Conduction block of whole nerve without onset firing using combined high frequency and direct current

D. Michael Ackermann1,2, Niloy Bhadra1,2, Emily Foldes1, Kevin L. Kilgore1,3,2
1Case Western Reserve University, Cleveland USA
2MetroHealth Medical Center, Cleveland, USA
3Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, USA

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Ackermann D, Foldes E, Bhadra N, Kilgore K (2009) Effect of bipolar cuff electrode design on block thresholds in high frequency electrical neural conduction block. IEEE Trans Neural Syst Rehabil Eng 17:469–477

Ackermann D, Foldes E, Bhadra N, Kilgore K (2009) Electrode design for high frequency block: effect of bipolar separation on block thresholds and onset activity. In: Conference proceedings: annual international conference of the IEEE Engineering in Medicine and Biology Society

Ackermann D, Foldes E, Bhadra N, Kilgore K (2010) Conduction block of peripheral nerve using high frequency alternating currents delivered through an intrafascicular electrode. Muscle Nerve 41(1):117–119

Ackermann D, Bhadra N, Foldes E, Kilgore K (2010) Effect of nerve cuff electrode geometry on onset response firing in conduction block of whole nerve using high frequency alternating currents. IEEE Trans Neural Syst Rehabil Eng (in press)

Beebe X, Rose TL (1988) Charge injection limits of activated iridium oxide electrodes with 0.2 ms pulses in bicarbonate buffered saline (neurological stimulation application). IEEE Trans Biomed Eng 35:494–495

Bergamini CM (2004) Oxygen, reactive oxygen species and tissue damage. Curr Pharm Des 10:1611

Bhadra N, Kilgore KL (2004) Direct current electrical conduction block of peripheral nerve. IEEE Trans Neural Syst Rehabil Eng 12:313

Bhadra N, Kilgore KL (2005) High-frequency electrical conduction block of mammalian peripheral motor nerve. Muscle Nerve 32:782

Bhadra N, Bhadra N, Kilgore K, Gustafson KJ (2006) High frequency electrical conduction block of the pudendal nerve. J Neural Eng 3:180

Boger A, Bhadra N, Gustafson KJ (2008) Bladder voiding by combined high frequency electrical pudendal nerve block and sacral root stimulation. Neurourol Urodyn 27:435

Bowman B, McNeal D (1986) Response of single alpha motorneurons to high-frequency pulse trains. Appl Neurophysiol 49:121–138

Brindley GS (1980) A technique for anodally blocking large nerve fibres through chronically implanted electrodes. J Neurol Neurosurg 43:1083

Casey KL, Blick M (1969) Observations on anodal polarization of cutaneous nerve. Brain Res 13:155

ElBasiouny SM, Mushahwar VK (2007) Modulation of motoneuronal firing behavior after spinal cord injury using intraspinal microstimulation current pulses: a modeling study. J Appl Physiol 103:276–286

Foldes E, Ackermann D, Bhadra N, Kilgore K (2009) Counted cycles method to quantify the onset activity in high-frequency peripheral nerve block. In: Conference proceedings: annual international conference of the IEEE Engineering in Medicine and Biology Society, pp 614–617

Gaunt R, Prochazka A (2009) Transcutaneously coupled, high-frequency electrical stimulation of the pudendal nerve blocks external urethral sphincter contractions. Neurorehabil Neural Repair 23:615

Goldman L, Albus J (1968) Computation of impulse conduction in myelinated fibers: theoretical basis of the velocity-diameter relation. Biophys J 8:596–607

Guyton DL (1974) Theory and design of capacitor electrodes for chronic stimulation. Medical 12:613

Guz A (1971) The role of non-myelinated vagal afferent fibres from the lungs in the genesis of tachypnoea in the rabbit. J Physiol (Paris) 213:345

Hennings K (2005) Orderly activation of human motor neurons using electrical ramp prepulses. Clin Neurophysiol 116:597

Joseph L, Haeffele BD, Butera RJ (2007) Conduction block induced by high frequency AC stimulation in unmyelinated nerves. In: Conference proceedings: annual international conference of the IEEE Engineering in Medicine and Biology Society, vol 2007, pp 1719

Karu ZZ, Durfee WK, Barzilai AM (1995) Reducing muscle fatigue in FES applications by stimulating with N-let pulse trains. IEEE Trans Biomed Eng 42:809

Kilgore K, Bhadra N (2004) Nerve conduction block utilizing high-frequency alternating current. Med Biol Eng Comput 42:394–406

Kilgore K, Foldes E, Ackermann D, Bhadra N (2009) Combined direct current and high frequency nerve block for elimination of the onset response. Presented at Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Kuffler SW (1947) The small-nerve motor system to skeletal muscle. J Neurophysiol 10:383

Kuffler SW (1953) Small-nerve junctional potentials. The distribution of small motor nerves to frog skeletal muscle, and the membrane characteristics of the fibres they innervate. J Physiol (Paris) 121:289

Manfredi M (1970) Differential block of conduction of larger fibers in peripheral nerve by direct current. Arch Ital Biol 108:52

McCloskey DI (1972) Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol (Paris) 224:173

Merrill D (2005) Electrical stimulation of excitable tissue: design of efficacious and safe protocols. J Neurosci Methods 141:171

Miles JD, Kilgore K, Bhadra N, Lahowetz E (2007) Effects of ramped amplitude waveforms on the onset response of high-frequency mammalian nerve block. J Neural Eng 4:390

Petruska JC, Hubscher CH, Johnson RD (1998) Anodally focused polarization of peripheral nerve allows discrimination of myelinated and unmyelinated fiber input to brainstem nuclei. Exp Brain Res Experimentelle Hirnforschung Experimentation Cerebrale 121:379

Pflüger E (1858) Untersuchungen Uber die Physiologie des Electrotonus. Hirschwald, Berlin

Rosenblueth A, Reboul J (1939) The blocking and deblocking effects of alternating currents on nerve. Am J Physiol 125:251–264

Sassen M, Zimmermann M (1973) Differential blocking of myelinated nerve fibres by transient depolarization. Pflugers Arch 341:179

Scheiner A, Mortimer J, Roessmann U (1990) Imbalanced biphasic electrical stimulation: muscle tissue damage. Ann Biomed Eng 18:407–425

Schmalbruch H (1986) Fiber composition of the rat sciatic nerve. Anat Rec 215:71

Sweeney JD, Mortimer JT (1986) An asymmetric two electrode cuf for generation of unidirectionally propagated action potentials. IEEE Trans Biomed Eng BME-33:541–549

Tai C, Roppolo JR, de Groat WC (2004) Block of external urethral sphincter contraction by high frequency electrical stimulation of pudendal nerve. J Urol 172:2069–2072

Van Den Honert C, Mortimer JT (1981) A technique for collision block of peripheral nerve: single stimulus analysis. IEEE Trans Biomed Eng BME-28:373

Whitwam JG, Kidd C (1975) The use of direct current to cause selective block of large fibres in peripheral nerves. Br J Anaesth 47:1123

Williamson RP, Andrews BJ (2005) Localized electrical nerve blocking. IEEE Trans Biomed Eng 52:362

Woo MY, Campbell B (1964) Asynchronous firing and block of peripheral nerve conduction by 20 kC alternating current. Bull Los Angel Neurol Soc 29:87

Zimmermann M (1968) Selective activation of C-fibers. Pflugers Arch 301:329