4049/jimmunol.1101660 Lin, 2009, Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice, PLoS Pathog., 5, 10.1371/journal.ppat.1000703 Cho, 2010, IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice, J. Clin. Invest., 120, 1762, 10.1172/JCI40891 Zhang, 2018, Protection against Staphylococcus aureus colonization and infection by B- and T-cell-mediated mechanisms, mBio, 9, 10.1128/mBio.01949-18 Cox, 2011, Cytokines and the inception of CD8 T cell responses, Trends Immunol., 32, 180, 10.1016/j.it.2011.01.004 Cruz-Adalia, 2017, Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses, Nat. Commun., 8, 1591, 10.1038/s41467-017-01661-7 Lin, 2015, CD8 T cells and Mycobacterium tuberculosis infection, Semin. Immunopathol., 37, 239, 10.1007/s00281-015-0490-8 Behar, 2013, Antigen-specific CD8(+) T cells and protective immunity to tuberculosis, Adv. Exp. Med. Biol., 783, 141, 10.1007/978-1-4614-6111-1_8 Lee, 2012, MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection, Immunol. Lett., 148, 138, 10.1016/j.imlet.2012.10.009 Rollin, 2017, Intracellular survival of Staphylococcus aureus in endothelial cells: a matter of growth or persistence, Front. Microbiol., 8, 1354, 10.3389/fmicb.2017.01354 Lacoma, 2017, Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line, Virulence, 8, 1761, 10.1080/21505594.2017.1361089 Brown, 2015, Memory Th1 cells are protective in invasive Staphylococcus aureus infection, PLoS Pathog., 11, 10.1371/journal.ppat.1005226 Uebele, 2017, Antigen delivery to dendritic cells shapes human CD4(+) and CD8(+) T cell memory responses to Staphylococcus aureus, PLoS Pathog., 13, 10.1371/journal.ppat.1006387 Xiao, 2017, Mucosal-associated invariant T cells: new insights into antigen recognition and activation, Front. Immunol., 8, 1540, 10.3389/fimmu.2017.01540 McCarthy, 2018, Human γδ T-cell control of mucosal immunity and inflammation, Front. Immunol., 9, 985, 10.3389/fimmu.2018.00985 Triggianese, 2016, Evidence of IL-17 producing innate lymphoid cells in peripheral blood from patients with enteropathic spondyloarthritis, Clin. Exp. Rheumatol., 34, 1085 Nielsen, 2017, γδ T cells in homeostasis and host defence of epithelial barrier tissues, Nat. Rev. Immunol., 17, 733, 10.1038/nri.2017.101 Lalor, 2016, Memory γδ T cells-newly appreciated protagonists in infection and immunity, Trends Immunol., 37, 690, 10.1016/j.it.2016.07.006 Sutton, 2009, Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity, Immunity, 31, 331, 10.1016/j.immuni.2009.08.001 Martin, 2009, Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals, Immunity, 31, 321, 10.1016/j.immuni.2009.06.020 Harly, 2012, Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset, Blood, 120, 2269, 10.1182/blood-2012-05-430470 Tyler, 2015, Human Vγ9/Vδ2 T cells: innate adaptors of the immune system, Cell. Immunol., 296, 10, 10.1016/j.cellimm.2015.01.008 Gu, 2015, Sensing of pyrophosphate metabolites by Vγ9Vδ2 T cells, Front. Immunol., 5, 688, 10.3389/fimmu.2014.00688 Misiak, 2017, IL-17-producing innate and pathogen-specific tissue resident memory γδ T cells expand in the lungs of Bordetella pertussis-infected mice, J. Immunol., 198, 363, 10.4049/jimmunol.1601024 Simonian, 2009, IL-17A-expressing T cells are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis, J. Immunol., 182, 6540, 10.4049/jimmunol.0900013 Sun, 2018, Vγ4+ T cells: a novel IL-17-producing γδ T subsets during the early phase of chlamydial airway infection in mice, Mediators Inflamm., 2018, 10.1155/2018/6265746 Dalton, 2004, Fas-Fas ligand interactions are essential for the binding to and killing of activated macrophages by γδ T cells, J. Immunol., 173, 3660, 10.4049/jimmunol.173.6.3660 Tuero, 2016, Mucosal and systemic γδ+ T cells associated with control of simian immunodeficiency virus infection, J. Immunol., 197, 4686, 10.4049/jimmunol.1600579 Hess, 2003, Intracellular survival of Staphylococcus aureus within cultured enterocytes, J. Surg. Res., 114, 42, 10.1016/S0022-4804(03)00314-7 Spencer, 2013, Granzyme A produced by γ9δ2 T cells induces human macrophages to inhibit growth of an intracellular pathogen, PLoS Pathog., 9, 10.1371/journal.ppat.1003119 Peng, 2008, Interleukin 17-producing γδ T cells increased in patients with active pulmonary