Consenso Mexicano de Hipertensión Portal

Revista de Gastroenterologia de Mexico - Tập 78 - Trang 92-113 - 2013
R.M. Narváez-Rivera1, C.A. Cortez-Hernández1, J.A. González-González1, J.L. Tamayo-de la Cuesta2, F. Zamarripa-Dorsey3, A. Torre-Delgadillo4, J.F.J. Rivera-Ramos5, J.I. Vinageras-Barroso5, J.E. Muneta-Kishigami6, J.M. Blancas-Valencia7, M. Antonio-Manrique8, F. Valdovinos-Andraca9, P. Brito-Lugo5, A. Hernández-Guerrero10, R. Bernal-Reyes11, S. Sobrino-Cossío10, G.R. Aceves-Tavares12, H.M. Huerta-Guerrero13, N. Moreno-Gómez14, F.J. Bosques-Padilla1
1Servicio de Gastroenterología, Departamento de Medicina Interna, Hospital Universitario «Dr. José Eleuterio González», Monterrey, N.L., México
2Servicio de Gastroenterología y Endoscopia, Hospital General de Culiacán «Dr. Bernardo J. Gastélum», Culiacán, Sinaloa, México
3Servicio de Gastroenterología, Hospital Angeles Lomas, Huixquilucan, Edo de México, México
4Servicio de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., México
5Servicio de Gastroenterología, Hospital Español de México, México, D.F., México
6Servicio de Endoscopía Gastrointestinal, Hospital Angeles Lomas, Huixquilucan, Edo de México, México
7Servicio de Endoscopia Gastrointestinal, Hospital de Especialidades «Dr. Bernardo Sepúlveda Gutiérrez», Centro Médico Nacional Siglo XXI, México D.F., México
8Servicio de Endoscopia, Hospital Juárez de México, México D.F., México
9Departamento de Endoscopia Gastrointestinal, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., México
10Servicio de Endoscopia, Instituto Nacional de Cancerología, México D.F., México
11Servicio de Gastroenterología, Hospital General de Pachuca, Pachuca, Hidalgo, México
12Servicio de Gastroenterología, Departamento de Medicina Interna, Hospital General del Estado de Sonora «Dr. Ernesto Ramos Bours», Hermosillo, Sonora, México
13Servicio de Urgencias, Departamento de Medicina Interna, Hospital General de Durango, Durango, México
14Hospital General Regional No. 1 IMSS, Culiacán, Sinaloa, México

Tài liệu tham khảo

Graham, 1981, The course of patients after variceal hemorrhage, Gastroenterology, 80, 800, 10.1016/0016-5085(81)90144-X Chalasani, 2003, Improved patient survival after acute variceal bleeding: a multicenter, cohort study, Am J Gastroenterol, 98, 653, 10.1111/j.1572-0241.2003.07294.x D’Amico, 2003, Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators, Hepatology, 38, 599, 10.1053/jhep.2003.50385 Carbonell, 2004, Improved survival after variceal bleeding in patients with cirrhosis over the past two decades, Hepatology, 40, 652, 10.1002/hep.20339 Bosch, 2008, Portal hypertension and gastrointestinal bleeding, Semin Liver Dis, 28, 3, 10.1055/s-2008-1040318 Maddur, 2011, Adherence and adequacy of therapy for esophageal varices prophylaxis, Dig Dis Sci, 56, 3129, 10.1007/s10620-011-1749-0 De Franchis, 2010, Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension, J Hepatol, 53, 762, 10.1016/j.jhep.2010.06.004 Le Moine, 1992, Factors related to early mortality in cirrhotic patients bleeding from varices and treated by urgent sclerotherapy, Gut, 33, 1381, 10.1136/gut.33.10.1381 Bosch, 2003, Prevention of variceal rebleeding, Lancet, 361, 952, 10.1016/S0140-6736(03)12778-X Groszmann, 2005, Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis, N Engl J Med, 353, 2254, 10.1056/NEJMoa044456 D’Amico, 1995, The treatment of portal hypertension: a meta-analytic review, Hepatology, 22, 332 D’Amico, 1997, Natural history. Clinical-haemodynamic correlations. Prediction of the risk of bleeding, Baillieres Clin Gastroenterol, 11, 243, 10.1016/S0950-3528(97)90038-5 Christensen, 1981, Aspects of the natural history of gastrointestinal bleeding in cirrhosis and the effect of prednisone, Gastroenterology, 81, 944, 10.1016/S0016-5085(81)80123-0 Merkel, 2004, A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis, Gastroenterology, 127 Merli, 2003, Incidence and natural history of small esophageal varices in cirrhotic patients, J Hepatol, 38, 266, 10.1016/S0168-8278(02)00420-8 Wiest, 2002, The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough, Hepatology, 35, 478, 10.1053/jhep.2002.31432 Iwakiri, 2007, Vascular endothelial dysfunction in cirrhosis, J Hepatol, 46, 927, 