Connecting genotypes to medically relevant phenotypes in major vector mosquitoes

WHO, 2014 WHO, 2015, Investing to overcome the global impact of neglected tropical diseases Verhulst, 2011, Improvement of a synthetic lure for Anopheles gambiae using compounds produced by human skin microbiota, Malar J, 10, 28, 10.1186/1475-2875-10-28 Wang, 2013, Genetic approaches to interfere with malaria transmission by vector mosquitoes, Trends Biotechnol, 31, 185, 10.1016/j.tibtech.2013.01.001 Armistead, 2014, Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of Plasmodium falciparum and Plasmodium vivax malaria, Infect Immun, 82, 818, 10.1128/IAI.01222-13 Burt, 2014, Heritable strategies for controlling insect vectors of disease, Philos Trans R Soc Lond B: Biol Sci, 369, 20130432, 10.1098/rstb.2013.0432 Takken, 2013, Host preferences of blood-feeding mosquitoes, Annu Rev Entomol, 58, 433, 10.1146/annurev-ento-120811-153618 Carey, 2010, Odorant reception in the malaria mosquito Anopheles gambiae, Nature, 464, 66, 10.1038/nature08834 Hodges, 2014, Species-specific chemosensory gene expression in the olfactory organs of the malaria vector Anopheles gambiae, BMC Genom, 15, 1089, 10.1186/1471-2164-15-1089 Rinker, 2013, Blood meal-induced changes to antennal transcriptome profiles reveal shifts in odor sensitivities in Anopheles gambiae, Proc Natl Acad Sci, 110, 8260, 10.1073/pnas.1302562110 DeGennaro, 2013, orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET, Nature, 498, 487, 10.1038/nature12206 McMeniman, 2014, Multimodal integration of carbon dioxide and other sensory cues drives mosquito attraction to humans, Cell, 156, 1060, 10.1016/j.cell.2013.12.044 McBride, 2014, Evolution of mosquito preference for humans linked to an odorant receptor, Nature, 515, 222, 10.1038/nature13964 Powell, 2013, History of domestication and spread of Aedes aegypti—a review, Mem Inst Oswaldo Cruz, 108, 11, 10.1590/0074-0276130395 Duchemin, 2001, Zoophily of Anopheles arabiensis and An. gambiae in Madagascar demonstrated by odour-baited entry traps, Med Vet Entomol, 15, 50, 10.1046/j.1365-2915.2001.00276.x Sim, 2014, Mosquito immunity against arboviruses, Viruses, 6, 4479, 10.3390/v6114479 Cirimotich, 2010, Mosquito immune defenses against Plasmodium infection, Dev Comp Immunol, 34, 387, 10.1016/j.dci.2009.12.005 Cohuet, 2006, Anopheles and Plasmodium: from laboratory models to natural systems in the field, EMBO Rep, 7, 1285, 10.1038/sj.embor.7400831 Jaramillo-Gutierrez, 2009, Mosquito immune responses and compatibility between Plasmodium parasites and anopheline mosquitoes, BMC Microbiol, 9, 154, 10.1186/1471-2180-9-154 Aguilar, 2005, Anopheles infection responses; laboratory models versus field malaria transmission systems, Acta Trop, 95, 285, 10.1016/j.actatropica.2005.06.005 Riehle, 2006, Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region, Science, 312, 577, 10.1126/science.1124153 Riehle, 2007, A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae, Malar J, 6, 87, 10.1186/1475-2875-6-87 Niaré, 2002, Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population, Science, 298, 213, 10.1126/science.1073420 Povelones, 2011, Structure–function analysis of the Anopheles gambiae LRIM1/APL1C complex and its interaction with complement C3-like protein TEP1, PLoS Pathog, 7, e1002023, 10.1371/journal.ppat.1002023 Fraiture, 2009, Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium, Cell Host Microbe, 5, 273, 10.1016/j.chom.2009.01.005 Mitri, 2009, Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species, PLoS