tuberculosis, Cell. Mol. Immunol., 5, 203, 10.1038/cmi.2008.25 Ma, 2008, Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3, J. Exp. Med., 205, 1551, 10.1084/jem.20080218 Maher, 2013, Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection, Infect. Immun., 81, 4478, 10.1128/IAI.01026-13 Murphy, 2014, Staphylococcus aureus infection of mice expands a population of memory γδ T cells that are protective against subsequent infection, J. Immunol., 192, 3697, 10.4049/jimmunol.1303420 Cheng, 2012, Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia, BMC Immunol., 13, 38, 10.1186/1471-2172-13-38 Dillen, 2018, Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection, J. Clin. Invest., 128, 1026, 10.1172/JCI96481 Wang, 2001, Antibacterial effect of human Vγ2Vδ2 T cells in vivo, J. Clin. Invest., 108, 1349, 10.1172/JCI200113584 Romagnoli, 2016, IL-17A–producing resident memory γδ T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection, Proc. Natl. Acad. Sci. U. S. A., 113, 8502, 10.1073/pnas.1600713113 Sun, 2009, Adaptive immune features of natural killer cells, Nature, 457, 557, 10.1038/nature07665 Sheridan, 2013, γδ T cells exhibit multifunctional and protective memory in intestinal tissues, Immunity, 39, 184, 10.1016/j.immuni.2013.06.015 Godfrey, 2018, Unconventional T cell targets for cancer immunotherapy, Immunity, 48, 453, 10.1016/j.immuni.2018.03.009 Wilhelm, 2014, Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells, J. Transl. Med., 12, 45, 10.1186/1479-5876-12-45 Qaqish, 2017, Adoptive transfer of phosphoantigen-specific γδ T cell subset attenuates Mycobacterium tuberculosis infection in nonhuman primates, J. Immunol., 198, 4753, 10.4049/jimmunol.1602019 Markovits, 2017, Immune-mediated syndromes following intravenous bisphosphonate therapy, Inflammopharmacology, 25, 665, 10.1007/s10787-017-0365-9 Spits, 2013, Innate lymphoid cells—a proposal for uniform nomenclature, Nat. Rev. Immunol., 13, 145, 10.1038/nri3365 Cherrier, 2018, Innate lymphoid cell development: a T cell perspective, Immunity, 48, 1091, 10.1016/j.immuni.2018.05.010 Mortha, 2018, Cytokine Networks between Innate Lymphoid Cells and Myeloid Cells, Frontiers in Immunology, 9 Sonnenberg, 2012, Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease, Immunity, 37, 601, 10.1016/j.immuni.2012.10.003 Hepworth, 2013, Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria, Nature, 498, 113, 10.1038/nature12240 Klose, 2013, A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells, Nature, 494, 261, 10.1038/nature11813 Simoni, 2017, Human innate lymphoid cell subsets possess tissue-type based heterogeneity in phenotype and frequency, Immunity, 46, 148, 10.1016/j.immuni.2016.11.005 Kim, 2016, Migration and tissue tropism of innate lymphoid cells, Trends Immunol., 37, 68, 10.1016/j.it.2015.11.003 Klose, 2014, Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages, Cell, 157, 340, 10.1016/j.cell.2014.03.030 Abt, 2015, Innate immune defenses mediated by two ILC subsets are critical for protection against acute Clostridium difficile infection, Cell Host Microbe, 18, 27, 10.1016/j.chom.2015.06.011 Goto, 2014, Innate lymphoid cells regulate intestinal epithelial cell glycosylation, Science, 345, 10.1126/science.1254009 Hasegawa, 2014, Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage, Immunity, 41, 620, 10.1016/j.immuni.2014.09.010 Satoh-Takayama, 2008, Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense, Immunity, 29, 958, 10.1016/j.immuni.2008.11.001 Van Maele, 2014, Activation of type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection, J. Infect. Dis., 210, 493, 10.1093/infdis/jiu106 Yang, 2015, Type 1 innate lymphoid cells contribute to the pathogenesis of chronic hepatitis B, Innate Immun., 21, 665, 10.1177/1753425915586074 Kramer, 2017, Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy, PLoS Pathog., 13, 10.1371/journal.ppat.1006373 Rak, 2016, IL-33-dependent group 2 innate lymphoid cells promote cutaneous wound healing, J. Invest. Dermatol., 136, 487, 10.1038/JID.2015.406 Yin, 2013, IL-33 promotes Staphylococcus aureus-infected wound healing in mice, Int. Immunopharmacol., 17, 432, 10.1016/j.intimp.2013.07.008 Gauguet, 2015, Intestinal microbiota of mice influences resistance to