10.1016/j.jhep.2007.02.006 Fernandez, 2004, Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice, Gastroenterology, 126, 886, 10.1053/j.gastro.2003.12.012 Fernandez, 2005, Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats, J Hepatol, 43, 98, 10.1016/j.jhep.2005.02.022 Angermayr, 2007, NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats, Gut, 56, 560, 10.1136/gut.2005.088013 Mejias, 2009, Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats, Hepatology, 49, 1245, 10.1002/hep.22758 Fernandez, 2007, Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats, Hepatology, 46, 1208, 10.1002/hep.21785 Iwakiri, 2006, The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule, Hepatology, 43, S121, 10.1002/hep.20993 Arguedas, 2003, The critically ill liver patient: the variceal bleeder, Semin Gastrointest Dis, 14, 34 Turnes, 2006, Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis, Am J Gastroenterol, 101, 506, 10.1111/j.1572-0241.2006.00453.x D’Amico, 2006, Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies, J Hepatol, 44, 217, 10.1016/j.jhep.2005.10.013 Bendtsen, 1990, Agreement among multiple observers on endoscopic diagnosis of esophageal varices before bleeding, Hepatology, 11, 341, 10.1002/hep.1840110302 Cales, 1990, Gastroesophageal endoscopic features in cirrhosis: comparison of intracenter and intercenter observer variability, Gastroenterology, 99, 1189, 10.1016/0016-5085(90)90652-H Sauerbruch, 1992, Upper gastrointestinal endoscopy in patients with portal hypertension, Endoscopy, 24, 45, 10.1055/s-2007-1010440 Rigo, 1992, A prospective study of the ability of three endoscopic classifications to predict hemorrhage from esophageal varices, Gastrointest Endosc, 38, 425, 10.1016/S0016-5107(92)70470-2 De Franchis, 1992, Definitions, methodology and therapeutic strategies in portal hypertension. A Consensus Development Workshop, Baveno, Lake Maggiore, Italy, April 5 and 6, 1990, J Hepatol, 15, 256, 10.1016/0168-8278(92)90044-P Calès, 2003, Evaluation of Baveno recommendations for grading esophageal varices, J Hepatol, 39, 657, 10.1016/S0168-8278(03)00404-5 1988, Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study, N Engl J Med, 319, 983, 10.1056/NEJM198810133191505 Merkel, 2000, Prognostic indicators of risk for first variceal bleeding in cirrhosis: a multicenter study in 711 patients to validate and improve the North Italian Endoscopic Club (NIEC) index, Am J Gastroenterol, 95, 2915, 10.1111/j.1572-0241.2000.03204.x Bosch, 2003, Current management of portal hypertension, J Hepatol, 38, S54, 10.1016/S0168-8278(02)00430-0 Zoli, 2000, Natural history of cirrhotic patients with small esophageal varices: a prospective study, Am J Gastroenterol, 95, 503, 10.1111/j.1572-0241.2000.01775.x Calés, 1999, Lack of effect of propranolol in the prevention of large oesophageal varices in patients with cirrhosis: a randomized trial. French-Speaking Club for the Study of Portal Hypertension, Eur J Gastroenterol Hepatol, 11, 741, 10.1097/00042737-199907000-00011 Garcia-Tsao, 1985, Portal pressure, presence of gastroesophageal varices and variceal bleeding, Hepatology, 5, 419, 10.1002/hep.1840050313 Ripoll, 2007, Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis, Gastroenterology, 133, 481, 10.1053/j.gastro.2007.05.024 Groszmann, 1990, Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage, Gastroenterology, 99, 1401, 10.1016/0016-5085(90)91168-6 Casado, 1998, Clinical events after transjugular intrahepatic portosystemic shunt: correlation with hemodynamic findings, Gastroenterology, 114, 1296, 10.1016/S0016-5085(98)70436-6 Feu, 1995, Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis, Lancet, 346, 1056, 10.1016/S0140-6736(95)91740-3 Myers, 1951, An estimation of portal venous pressure by occlusive catheterization of an hepatic venule, J Clin Investigation, 6, 662 Groszmann, 1979, Wedged and free hepatic venous pressure measured with a balloon catheter, Gastroenterology, 76, 253, 10.1016/0016-5085(79)90330-5 Garcia-Tsao, 2008, Portal hypertension and variceal bleeding--unresolved issues. Summary of an American Association for the study of liver diseases and European Association for the study of the liver single-topic conference, Hepatology, 47, 1764, 10.1002/hep.22273 