Pathog, 5, e1000576, 10.1371/journal.ppat.1000576 Harris, 2010, Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum, PLoS Pathog, 6, e1001112, 10.1371/journal.ppat.1001112 Lambrechts, 2005, Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum, Malar J, 4, 3, 10.1186/1475-2875-4-3 Sangare, 2013, Studying fitness cost of Plasmodium falciparum infection in malaria vectors: validation of an appropriate negative control, Malar J, 12, 2, 10.1186/1475-2875-12-2 Ferguson, 2002, Why is the effect of malaria parasites on mosquito survival still unresolved?, Trends Parasitol, 18, 256, 10.1016/S1471-4922(02)02281-X White, 2011, Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodium, Proc Natl Acad Sci USA, 108, 244, 10.1073/pnas.1013648108 Gnémé, 2013, Equivalent susceptibility of Anopheles gambiae M and S molecular forms and Anopheles arabiensis to Plasmodium falciparum infection in Burkina Faso, Malar J, 12, 204, 10.1186/1475-2875-12-204 Ndiath, 2008, Dynamics of transmission of Plasmodium falciparum by Anopheles arabiensis and the molecular forms M and S of Anopheles gambiae in Dielmo, Senegal, Malar J, 7, 136, 10.1186/1475-2875-7-136 Ndiath, 2011, Comparative susceptibility to Plasmodium falciparum of the molecular forms M and S of Anopheles gambiae and Anopheles arabiensis, Malar J, 10, 269, 10.1186/1475-2875-10-269 Mendes, 2008, Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa, PLoS Pathog, 4, e1000069, 10.1371/journal.ppat.1000069 Dinglasan, 2007, Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion, Proc Natl Acad Sci USA, 104, 15882, 10.1073/pnas.0706340104 Vega-Rodriguez, 2014, Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut, Proc Natl Acad Sci USA, 111, E492, 10.1073/pnas.1315517111 Oliveira, 2012, Epithelial nitration by a peroxidase/NOX5 system mediates mosquito antiplasmodial immunity, Science, 335, 856, 10.1126/science.1209678 Malaria Genomic Epidemiology Network, 2014, Reappraisal of known malaria resistance loci in a large multicenter study, Nat Genet, 46, 1197, 10.1038/ng.3107 Doolan, 2009, Acquired immunity to malaria, Clin Microbiol Rev, 22, 13, 10.1128/CMR.00025-08 Molina-Cruz, 2013, The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system, Science, 340, 984, 10.1126/science.1235264 Ramphul, 2014, Plasmodium falciparum evades mosquito immunity by disrupting JNK-mediated apoptosis of invaded midgut cells, Proc Natl Acad Sci USA Luijckx, 2013, A matching-allele model explains host resistance to parasites, Curr Biol, 23, 1085, 10.1016/j.cub.2013.04.064 Tabachnick, 2013, Nature, nurture and evolution of intra-species variation in mosquito arbovirus transmission competence, Int J Environ Res Public Health, 10, 249, 10.3390/ijerph10010249 Lambrechts, 2013, Specificity of resistance to dengue virus isolates is associated with genotypes of the mosquito antiviral gene Dicer-2, Proc Biol Sci, 280, 20122437, 10.1098/rspb.2012.2437 Fansiri, 2013, Genetic mapping of specific interactions between Aedes aegypti mosquitoes and dengue viruses, PLoS Genet, 9, e1003621, 10.1371/journal.pgen.1003621 Lambrechts, 2009, Genetic specificity and potential for local adaptation between dengue viruses and mosquito vectors, BMC Evol Biol, 9, 160, 10.1186/1471-2148-9-160 Zouache, 2014, Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential, Proc Biol Sci, 281 Dennison, 2014, The mosquito microbiota influences vector competence for human pathogens, Curr Opin Insect Sci, 3, 6, 10.1016/j.cois.2014.07.004 Moreira, 2009, A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium, Cell, 