Staphylococcus aureus pneumonia, Infect. Immun., 83, 4003, 10.1128/IAI.00037-15 Mulcahy, 2016, Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa, Mucosal Immunol., 9, 1429, 10.1038/mi.2016.24 McKenzie, 2006, Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL, Int. Immunol., 18, 837, 10.1093/intimm/dxl020 van de Pavert, 2014, Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity, Nature, 508, 123, 10.1038/nature13158 Perry, 2012, Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis, Sci. Transl. Med., 4, 10.1126/scitranslmed.3004140 Corren, 2011, Lebrikizumab treatment in adults with asthma, N. Engl. J. Med., 365, 1088, 10.1056/NEJMoa1106469 Pavord, 2012, Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial, Lancet, 380, 651, 10.1016/S0140-6736(12)60988-X Eberl, 2015, Innate lymphoid cells: a new paradigm in immunology, Science, 348, 10.1126/science.aaa6566 Gherardin, 2018, Human blood MAIT cell subsets defined using MR1 tetramers, Immunol. Cell Biol., 96, 507, 10.1111/imcb.12021 Treiner, 2005, Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset, Microbes Infect., 7, 552, 10.1016/j.micinf.2004.12.013 Tsukamoto, 2013, Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals, Immunogenetics, 65, 115, 10.1007/s00251-012-0666-5 Mori, 2016, The immunology of CD1- and MR1-restricted T cells, Annu. Rev. Immunol., 34, 479, 10.1146/annurev-immunol-032414-112008 Kjer-Nielsen, 2012, MR1 presents microbial vitamin B metabolites to MAIT cells, Nature, 491, 717, 10.1038/nature11605 Ussher, 2014, CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner, Eur. J. Immunol., 44, 195, 10.1002/eji.201343509 Loh, 2016, Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation, Proc. Natl. Acad. Sci. U. S. A., 113, 10133, 10.1073/pnas.1610750113 Jiang, 2016, Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling, Sci. Rep., 6 Chiba, 2018, Mucosal-associated invariant T cells in autoimmune diseases, Front. Immunol., 9, 1333, 10.3389/fimmu.2018.01333 Chiba, 2017, Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus, Arthritis Res. Ther., 19, 58, 10.1186/s13075-017-1257-5 Meierovics, 2013, MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection, Proc. Natl. Acad. Sci. U. S. A., 110, E3119, 10.1073/pnas.1302799110 Chua, 2012, Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection, Infect. Immun., 80, 3256, 10.1128/IAI.00279-12 Georgel, 2011, The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice, Mol. Immunol., 48, 769, 10.1016/j.molimm.2010.12.002 Chen, 2016, Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals, Mucosal Immunol., 10, 58, 10.1038/mi.2016.39 Wang, 2018, MAIT cells protect against pulmonary Legionella longbeachae infection, Nat. Commun., 9 Grimaldi, 2014, Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections, Intensive Care Med., 40, 192, 10.1007/s00134-013-3163-x Wong, 2014, Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection, PLoS One, 8 Cui, 2015, Mucosal-associated invariant T cell–rich congenic mouse strain allows functional evaluation, J. Clin. Invest., 125, 4171, 10.1172/JCI82424 Le Bourhis, 2010, Antimicrobial activity of mucosal-associated invariant T cells, Nat. Immunol., 11, 701, 10.1038/ni.1890 Gold, 2010, Human mucosal associated invariant T cells detect bacterially infected cells, PLoS Biol., 8, 10.1371/journal.pbio.1000407 Sandberg, 2017, Bacterial deception of MAIT cells in a cloud of superantigen and cytokines, PLoS Biol., 15, 10.1371/journal.pbio.2003167 Le Bourhis, 2013, MAIT cells detect and efficiently lyse bacterially-infected epithelial cells, PLoS Pathog., 9, 10.1371/journal.ppat.1003681 Kurioka, 2014, MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets, Mucosal Immunol., 8, 429, 10.1038/mi.2014.81 Fernandez, 2015, MAIT cells are depleted early but retain functional cytokine expression in HIV infection, Immunol. Cell Biol., 93, 177, 10.1038/icb.2014.91 Wakao, 2017, Mucosal-associated invariant T cells in regenerative medicine, Front. Immunol., 8, 1711, 10.3389/fimmu.2017.01711 Howson, 2018, MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A, Nat. Commun., 9, 10.1038/s41467-017-02540-x Greenberg, 2018, Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality, Crit. Care, 22, 107, 10.1186/s13054-018-2025-x