Primignani, 2000, Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. The New Italian Endoscopic Club for the study and treatment of esophageal varices (NIEC), Gastroenterology, 119, 181, 10.1053/gast.2000.8555 Giannini, 2003, Platelet count/spleen diameter ratio: proposal and validation of a non-invasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis, Gut, 52, 1200, 10.1136/gut.52.8.1200 Kazemi, 2006, Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices, J Hepatol, 45, 230, 10.1016/j.jhep.2006.04.006 D’Amico, 2004, Noninvasive markers of esophageal varices: another round, not the last, Hepatology, 39, 30, 10.1002/hep.20018 Grace, 1998, Portal hypertension and variceal bleeding: an AASLD single topic symposium, Hepatology, 28, 868, 10.1002/hep.510280339 Fleig, 2001, To scope or not to scope: still a question, Hepatology, 33, 471, 10.1053/jhep.2001.22342 Lin, 1991, Early chronic administration of propranolol reduces the severity of portal hypertension and portal-systemic shunts in conscious portal vein stenosed rats, J Hepatol, 13, 213, 10.1016/0168-8278(91)90817-U Sarin, 1991, Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension, J Clin Invest, 87, 1032, 10.1172/JCI115062 Feu, 1991, Double-blind investigation of the effects of propranolol and placebo on the pressure of esophageal varices in patients with portal hypertension, Hepatology, 13, 917, 10.1002/hep.1840130519 D’Amico, 1999, Pharmacological treatment of portal hypertension: an evidence-based approach, Semin Liver Dis, 19, 475, 10.1055/s-2007-1007133 Garcia-Tsao, 1986, Short-term effects of propranolol on portal venous pressure, Hepatology, 6, 101, 10.1002/hep.1840060119 Gengo, 1987, Lipid-soluble and water-soluble beta-blockers. Comparison of the central nervous system depressant effect, Arch Intern Med, 147, 39, 10.1001/archinte.1987.00370010043011 Berzigotti, 2006, Primary prophylaxis with nadolol in cirrhotic patients: Doppler patterns of splanchnic hemodynamics in good and poor responders, J Hepatol, 44, 310, 10.1016/j.jhep.2005.10.015 García-Pagán, 2003, Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: a double-blind RCT, Hepatology, 37, 1260, 10.1053/jhep.2003.50211 García-Pagán, 2001, Isosorbide mononitrate in the prevention of first variceal bleed in patients who cannot receive beta-blockers, Gastroenterology, 121, 908, 10.1016/S0016-5085(01)81028-3 Sersté, 2010, Deleterious effects of beta-blockers on survival in patients with cirrhosis and refractory ascites, Hepatology, 52, 1017, 10.1002/hep.23775 Ruiz-del-Arbol, 2005, Circulatory function and hepatorenal syndrome in cirrhosis, Hepatology, 42, 439, 10.1002/hep.20766 Ma, 1996, Cirrhotic cardiomyopathy: getting to the heart of the matter, Hepatology, 24, 451, 10.1002/hep.510240226 Wong, 1999, Role of cardiac structural and functional abnormalities in the pathogenesis of hyperdynamic circulation and renal sodium retention in cirrhosis, Clin Sci, 97, 259, 10.1042/cs0970259 Pozzi, 1997, Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites, Hepatology, 26, 1131 Møller, 2004, Review article: pathogenesis and pathophysiology of hepatorenal syndrome--is there scope for prevention, Aliment Pharmacol Ther, 20, 31, 10.1111/j.1365-2036.2004.02112.x Blei, 1987, Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis. Pharmacokinetic-hemodynamic interactions, Gastroenterology, 93, 576, 10.1016/0016-5085(87)90921-8 Borroni, 2002, Nadolol is superior to isosorbide mononitrate for the prevention of the first variceal bleeding in cirrhotic patients with ascites, J Hepatol, 37, 315, 10.1016/S0168-8278(02)00174-5 García-Pagán, 1991, Propranolol compared with propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis. A randomized controlled study, Ann Intern Med, 114, 869, 10.7326/0003-4819-114-10-869 Merkel, 1996, Randomised trial of nadolol alone or with isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Gruppo-Triveneto per L‘ipertensione portale (GTIP), Lancet, 348, 1677, 10.1016/S0140-6736(96)05406-2 Merkel, 2000, Long-term results of a clinical trial of nadolol with or without isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis, Hepatology, 31, 324, 10.1002/hep.510310210 Sharma, 2009, Early identification of haemodynamic response to pharmacotherapy