139, 1268, 10.1016/j.cell.2009.11.042 Walker, 2011, The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations, Nature, 476, 450, 10.1038/nature10355 Hoffmann, 2011, Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission, Nature, 476, 454, 10.1038/nature10356 Cirimotich, 2011, Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae, Science, 332, 855, 10.1126/science.1201618 Kambris, 2009, Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes, Science, 326, 134, 10.1126/science.1177531 Stathopoulos, 2014, Genetic dissection of Anopheles gambiae gut epithelial responses to Serratia marcescens, PLoS Pathog, 10, e1003897, 10.1371/journal.ppat.1003897 Neafsey, 2015, Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes, Science, 347, 1258522, 10.1126/science.1258522 Lawniczak, 2010, Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences, Science, 330, 512, 10.1126/science.1195755 Fontaine, 2015, Mosquito genomics. Extensive introgression in a malaria vector species complex revealed by phylogenomics, Science, 347, 1258524, 10.1126/science.1258524 Chandler, 2013, Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution, Trends Genet, 29, 358, 10.1016/j.tig.2013.01.009 Turissini, 2014, Genome-wide patterns of polymorphism in an inbred line of the African malaria mosquito Anopheles gambiae, Genome Biol Evol, 6, 3094, 10.1093/gbe/evu243 Rockman, 2012, The QTN program and the alleles that matter for evolution: all that's gold does not glitter, Evolution, 66, 1, 10.1111/j.1558-5646.2011.01486.x Teslovich, 2010, Biological, clinical and population relevance of 95 loci for blood lipids, Nature, 466, 707, 10.1038/nature09270 Lander, 2011, Initial impact of the sequencing of the human genome, Nature, 470, 187, 10.1038/nature09792 Gatton, 2013, The importance of mosquito behavioural adaptations to malaria control in Africa, Evolution, 67, 1218, 10.1111/evo.12063 Anderson, 2000, Plasmodium falciparum sporozoites increase feeding-associated mortality of their mosquito hosts Anopheles gambiae s.l, Parasitology, 120, 329, 10.1017/S0031182099005570 Lehmann, 2008, The molecular forms of Anopheles gambiae: a phenotypic perspective, Infect Genet Evol, 8, 737, 10.1016/j.meegid.2008.06.003 Lehmann, 2010, Aestivation of the African malaria mosquito, Anopheles gambiae in the Sahel, Am J Trop Med Hyg, 83, 601, 10.4269/ajtmh.2010.09-0779 Dao, 2014, Signatures of aestivation and migration in Sahelian malaria mosquito populations, Nature, 10.1038/nature13987 Fialho, 1995, Thermal ecology of a malarial parasite and its insect vector: consequences for the parasite's transmission success, J Anim Ecol, 64, 553, 10.2307/5799 Boete, 2004, Direct and indirect immunosuppression by a malaria parasite in its mosquito vector, Proc Roy Soc B: Biol Sci, 271, 1611, 10.1098/rspb.2004.2762 Alout, 2014, Interplay between plasmodium infection and resistance to insecticides in vector mosquitoes, J Infect Dis, 10.1093/infdis/jiu276 Sharma, 2014, Salivary glands harbor more diverse microbial communities than gut in Anopheles culicifacies, Parasit Vectors, 7, 235, 10.1186/1756-3305-7-235 Murdock, 2012, Rethinking vector immunology: the role of environmental temperature in shaping resistance, Nat Rev Microbiol, 10, 869, 10.1038/nrmicro2900 Smith, 2014, Recasting the theory of mosquito-borne pathogen transmission dynamics and control, Trans R Soc Trop Med Hyg, 108, 185, 10.1093/trstmh/tru026 Godfray, 2013, Mosquito ecology and control of malaria, J Anim Ecol, 82, 15, 10.1111/1365-2656.12003