is essential for primary prophylaxis of variceal bleeding in patients with «high-risk» varices, Aliment Pharmacol Ther, 30, 48, 10.1111/j.1365-2036.2009.04015.x Funakoshi, 2012, Meta-analysis: beta-blockers versus banding ligation for primary prophylaxis of esophageal variceal bleeding, Ann Hepatol, 11, 369, 10.1016/S1665-2681(19)30934-2 Watanabe, 1988, Portal hemodynamics in patients with gastric varices. A study in 230 patients with esophageal and/or gastric varices using portal vein catheterization, Gastroenterology, 95, 434, 10.1016/0016-5085(88)90501-X Sarin, 1989, Gastric varices: profile, classification, and management, Am J Gastroenterol, 84, 1244 Sarin, 1992, Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients, Hepatology, 16, 1343, 10.1002/hep.1840160607 Trudeau, 1986, Endoscopic injection sclerosis in bleeding gastric varices, Gastrointest Endosc, 32, 264, 10.1016/S0016-5107(86)71843-9 Hashizume, 1990, Endoscopic classification of gastric varices, Gastrointest Endosc, 36, 276, 10.1016/S0016-5107(90)71023-1 Korula, 1991, Demonstration of two distinct subsets of gastric varices, Dig Dis Sci, 36, 303, 10.1007/BF01318201 Sarin, 1997, Long-term follow-up of gastric variceal sclerotherapy: an eleven-year experience, Gastrointest Endosc, 46, 8, 10.1016/S0016-5107(97)70202-5 Chey, 1993, Natural history of gastric varices, Gastroenterology, 105, 599, 10.1016/0016-5085(93)90743-V Matsumoto, 2006, Gastric fundal varices: new aspects of nonsurgical treatment in Japan, Nat Clin Pract Gastroenterol Hepatol, 3, 4, 10.1038/ncpgasthep0364 Mishra, 2011, Primary prophylaxis of gastric variceal bleeding comparing cyanoacrylate injection and beta-blockers: a randomized controlled trial, J Hepatol, 54, 1161, 10.1016/j.jhep.2010.09.031 Terés, 1976, Upper gastrointestinal bleeding in cirrhosis: clinical and endoscopic correlations, Gut, 17, 37, 10.1136/gut.17.1.37 Villanueva, 2006, A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding, J Hepatol, 45, 560, 10.1016/j.jhep.2006.05.016 Abraldes, 2008, Hepatic venous pressure gradient and prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapy, J Hepatol, 48, 229, 10.1016/j.jhep.2007.10.008 Goulis, 1998, Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage, Hepatology, 27, 1207, 10.1002/hep.510270504 Bernard, 1995, Prognostic significance of bacterial infection in bleeding cirrhotic patients: a prospective study, Gastroenterology, 108, 1828, 10.1016/0016-5085(95)90146-9 Abraldes, 2006, Value of hvpg predicting 5-day treatment failure in acute variceal bleeding. Comparison with clinical variables, J Hepatol, 44, S12, 10.1016/S0168-8278(06)80026-7 Moitinho, 1999, Prognostic value of early measurements of portal pressure in acute variceal bleeding, Gastroenterology, 117, 626, 10.1016/S0016-5085(99)70455-5 Monescillo, 2004, Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding, Hepatology, 40, 793, 10.1002/hep.20386 Garcia-Pagan, 2010, Early use of TIPS in patients with cirrhosis and variceal bleeding, N Engl J Med, 362, 2370, 10.1056/NEJMoa0910102 Lee, 2009, Independent factors associated with recurrent bleeding in cirrhotic patients with esophageal variceal hemorrhage, Dig Dis Sci, 54, 1128, 10.1007/s10620-008-0454-0 De Franchis, 2005, Evolving Consensus in Portal Hypertension. Report of the Baveno IV Consensus Workshop on methodology of diagnosis and therapy in portal hypertension, J Hepatol, 43, 167, 10.1016/j.jhep.2005.05.009 Cárdenas, 2001, Renal failure after upper gastrointestinal bleeding in cirrhosis: incidence, clinical course, predictive factors, and short-term prognosis, Hepatology, 34, 671, 10.1053/jhep.2001.27830 Bambha, 2008, Predictors of early re-bleeding and mortality after acute variceal haemorrhage in patients with cirrhosis, Gut, 57, 814, 10.1136/gut.2007.137489 McCormick, 1995, Why portal hypertensive varices bleed and bleed: a hypothesis, Gut, 36, 100, 10.1136/gut.36.1.100 Castañeda, 2000, The role of portal pressure in the severity of bleeding in portal hypertensive rats, Hepatology, 31, 581, 10.1002/hep.510310306 Villanueva, 2001, Somatostatin treatment and risk stratification by continuous portal pressure monitoring during acute variceal bleeding, Gastroenterology, 121, 110, 10.1053/gast.2001.25536 Morales, 2003, Effects of the V1a vasopressin agonist F-180 on portal hypertension-related bleeding in portal hypertensive rats, Hepatology, 38, 1378, 10.1016/j.hep.2003.09.023 Kravetz, 1986, Splanchnic and systemic hemodynamics in portal hypertensive rats during hemorrhage and blood volume restitution, Gastroenterology, 90, 1232, 10.1016/0016-5085(86)90390-2 Castañeda, 2001, Effects of blood volume restitution following a portal hypertensive-related bleeding in anesthetized cirrhotic rats, Hepatology, 33, 821, 10.1053/jhep.2001.23437 Garcia-Tsao, 2007, Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis, Am J Gastroenterol, 102, 2086, 10.1111/j.1572-0241.2007.01481.x Thabut, 2007, Management of acute bleeding from portal hypertension, Best Pract Res Clin Gastroenterol, 21, 19, 10.1016/j.bpg.2006.07.010 Hsu, 2009, Delayed endoscopy as a risk factor for in-hospital mortality in cirrhotic patients with acute variceal hemorrhage, J Gastroenterol Hepatol, 24, 1294, 10.1111/j.1440-1746.2009.05903.x Cheung, 2009, Urgent vs. non-urgent endoscopy in stable acute variceal bleeding, Am J Gastroenterol, 104, 1125, 10.1038/ajg.2009.78 Vivas, 2001, Presence of bacterial infection in bleeding cirrhotic patients is independently associated with early mortality and failure to control bleeding, Dig Dis Sci, 46, 2752, 10.1023/A:1012739815892 Soares-Weiser, 2002, Antibiotic prophylaxis for cirrhotic patients with gastrointestinal bleeding, Cochrane Database Syst Rev, CD002907 Hou, 2004, Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial, Hepatology, 39, 746, 10.1002/hep.20126 Fernández, 2006, Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage, Gastroenterology, 131, 1049, 10.1053/j.gastro.2006.07.010 Bernard, 1999, Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis, Hepatology, 29, 1655, 10.1002/hep.510290608 Rimola, 2000, Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club, J Hepatol, 32, 142, 10.1016/S0168-8278(00)80201-9 Cabrera, 1982, Aminoglycoside nephrotoxicity in cirrhosis. Value of urinary beta 2-microglobulin to discriminate functional renal failure from acute tubular damage, Gastroenterology, 82, 97, 10.1016/0016-5085(82)90129-9 Vinel, 1986, Assessment of short-term prognosis after variceal bleeding in patients with alcoholic cirrhosis by early measurement of portohepatic gradient, Hepatology, 6, 116, 10.1002/hep.1840060122 Levacher, 1995, Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients, Lancet, 346, 865, 10.1016/S0140-6736(95)92708-5 Escorsell, 2000, Multicenter randomized controlled trial of terlipressin versus sclerotherapy in the treatment of acute variceal bleeding: the TEST study, Hepatology, 32, 471, 10.1053/jhep.2000.16601 Møllerr, 2000, Central and systemic haemodynamic effects of terlipressin in portal hypertensive patients, Liver, 20, 51, 10.1034/j.1600-0676.2000.020001051.x Ioannou, 2003, Systematic review: terlipressin in acute oesophageal variceal haemorrhage, Aliment Pharmacol Ther, 17, 53, 10.1046/j.1365-2036.2003.01356.x Moitinho, 2001, Multicenter randomized controlled trial comparing different schedules of somatostatin in the treatment of acute variceal bleeding, J Hepatol, 35, 712, 10.1016/S0168-8278(01)00206-9 Escorsell, 1998, Randomized controlled trial of sclerotherapy versus somatostatin infusion in the prevention of early rebleeding following acute variceal hemorrhage in patients with cirrhosis. Variceal Bleeding Study Group, J Hepatol, 29, 779, 10.1016/S0168-8278(98)80259-6 Villanueva, 1999, Somatostatin alone or combined with emergency sclerotherapy in the treatment of acute esophageal variceal bleeding: a prospective randomized trial, Hepatology, 30, 384, 10.1002/hep.510300222 Escorsell, 2001, Desensitization to the effects of intravenous octreotide in cirrhotic patients with portal hypertension, Gastroenterology, 120, 161, 10.1053/gast.2001.20892 Abraldes, 2002, Somatostatin and analogues in portal hypertension, Hepatology, 35, 1305, 10.1053/jhep.2002.33469 Corley, 2001, Octreotide for acute esophageal variceal bleeding: a meta-analysis, Gastroenterology, 120, 946, 10.1053/gast.2001.22451 Lo, 1997, Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices, Hepatology, 25, 1101, 10.1002/hep.510250509 Laine, 1995, Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis, Ann Intern Med, 123, 280, 10.7326/0003-4819-123-4-199508150-00007 De Franchis, 1999, Endoscopic treatments for portal hypertension, Semin Liver Dis, 19, 439, 10.1055/s-2007-1007131 D’Amico, 2003, Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: a Cochrane meta-analysis, Gastroenterology, 124, 1277, 10.1016/S0016-5085(03)00269-5 Avgerinos, 2004, Sustained rise of portal pressure after sclerotherapy, but not band ligation, in acute variceal bleeding in cirrhosis, Hepatology, 39, 1623, 10.1002/hep.20236 Krag A, Adamsen S, Bendtsen F. Endoscopic treatment of bleeding esophageal varices. Endoscopy 2007;39:373; author reply 4. Avgerinos, 1997, Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: the European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomised trial, Lancet, 350, 1495, 10.1016/S0140-6736(97)05099-X Calès, 2001, Early administration of vapreotide for variceal bleeding in patients with cirrhosis, N Engl J Med, 344, 23, 10.1056/NEJM200101043440104 Bañares, 2002, Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis, Hepatology, 35, 609, 10.1053/jhep.2002.31354 García-Pagán, 2012, Acute variceal bleeding, Semin Respir Crit Care Med, 33, 46, 10.1055/s-0032-1301734 Tripodi, 2009, An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis, Gastroenterology, 137, 2105, 10.1053/j.gastro.2009.08.045 Ejlersen, 2001, Recombinant activated factor VII (rFVIIa) acutely normalizes prothrombin time in patients with cirrhosis during bleeding from oesophageal varices, Scand J Gastroenterol, 36, 1081, 10.1080/003655201750422701 Bosch, 2008, Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: A randomized, controlled trial, Hepatology, 47, 1604, 10.1002/hep.22216 Bosch, 2004, Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial, Gastroenterology, 127, 1123, 10.1053/j.gastro.2004.07.015 Garcia-Pagan, 2012, Use of early-TIPS for high-risk variceal bleeding: Results of a post-RCT surveillance study, J Hepatol Panés, 1988, Efficacy of balloon tamponade in treatment of bleeding gastric and esophageal varices. Results in 151 consecutive episodes, Dig Dis Sci, 33, 454, 10.1007/BF01536031 Cook, 1992, Indications, technique, and complications of balloon tamponade for variceal gastrointestinal bleeding, J Intensive Care Med, 7, 212, 10.1177/088506669200700408 Hubmann, 2006, The use of self-expanding metal stents to treat acute esophageal variceal bleeding, Endoscopy, 38, 896, 10.1055/s-2006-944662 Bureau, 2004, Improved clinical outcome using polytetrafluoroethylene-coated stents for TIPS: results of a randomized study, Gastroenterology, 126, 469, 10.1053/j.gastro.2003.11.016 Boyer, 2008, Cost of preventing variceal rebleeding with transjugular intrahepatic portal systemic shunt and distal splenorenal shunt, J Hepatol, 48, 407, 10.1016/j.jhep.2007.08.014 Garcia-Tsao, 2001, Current management of the complications of cirrhosis and portal hypertension: variceal hemorrhage, ascites, and spontaneous bacterial peritonitis, Gastroenterology, 120, 726, 10.1053/gast.2001.22580 Cello, 1987, Endoscopic sclerotherapy versus portacaval shunt in patient with severe cirrhosis and acute variceal hemorrhage. Long-term follow-up, N Engl J Med, 316, 11, 10.1056/NEJM198701013160103 Huizinga, 1985, Esophageal transection versus injection sclerotherapy in the management of bleeding esophageal varices in patients at high risk, Surg Gynecol Obstet, 160, 539 Teres, 1987, Randomized trial of portacaval shunt, stapling transection and endoscopic sclerotherapy in uncontrolled variceal bleeding, J Hepatol, 4, 159, 10.1016/S0168-8278(87)80075-2 Rikkers, 1993, Variceal hemorrhage: surgical therapy, Gastroenterol Clin North Am, 22, 821, 10.1016/S0889-8553(21)00108-4 Smith, 1980, Dacron interposition shunts for portal hypertension. An analysis of morbidity correlates, Ann Surg, 192, 9, 10.1097/00000658-198007000-00002 Soutter, 1989, Emergency portasystemic shunting in cirrhotics with bleeding varices--a comparison of portacaval and mesocaval shunts, HPB Surg, 1, 107, 10.1155/1989/70865 Villeneuve, 1987, Emergency portacaval shunt for variceal hemorrhage. A prospective study, Ann Surg, 206, 48, 10.1097/00000658-198707000-00007 Rikkers, 1994, Surgical management of acute variceal hemorrhage, World J Surg, 18, 193, 10.1007/BF00294400 Cello, 1982, Endoscopic sclerotherapy versus esophageal transection of Child's class C patients with variceal hemorrhage. Comparison with results of portacaval shunt: preliminary report, Surgery, 91, 333 Burroughs, 1989, A comparison of sclerotherapy with staple transection of the esophagus for the emergency control of bleeding from esophageal varices, N Engl J Med, 321, 857, 10.1056/NEJM198909283211303 Sugiura, 1984, Esophageal transection with paraesophagogastric devascularizations (the Sugiura procedure) in the treatment of esophageal varices, World J Surg, 8, 673, 10.1007/BF01655762 Patch, 1998, Factors related to early mortality after transjugular intrahepatic portosystemic shunt for failed endoscopic therapy in acute variceal bleeding, J Hepatol, 28, 454, 10.1016/S0168-8278(98)80320-6 Orozco, 2000, The evolution of portal hypertension surgery: lessons from 1000 operations and 50 Years’ experience, Arch Surg, 135, 1389, 10.1001/archsurg.135.12.1389 Ryan, 2004, A pathophysiologic, gastroenterologic, and radiologic approach to the management of gastric varices, Gastroenterology, 126, 1175, 10.1053/j.gastro.2004.01.058 Soehendra, 1986, Endoscopic obliteration of large esophagogastric varices with bucrylate, Endoscopy, 18, 25, 10.1055/s-2007-1013014 Yang, 2002, Endoscopic use of human thrombin in bleeding gastric varices, Am J Gastroenterol, 97, 1381, 10.1111/j.1572-0241.2002.05776.x Shiha, 1999, Gastric variceal ligation: a new technique, Gastrointest Endosc, 49, 437, 10.1016/S0016-5107(99)70039-8 Rengstorff, 2004, A pilot study of 2-octyl cyanoacrylate injection for treatment of gastric fundal varices in humans, Gastrointest Endosc, 59, 553, 10.1016/S0016-5107(03)02865-7 Oho, 1995, Ethanolamine oleate versus butyl cyanoacrylate for bleeding gastric varices: a nonrandomized study, Endoscopy, 27, 349, 10.1055/s-2007-1005712 Lo, 2001, A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices, Hepatology, 33, 1060, 10.1053/jhep.2001.24116 Huang, 2000, Endoscopic treatment of bleeding gastric varices by N-butyl-2-cyanoacrylate (Histoacryl) injection: long-term efficacy and safety, Gastrointest Endosc, 52, 160, 10.1067/mge.2000.104976 Chiu, 1997, Endoscopic injection sclerotherapy with 1.5% Sotradecol for bleeding cardiac varices, J Clin Gastroenterol, 24, 161, 10.1097/00004836-199704000-00008 Seewald, 2002, Cyanoacrylate glue in gastric variceal bleeding, Endoscopy, 34, 926, 10.1055/s-2002-35312 Binmoeller, 1995, Superglue”: the answer to variceal bleeding and fundal varices?, Endoscopy, 27, 392, 10.1055/s-2007-1005720 Akahoshi, 2002, Long-term results of endoscopic Histoacryl injection sclerotherapy for gastric variceal bleeding: a 10-year experience, Surgery, 131, S176, 10.1067/msy.2002.119501 Ninoi, 2005, Balloon-occluded retrograde transvenous obliteration of gastric varices with gastrorenal shunt: long-term follow-up in 78 patients, AJR Am J Roentgenol, 184, 1340, 10.2214/ajr.184.4.01841340 Kiyosue, 2003, Transcatheter obliteration of gastric varices. Part 1. Anatomic classification, Radiographics, 23, 911, 10.1148/rg.234025044 Lee, 2000, EUS-guided injection of cyanoacrylate for bleeding gastric varices, Gastrointest Endosc, 52, 168, 10.1067/mge.2000.107911 Pugh, 1973, Transection of the oesophagus for bleeding oesophageal varices, Br J Surg, 60, 646, 10.1002/bjs.1800600817 Sarin, 2001, Gastric varices and portal hypertensive gastropathy, Clin Liver Dis, 5, 727, 10.1016/S1089-3261(05)70190-2 Tan, 2006, A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation, Hepatology, 43, 690, 10.1002/hep.21145 Hwang, 2001, N-butyl-2-cyanoacrylate pulmonary embolism after endoscopic injection sclerotherapy for gastric variceal bleeding, J Comput Assist Tomogr, 25, 16, 10.1097/00004728-200101000-00003 Sarin, 2002, A randomized controlled trial of cyanoacrylate versus alcohol injection in patients with isolated fundic varices, Am J Gastroenterol, 97, 1010, 10.1111/j.1572-0241.2002.05622.x Ramond, 1989, Successful endoscopic obturation of gastric varices with butyl cyanoacrylate, Hepatology, 10, 488, 10.1002/hep.1840100415 Suga, 2002, Actual behaviour of N-butyl-2-cyanoacrylate (histoacryl) in a blood vessel: a model of the varix, Endoscopy, 34, 73, 10.1055/s-2002-19384 Chen, 2001, Bacteremia after endoscopic injection of N-butyl-2-cyanoacrylate for gastric variceal bleeding, Gastrointest Endosc, 54, 214, 10.1067/mge.2001.116566 Stanley, 1997, A comparison between gastric and oesophageal variceal haemorrhage treated with transjugular intrahepatic portosystemic stent shunt (TIPSS), Aliment Pharmacol Ther, 11, 171, 10.1046/j.1365-2036.1997.106277000.x Miyazaki, 1998, Injection sclerotherapy for gastric varices using N-butyl-2-cyanoacrylate and ethanolamine oleate, Hepatogastroenterology, 45, 1155 Greenwald, 2003, N-2-butyl-cyanoacrylate for bleeding gastric varices: a United States pilot study and cost analysis, Am J Gastroenterol, 98, 1982, 10.1111/j.1572-0241.2003.07637.x Zhou, 2002, Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: a controlled study, J Gastroenterol Hepatol, 17, 973, 10.1046/j.1440-1746.2002.02775.x Kamath, 2000, Gastric mucosal responses to intrahepatic portosystemic shunting in patients with cirrhosis, Gastroenterology, 118, 905, 10.1016/S0016-5085(00)70176-4 Gournay, 2000, Isosorbide mononitrate and propranolol compared with propranolol alone for the prevention of variceal rebleeding, Hepatology, 31, 1239, 10.1053/jhep.2000.8106 Yang, 1998, Effect of sucralfate granules in suspension on endoscopic variceal sclerotherapy induced ulcer: analysis of the factors determining ulcer healing, J Gastroenterol Hepatol, 13, 225, 10.1111/j.1440-1746.1998.tb00642.x Polson, 1989, Sucralfate for the prevention of early rebleeding following injection sclerotherapy for esophageal varices, Hepatology, 10, 279, 10.1002/hep.1840100304 Lo, 2000, Endoscopic variceal ligation plus nadolol and sucralfate compared with ligation alone for the prevention of variceal rebleeding: a prospective, randomized trial, Hepatology, 32, 461, 10.1053/jhep.2000.16236 Shaheen, 2005, Pantoprazole reduces the size of postbanding ulcers after variceal band ligation: a randomized, controlled trial, Hepatology, 41, 588, 10.1002/hep.20593 Laine, 1993, Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices, Ann Intern Med, 119, 1, 10.7326/0003-4819-119-1-199307010-00001 Bernard, 1997, Beta-adrenergic antagonists in the prevention of gastrointestinal rebleeding in patients with cirrhosis: a meta-analysis, Hepatology, 25, 63, 10.1002/hep.510250112 De la Peña, 2005, Variceal ligation plus nadolol compared with ligation for prophylaxis of variceal rebleeding: a multicenter trial, Hepatology, 41, 572, 10.1002/hep.20584 Villanueva, 2001, Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding, N Engl J Med, 345, 647, 10.1056/NEJMoa003223 Lo, 2002, Banding ligation versus nadolol and isosorbide mononitrate for the prevention of esophageal variceal rebleeding, Gastroenterology, 123, 728, 10.1053/gast.2002.35351 Patch, 2002, A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis, Gastroenterology, 123, 1013, 10.1053/gast.2002.35955 Grace, 1988, Distal splenorenal vs. portal-systemic shunts after hemorrhage from varices: a randomized controlled trial, Hepatology, 8, 1475, 10.1002/hep.1840080602 Boyer, 2005, The role of transjugular intrahepatic portosystemic shunt in the management of portal hypertension, Hepatology, 41, 386, 10.1002/hep.20559 Papatheodoridis, 1999, Transjugular intrahepatic portosystemic shunt compared with endoscopic treatment for prevention of variceal rebleeding: a meta-analysis, Hepatology, 30, 612, 10.1002/hep.510300316 Escorsell, 2002, TIPS versus drug therapy in preventing variceal rebleeding in advanced cirrhosis: a randomized controlled trial, Hepatology, 35, 385, 10.1053/jhep.2002.30418 Henderson, 2006, Distal splenorenal shunt versus transjugular intrahepatic portal systematic shunt for variceal bleeding: a randomized trial, Gastroenterology, 130, 1643, 10.1053/j.gastro.2006.02.008 Rosemurgy, 2005, H-graft portacaval shunts versus TIPS: ten-year follow-up of a randomized trial with comparison to predicted survivals, Ann Surg, 241, 238, 10.1097/01.sla.0000151884.67600.b6 Pérez-Ayuso, 1991, Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis, Lancet, 337, 1431, 10.1016/0140-6736(91)93125-S Panés, 1993, Effects of propranolol on gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy, Hepatology, 17, 213